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11. 发明申请

US20100030230A1 MEDICAL DEVICE SYSTEM AND APPARATUS FOR GUIDING THE PLACEMENT OF A SUBCUTANEOUS DEVICE 审中-公开
标题翻译：医疗装置系统及用于指导装置的装置
公开(公告)号：US20100030230A1
公开(公告)日：2010-02-04
申请号：US12432052
申请日：2009-04-29
申请人： William J. Havel , Vladimir P. Nikolski , Matthew D. Bonner
发明人： William J. Havel , Vladimir P. Nikolski , Matthew D. Bonner
IPC分类号： A61B17/32
CPC分类号： A61B17/3468 , A61B17/3462 , A61B17/3472 , A61B2017/00026 , A61B2017/0003 , A61B2017/00561 , A61B2017/306 , A61B2017/320044 , A61B2017/320056 , A61M5/425 , A61M5/427 , A61M2005/1586 , A61N1/046 , A61N1/0504
摘要： A medical device system for guiding placement of a subcutaneous medical device that includes a strap extending along a length from a proximal end to a distal end, a first flange and a second flange extending along a portion of the length of the strap, a base portion extending along a portion of the length of the strap between the first flange and the second flange, an orientation member extending along the strap to limit a predetermined radius of curvature of the strap, and an indentation extending from the proximal end to the distal end of the strap, the indentation formed by the first flange, the second flange, and the base portion, wherein the first flange and the second flange include curved bottom portions that make contact with and compress a tissue layer to position the tissue layer within the indentation during the placement of the subcutaneous device.
摘要翻译：一种用于引导皮下医疗装置的放置的医疗装置系统，该皮下医疗装置包括沿着从近端到远端的长度延伸的带，沿着带的长度的一部分延伸的第一凸缘和第二凸缘，沿着所述带的长度的一部分延伸在所述第一凸缘和所述第二凸缘之间，定向构件沿着所述带延伸以限制所述带的预定曲率半径，以及从所述近端延伸到所述第二凸缘的远端所述带，由所述第一凸缘，所述第二凸缘和所述基部形成的所述凹口，其中所述第一凸缘和所述第二凸缘包括弯曲的底部部分，所述弯曲底部部分与所述组织层接触并压缩所述组织层以将所述组织层定位在所述凹陷内放置皮下装置。

12. 发明申请

US20090177242A1 Apparatus and method for non-invasive induction of ventricular fibrillation 有权
标题翻译：用于非侵入性诱发心室颤动的装置和方法
公开(公告)号：US20090177242A1
公开(公告)日：2009-07-09
申请号：US11969663
申请日：2008-01-04
申请人： Vladimir P. Nikolski , William J. Havel , Joseph L. Sullivan , Daniel W. Piraino , Eric R. Williams
发明人： Vladimir P. Nikolski , William J. Havel , Joseph L. Sullivan , Daniel W. Piraino , Eric R. Williams
IPC分类号： A61N1/39
CPC分类号： A61N1/39 , A61N1/3943 , A61N1/3962
摘要： An apparatus and method for delivering an external shock pulse receive pacing pulses generated by a first device and a shock pulse generated by a second device. An output of the apparatus is coupled to patient electrodes and the apparatus controls delivery of the received pacing pulses to the output and delivery of the received shock pulse to the output. A control module, pacing control and shock control included in the apparatus cooperatively control delivery of the received shock pulse to the output at a predetermined delay after one of the received pacing pulses.
摘要翻译：用于递送外部冲击脉冲的装置和方法接收由第一装置产生的起搏脉冲和由第二装置产生的冲击脉冲。该装置的输出耦合到患者电极，并且该装置控制所接收的起搏脉冲的输出到接收的冲击脉冲的输出和输出。装置中包括的控制模块，起搏控制和冲击控制协调地控制接收到的冲击脉冲在一个接收到的起搏脉冲之后以预定延迟输出到输出端。

13. 发明授权

US07151963B2 Control of arbitrary waveforms for constant delivered energy 有权
公开(公告)号：US07151963B2
公开(公告)日：2006-12-19
申请号：US10308832
申请日：2002-12-03
申请人： William J. Havel , Paul J. DeGroot , Thomas W. Sinner , Kevin Kuehn , Gary Kemmetmueller , Warren W. Wold
发明人： William J. Havel , Paul J. DeGroot , Thomas W. Sinner , Kevin Kuehn , Gary Kemmetmueller , Warren W. Wold
IPC分类号： A61N1/39
CPC分类号： A61N1/3906 , A61N1/3912 , A61N1/3937
摘要： The present invention outlines structures and methods for delivering a controllable amount of energy to a patient by automatically compensating for the load impedance detected by an implantable-cardioverter defibrillator (ICD). The invention employs high speed, switching power converter technology for the efficient generation of high energy, arbitrary waveforms. Unlike a linear amplifier, switching power converters deliver high-energy waveforms with an efficiency that is independent of the size and amplitude of the desired waveform. An ICD that uses a switching power converter to deliver the desired energy to the patient stores the energy to be delivered in a storage capacitor. The converter then transforms this energy into an arbitrarily shaped output voltage-controlled or current-controlled waveform by switching the storage capacitor in and out of the output circuit at a high rate of speed. Preferably, the waveform comprises a ramp-type waveform.

