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11. 发明授权

US07611699B2 Methods of using cytokine zalpha11 ligand 有权
标题翻译：使用细胞因子zalpha11配体的方法
公开(公告)号：US07611699B2
公开(公告)日：2009-11-03
申请号：US11551349
申请日：2006-10-20
申请人： Julia E. Novak , Scott R. Presnell , Cindy A. Sprecher , Donald C. Foster , Richard D. Holly , Jane A. Gross , Janet V. Johnston , Andrew J. Nelson , Stacey R. Dillon , Angela K. Hammond
发明人： Julia E. Novak , Scott R. Presnell , Cindy A. Sprecher , Donald C. Foster , Richard D. Holly , Jane A. Gross , Janet V. Johnston , Andrew J. Nelson , Stacey R. Dillon , Angela K. Hammond
IPC分类号： A61K38/20 , A61K38/00
CPC分类号： C07K14/001 , A01K67/0275 , A01K2217/05 , A01K2227/105 , A01K2267/03 , A61K38/00 , A61K38/18 , C07K14/52 , C07K14/535 , C07K14/54 , C07K14/5406 , C07K14/715 , C07K16/24 , C07K16/2866 , C07K2317/73 , C07K2319/00 , C07K2319/21 , C07K2319/24 , C07K2319/30 , C07K2319/55 , C12N15/62 , C12N15/8509 , C12N2799/026 , G01N2333/52 , A61K2300/00
摘要： Antibodies that bind to polypeptides and peptides comprising the sequence of zalpha11 Ligand as shown in SEQ ID NO: 2 are described. The antibodies may bind the full length sequence of 162 amino acid residues or a fragment thereof, including a mature polypeptide of 131 amino acid residues and smaller polypeptide and peptide sequences. The antibodies may include antibodies that are polyclonal, monoclonal, murine, humanized or neutralizing. Methods for producing the antibodies are also described.
摘要翻译：描述了与SEQ ID NO：2所示的包含zalpha11配体的序列的多肽和肽结合的抗体。抗体可以结合162个氨基酸残基或其片段的全长序列，包括131个氨基酸残基的成熟多肽和较小的多肽和肽序列。抗体可以包括多克隆，单克隆，鼠，人源化或中和的抗体。还描述了产生抗体的方法。

12. 发明授权

US07592425B2 Cytokine zalpha11 ligand fusion proteins 有权
公开(公告)号：US07592425B2
公开(公告)日：2009-09-22
申请号：US11551362
申请日：2006-10-20
申请人： Julia E. Novak , Scott R. Presnell , Cindy A. Sprecher , Donald C. Foster , Richard D. Holly , Jane A. Gross , Janet V. Johnston , Andrew J. Nelson , Stacey R. Dillon , Angela K. Hammond
发明人： Julia E. Novak , Scott R. Presnell , Cindy A. Sprecher , Donald C. Foster , Richard D. Holly , Jane A. Gross , Janet V. Johnston , Andrew J. Nelson , Stacey R. Dillon , Angela K. Hammond
IPC分类号： C07K14/52 , C07K14/00 , C12N15/00 , A61K39/00
CPC分类号： C07K14/001 , A01K67/0275 , A01K2217/05 , A01K2227/105 , A01K2267/03 , A61K38/00 , A61K38/18 , C07K14/52 , C07K14/535 , C07K14/54 , C07K14/5406 , C07K14/715 , C07K16/24 , C07K16/2866 , C07K2317/73 , C07K2319/00 , C07K2319/21 , C07K2319/24 , C07K2319/30 , C07K2319/55 , C12N15/62 , C12N15/8509 , C12N2799/026 , G01N2333/52 , A61K2300/00
摘要： Antibodies that bind to polypeptides and peptides comprising the sequence of zalpha11 Ligand as shown in SEQ ID NO: 2 are described. The antibodies may bind the full length sequence of 162 amino acid residues or a fragment thereof, including a mature polypeptide of 131 amino acid residues and smaller polypeptide and peptide sequences. The antibodies may include antibodies that are polyclonal, monoclonal, murine, humanized or neutralizing. Methods for producing the antibodies are also described.

