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11. 发明授权

US4734527A Process for preparing 2,6-di-tertiarybutyl-4-mercaptophenol 失效
标题翻译：制备2,6-二叔丁基-4-巯基苯酚的方法
公开(公告)号：US4734527A
公开(公告)日：1988-03-29
申请号：US920813
申请日：1986-10-17
申请人： Richard C. Krauss
发明人： Richard C. Krauss
IPC分类号： C07C319/14 , B01J23/14 , C07B61/00 , C07C67/00 , C07C313/00 , C07C319/06 , C07C319/24 , C07C323/20 , C07C149/36
CPC分类号： C07C323/00
摘要： In a process for making 2,6-di-tertiarybutyl-4-mercaptophenol by the Zn/acid reduction of bis (3,5-di-tertiarybutyl-4-hydroxyphenyl)polysulfide the addition of catalytic amounts of lead to the zinc reagent results in substantial improvement in the process.

12. 发明授权

US4645852A One step conversion of epoxyalkanes to alkyl esters of alkyl and aryl sulfonic acids 失效
标题翻译：将环氧烷烃一步转化为烷基和芳基磺酸的烷基酯
公开(公告)号：US4645852A
公开(公告)日：1987-02-24
申请号：US776244
申请日：1985-09-16
申请人： Lennon H. McKendry , Richard C. Krauss
发明人： Lennon H. McKendry , Richard C. Krauss
IPC分类号： C07C33/22 , C07C33/46 , C07C233/00 , C07C309/63 , C07C143/68 , C07C103/22
CPC分类号： C07C309/00
摘要： In an improved process of converting a 1,2-epoxy-2-phenylbutane or a 1,2-epoxy-2-phenylpentane to a 2-hydroxy-2-phenylbutylsulfonate, sulfamate, or halide, or the corresponding 2-hydroxy-2-phenylpentyl compound, respectively, by the reaction at about 40.degree. to 120.degree. C. in the presence of an organic solvent of the requisite epoxybutane or epoxypentane with a proton source and a nucleophile. The proton source can be a free strong acid such as a sulfonic, sulfamic acid, or hydrohalide acid, or the proton source can be derived from an equilibrium system comprising a free strong acid and weak base in equilibrium with the respective deprotonated strong acid and protonated weak base. The process is carried out in one step with reduction or avoidance of aldehyde formation by rearrangement of the epoxyalkane.
摘要翻译：在将1,2-环氧-2-苯基丁烷或1,2-环氧-2-苯基戊烷转化为2-羟基-2-苯基丁基磺酸盐，氨基磺酸盐或卤化物或相应的2-羟基-2 - 苯基戊基化合物分别通过在约40-120℃下在需要的环氧丁烷或环氧戊烷的有机溶剂与质子源和亲核试剂的存在下反应。质子源可以是游离的强酸如磺酸，氨基磺酸或氢卤酸，或者质子源可以衍生自包含游离强酸和弱碱的平衡体系，与相应去质子化的强酸和质子化的弱碱。该方法在一个步骤中进行，通过环氧烷烃的重排减少或避免形成醛。

13. 发明申请

US20110155660A1 MODIFIED MEMBRANE 审中-公开
标题翻译：改性膜
公开(公告)号：US20110155660A1
公开(公告)日：2011-06-30
申请号：US12967092
申请日：2010-12-14
申请人： William E. Mickols , Richard C. Krauss , Qingshan Jason Niu , Carleton L. Gaupp
发明人： William E. Mickols , Richard C. Krauss , Qingshan Jason Niu , Carleton L. Gaupp
IPC分类号： B01D39/16 , B05D7/24
CPC分类号： B01D61/025 , B01D67/0093 , B01D69/125 , B01D71/56 , B01D2323/02 , B01D2323/12 , B01D2325/28 , B01D2325/48
摘要： A multilayered modified membrane and method for making the same, comprising a modified discriminating layer that can have a fouling resistant surface, improved salt rejection, antimicrobial properties, and/or improved solute, and/or small organics rejection as compared to membranes with unmodified discriminating layers.
摘要翻译：一种多层改性膜及其制备方法，包括与具有未改性鉴别的膜相比具有耐污垢表面，改善的盐排斥，抗微生物性能和/或改进的溶质和/或小的有机物排斥的修饰鉴别层层。