14. 发明授权

US07096063B2 Method and apparatus for delivering multi-directional defibrillation waveforms 有权
标题翻译：用于递送多方向除颤波形的方法和装置
公开(公告)号：US07096063B2
公开(公告)日：2006-08-22
申请号：US10804780
申请日：2004-03-19
申请人： Kevin A. Wanasek , William J. Havel
发明人： Kevin A. Wanasek , William J. Havel
IPC分类号： A61N1/39
CPC分类号： A61N1/3622 , A61N1/3925 , A61N1/3956
摘要： A method and device for delivering a pulse waveform to a target site of a patient that includes an energy storage device storing electrical energy, and a plurality of electrodes electrically coupled to the energy storage device. Control circuitry, coupled to a plurality of switching elements coupled to the plurality of electrodes, selectively switches the plurality of switching elements between a first state and a second state to direct discharge of the stored energy to be simultaneously output at selected electrodes of the plurality of electrodes to generate discrete sequential resultant output pulses across multiple pathways, the discrete sequential resultant output pulses generating a multi-directional waveform at the target site.
摘要翻译：一种用于将脉搏波形传送到患者的靶位置的方法和装置，所述方法和装置包括存储电能的能量存储装置，以及电耦合到所述能量存储装置的多个电极。耦合到耦合到多个电极的多个开关元件的控制电路在第一状态和第二状态之间选择性地切换多个开关元件，以直接放电存储的能量，以同时在多个电极中的选定电极处输出电极，用于在多个路径上产生离散的顺序结果输出脉冲，离散的顺序结果输出脉冲在目标位置处产生多方向波形。

15. 发明授权

US09854982B2 Implantable medical device deployment within a vessel 有权
公开(公告)号：US09854982B2
公开(公告)日：2018-01-02
申请号：US13482880
申请日：2012-05-29
申请人： James Calvin Allan , Erik C. Griswold , William J. Havel , Steven L. Waldhauser , Kelly M. Wien , Kendra Yasger , Rudolph A. Beasley , Jon D. Schell , Don H. Tran
发明人： James Calvin Allan , Erik C. Griswold , William J. Havel , Steven L. Waldhauser , Kelly M. Wien , Kendra Yasger , Rudolph A. Beasley , Jon D. Schell , Don H. Tran
IPC分类号： A61B5/0215 , A61B6/00 , A61B5/00 , A61M25/04 , A61B5/042 , A61N1/365
CPC分类号： A61B5/0215 , A61B5/0031 , A61B5/042 , A61B5/686 , A61B6/00 , A61M25/04 , A61N1/36564
摘要： In one example, this disclosure is directed to a method for intravascular implantation of an implantable medical device comprising positioning a distal end of an elongated outer sheath forming an inner lumen adjacent a target site within a vasculature of a patient, and partially deploying an implantable medical device from the distal opening, wherein the implantable medical device includes an expandable fixation element. A portion of the expandable fixation element assumes an expanded position when the implantable medical device is partially deployed from the distal opening. The method including advancing the distal end of the outer sheath within the vasculature with the implantable medical device partially deployed from the distal opening, and monitoring at least one of the vasculature and the portion of the expandable fixation element for deflection to determine when the size of the portion of the expandable fixation element corresponds to the size of the vasculature.

