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11. 发明授权

US08827991B2 Medical laser treatment device and method utilizing total reflection induced by radiation 有权
标题翻译：医疗激光治疗装置及利用辐射引起的全反射的方法
公开(公告)号：US08827991B2
公开(公告)日：2014-09-09
申请号：US12756010
申请日：2010-04-07
申请人： Wolfgang Neuberger , Walter Cecchetti
发明人： Wolfgang Neuberger , Walter Cecchetti
IPC分类号： A61B18/18
CPC分类号： A61B18/22 , A61B2017/00274 , A61B2018/00005 , A61B2018/00547 , A61B2018/2272 , A61B2018/2288
摘要： A device for improved surgical procedures to remove unwanted or hyperplasic tissue from a patient during laser ablation, urological treatments, benign prostatic hyperplasia treatments and other applications. Specially prepared optical waveguide tips allow for enhanced irradiation of desired tissues with light sources including laser diodes, bright LEDs or lamps. A significant fraction of the optical radiation, being transported in the waveguide, is coupled out of the waveguide into the surrounding medium through a peripheral surface at or near the distal end. The optical radiation is chosen to have an appropriate wavelength and sufficient power density, so that the surrounding medium will be changed in the vicinity of at least a part of the peripheral surface area. The changes of the surrounding medium result in a change of its refractive index such that the optical radiation is redirected.
摘要翻译：一种用于在激光消融，泌尿系统治疗，良性前列腺增生治疗和其他应用中从患者中去除不需要的或超增生组织的外科手术的装置。特别制备的光波导尖端允许用包括激光二极管，亮LED或灯的光源对所需组织进行增强的照射。在波导中传输的光辐射的很大一部分通过远端处或附近的外围表面耦合到波导外部到周围介质中。选择光辐射具有适当的波长和足够的功率密度，使得周围介质将在周边表面区域的至少一部分附近改变。周围介质的变化导致其折射率的变化，使得光辐射被重定向。

12. 发明授权

US08721631B2 Twister fiber optic systems and their use in medical applications 有权
标题翻译：扭转光纤系统及其在医疗应用中的应用
公开(公告)号：US08721631B2
公开(公告)日：2014-05-13
申请号：US12714155
申请日：2010-02-26
申请人： Wolfgang Neuberger
发明人： Wolfgang Neuberger
IPC分类号： A61B18/16
CPC分类号： A61B18/22 , A61B2018/0019 , A61B2018/1861 , A61B2018/2211 , A61B2018/2272 , A61B2018/2288
摘要： An improved device and method for safe, accurate and efficient surgical procedures are disclosed. The disclosed device is an optical fiber set with an asymmetric distal end configuration, comprising a bent tip fiber with a fused sleeve as an integral part of it, placed at the fiber's distal (output) end and with a rotatable connector at the proximal (input) side. Fiber tip and tissue-contacting surface located at the distal end of the tip may be constructed with different shape configurations, such as convex tip to improve focusing characteristics, concave tip to achieve diverging irradiation or an expanded beam tip to achieve an effect similar to that obtained by electrosurgical tools. A grip guarantees and enhances the ability to twist and rotate it easily. In another preferred embodiment, twisting maneuvers are enhanced through a special configuration. Both special features (bent tip and rotatable connector), allow for improved and enhanced treatment of diverse pathologies, making possible to efficiently and easily reach and treat specific tissues. Optical fiber's steerability, twistability and rotation lead to a more precise and improved effect on tissues.
摘要翻译：公开了一种用于安全，准确和有效的外科手术的改进的装置和方法。所公开的装置是具有不对称远端构造的光纤组件，其包括具有作为其整体部分的熔融套筒的弯曲尖端纤维，放置在光纤的远端（输出端）处并且在近端（输入端）处具有可旋转连接器）侧。位于尖端远端处的纤维尖端和组织接触表面可以被构造成具有不同的形状构造，例如凸尖以改善聚焦特性，凹形尖端以实现发散照射或扩张的束尖以实现类似于通过电外科手术获得。抓地力保证并增强扭曲和旋转的能力。在另一优选实施例中，通过特殊配置来增强扭转机动。两个特殊功能（弯尖和可旋转连接器），可以改善和增强各种病态的治疗，使得有效和容易地达到和治疗特定组织成为可能。光纤的可操纵性，扭曲性和旋转性导致对组织的更精确和改善的影响。