14. 发明授权

US06559312B2 Intermediates useful for the preparation of antihistaminic piperidine derivatives 失效
标题翻译：用于制备抗组胺型哌啶衍生物的中间体
公开(公告)号：US06559312B2
公开(公告)日：2003-05-06
申请号：US09731654
申请日：2000-12-08
申请人： Richard C. Krauss , Robert M. Strom , Carey L. Scortichini , William J. Kruper , Richard A. Wolf , Weishi W. Wu , Albert A. Carr , David A. Hay , Duane E. Rudisill , Gianbattista Panzone
发明人： Richard C. Krauss , Robert M. Strom , Carey L. Scortichini , William J. Kruper , Richard A. Wolf , Weishi W. Wu , Albert A. Carr , David A. Hay , Duane E. Rudisill , Gianbattista Panzone
IPC分类号： C07D21122
CPC分类号： C07D295/185 , C07C33/46 , C07C45/46 , C07C45/63 , C07C45/65 , C07C45/673 , C07C49/792 , C07C49/798 , C07C49/80 , C07C49/813 , C07C49/82 , C07C49/825 , C07C49/83 , C07C49/835 , C07C49/86 , C07C59/86 , C07C59/88 , C07C69/007 , C07C69/738 , C07C235/78 , C07C255/16 , C07C259/06 , C07C2601/02 , C07D211/22 , C07D401/06 , C07D401/10
摘要： The present invention is related to a novel intermediates and processes which are useful in the preparation of certain antihistaminic piperidine derivatives of the formula wherein W represents —C(═O)— or —CH(OH)—; R1 represents hydrogen or hydroxy; R2 represents hydrogen; R1 and R2 taken together form a second bond between the carbon atoms bearing R1 and R2; n is an integer of from 1 to 5; m is an integer of 0 or 1; R3 is —COOH or —COOalkyl wherein the alkyl moiety has from 1 to 6 carbon atoms and is straight or branched each of A is hydrogen or hydroxy; and pharmaceutically acceptable salts and individual optical isomers thereof, with the proviso that where R1 and R2 are taken together to form a second bond between the carbon atoms bearing R1 and R2 or where R1 represented hydroxy, m is an integer 0.
摘要翻译：本发明涉及一种新的中间体和方法，其可用于制备W代表-C（= O） - 或-CH（OH） - 的某些抗组胺型哌啶衍生物; R 1表示氢或羟基; R 2表示氢 R 1和R 2一起形成在具有R 1和R 2的碳原子之间的第二个键; n是1至5的整数; m是0或1的整数; R 3是-COOH或-COO烷基，其中烷基部分具有 1至6个碳原子，并且是直链或支链的，每个A是氢或羟基; 其药学上可接受的盐和单独的光学异构体，条件是其中R 1和R 2一起形成在具有R 1和R 2的碳原子之间或其中R 1表示羟基的第二个键，m是整数0。