13. 发明授权

US06686178B2 Cytokine zalpha11 ligand polynucleotides 有权
标题翻译：细胞因子zalpha11配体多核苷酸
公开(公告)号：US06686178B2
公开(公告)日：2004-02-03
申请号：US10295723
申请日：2002-11-15
申请人： Julia E. Novak , Scott R. Presnell , Cindy A. Sprecher , Donald C. Foster , Richard D. Holly , Jane A. Gross , Janet V. Johnston , Andrew J. Nelson , Stacey R. Dillon , Angela K. Hammond
发明人： Julia E. Novak , Scott R. Presnell , Cindy A. Sprecher , Donald C. Foster , Richard D. Holly , Jane A. Gross , Janet V. Johnston , Andrew J. Nelson , Stacey R. Dillon , Angela K. Hammond
IPC分类号： C12N1524
CPC分类号： C07K14/001 , A01K67/0275 , A01K2217/05 , A01K2227/105 , A01K2267/03 , A61K38/00 , A61K38/18 , C07K14/52 , C07K14/535 , C07K14/54 , C07K14/5406 , C07K14/715 , C07K16/24 , C07K16/2866 , C07K2317/73 , C07K2319/00 , C07K2319/21 , C07K2319/24 , C07K2319/30 , C07K2319/55 , C12N15/62 , C12N15/8509 , C12N2799/026 , G01N2333/52 , A61K2300/00
摘要： The present invention relates to zalpha11 Ligand polynucleotide and polypeptide molecules. The zalpha11 Ligand is a novel cytokine. The polypeptides may be used within methods for stimulating the proliferation and/or development of hematopoietic cells in vitro and in vivo. The present invention also includes methods for producing the protein, uses therefor and antibodies thereto.
摘要翻译：本发明涉及zalpha11配体多核苷酸和多肽分子。 zalpha11配体是一种新型细胞因子。多肽可用于在体外和体内刺激造血细胞的增殖和/或发育的方法中。本发明还包括生产蛋白质的方法，用途及其抗体。

14. 发明授权

US08383775B2 Cytokine zalpha11 ligand 有权
标题翻译：细胞因子zalpha11配体的方法和用途
公开(公告)号：US08383775B2
公开(公告)日：2013-02-26
申请号：US13339639
申请日：2011-12-29
申请人： Julia E. Novak , Scott R. Presnell , Cindy A. Sprecher , Donald C. Foster , Richard D. Holly , Jane A. Gross , Janet V. Johnston , Andrew J. Nelson , Stacey R. Dillon , Angela K. Hammond
发明人： Julia E. Novak , Scott R. Presnell , Cindy A. Sprecher , Donald C. Foster , Richard D. Holly , Jane A. Gross , Janet V. Johnston , Andrew J. Nelson , Stacey R. Dillon , Angela K. Hammond
IPC分类号： C07K14/52 , C07K14/00 , C07K1/00 , C12P21/04 , A61K45/00 , A61K39/395
CPC分类号： C07K14/001 , A01K67/0275 , A01K2217/05 , A01K2227/105 , A01K2267/03 , A61K38/00 , A61K38/18 , C07K14/52 , C07K14/535 , C07K14/54 , C07K14/5406 , C07K14/715 , C07K16/24 , C07K16/2866 , C07K2317/73 , C07K2319/00 , C07K2319/21 , C07K2319/24 , C07K2319/30 , C07K2319/55 , C12N15/62 , C12N15/8509 , C12N2799/026 , G01N2333/52 , A61K2300/00
摘要： Antibodies that bind to polypeptides and peptides comprising the sequence of zalpha11 Ligand as shown in SEQ ID NO: 2 are described. The antibodies may bind the full length sequence of 162 amino acid residues or a fragment thereof, including a mature polypeptide of 131 amino acid residues and smaller polypeptide and peptide sequences. The antibodies may include antibodies that are polyclonal, monoclonal, murine, humanized or neutralizing. Methods for producing the antibodies are also described.
摘要翻译：描述了与SEQ ID NO：2所示的包含zalpha11配体的序列的多肽和肽结合的抗体。抗体可以结合162个氨基酸残基或其片段的全长序列，包括131个氨基酸残基的成熟多肽和较小的多肽和肽序列。抗体可以包括多克隆，单克隆，鼠，人源化或中和的抗体。还描述了产生抗体的方法。