13. 发明授权

US08685072B2 Device and method for vessel treatment 有权
标题翻译：血管治疗的装置和方法
公开(公告)号：US08685072B2
公开(公告)日：2014-04-01
申请号：US12877721
申请日：2010-09-08
申请人： Wolfgang Neuberger
发明人： Wolfgang Neuberger
IPC分类号： A61N5/06
CPC分类号： A61N5/0601 , A61B90/36 , A61N2005/063 , A61N2005/0659
摘要： A device and method for restoring functionality of blood vessels are disclosed. Laser energy is accurately and precisely applied in order to restore vessel functionality. This is accomplished by a controlled, reliable and specific shrinkage and/or strengthening of the vessel structure by controlled transport of laser radiation via an optical fiber to the treatment site. Laser wavelength is chosen according to the required penetration depth in tissue. In a preferred embodiment, wavelength of approximately 1470 nm is used. A mini-endoscope is preferably used to control the process by visual inspection from the inside of the vessel but other means may also be combined to control the procedure. Full 360° radial emission, i.e., delivery of laser radiation perpendicularly or fairly inclined relative to the veins axis, is beneficial, and is accomplished by means of a radial emitting fiber. In another preferred embodiment, a 360 degree radiation pattern can be achieved by using a twister or side-emitting fiber, along with rotational and sweeping movements to apply energy in an even, more-controlled, and guided manner. Valve function is restored to recover whole vein functionality, avoiding the need of closing it. In a preferred embodiment, energy is applied from the outside of the vessel, by inserting a device through the skin and tissue. In another preferred embodiment, specific radiation absorbers are located at suitable positions inside the vessel wall, to selectively target radiation to tagged locations. Vessel function is restored preserving its structure. A wide range of vessel diameters are effectively treated. Vessels include veins, arteries and fistulas.
摘要翻译：公开了恢复血管功能的装置和方法。激光能量准确而精确地应用于恢复血管功能。这是通过受控的，可靠的和具体的收缩和/或通过经由光纤将激光辐射控制传输到处理部位来加强容器结构来实现的。根据组织中所需的穿透深度选择激光波长。在优选实施例中，使用约1470nm的波长。微型内窥镜优选地用于通过目视检查从容器的内部控制过程，但也可以组合其它装置来控制该过程。完全360°径向辐射，即相对于静脉轴线垂直或相当倾斜的激光辐射的传送是有益的，并且通过径向发射光纤实现。在另一个优选实施例中，360度辐射图可以通过使用捻线机或侧发射光纤以及旋转和扫掠运动来实现，以以均匀，更受控制和引导的方式施加能量。阀功能恢复恢复整个静脉功能，避免了关闭它。在优选实施例中，通过将装置插入皮肤和组织，从容器的外部施加能量。在另一优选实施例中，特定的辐射吸收器位于血管壁内的适当位置，以选择性地将辐射靶向到标记位置。船舶功能恢复保存其结构。有效处理各种血管直径。血管包括静脉，动脉和瘘管。

14. 发明申请

US20120101427A1 NOVEL PHOTOSENSITIZER FORMULATIONS FOR ORAL ADMINISTRATION 审中-公开
标题翻译：用于口腔管理的新型光敏剂配方
公开(公告)号：US20120101427A1
公开(公告)日：2012-04-26
申请号：US13266056
申请日：2009-04-28
申请人： Gerard Farmer , Gerhard Wieland , Dietrich Scheglmann , Arno Wiehe , Susanna Gräfe , Nikolay E. Nufantiev , Volker Albrecht , Wolfgang Neuberger
发明人： Gerard Farmer , Gerhard Wieland , Dietrich Scheglmann , Arno Wiehe , Susanna Gräfe , Nikolay E. Nufantiev , Volker Albrecht , Wolfgang Neuberger
IPC分类号： A61M37/00 , A61K31/498 , C07D487/22 , C07D241/46 , A61K9/127 , A61K38/02 , A61K31/7056 , A61K31/706 , A61K31/79 , A61P35/00 , A61P17/00 , A61P9/00 , A61P19/02 , A61P31/04 , A61P33/02 , A61P31/12 , A61P31/00 , A61K31/409 , B82Y5/00
CPC分类号： A61K31/122 , A61K31/40 , A61K31/498 , A61K41/0071
摘要： The present invention provides novel drug formulations for oral administration for diverse medical applications including anticancer, antimetastatic, antibacterial, antifungal, antiprotozoic, antiviral, antiprionic and PDT treatments for diagnostic and therapeutic purposes. In a preferred embodiment the oral drug formulation comprises a photosensitizer and suitable excipients and may be administered in multiple doses over an extended period of time with exposure to activating radiation occurring generally between individual doses or in a light-independent manner. In another preferred embodiment PDT methods for treating hyperplasia and neoplasia, for localizing hyperplasic and neoplasic tissues and pathogen bacteria by fluorescence, for treating infections caused by pathogen bacteria in complex body fluids and for fat reduction, skin disorders and vascular diseases are provided.
摘要翻译：本发明提供用于口服给药以用于各种医学应用的新型药物制剂，包括用于诊断和治疗目的的抗癌，抗转移，抗细菌，抗真菌，抗原生动脉，抗病毒，抗细胞和PDT治疗。在优选的实施方案中，口服药物制剂包含光敏剂和合适的赋形剂，并且可以在延长的时间段内以多个剂量施用，暴露于通常在单独剂量之间或以轻轻独立的方式发生的活化辐射。在另一个优选实施方案中，提供了用于治疗增生和瘤形成的PDT方法，用于通过荧光定位超基质和新生组织和病原体细菌，用于治疗复杂体液中由病原体引起的感染和用于减脂，皮肤病和血管疾病。