15. 发明授权

US06552200B2 Intermediates useful for the preparation of antihistaminic piperidine derivatives 失效
标题翻译：用于制备抗组胺型哌啶衍生物的中间体
公开(公告)号：US06552200B2
公开(公告)日：2003-04-22
申请号：US09725259
申请日：2000-11-29
申请人： Richard C. Krauss , Robert M. Strom , Carey L. Scortichini , William J. Kruper , Richard A. Wolf , Weishi W. Wu , Albert A. Carr , David A. Hay , Duane E. Rudisill , Gianbattista Panzone
发明人： Richard C. Krauss , Robert M. Strom , Carey L. Scortichini , William J. Kruper , Richard A. Wolf , Weishi W. Wu , Albert A. Carr , David A. Hay , Duane E. Rudisill , Gianbattista Panzone
IPC分类号： C07D21122
CPC分类号： C07D295/185 , C07C33/46 , C07C45/46 , C07C45/63 , C07C45/65 , C07C45/673 , C07C49/792 , C07C49/798 , C07C49/80 , C07C49/813 , C07C49/82 , C07C49/825 , C07C49/83 , C07C49/835 , C07C49/86 , C07C59/86 , C07C59/88 , C07C69/007 , C07C69/738 , C07C235/78 , C07C255/16 , C07C259/06 , C07C2601/02 , C07D211/22 , C07D401/06 , C07D401/10
摘要： The present invention is related to a novel intermediates and processes which are useful in the preparation of certain antihistaminic piperidine derivatives of the formula wherein W represents —C(═O)— or —CH(OH)—; R1 represents hydrogen or hydroxy; R2 represents hydrogen; R1 and R2 taken together form a second bond between the carbon atoms bearing R1 and R2; n is an integer of from 1 to 5; m is an integer 0 or 1; R3 is —COOH or —COOalkyl wherein the alkyl moiety has from 1 to 6 carbon atoms and is straight or branched each of A is hydrogen or hydroxy; and pharmaceutically acceptable salts and individual optical isomers thereof, with the proviso that where R1 and R2 are taken together to form a second bond between the carbon atoms bearing R1 and R2 or where R1represented hydroxy, n is an integer 0.
摘要翻译：本发明涉及一种新的中间体和方法，其可用于制备W代表-C（= O） - 或-CH（OH） - 的某些抗组胺型哌啶衍生物; R 1表示氢或羟基; R 2表示氢 R 1和R 2一起形成在具有R 1和R 2的碳原子之间的第二个键; n是1至5的整数; m是整数0或1; R 3是-COOH或-COO烷基，其中烷基部分具有 1至6个碳原子，并且是直链或支链的，每个A是氢或羟基; 其药学上可接受的盐和单独的光学异构体，条件是其中R 1和R 2一起形成在具有R 1和R 2的碳原子之间或其中R 1表示羟基，n为整数0的第二个键。

16. 发明授权

US06479663B2 Intermediates useful for the preparation of antihistaminic piperidine derivatives 失效
标题翻译：用于制备抗组胺型哌啶衍生物的中间体
公开(公告)号：US06479663B2
公开(公告)日：2002-11-12
申请号：US09726625
申请日：2000-12-01
申请人： Richard C. Krauss , Robert M. Strom , Carey L. Scortichini , William J. Kruper , Richard A. Wolf , Weishi W. Wu , Albert A. Carr , David A. Hay , Duane E. Rudisill , Gianbattista Panzone
发明人： Richard C. Krauss , Robert M. Strom , Carey L. Scortichini , William J. Kruper , Richard A. Wolf , Weishi W. Wu , Albert A. Carr , David A. Hay , Duane E. Rudisill , Gianbattista Panzone
IPC分类号： C07D21114
CPC分类号： C07D295/185 , C07C33/46 , C07C45/46 , C07C45/63 , C07C45/65 , C07C45/673 , C07C49/792 , C07C49/798 , C07C49/80 , C07C49/813 , C07C49/82 , C07C49/825 , C07C49/83 , C07C49/835 , C07C49/86 , C07C59/86 , C07C59/88 , C07C69/007 , C07C69/738 , C07C235/78 , C07C255/16 , C07C259/06 , C07C2601/02 , C07D211/22 , C07D401/06 , C07D401/10
摘要： The present invention is related to a novel intermediates and processes which are useful in the preparation of certain antihistaminic piperidine derivatives of the formula wherein W represents —C(═O)— or —CH(OH)—; R1 represents hydrogen or hydroxy; R2 represents hydrogen; R1 and R2 taken together form a second bond between the carbon atoms bearing R1 and R2; n is an integer of from 1 to 5; m is an integer 0 or 1; R3 is —COOH or —COOalkyl wherein the alkyl moiety has from 1 to 6 carbon atoms and is straight or branched each of A is hydrogen or hydroxy; and pharmaceutically acceptable salts and individual optical isomers thereof, with the proviso that where R1 and R2 are taken together to form a second bond between the carbon atoms bearing R1 and R2 or where R1 represented hydroxy m is an integer 0.
摘要翻译：本发明涉及一种新的中间体和方法，其可用于制备W代表-C（= O） - 或-CH（OH） - 的某些抗组胺型哌啶衍生物; R 1表示氢或羟基; R 2表示氢 R 1和R 2一起形成在具有R 1和R 2的碳原子之间的第二个键; n是1至5的整数; m是整数0或1; R 3是-COOH或-COO烷基，其中烷基部分具有 1至6个碳原子，并且是直链或支链的，每个A是氢或羟基; 其药学上可接受的盐和单独的光学异构体，条件是其中R 1和R 2一起形成在具有R 1和R 2的碳原子之间或其中R 1表示羟基的整数为0的第二个键。