15. 发明授权

US07998468B2 Cytokine zalpha11 ligand antibodies 有权
标题翻译：细胞因子zalpha11配体抗体
公开(公告)号：US07998468B2
公开(公告)日：2011-08-16
申请号：US12469303
申请日：2009-05-20
申请人： Julia E. Novak , Scott R. Presnell , Cindy A. Sprecher , Donald C. Foster , Richard D. Holly , Jane A. Gross , Janet V. Johnston , Andrew J. Nelson , Stacey R. Dillon , Angela K. Hammond
发明人： Julia E. Novak , Scott R. Presnell , Cindy A. Sprecher , Donald C. Foster , Richard D. Holly , Jane A. Gross , Janet V. Johnston , Andrew J. Nelson , Stacey R. Dillon , Angela K. Hammond
IPC分类号： A61K38/20 , A61K38/00
CPC分类号： C07K14/001 , A01K67/0275 , A01K2217/05 , A01K2227/105 , A01K2267/03 , A61K38/00 , A61K38/18 , C07K14/52 , C07K14/535 , C07K14/54 , C07K14/5406 , C07K14/715 , C07K16/24 , C07K16/2866 , C07K2317/73 , C07K2319/00 , C07K2319/21 , C07K2319/24 , C07K2319/30 , C07K2319/55 , C12N15/62 , C12N15/8509 , C12N2799/026 , G01N2333/52 , A61K2300/00
摘要： Antibodies that bind to polypeptides and peptides comprising the sequence of zalpha11 Ligand as shown in SEQ ID NO: 2 are described. The antibodies may bind the full length sequence of 162 amino acid residues or a fragment thereof, including a mature polypeptide of 131 amino acid residues and smaller polypeptide and peptide sequences. The antibodies may include antibodies that are polyclonal, monoclonal, murine, humanized or neutralizing. Methods for producing the antibodies are also described.
摘要翻译：描述了与SEQ ID NO：2所示的包含zalpha11配体的序列的多肽和肽结合的抗体。抗体可以结合162个氨基酸残基或其片段的全长序列，包括131个氨基酸残基的成熟多肽和较小的多肽和肽序列。抗体可以包括多克隆，单克隆，鼠，人源化或中和的抗体。还描述了产生抗体的方法。

16. 再颁专利

USRE41129E1 Cytokine zalpha11 ligand polynucleotides 有权
标题翻译：细胞因子zalpha11配体多核苷酸
公开(公告)号：USRE41129E1
公开(公告)日：2010-02-16
申请号：US11346580
申请日：2006-02-02
申请人： Julia E. Novak , Scott R. Presnell , Cindy A. Sprecher , Donald C. Foster , Richard D. Holly , Jane A. Gross , Janet V. Johnston , Andrew J. Nelson , Stacey R. Dillon , Angela K. Hammond
发明人： Julia E. Novak , Scott R. Presnell , Cindy A. Sprecher , Donald C. Foster , Richard D. Holly , Jane A. Gross , Janet V. Johnston , Andrew J. Nelson , Stacey R. Dillon , Angela K. Hammond
IPC分类号： C12N15/24 , C12N15/00 , C12N15/63 , C12N15/85 , C12P21/00 , C07H21/04
CPC分类号： C07K14/001 , A01K67/0275 , A01K2217/05 , A01K2227/105 , A01K2267/03 , A61K38/00 , A61K38/18 , C07K14/52 , C07K14/535 , C07K14/54 , C07K14/5406 , C07K14/715 , C07K16/24 , C07K16/2866 , C07K2317/73 , C07K2319/00 , C07K2319/21 , C07K2319/24 , C07K2319/30 , C07K2319/55 , C12N15/62 , C12N15/8509 , C12N2799/026 , G01N2333/52 , A61K2300/00
摘要： The present invention relates to zalpha11 Ligand polynucleotide and polypeptide molecules. The zalpha11 Ligand is a novel cytokine. The polypeptides may be used within methods for stimulating the proliferation and/or development of hematopoietic cells in vitro and in vivo. The present invention also includes methods for producing the protein, uses therefor and antibodies thereto.
摘要翻译：本发明涉及zalpha11配体多核苷酸和多肽分子。 zalpha11配体是一种新型细胞因子。多肽可用于在体外和体内刺激造血细胞的增殖和/或发育的方法中。本发明还包括生产蛋白质的方法，用途及其抗体。