15. 发明申请

US20110213348A1 METHOD AND DEVICE FOR VALVE REPAIR 有权
标题翻译：阀门维修的方法和装置
公开(公告)号：US20110213348A1
公开(公告)日：2011-09-01
申请号：US13102830
申请日：2011-05-06
申请人： Enrique Ferracani , Wolfgang Neuberger
发明人： Enrique Ferracani , Wolfgang Neuberger
IPC分类号： A61B18/20 , A61B17/00
CPC分类号： A61B18/24 , A61B2018/00029 , A61B2018/00982
摘要： A method and a device for minimally invasive treatment of diseased deep and superficial venous valves are disclosed. Treatment seeks to repair/rejuvenate dysfunctional valve by reducing the circumference of dilated valve rings and by restoring their original shape and function using laser energy to make physical suture points and shrink collagen in selected points. Real time monitoring is by angioscopic view and endovenous echographic control. In a preferred embodiment, system comprises a specific catheter-like device for endovenous insertion that allows for real time view of energy emission and venous surface to be corrected. Catheter flexibility is such that viewing angle and direct energy emission can be oriented properly. Catheter can comprise channels for irrigation or for interchange of laser fibers according to desired irradiation pattern. A preferred embodiment of catheter device also comprises cuffs for temporary occlusion, by inflation and deflation. In preferred embodiments, 1470 nm, 1550 nm or 1900 nm laser energy is applied. This treatment can be applied to venous valves of the deep venous system, as well as valves of the sapheno-femoral junction, terminal valve and pre-terminal valve.
摘要翻译：公开了用于微创治疗患病深部和浅静脉瓣的方法和装置。治疗旨在通过减小扩张瓣环的周长并通过使用激光能量恢复其原始形状和功能来修复/恢复功能失调的瓣膜，以在选定的点产生物理缝合点和收缩胶原蛋白。实时监测是通过血管镜观察和静态回波控制。在优选实施例中，系统包括用于静脉内插入的特定导管状装置，其允许实时观察要校正的能量排出和静脉表面。导管的灵活性使得视角和直接能量发射可以适当地定向。导管可以包括根据所需照射模式进行冲洗或激光纤维交换的通道。导管装置的优选实施例还包括用于暂时闭塞的袖口，通过充气和放气。在优选实施例中，施加1470nm，1550nm或1900nm的激光能量。这种治疗可以应用于深静脉系统的静脉瓣膜，以及隐静脉股关节，终端阀和前端阀的阀门。

