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11. 发明申请

WO2002102971A2 METHODS OF UTILIZING CULTURED HEMATOPOIETIC PROGENITOR CELLS FOR INDUCING IMMUNOLOGICAL TOLERANCE 审中-公开
标题翻译：利用培养的HEMATOPOIETIC PROGENITOR细胞诱导免疫耐受性的方法
公开(公告)号：WO2002102971A2
公开(公告)日：2002-12-27
申请号：PCT/IL2002/000476
申请日：2002-06-18
申请人： YEDA RESEARCH AND DEVELOPMENT CO. LTD. , REISNER, Yair
发明人： REISNER, Yair
IPC分类号： C12N
CPC分类号： A61K39/001 , A61K39/0008 , A61K2035/122 , A61K2035/124 , A61K2039/515
摘要： A method of inducing tolerance to a transplant transplanted from a donor to a recipient is disclosed. The method comprises (a) culturing a hematopoietic progenitor cell (HPC) population under growth conditions suitable for inducing or enhancing veto activity in at least a portion of the HPC population, thereby generating a tolerance-inducing cell population; and (b) administering a dose of the tolerance-inducing cell population prior to, concomitantly with or following transplantation of the transplant, thereby inducing tolerance to the transplant in the recipient.
摘要翻译：公开了一种诱导从供体到接受者的移植过程的耐受性的方法。该方法包括（a）在适于在HPC群体的至少一部分中诱导或增强否决权活性的生长条件下培养造血祖细胞（HPC）群体，从而产生耐受诱导细胞群体; 和（b）在移植之前，伴随或移植后施用一定剂量的耐受诱导细胞群，从而诱导接受者移植的耐受性。

12. 发明申请

WO2006077592A3 THERAPEUTIC TRANSPLANTATION USING DEVELOPING, HUMAN OR PORCINE, RENAL OR HEPATIC, GRAFTS 审中-公开
公开(公告)号：WO2006077592A3
公开(公告)日：2006-07-27
申请号：PCT/IL2006/000085
申请日：2006-01-19
申请人： YEDA RESEARCH AND DEVELOPMENT CO. LTD. , REISNER, Yair , DEKEL, Benjamin , EVENTOV-FRIEDMAN, Smadar , KATCHMAN, Helena , SHEZEN, Elias , ARONOVICH, Anna , TCHORSH, Dalit
发明人： REISNER, Yair , DEKEL, Benjamin , EVENTOV-FRIEDMAN, Smadar , KATCHMAN, Helena , SHEZEN, Elias , ARONOVICH, Anna , TCHORSH, Dalit
IPC分类号： A61K35/23 , A61K35/407
摘要： A method of treating a renal, hepatic or enzyme-deficiency disorder in a subject in need thereof is disclosed. The method is effected by transplanting into the subject tissue derived from a human or porcine, kidney or liver, the kidney or liver being at a selected gestational stage.

13. 发明申请

WO2004078022A2 METHODS OF TREATING DISEASE BY TRANSPLANTATION OF DEVELOPING ALLOGENEIC OR XENOGENEIC ORGANS OR TISSUES 审中-公开
标题翻译：通过转运发育异源性或发育性器官或组织来治疗疾病的方法
公开(公告)号：WO2004078022A2
公开(公告)日：2004-09-16
申请号：PCT/IL2004/000217
申请日：2004-03-04
申请人： YEDA RESEARCH AND DEVELOPMENT CO. LTD , REISNER, Yair , DEKEL, Benjamin
发明人： REISNER, Yair , DEKEL, Benjamin
IPC分类号： A61B
CPC分类号： A61K39/001 , A61K35/12 , A61K38/1774 , A61K2039/55 , C12N5/0648 , C12N5/065 , C12N5/0651 , C12N5/0657 , C12N5/067 , C12N5/0676 , C12N5/0686 , G01N2800/245
摘要： A method of treating a disorder associated with pathological organ or tissue physiology or morphology is disclosed. The method is effected by transplanting into a subject in need thereof a therapeutically effective mammalian organ or tissue graft selected not substantially expressing or presenting at least one molecule capable of stimulating or enhancing an immune response in the subject.
摘要翻译：公开了治疗与病理器官或组织生理学或形态相关的病症的方法。该方法通过将有希望的哺乳动物器官或组织移植到需要的受试者中来实现，所述哺乳动物器官或组织移植物基本上不表达或呈递至少一种能够刺激或增强受试者的免疫应答的分子。

14. 发明申请

WO2003022123A3 METHODS OF KIDNEY TRANSPLANTATION UTILIZING DEVELOPING NEPHRIC TISSUE 审中-公开
公开(公告)号：WO2003022123A3
公开(公告)日：2003-03-20
申请号：PCT/IL2002/000722
申请日：2002-09-01
申请人： YEDA RESEARCH AND DEVELOPMENT CO. LTD. , REISNER, Yair , DEKEL, Benjamin
发明人： REISNER, Yair , DEKEL, Benjamin
IPC分类号： C12N5/00
摘要： A method of treating a kidney disease in a subject is disclosed. The method is effected by transplanting into the subject a graft of nephric tissue at a predetermined developmental stage thereby treating the kidney disease in the subject.