17. 发明授权

US07579441B2 Cytokine zalpha11 ligand fusion proteins 有权
公开(公告)号：US07579441B2
公开(公告)日：2009-08-25
申请号：US11551811
申请日：2006-10-23
申请人： Julia E. Novak , Scott R. Presnell , Cindy A. Sprecher , Donald C. Foster , Richard D. Holly , Jane A. Gross , Janet V. Johnston , Andrew J. Nelson , Stacey R. Dillon , Angela K. Hammond
发明人： Julia E. Novak , Scott R. Presnell , Cindy A. Sprecher , Donald C. Foster , Richard D. Holly , Jane A. Gross , Janet V. Johnston , Andrew J. Nelson , Stacey R. Dillon , Angela K. Hammond
IPC分类号： C07K17/00 , C07K14/00 , A61K39/00
CPC分类号： C07K14/001 , A01K67/0275 , A01K2217/05 , A01K2227/105 , A01K2267/03 , A61K38/00 , A61K38/18 , C07K14/52 , C07K14/535 , C07K14/54 , C07K14/5406 , C07K14/715 , C07K16/24 , C07K16/2866 , C07K2317/73 , C07K2319/00 , C07K2319/21 , C07K2319/24 , C07K2319/30 , C07K2319/55 , C12N15/62 , C12N15/8509 , C12N2799/026 , G01N2333/52 , A61K2300/00
摘要： Antibodies that bind to polypeptides and peptides comprising the sequence of zalpha11 Ligand as shown in SEQ ID NO: 2 are described. The antibodies may bind the full length sequence of 162 amino acid residues or a fragment thereof, including a mature polypeptide of 131 amino acid residues and smaller polypeptide and peptide sequences. The antibodies may include antibodies that are polyclonal, monoclonal, murine, humanized or neutralizing. Methods for producing the antibodies are also described.

18. 发明授权

US5989537A Methods for stimulating granulocyte/macrophage lineage using thrombopoietin 失效
标题翻译：使用血小板生成素刺激粒细胞/巨噬细胞谱系的方法
公开(公告)号：US5989537A
公开(公告)日：1999-11-23
申请号：US484257
申请日：1995-06-07
申请人： Richard D. Holly , Si Lok , Donald C. Foster , Frederick S. Hagen , Kenneth Kaushansky , Joseph L. Kuijper , Catherine E. Lofton-Day , Pieter J. Oort
发明人： Richard D. Holly , Si Lok , Donald C. Foster , Frederick S. Hagen , Kenneth Kaushansky , Joseph L. Kuijper , Catherine E. Lofton-Day , Pieter J. Oort
IPC分类号： A01K67/027 , A61K35/12 , A61K38/19 , A61K38/22 , A61P7/00 , A61P7/06 , C07H21/04 , C07K1/22 , C07K14/52 , C07K14/705 , C07K14/715 , C07K16/24 , C12N1/19 , C12N5/0787 , C12N5/10 , C12N15/09 , C12N15/19 , C12P21/02 , C12Q1/68 , C12R1/865 , C12R1/91 , G01N33/50
CPC分类号： G01N33/5055 , A61K38/196 , C07K14/705 , C07K14/715 , C12N5/0642 , G01N33/5005 , G01N33/5008 , G01N33/5088 , G01N33/5094 , C12N2501/145 , C12N2501/22
摘要： Methods for stimulating granulocyte/macrophage lineage cells using thrombopoiet in are provided. The methods provided may be used to stimulate granulocyte/macrophage progenitors and neutrophils in bone marrow and peripheral blood cells and in vitro and in vivo. In addition, methods for treatment of neutropenia in patients are disclosed.
摘要翻译：提供了使用血小板生成刺激粒细胞/巨噬细胞谱系细胞的方法。所提供的方法可用于在骨髓和外周血细胞以及体外和体内刺激粒细胞/巨噬细胞祖细胞和嗜中性粒细胞。另外，还公开了治疗患者中性粒细胞减少症的方法。