16. 发明申请

US20110034854A1 PDT ASSISTED VISION CORRECTION AND SCAR PREVENTION 审中-公开
标题翻译： PDT辅助视力矫正和防护
公开(公告)号：US20110034854A1
公开(公告)日：2011-02-10
申请号：US12743515
申请日：2008-11-20
申请人： Wolfgang Neuberger , Volker Albrecht
发明人： Wolfgang Neuberger , Volker Albrecht
IPC分类号： A61M37/00 , A61K31/409 , A61K9/127 , A61P17/02
CPC分类号： A61N5/062 , A61F9/00802 , A61F2009/00872
摘要： A method and formulation are disclosed for improving the results of corneal refractive surgery, and generally reducing post-operative scarring and scarring arising from other traumas. In the vision examples, after completion of a procedure, including Photorefractive Keratotomy (PRK) or Laser-In-Situ Keratomileusis (LASIK), a photosensitizer or photosensitizer precursor is applied to the treatment site. After allowing sufficient time for the photosensitizers to accumulate among proliferating cells that occur as a result of ablation, radiation appropriate to activate the photosensitizers is administered to the treatment site. The photosensitizer is thus activated to destroy only those proliferating cells. In this way, proliferating tissue is eliminated and the cornea maintains the shape created during the surgery. As a result, instances of regression and the need for follow-up treatments, is minimized. This method is also useful for preventing post-surgical scarring that can lead to vision problems such as corneal haze. Likewise the method and formulations, presented here, are suitable for reducing post-operative scarring, and trauma cased scarring in general. For such scars, a photosensitizer or photosensitizer precursor is topically applied to the treatment site. After allowing sufficient time for the photosensitizers to attach to proliferating cells, radiation appropriate to activate the photosensitizers is administered to the treatment site. The photosensitizer is activated to destroy only those proliferating cells.
摘要翻译：公开了用于改善角膜屈光手术结果的方法和制剂，并且通常减少由其他创伤引起的术后瘢痕形成和瘢痕形成。在视觉实例中，在完成包括光折射角膜切开术（PRK）或激光原位角膜磨镶术（LASIK））的手术完成后，将光敏剂或光敏剂前体施用于治疗部位。在允许足够的时间使光敏剂在由于消融引起的增殖细胞之间累积，适当激活光敏剂的辐射被施用于治疗部位。因此，光敏剂被激活以仅破坏那些增殖细胞。以这种方式，消除增殖组织，并且角膜保持手术期间产生的形状。因此，尽可能减少了回归和后续治疗的需要。这种方法也可用于预防术后瘢痕形成，导致视力问题，如角膜混浊。同样地，这里给出的方法和制剂适用于减少手术后瘢痕形成和一般的外伤瘢痕形成。对于这种疤痕，将光敏剂或光敏剂前体局部施用于治疗部位。在允许足够的时间使光敏剂附着于增殖细胞之后，向治疗部位施用适于激活光敏剂的辐射。光敏剂被激活以仅破坏那些增殖细胞。

17. 发明申请

US20100137847A1 METHOD AND DEVICE FOR LASER LITHOTRIPSY 失效
标题翻译：激光雷达的方法和装置
公开(公告)号：US20100137847A1
公开(公告)日：2010-06-03
申请号：US12628634
申请日：2009-12-01
申请人： Walter Cecchetti , Wolfgang Neuberger , Leonardo Cecchetti
发明人： Walter Cecchetti , Wolfgang Neuberger , Leonardo Cecchetti
IPC分类号： A61B17/225
CPC分类号： A61B18/26 , A61B18/24 , A61B2017/2215 , A61B2018/00029 , A61B2018/263
摘要： A system and method for the destruction/ablation of stones, calculi or other hard substances by means of laser energy is disclosed. As a consequence, several important medical treatments can be performed, especially lithotripsy. The system comprises a diode laser source emitting at least at one wavelength, one or more optical fibers which convey laser radiation to the treatment site and a liquid delivery system used for creating a liquid environment around the stones (calculi). The laser device emits at least one wavelength which is highly absorbed in the surrounding/covering medium, thus causing evaporation and cavitation effects that lead to stone/calculi destruction. Different radiation configurations may be used. In one embodiment continuous radiation is used to create sparkler-less plasma bubbles able to destroy hard substances. In another embodiment high peak power pulsed radiation is used. Wavelengths of 1470 nm, 1940 nm, or 1550 nm are preferred. Additionally it can be applied in combination with another wavelength with medium absorption in water such as 980 nm. In another embodiment a concentric double core fiber is used, in which the ignition radiation is guided in near single mode, inner core and the radiation used to maintain and enhance the pulse is guided into the surrounding second outer core. In another preferred embodiment, the use of multiple optical fibers allows for treating larger stones in a shorter time period. In another preferred embodiment, cooling liquid is supplied to the impact site to further reduce thermal heating of the stone, thus diminishing risks of tissue damage caused by stone fragment anchorage and thermal energy. With these safer and improved methods and system, enhanced lithotripsy treatments can be performed in a shorter treatment time, destroying a wider range of stones with less risk of tissue damage, and less patient and physician stress.
摘要翻译：公开了一种用于通过激光能量破坏/消融石头，结石或其它硬物质的系统和方法。因此，可以进行若干重要的医疗治疗，特别是碎石术。该系统包括发射至少一个波长的二极管激光源，将激光辐射传送到治疗部位的一个或多个光纤和用于在石头周围产生液体环境（结石）的液体输送系统。激光装置发射至少一种在周围/覆盖介质中被高度吸收的波长，从而导致导致石头/结石破坏的蒸发和气蚀效应。可以使用不同的辐射配置。在一个实施例中，使用连续辐射来产生能够破坏硬物质的无闪蒸的等离子体气泡。在另一个实施例中，使用高峰值功率脉冲辐射。优选1470nm，1940nm或1550nm的波长。此外，它可以与另外一种在水中具有介质吸收的波长（例如980nm）结合使用。在另一个实施例中，使用同心双芯纤维，其中点火辐射在近单模模式内引导，并且用于维持和增强脉冲的辐射被引导到周围的第二外核中。在另一个优选实施例中，使用多根光纤允许在更短的时间段内处理较大的石头。在另一个优选实施例中，将冷却液供应到冲击部位以进一步减少石头的热加热，从而降低由石块碎片锚固和热能引起的组织损伤的风险。使用这些更安全和改进的方法和系统，可以在更短的治疗时间内进行增强的碎石治疗，破坏更广泛的石块，同时组织损伤的风险较小，患者和医生的压力较小。

