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11. 发明申请

WO2006041978A2 MULTIVALENT AVIAN INFLUENZA VACCINES 审中-公开
标题翻译：多价AVIV流感疫苗
公开(公告)号：WO2006041978A2
公开(公告)日：2006-04-20
申请号：PCT/US2005/035925
申请日：2005-10-06
申请人： WYETH , PLANA-DURAN, Juan , VILA-QUINTANA, Rut , TARRES-CALL, Jordi , KUMAR, Mahesh
发明人： PLANA-DURAN, Juan , VILA-QUINTANA, Rut , TARRES-CALL, Jordi , KUMAR, Mahesh
CPC分类号： A61K39/145 , A61K39/00 , A61K39/12 , A61K2039/5252 , A61K2039/552 , A61K2039/55566 , A61K2039/70 , C12N2760/16134
摘要： A vaccine composition and method which is effective in preventing or ameliorating Avian Influenza Virus infection is set forth herein. The vaccine contains at least two inactivated strains of avian influenza virus, wherein the combined haemoagglutinin (HA) total is at least about 200 HA/dose of the vaccine composition, and wherein each of the strains presents at least about 128 HA/dose, and further wherein one of the strains has the same HA subtype as that of a challenge virus, and wherein at least one of the strains has a different NA subtype than the challenge virus.
摘要翻译：本文阐述了有效预防或改善禽流感病毒感染的疫苗组合物和方法。疫苗含有至少两种灭活的禽流感病毒株，其中组合的血凝素（HA）总量为至少约200HA /剂量的疫苗组合物，并且其中每种毒株呈现至少约128HA /剂量，和进一步其中一种菌株具有与攻击病毒相同的HA亚型，并且其中至少一种菌株具有与攻击病毒不同的NA亚型。

12. 发明申请

WO2005089795A2 INFECTIOUS BURSAL DISEASE VIRUS ANTIGENIC ISOLATES AND VACCINES 审中-公开
标题翻译：感染性皮疹病毒抗原分离物和疫苗
公开(公告)号：WO2005089795A2
公开(公告)日：2005-09-29
申请号：PCT/US2005/007879
申请日：2005-03-10
申请人： WYETH , RODENBERG, Jeffrey, Harold , KUMAR, Mahesh , COOKSON, Kalen
发明人： RODENBERG, Jeffrey, Harold , KUMAR, Mahesh , COOKSON, Kalen
IPC分类号： A61K39/12
CPC分类号： C07K14/005 , A61K39/12 , A61K39/15 , A61K2039/5252 , A61K2039/5254 , A61K2039/552 , A61K2039/55566 , A61K2039/70 , C12N7/00 , C12N2720/10022 , C12N2720/10034 , C12N2720/12022 , C12N2720/12034
摘要： Antigenic isolates and vaccines for Infectious Bursal Disease Virus include variants of the molecular Group 6 family of IBDV isolates, in particular the 28-1 isolate.
摘要翻译：用于传染性法氏囊病病毒的抗原分离物和疫苗包括IBDV分离株的分子6族家族的变体，特别是28-1株。

13. 发明申请

WO2003032123A2 CLUSTERING 审中-公开
标题翻译：聚类
公开(公告)号：WO2003032123A2
公开(公告)日：2003-04-17
申请号：PCT/US2002/032234
申请日：2002-10-09
申请人： PROFITLOGIC, INC. , KUMAR, Mahesh , GAIDAREV, Peter , WOO, Jonathan, W.
发明人： KUMAR, Mahesh , GAIDAREV, Peter , WOO, Jonathan, W.
IPC分类号： G06F
CPC分类号： G06Q30/0201 , G06Q10/087 , G06Q30/0204
摘要： A set of data is received containing values associated with respective data points, the values associated with each of the data points being characterized by a distribution. The values for each of the data points are expressed in a form that includes information about a distribution of the values for each of the data points. The distribution information is used in clustering the set of data with at least one other set of data containing values associated with data points.
摘要翻译：接收包含与相应数据点（40,42,50）相关联的值的一组数据，与通过分布表征的每个数据点相关联的值。每个数据点的值以包括关于每个数据点的值的分布的信息的形式表示。分发信息用于使用包含与数据点（86）相关联的值的至少一个其它数据集进行聚类（86）数据集。

14. 发明公开

EP1796720A2 MULTIVALENT AVIAN INFLUENZA VACCINES 有权转让
标题翻译：二价禽流感疫苗
公开(公告)号：EP1796720A2
公开(公告)日：2007-06-20
申请号：EP05816010.2
申请日：2005-10-06
申请人： Wyeth
发明人： PLANA-DURAN, Juan , VILA-QUINTANA, Rut , TARRES-CALL, Jordi , KUMAR, Mahesh
IPC分类号： A61K39/145 , A61K39/295 , A61K39/39
CPC分类号： A61K39/145 , A61K39/00 , A61K39/12 , A61K2039/5252 , A61K2039/552 , A61K2039/55566 , A61K2039/70 , C12N2760/16134
摘要： A vaccine composition and method which is effective in preventing or ameliorating Avian Influenza Virus infection is set forth herein. The vaccine contains at least two inactivated strains of avian influenza virus, wherein the combined haemoagglutinin (HA) total is at least about 200 HA/dose of the vaccine composition, and wherein each of the strains presents at least about 128 HA/dose, and further wherein one of the strains has the same HA subtype as that of a challenge virus, and wherein at least one of the strains has a different NA subtype than the challenge virus.