19. 发明授权

US5766921A Hybrid protein C 失效
标题翻译：杂交蛋白C
公开(公告)号：US5766921A
公开(公告)日：1998-06-16
申请号：US318579
申请日：1994-10-05
申请人： Donald C. Foster , Richard D. Holly
发明人： Donald C. Foster , Richard D. Holly
IPC分类号： A61K38/43 , A61P7/02 , C07K14/00 , C07K14/745 , C07K19/00 , C12N5/10 , C12N9/60 , C12N9/64 , C12N15/09 , C12N15/00 , C07H21/02 , C12N5/00 , C12P21/06
CPC分类号： C12N9/6464 , C12N9/60 , C12Y304/21069 , C07K2319/00
摘要： Human protein C molecules are modified to provide increased resistance to inactivation by human plasma factors while retaining substantially the biological activity of human protein C. The modifications are generally to the heavy chain of protein C, which chain may be substituted with a protein C heavy chain of non-human origin, such as bovine, yielding a chimeric protein C molecule. The human protein C heavy chain may also be modified to be human-like, in that at least one amino acid from a non-human sequence may be substituted for the corresponding residue(s) of the human sequence, thereby allowing the molecule to retain substantially human characteristics yet having increased resistance to inactivation. Also included are methods for producing the modified protein C molecules and pharmaceutical compositions thereof. The modified molecules, having an increased half-life in human plasma, are particularly useful for treating coagulation-related disorders, such as protein C deficiency or thrombosis, or for promoting fibrinolysis in a patient.
摘要翻译：人蛋白C分子被修饰以提供对人血浆因子的失活增强的抗性，同时保留人蛋白C的生物活性。修饰通常是蛋白C的重链，该链可被C蛋白重链取代非人源的，如牛，产生嵌合蛋白C分子。人蛋白C重链也可以被修饰为人样，因为来自非人序列的至少一个氨基酸可以被人序列的相应残基取代，从而允许分子保留基本上人的特征，但具有增加的失活抗性。还包括生产修饰的蛋白C分子的方法及其药物组合物。在人血浆中具有增加的半衰期的改性分子对于治疗凝血相关疾病如蛋白C缺乏或血栓形成或促进患者的纤维蛋白溶解特别有用。

20. 发明授权

US08227575B2 Cytokine zalpha11 ligand antibodies 有权
标题翻译：细胞因子zalpha11配体抗体
公开(公告)号：US08227575B2
公开(公告)日：2012-07-24
申请号：US12626307
申请日：2009-11-25
申请人： Julia E. Novak , Scott R. Presnell , Cindy A. Sprecher , Donald C. Foster , Richard D. Holly , Jane A. Gross , Janet V. Johnston , Andrew J. Nelson , Stacey R. Dillon , Angela K. Hammond
发明人： Julia E. Novak , Scott R. Presnell , Cindy A. Sprecher , Donald C. Foster , Richard D. Holly , Jane A. Gross , Janet V. Johnston , Andrew J. Nelson , Stacey R. Dillon , Angela K. Hammond
IPC分类号： C07K16/00 , A61K39/395 , A61K38/00 , C07K14/00 , C07K5/00
CPC分类号： C07K14/001 , A01K67/0275 , A01K2217/05 , A01K2227/105 , A01K2267/03 , A61K38/00 , A61K38/18 , C07K14/52 , C07K14/535 , C07K14/54 , C07K14/5406 , C07K14/715 , C07K16/24 , C07K16/2866 , C07K2317/73 , C07K2319/00 , C07K2319/21 , C07K2319/24 , C07K2319/30 , C07K2319/55 , C12N15/62 , C12N15/8509 , C12N2799/026 , G01N2333/52 , A61K2300/00
摘要： Antibodies that bind to polypeptides and peptides comprising the sequence of zalpha11 Ligand as shown in SEQ ID NO: 2 are described. The antibodies may bind the full length sequence of 162 amino acid residues or a fragment thereof, including a mature polypeptide of 131 amino acid residues and smaller polypeptide and peptide sequences. The antibodies may include antibodies that are polyclonal, monoclonal, murine, humanized or neutralizing. Methods for producing the antibodies are also described.
摘要翻译：描述了与SEQ ID NO：2所示的包含zalpha11配体的序列的多肽和肽结合的抗体。抗体可以结合162个氨基酸残基或其片段的全长序列，包括131个氨基酸残基的成熟多肽和较小的多肽和肽序列。抗体可以包括多克隆，单克隆，鼠，人源化或中和的抗体。还描述了产生抗体的方法。

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