16. 发明申请

US20110066206A1 METHOD AND APPARATUS FOR POST-SHOCK EVALUATION USING TISSUE OXYGENATION MEASUREMENTS 有权
标题翻译：使用组织氧化测量法进行后期评估的方法和装置
公开(公告)号：US20110066206A1
公开(公告)日：2011-03-17
申请号：US12845843
申请日：2010-07-29
申请人： Jonathan L. Kuhn , Can Cinbis , David A. Anderson , William J. Havel
发明人： Jonathan L. Kuhn , Can Cinbis , David A. Anderson , William J. Havel
IPC分类号： A61N1/365
CPC分类号： A61B5/14551 , A61B5/1459 , A61B5/6846 , A61B5/7285 , A61N1/36557 , A61N1/3925 , A61N1/3956
摘要： A method and device for delivering therapy that includes an electrode to sense cardiac signals and to deliver a therapy, a monitoring module detecting a cardiac event in response to the sensed cardiac signals using first detection criteria, a sensor emitting light and detecting emitted light scattered by a tissue volume adjacent the sensor to generate a corresponding detected light intensity output signal, a control module coupled to the sensor to control light emission of the sensor in response to delivering the therapy, and a controller coupled to the monitoring module, the therapy delivery module and the sensor, the controller configured to determine tissue oxygenation measurements in response to the output signal, determine a tissue oxygenation trend in response to the tissue oxygenation measurements, determine a recovery index in response to the determined tissue oxygenation trend, and control one or both of detecting a cardiac event by the monitoring module and delivery of therapy by the therapy delivery module in response to the determined recovery index.
摘要翻译：一种用于递送疗法的方法和装置，其包括用于感测心脏信号并递送治疗的电极，监测模块，响应于使用第一检测标准的所感测到的心脏信号检测心脏事件，发射光并检测由与所述传感器相邻的组织体积以产生相应的检测到的光强度输出信号;控制模块，耦合到所述传感器以响应于递送所述治疗来控制所述传感器的光发射;以及控制器，耦合到所述监测模块，所述治疗递送模块以及所述传感器，所述控制器被配置为响应于所述输出信号确定组织氧合测量，响应于组织氧合测量确定组织氧合趋势，响应于所确定的组织氧合趋势确定恢复指数，并且控制一个或两个通过监测模块检测心脏事件并进行治疗 y由治疗递送模块响应于确定的恢复指数。

17. 发明申请

US20110066204A1 METHOD AND APPARATUS FOR POST-SHOCK EVALUATION USING TISSUE OXYGENATION MEASUREMENTS 有权
标题翻译：使用组织氧化测量法进行后期评估的方法和装置
公开(公告)号：US20110066204A1
公开(公告)日：2011-03-17
申请号：US12845818
申请日：2010-07-29
申请人： Jonathan L. Kuhn , Can Cinbis , David A. Anderson , William J. Havel
发明人： Jonathan L. Kuhn , Can Cinbis , David A. Anderson , William J. Havel
IPC分类号： A61B5/1455 , A61N1/365
CPC分类号： A61B5/14551 , A61B5/1459 , A61B5/6846 , A61B5/7285 , A61N1/36557 , A61N1/3925 , A61N1/3956
摘要： A method and device for delivering therapy that includes an electrode to sense cardiac signals and to deliver a therapy, a therapy delivery module coupled to the electrode to deliver a therapy via the electrode in response to the sensed cardiac signals, a sensor emitting light and detecting emitted light scattered by a tissue volume adjacent the sensor to generate a corresponding detected light intensity output signal, a control module coupled to the sensor to control light emission of the sensor in response to delivering the therapy; and a controller coupled to the therapy delivery module and the sensor, the controller configured to determine a tissue oxygenation measurement in response to the output signal, and determine whether the delivered therapy was successful in restoring cardiac hemodynamic function in response to the tissue oxygenation measurement.
摘要翻译：一种用于递送治疗的方法和装置，其包括用于感测心脏信号并递送治疗的电极，治疗递送模块，其耦合到所述电极，以响应于感测到的心脏信号经由所述电极递送治疗;发射光和检测的传感器发射由邻近传感器的组织体积散射的光，以产生相应的检测到的光强度输出信号;控制模块，其耦合到所述传感器，以响应于递送所述治疗来控制所述传感器的光发射; 以及耦合到所述治疗递送模块和所述传感器的控制器，所述控制器被配置为响应于所述输出信号确定组织氧合测量，并且确定所递送的治疗是否成功响应于所述组织氧合测量来恢复心脏血液动力学功能。

18. 发明申请

US20100030229A1 MEDICAL DEVICE SYSTEM AND APPARATUS FOR GUIDING THE PLACEMENT OF A SUBCUTANEOUS DEVICE 有权
标题翻译：医疗装置系统及用于指导装置的装置
公开(公告)号：US20100030229A1
公开(公告)日：2010-02-04
申请号：US12432028
申请日：2009-04-29
申请人： William J. Havel , Vladimir P. Nikolski
发明人： William J. Havel , Vladimir P. Nikolski
IPC分类号： A61B17/00
CPC分类号： A61B17/3468 , A61B17/3462 , A61B17/3472 , A61B2017/00026 , A61B2017/0003 , A61B2017/00561 , A61B2017/306 , A61B2017/320044 , A61B2017/320056 , A61M5/425 , A61M5/427 , A61M2005/1586 , A61N1/046 , A61N1/0504
摘要： A medical device system for advancing a subcutaneous device to a desired implant site that includes a strap extending along a length from a proximal end to a distal end, a first flange and a second flange extending along a portion of the length of the strap, a base portion extending along a portion of the length of the strap between the first flange and the second flange, and an indentation extending from the proximal end to the distal end of the strap, the indentation formed by the first flange, the second flange, and the base portion, wherein the first flange and the second flange include curved bottom portions that make contact with and compress a tissue layer to position the tissue layer within the indentation during the placement of the subcutaneous device.
摘要翻译：一种用于将皮下装置推进到期望的植入部位的医疗装置系统，所述植入部位包括沿着从近端到远端的长度延伸的带，沿着带的长度的一部分延伸的第一凸缘和第二凸缘，所述基部沿着所述带的所述长度的第一凸缘和所述第二凸缘之间的部分延伸，以及从所述带的近端延伸到所述远端，所述凹陷由所述第一凸缘，所述第二凸缘和所述基部部分，其中所述第一凸缘和所述第二凸缘包括弯曲的底部部分，所述弯曲的底部部分在所述皮下装置的放置期间与所述组织层接触并将所述组织层定位在所述凹陷内。