15. 发明申请

WO2018002924A1 VETO CELLS GENERATED FROM MEMORY T CELLS 审中-公开
标题翻译：记忆T细胞产生的VETO细胞
公开(公告)号：WO2018002924A1
公开(公告)日：2018-01-04
申请号：PCT/IL2017/050716
申请日：2017-06-27
申请人： YEDA RESEARCH AND DEVELOPMENT CO. LTD.
发明人： REISNER, Yair , OR-GEVA, Noga , GIDRON BUDOVSKY, Rotem , BACHAR-LUSTIG, Esther , LASK, Assaf , KAGAN, Sivan
IPC分类号： C12N5/0783 , A61K39/00 , A61K35/12 , A01K67/00
摘要： A method of generating an isolated population of non graft versus host disease (GvHD) inducing cells comprising a central memory T-lymphocyte (Tcm) phenotype, the cells being tolerance inducing cells and/or endowed with anti-disease activity, and capable of homing to the lymph nodes following transplantation is disclosed. The method comprising: (a) providing a population of at least 70 % memory T cells; (b) contacting the population of memory T cells with an antigen or antigens so as to allow enrichment of antigen reactive cells; and (c) culturing the cells resulting from step (b) in the presence of cytokines so as to allow proliferation of cells comprising the Tcm phenotype. Cells generated by the method, pharmaceutical compositions and methods of treatment are also disclosed.
摘要翻译：产生包含中央记忆T淋巴细胞（Tcm）表型的分离的非移植物抗宿主病（GvHD）细胞群的方法，所述细胞为耐受诱导细胞和/或赋予抗 - 疾病活动，并且能够在移植后归巢至淋巴结。该方法包括：（a）提供至少70％记忆T细胞的群体; （b）使记忆T细胞群体与一种或多种抗原接触以便富集抗原反应性细胞; 和（c）在存在细胞因子的情况下培养步骤（b）产生的细胞，以允许包含Tcm表型的细胞增殖。还公开了由该方法产生的细胞，药物组合物和治疗方法。

16. 发明申请

WO2017203520A1 METHODS OF USING PULMONARY CELLS FOR TRANSPLANTATION AND INDUCTION OF TOLERANCE 审中-公开
标题翻译：使用肺细胞移植和诱导耐受的方法
公开(公告)号：WO2017203520A1
公开(公告)日：2017-11-30
申请号：PCT/IL2017/050569
申请日：2017-05-22
申请人： YEDA RESEARCH AND DEVELOPMENT CO. LTD.
发明人： REISNER, Yair , HILLEL-KARNIEL, Carmit , ROSEN, Chava , BACHAR-LUSTIG, Esther , SHEZEN, Elias
IPC分类号： A61K35/42 , A61P11/00
摘要： A method of treating a pulmonary disorder or injury in a subject in need thereof is disclosed. The method comprising administering to the subject non-syngeneic pulmonary tissue cells in suspension comprising an effective amount of hematopoietic precursor cells (HPCs) or supplemented with HPCs, wherein the effective amount is a sufficient amount to achieve tolerance to the pulmonary tissue cells in the absence of chronic immunosuppressive regimen. A method of inducing donor specific tolerance in a subject in need of a pulmonary cell or tissue transplantation is also disclosed.
摘要翻译：公开了一种治疗有需要的受试者的肺部病症或损伤的方法。所述方法包括向所述对象施用包含有效量的造血前体细胞（HPC）或补充有HPC的悬浮液中的非同基因肺组织细胞，其中所述有效量足以在不存在的情况下实现对肺组织细胞的耐受性慢性免疫抑制治疗方案。还公开了在需要肺细胞或组织移植的受试者中诱导供体特异性耐受的方法。