18. 发明申请

US20100100030A1 Microbe Reductions with Photosensitizers 审中-公开
标题翻译：微生物减少与光敏剂
公开(公告)号：US20100100030A1
公开(公告)日：2010-04-22
申请号：US12643467
申请日：2009-12-21
申请人： Tim Driscoll , Verónica Inés Mega , Wolfgang Neuberger
发明人： Tim Driscoll , Verónica Inés Mega , Wolfgang Neuberger
IPC分类号： A61M37/00 , A61K9/14 , A61K31/195 , A61N5/06
CPC分类号： A61K8/494 , A61K8/0241 , A61K8/19 , A61K41/0038 , A61K2800/413 , A61K2800/81 , A61Q3/00 , A61Q11/00 , A61Q17/005 , B82Y5/00
摘要： Methods, devices and composition are disclosed for treating oral, skin and nail diseases, including inflammatory periodontal disease, onychomycosis and dermatophytosis. In a preferred embodiment a method for treating oral, skin and nail infections comprises administering a photosensitizing compound in long term effect or timed release formulations, including local highly concentrated formulations, and activating the photosensitizer with radiation to selectively destroy bacteria, fungi and other microbial bodies. In another preferred embodiment, photosensitizers are housed within nanoparticles, and can be gradually released through biodegradation or periodically released by such processes as brushing, irradiation and chemically induced release. The diffusion speed of the photosensitizers can be accelerated by brushing. In another embodiment, the photosensitizer molecule is also modified to more effectively target the molecule to the unwanted oral bacterial and fungal species. In another embodiment devices for treating oral, skin and nail infections includes a laser radiation source and delivery apparatuses such as brush or teethed comb for nail and scalp infections respectively.
摘要翻译：公开了用于治疗口腔，皮肤和指甲疾病的方法，装置和组合物，包括炎症性牙周病，甲真菌病和皮肤癣菌病。在优选的实施方案中，用于治疗口腔，皮肤和指甲感染的方法包括长期作用或定时释放制剂（包括局部高度浓缩的制剂）施用光敏化合物，并用放射线激活光敏剂以选择性地破坏细菌，真菌和其它微生物体。在另一个优选的实施方案中，光敏剂容纳在纳米颗粒内，并且可以通过生物降解逐渐释放或通过诸如刷洗，照射和化学诱导释放的过程周期性释放。通过刷涂可以加速光敏剂的扩散速度。在另一个实施方案中，光敏剂分子也被修饰以更有效地将分子靶向不需要的口腔细菌和真菌物种。在另一个实施方案中，用于治疗口腔，皮肤和指甲感染的装置分别包括激光辐射源和递送装置，例如用于指甲和头皮感染的刷子或牙齿梳。