17. 发明授权

US5276128A Salts of polybenzazole monomers and their use 失效
标题翻译：聚吲哚单体的盐及其用途
公开(公告)号：US5276128A
公开(公告)日：1994-01-04
申请号：US780493
申请日：1991-10-22
申请人： Steven Rosenberg , Richard C. Krauss , Ming-Biann Liu , Luke R. Kleiss
发明人： Steven Rosenberg , Richard C. Krauss , Ming-Biann Liu , Luke R. Kleiss
IPC分类号： C07C63/28 , C07C213/00 , C07C215/80 , C07C323/33 , C07C323/34 , C08G73/18 , C08G73/22 , C08G75/00 , C08G75/32 , C08G63/00
CPC分类号： C07C323/34 , C07C215/80 , C08G73/22 , C08G75/32
摘要： Salts that contain AA-PBZ monomer ions and BB-PBZ monomer ions can be precipitated from an aqueous solution by contacting soluble salts of the monomers in an aqueous solution. The monomer salt can be polymerized by ordinary techniques to form polybenzazole polymers without the need for devolatilization and with very accurate stoichiometric control.
摘要翻译：含有AA-PBZ单体离子和BB-PBZ单体离子的盐可以通过将单体的可溶性盐溶解在水溶液中从水溶液中沉淀出来。单体盐可以通过常规技术聚合以形成聚吲哚聚合物，而不需要脱挥发分和非常精确的化学计量控制。

18. 发明授权

US07882963B2 Modified membrane 有权
标题翻译：改性膜
公开(公告)号：US07882963B2
公开(公告)日：2011-02-08
申请号：US12299849
申请日：2007-04-12
申请人： William E. Mickols , Richard C. Krauss , Q. Jason Niu , Carleton L Gaupp
发明人： William E. Mickols , Richard C. Krauss , Q. Jason Niu , Carleton L Gaupp
IPC分类号： B01D71/56 , B01D71/00
CPC分类号： B01D61/025 , B01D67/0093 , B01D69/125 , B01D71/56 , B01D2323/02 , B01D2323/12 , B01D2325/28 , B01D2325/48
摘要： A multilayered modified membrane and method for making the same, comprising a modified discriminating layer that can have a fouling resistant surface, improved salt rejection, antimicrobial properties, and/or improved solute, and/or small organics rejection as compared to membranes with unmodified discriminating layers.
摘要翻译：一种多层改性膜及其制备方法，包括与具有未改性鉴别的膜相比具有耐污垢表面，改善的盐排斥，抗微生物性能和/或改进的溶质和/或小的有机物排斥的修饰鉴别层层。