17. 发明申请

WO1994027556A2 ANIMAL MODEL FOR HEPATITIS VIRUS INFECTION 审中-公开
标题翻译：用于感染乙型肝炎病毒的动物模型
公开(公告)号：WO1994027556A2
公开(公告)日：1994-12-08
申请号：PCT/US1994005410
申请日：1994-05-13
申请人： YEDA RESEARCH AND DEVELOPMENT CO. LTD. , DAGAN, Shlomo
发明人： YEDA RESEARCH AND DEVELOPMENT CO. LTD. , DAGAN, Shlomo , REISNER, Yair
IPC分类号： A61K00/00
CPC分类号： A61K35/28 , A01K67/0271 , A61K35/38 , A61K35/407 , C07K16/109
摘要： A non-human chimeric animal useful as a model for human HV infection, comprising a mammal M5 having xenogeneic cells; mammal M5 being derived from a mammal M1 treated to substantially destroy its hematopoietic cells and then transplanted with hematopoietic cells derived from one or more mammals M2 and transplanted with liver tissue from a mammal M3, the one or more mammals M2 and mammal M3 being from the same or from a different species; the transplanted hematopoietic cells from the one or more mammals M2 being either one or both of a hematopoietic cell preparation from a T cell deficient mammal or of a T cell depleted mammalian stem cell or bone marrow preparation; the transplanted liver tissue from mammal M3 being either a human liver tissue preparation or a liver tissue preparation from a non-human mammal capable of being infected by HV; the liver tissue preparation in the M5 mammal being infected by HV.
摘要翻译：可用作人HV感染模型的非人嵌合动物，其包含具有异种细胞的哺乳动物M5; 哺乳动物M5衍生自被治疗以基本上破坏其造血细胞并随后从源自一种或多种哺乳动物M2并从哺乳动物M3移植到肝组织的造血细胞移植的哺乳动物M1，一种或多种哺乳动物M2和哺乳动物M3来自相同或不同的物种; 来自一种或多种哺乳动物M2的移植的造血细胞是来自T细胞缺陷型哺乳动物或T细胞缺失的哺乳动物干细胞或骨髓制剂的造血细胞制剂中的一种或两种; 来自哺乳动物M3的移植的肝组织是人肝组织制剂或能够被HV感染的非人哺乳动物的肝组织制剂; M5哺乳动物的肝组织制剂被HV感染。

18. 发明申请

WO2017042816A1 ABLATION OF PERFORIN POSITIVE DENDRITIC CELLS IN CANCER TREATMENT 审中-公开
标题翻译：在癌症治疗中执行阳性细胞的排列
公开(公告)号：WO2017042816A1
公开(公告)日：2017-03-16
申请号：PCT/IL2016/051003
申请日：2016-09-08
申请人： YEDA RESEARCH AND DEVELOPMENT CO. LTD.
发明人： REISNER, Yair , ZLOTNIKOV KLIONSKY, Yael , NATHANSOHN-LEVI, Bar , YARIMI, Liran , KAGAN, Sivan
IPC分类号： C12N5/00 , A61K39/395 , A61P35/00 , A61K47/48
CPC分类号： C12N5/064 , A01K67/0271 , A01K2267/0331 , A01K2267/0368 , A61K39/0008 , A61K2039/5154 , C12N2501/02 , C12N2501/04 , C12N2501/125 , C12N2501/145 , C12N2501/22 , C12N2501/2303 , C12N2501/2306 , C12N2501/26 , C12N2501/71
摘要： A method of treating a malignant disease in a subject in need thereof is disclosed. The method comprises subjecting cells of the subject to a therapeutically effective amount of an agent capable of ablating Perforin positive dendritic cells (Perf+ DCs) of the subject, thereby treating the malignant disease.
摘要翻译：公开了在有需要的受试者中治疗恶性疾病的方法。该方法包括使受试者的细胞经受治疗有效量的能够消融受试者的Perforin阳性树突细胞（Perf + DCs）的试剂，从而治疗恶性疾病。