19. 发明申请

US20090210038A1 Medical Light Diffusers for High Power Applications and their Manufacture 审中-公开
标题翻译：用于大功率应用的医用光扩散器及其制造
公开(公告)号：US20090210038A1
公开(公告)日：2009-08-20
申请号：US12227078
申请日：2007-08-22
申请人： Wolfgang Neuberger , Stefan Spaniol
发明人： Wolfgang Neuberger , Stefan Spaniol
IPC分类号： A61N5/067
CPC分类号： G02B6/262 , A61B2018/2261 , A61N5/0601 , A61N5/062
摘要： A high power density light delivery device is presented that uses an optical fiber with a diffuser attached at a distal end for use in, for example, photodynamic therapy (PDT) and laser induced thermotherapy (LITT). Uniform scattering in the diffuser section is obtained by either inducing differences in refractive index profiles of the core or in the core-cladding interface with the use of scattering centers or nano-voids. Nano-voids are created in the core or core-cladding interface by focusing high power laser energy or picosecond/femtosecond laser pulses on the quartz fiber material to induce defects. A special method is used that writes defects into or near to the core/cladding boundary through the jacket, without the necessity to first remove the jacket and then recoat the fiber. The method uses a wavelength that is highly transmissive in the jacket and fiber but absorbed in the fiber at very short laser pulses with high peak power. These processes allow the use of high power laser energy and the emission of the resulting high power densities in quartz fibers. The disclosed optical fiber delivery system is suitable for high power applications that require optical fibers with high flexibility and strength and core diameters from about 50 to about 400 microns.
摘要翻译：提出了一种高功率密度光输送装置，其使用具有连接在远端的扩散器的光纤用于例如光动力疗法（PDT）和激光诱导热疗法（LITT）。通过使用散射中心或纳米空隙，通过诱导芯的折射率分布或芯 - 包层界面的差异来获得扩散器部分中的均匀散射。通过将高功率激光能量或皮秒/飞秒激光脉冲聚焦在石英纤维材料上以引起缺陷，在芯或芯 - 包层界面中产生纳米空隙。使用一种特殊的方法，其通过夹套将缺陷写入芯/包层边界或靠近芯/包层边界，而不需要首先除去护套然后再覆盖光纤。该方法使用在护套和光纤中高度透射的波长，但是以非常短的具有高峰值功率的激光脉冲吸收在光纤中。这些过程允许使用高功率激光能量并且在石英纤维中发射所得到的高功率密度。所公开的光纤传送系统适用于需要高柔性和强度以及约50至约400微米的芯直径的光纤的高功率应用。

20. 发明申请

US20070219601A1 Benign prostatic hyperplasia treatment method and device 有权
标题翻译：良性前列腺增生治疗方法及装置
公开(公告)号：US20070219601A1
公开(公告)日：2007-09-20
申请号：US11714370
申请日：2007-03-06
申请人： Wolfgang Neuberger
发明人： Wolfgang Neuberger
IPC分类号： A61N5/06
CPC分类号： A61B18/24 , A61B2017/00274 , A61B2018/00547 , A61B2018/2005 , A61B2018/207 , A61B2018/2272 , A61N2005/0659
摘要： A device and method are provided which achieve tissue ablation as well as tissue coagulation substantially simultaneously during the treatment of BPH by utilizing at least two wavelengths of light. The device and method improve urinary flow and minimize post-treatment blood loss and edema while maintaining a nearly blood-free operating field during treatment by irradiating substantially simultaneously with at least two different wavelengths of light. According to the present invention, tissue ablation is affected by having one wavelength that is highly absorbed in the prostatic tissue while another less highly absorbed wavelength coagulates surrounding tissues while maintaining minimal thermal damage to surrounding tissue. In a preferred embodiment the highly absorbed wavelength is about 1460 nm and the less absorbed by water but with some significant hemoglobin absorption is about 980 nm. This combination aids the patient by reducing blood loss and edema. It can aid the practitioner, especially where imaging is employed, by maintaining a substantially blood-free area during treatment. The present device and method is used in conjunction with optical fibers including side emitting optical fibers to provide a practical, minimally invasive treatment of enlarged prostates.
摘要翻译：提供了一种通过利用至少两个波长的光来在BPH治疗期间基本上同时实现组织消融以及组织凝固的装置和方法。该装置和方法改善尿流量并且使治疗后的失血和水肿最小化，同时通过基本同时照射至少两种不同波长的光而在治疗期间保持几乎无血液的操作区域。根据本发明，组织消融受到在前列腺组织中高度吸收的一种波长的影响，而另一较低吸收波长使周围组织凝结，同时保持对周围组织的最小热损伤。在优选的实施方案中，高吸收波长为约1460nm，并且较少被水吸收，但具有一些显着的血红蛋白吸收约为980nm。该组合通过减少失血和水肿来帮助患者。它可以帮助医生，特别是在使用成像的地方，通过在治疗期间维持基本上无血液的区域。本发明的装置和方法与包括侧向发射光纤的光纤结合使用以提供对扩大的前列腺的实用的，微创的治疗。

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