19. 发明授权

US07181273B2 Tachycardia synchronization delays 有权
标题翻译：心动过速同步延迟
公开(公告)号：US07181273B2
公开(公告)日：2007-02-20
申请号：US10418853
申请日：2003-04-18
申请人： William J. Havel , Paul J. Degroot , Paul M. Stein
发明人： William J. Havel , Paul J. Degroot , Paul M. Stein
IPC分类号： A61N1/39
CPC分类号： A61N1/3987 , A61N1/3956
摘要： An implantable medical device (IMD) provides for adaptive timing of the delivery of cardioversion shocks. In particular, the invention IMD provides for an adaptive cardioversion synchronization delay with respect to a cardiac event, such as a sensed P-wave or R-wave. When cardioversion with a first synchronization delay fails to terminate a tachycardia, for example, cardioversion may be attempted again with a second synchronization delay. The IMD may keep track of whether each synchronization delay is effective in terminating the tachycardia, and may employ a historically effective synchronization delay when applying cardioversion therapy to treat a subsequent tachycardia episode.
摘要翻译：可植入医疗设备（IMD）提供了心脏复律冲击的适应性定时。特别地，本发明IMD提供关于心脏事件（例如感测的P波或R波）的自适应心脏复律同步延迟。当具有第一同步延迟的心脏复律不能终止心动过速时，例如，可以以第二同步延迟再次尝试心脏复律。 IMD可以跟踪每个同步延迟是否有效终止心动过速，并且当应用心脏复律治疗以治疗随后的心动过速发作时，可以采用历史上有效的同步延迟。

20. 发明申请

US20130253346A1 PASS-THROUGH IMPLANTABLE MEDICAL DEVICE DELIVERY CATHETER WITH REMOVEABLE DISTAL TIP 审中-公开
标题翻译：通过可移植的医疗设备输送导管与可拆卸的远程提示
公开(公告)号：US20130253346A1
公开(公告)日：2013-09-26
申请号：US13482883
申请日：2012-05-29
申请人： Erik C. Griswold , James Calvin Allan , Rudolph A. Beasley , William J. Havel , Jon D. Schell , Don H. Tran , Steven L. Waldhauser
发明人： Erik C. Griswold , James Calvin Allan , Rudolph A. Beasley , William J. Havel , Jon D. Schell , Don H. Tran , Steven L. Waldhauser
IPC分类号： A61M25/00 , A61B5/0215 , A61B19/00 , A61M25/092 , A61M25/14
CPC分类号： A61B5/0215 , A61B5/042 , A61B5/0538 , A61M25/0169 , A61M2025/0175 , A61M2025/0183 , A61N1/057 , A61N1/36514 , A61N1/36564 , A61N1/3756 , A61N2001/0585
摘要： In one example, this disclosure is directed to a kit for intravascular implantation of an implantable medical device, the kit comprising an outer sheath, the outer sheath sized to traverse a vasculature of the patient, and an elongated inner sheath with a tapered distal end. The inner sheath is slidable within the inner lumen of the outer sheath and is selectably removable from the inner lumen of the outer sheath by sliding the inner sheath out of the proximal opening of the outer sheath. The kit includes an elongated deployment receptacle including a deployment bay slidable within the inner lumen of the outer sheath when the inner sheath is not within the inner lumen of the outer sheath. The deployment bay carries an implantable medical device through the inner lumen of the outer sheath and facilitates deployment of the implantable medical device from the distal end of the outer sheath.
摘要翻译：在一个示例中，本公开涉及用于可植入医疗装置的血管内植入的套件，所述套件包括外护套，外护套的尺寸设置成穿过患者的脉管系统，以及具有锥形远端的细长内护套。内护套可以在外护套的内腔内滑动，并且通过将内护套从外护套的近侧开口滑出，可选择地从外护套的内腔移除。套件包括细长部署插座，其包括当内护套不在外护套的内腔内时可在外护套的内腔内滑动的展开室。部署隔间通过外护套的内腔运送植入式医疗装置，并且便于从外护套的远端部署可植入医疗装置。

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