19. 发明申请

US20090159527A1 MODIFIED MEMBRANE 有权
标题翻译：改性膜
公开(公告)号：US20090159527A1
公开(公告)日：2009-06-25
申请号：US12299849
申请日：2007-04-12
申请人： William E. Mickols , Richard C. Krauss , Q. Jason Niu , Carleton L. Gaupp
发明人： William E. Mickols , Richard C. Krauss , Q. Jason Niu , Carleton L. Gaupp
IPC分类号： B01D71/06 , C08G69/48
CPC分类号： B01D61/025 , B01D67/0093 , B01D69/125 , B01D71/56 , B01D2323/02 , B01D2323/12 , B01D2325/28 , B01D2325/48
摘要： A multilayered modified membrane and method for making the same, comprising a modified discriminating layer that can have a fouling resistant surface, improved salt rejection, antimicrobial properties, and/or improved solute, and/or small organics rejection as compared to membranes with unmodified discriminating layers.
摘要翻译：一种多层改性膜及其制备方法，包括与具有未改性鉴别的膜相比具有耐污垢表面，改善的盐排斥，抗微生物性能和/或改进的溶质和/或小的有机物排斥的修饰鉴别层层。

20. 发明授权

US06566526B2 Intermediates useful for the preparation of antihistaminic piperidine derivatives 失效
标题翻译：用于制备抗组胺型哌啶衍生物的中间体
公开(公告)号：US06566526B2
公开(公告)日：2003-05-20
申请号：US09725291
申请日：2000-11-29
申请人： Richard C. Krauss , Robert M. Strom , Carey L. Scortichini , William J. Kruper , Richard A. Wolf , Weishi W. Wu , Albert A. Carr , David A. Hay , Duane E. Rudisill , Gianbattista Panzone
发明人： Richard C. Krauss , Robert M. Strom , Carey L. Scortichini , William J. Kruper , Richard A. Wolf , Weishi W. Wu , Albert A. Carr , David A. Hay , Duane E. Rudisill , Gianbattista Panzone
IPC分类号： C07D21122
CPC分类号： C07D295/185 , C07C33/46 , C07C45/46 , C07C45/63 , C07C45/65 , C07C45/673 , C07C49/792 , C07C49/798 , C07C49/80 , C07C49/813 , C07C49/82 , C07C49/825 , C07C49/83 , C07C49/835 , C07C49/86 , C07C59/86 , C07C59/88 , C07C69/007 , C07C69/738 , C07C235/78 , C07C255/16 , C07C259/06 , C07C2601/02 , C07D211/22 , C07D401/06 , C07D401/10
摘要： The present invention is related to a novel intermediates and processes which are useful in the preparation of certain antihistaminic piperidine derivatives of the formula wherein W represents —C(═O)— or —CH(OH)—; R1 represents hydrogen or hydroxy; R2 represents hydrogen; R1 and R2 taken together form a second bond between the carbon atoms bearing R1 and R2; n is an integer of from 1 to 5; m is an integer 0 to 1; R3 is —COOH or —COOalkyl wherein the alkyl moiety has from 1 to 6 carbon atoms and is straight or branched; each of A is hydrogen or hydroxy; and pharmaceutically acceptable salts and individual optical isomers thereof, with the proviso that where R1 and R2 are taken together to form a second bond between the carbon atoms bearing R1 and R2 or where R1 represented hydroxy, m is an integer 0.
摘要翻译：本发明涉及一种新的中间体和方法，其可用于制备W代表-C（= O） - 或-CH（OH） - 的某些抗组胺型哌啶衍生物; R 1表示氢或羟基; R 2表示氢 ; R 1和R 2一起形成带有R 1和R 2的碳原子之间的第二个键; n是1至5的整数; m是0至1的整数; R 3是-COOH或-COO烷基，其中烷基部分具有 1至6个碳原子，为直链或支链; A为氢或羟基; 其药学上可接受的盐和单独的光学异构体，条件是其中R 1和R 2一起形成在具有R 1和R 2的碳原子之间或其中R 1表示羟基的第二个键，m是整数0。

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