19. 发明申请

WO2013093920A2 A COMBINATION THERAPY FOR A STABLE AND LONG TERM ENGRAFTMENT 审中-公开
标题翻译：用于稳定和长期整合的组合治疗
公开(公告)号：WO2013093920A2
公开(公告)日：2013-06-27
申请号：PCT/IL2012/050542
申请日：2012-12-20
申请人： YEDA RESEARCH AND DEVELOPMENT CO. LTD.
发明人： REISNER, Yair , BACHAR-LUSTIG, Esther
IPC分类号： A61K35/18
CPC分类号： A61K35/28 , A61K31/198 , A61K31/255 , A61K31/661 , A61K31/675 , A61K31/7076 , A61K35/22 , A61K35/34 , A61K35/36 , A61K35/38 , A61K35/39 , A61K35/407 , A61K35/42 , A61K39/3955 , A61K2035/124 , A61K2039/507 , A61K2039/515 , C12N5/0087 , A61K2300/00
摘要： A method of treating a subject in need of a non-syngeneic cell or tissue graft is disclosed. The method comprising: (a) transplanting into a subject a dose of T cell depleted immature hematopoietic cells, wherein the T cell depleted immature hematopoietic cells comprise less than 5 x 105 CD3+ T cells per kilogram body weight of the subject, and wherein the dose comprises at least about 5 x 106 CD34+ cells per kilogram body weight of the subject; and subsequently (b) administering to the subject a therapeutically effective amount of cyclophosphamide, wherein the therapeutically effective amount comprises 25-200 mg per kilogram body weight, thereby treating the subject.
摘要翻译：公开了一种治疗需要非同基因细胞或组织移植物的受试者的方法。所述方法包括：（a）向受试者移植剂量的T细胞耗尽的未成熟造血细胞，其中所述T细胞耗尽的未成熟造血细胞每个体重每公斤体重小于5×10 5个CD3 + T细胞，其中所述剂量包括至少约5×10 6个CD34 +细胞/每公斤体重的受试者; 并且随后（b）向受试者施用治疗有效量的环磷酰胺，其中治疗有效量包含25-200mg /千克体重，从而治疗受试者。

20. 发明申请

WO2013093919A2 A COMBINATION THERAPY FOR A STABLE AND LONG TERM ENGRAFTMENT USING SPECIFIC PROTOCOLS FOR T/B CELL DEPLETION 审中-公开
标题翻译：使用特定协议对T / B细胞去除的稳定和长期植入的组合治疗
公开(公告)号：WO2013093919A2
公开(公告)日：2013-06-27
申请号：PCT/IL2012/050541
申请日：2012-12-20
申请人： YEDA RESEARCH AND DEVELOPMENT CO. LTD.
发明人： REISNER, Yair , BACHAR-LUSTIG, Esther
IPC分类号： A61K35/18
CPC分类号： A61K35/28 , A61K31/198 , A61K31/255 , A61K31/661 , A61K31/675 , A61K31/7076 , A61K35/22 , A61K35/34 , A61K35/36 , A61K35/38 , A61K35/39 , A61K35/407 , A61K35/42 , A61K39/3955 , A61K2035/124 , A61K2039/507 , A61K2039/515 , C12N5/0087 , A61K2300/00
摘要： A method of treating a subject in need of a non-syngeneic cell or tissue graft is disclosed. The method comprising: (a) transplanting into a subject a dose of T cell depleted immature hematopoietic cells, wherein the T cell depleted immature hematopoietic cells comprise less than 5 x 105 CD3+ T cells per kilogram body weight of the subject, and wherein the dose comprises at least about 5 x 106 CD34+ cells per kilogram body weight of the subject, and wherein the T cell depleted immature hematopoietic cells are obtained by separating the T cells from the immature hematopoietic cells, by a method comprising: (i) adding an antibody to the immature hematopoietic cells that specifically binds to a surface marker, wherein the antibody is labeled with a magnetically responsive agent; (ii) immobilizing the immature hematopoietic cells specifically bound to the antibody labeled with the magnetically responsive agent in a matrix through a magnetic field; (iii) washing the matrix to remove unbound cells; and (iv) removing the magnetic field to elute bound cells from the matrix; and subsequently (b) administering to the subject a therapeutically effective amount of cyclophosphamide, wherein the therapeutically effective amount comprises 25-200 mg per kilogram body weight, thereby treating the subject.
摘要翻译：公开了一种治疗需要非同基因细胞或组织移植物的受试者的方法。所述方法包括：（a）向受试者移植剂量的T细胞耗尽的未成熟造血细胞，其中所述T细胞耗尽的未成熟造血细胞每个体重每公斤体重小于5×10 5个CD3 + T细胞，其中所述剂量包括至少约5×10 6个CD34 +细胞/千克体重的受试者，并且其中所述T细胞耗尽的未成熟造血细胞是通过从未成熟的造血细胞中分离T细胞获得的，方法包括：（i）涉及特异性结合表面标志物的未成熟造血细胞，其中所述抗体用磁性响应剂标记; （ii）通过磁场将特异性结合于用磁响应剂标记的抗体的未成熟造血细胞固定在基质中; （iii）洗涤基质以除去未结合的细胞; 和（iv）去除磁场以从基质中洗脱结合的细胞; 并且随后（b）向受试者施用治疗有效量的环磷酰胺，其中治疗有效量包含25-200mg /千克体重，从而治疗受试者。

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