15. 发明公开

EP1722814A2 INFECTIOUS BURSAL DISEASE VIRUS ANTIGENIC ISOLATES AND VACCINES 有权转让
标题翻译：抗原和疫苗隔离病毒传染性法氏囊病
公开(公告)号：EP1722814A2
公开(公告)日：2006-11-22
申请号：EP05732938.5
申请日：2005-03-10
申请人： Wyeth Incoporated
发明人： RODENBERG, Jeffrey, Harold , KUMAR, Mahesh , COOKSON, Kalen
IPC分类号： A61K39/12
CPC分类号： C07K14/005 , A61K39/12 , A61K39/15 , A61K2039/5252 , A61K2039/5254 , A61K2039/552 , A61K2039/55566 , A61K2039/70 , C12N7/00 , C12N2720/10022 , C12N2720/10034 , C12N2720/12022 , C12N2720/12034
摘要： Antigenic isolates and vaccines for Infectious Bursal Disease Virus include variants of the molecular Group 6 family of IBDV isolates, in particular the 28-1 isolate.

16. 发明公开

EP2209489A1 LIVE ATTENUATED MYCOPLASMA STRAINS 审中-公开
标题翻译：减毒活株支原体
公开(公告)号：EP2209489A1
公开(公告)日：2010-07-28
申请号：EP08830393.8
申请日：2008-09-12
申请人： Wyeth LLC
发明人： KUMAR, Mahesh , KHAN, Muhammad Ayub
IPC分类号： A61K39/02 , C12Q1/68 , G01N33/569
CPC分类号： A61K39/0241 , A61K2039/522 , G01N33/56933 , G01N33/6803 , G01N2333/30
摘要： The present invention provides live, attenuated Mycoplasma bacteria that exhibit reduced expression of one or more proteins selected from the group consisting of pyruvate dehydrogenase, phosphopyruvate hydratase, 2-deoxyribose-5-phosphate aldolase, and ribosomal protein L35, relative to a wild-type Mycoplasma bacterium of the same species. Also provided are vaccines and vaccination methods involving the use of the live, attenuated Mycoplasma bacteria, and methods for making live attenuated Mycoplasma bacteria.

17. 发明公开

EP2200640A1 ATTENUATED MYCOPLASMA GALLISEPTICUM STRAINS 有权
标题翻译：鸡毒支原体的减毒株
公开(公告)号：EP2200640A1
公开(公告)日：2010-06-30
申请号：EP08830621.2
申请日：2008-09-10
申请人： Wyeth LLC
发明人： KUMAR, Mahesh , KHAN, Muhammad, Ayub
IPC分类号： A61K39/02 , C12N1/36 , C12R1/35
CPC分类号： C12N1/36 , A61K39/0241 , A61K2039/522 , A61K2039/552 , C12N1/20 , C12R1/35
摘要： The present invention provides live, attenuated Mycoplasma gallisepticum bacteria that exhibit reduced expression of a protein identified as MGA_0621. In certain embodiments, the attenuated bacteria may additionally exhibit reduced expression of one or more proteins selected from the group consisting of pyruvate dehydrogenase, phosphopyruvate hydratase, 2-deoxyribose-5-phosphate aldolase, and ribosomal protein L35, relative to a wild-type M. gallisepticum bacterium. Also provided are vaccines and vaccination methods involving the use of the live, attenuated M. gallisepticum bacteria, and methods for making live attenuated M. gallisepticum bacteria. An exemplary live, attenuated strain of M. gallisepticum is provided, designated MGx+47, which was shown by proteomics analysis to exhibit significantly reduced expression of MGA_0621, and was shown to be safe and effective when administered as a vaccine against M. gallisepticum infection in chickens.

18. 发明公开

EP1622642A1 AVIAN E. COLI VACCINE FOR THE PROTECTION AGAINST COLIBACILLOSIS 有权转让
标题翻译：大肠杆菌疫苗保护家禽抗colibacilosis的
公开(公告)号：EP1622642A1
公开(公告)日：2006-02-08
申请号：EP04751979.8
申请日：2004-05-12
申请人： Wyeth
发明人： FAN, Henry, H. , KUMAR, Mahesh , LA RAGIONE, Roberto, Marcello , WOODWARD, Martin, John, 23 Burnsall Close
IPC分类号： A61K39/108
CPC分类号： A61K39/0258 , A61K2039/522 , A61K2039/55 , A61K2039/552 , Y02A50/474
摘要： A genetic deletion mutant live E. coli vaccine suitable for mass application to poultry, including chickens, is provided. Also provided is a safe and effective method to protect poultry against the ravages of Escherichia coli bacillosis infection and disease in which a live mutant aroA-gene deleted E. coli immunogen is administered to chickens, turkeys and the like via mass application routes such as coarse sprays and drinking water.

19. 发明公开

EP2242444A2 SWINE VACCINATION SYSTEM 有权转让
标题翻译： IMPFSYSTEMFÜRSCHWEINE
公开(公告)号：EP2242444A2
公开(公告)日：2010-10-27
申请号：EP09709150.8
申请日：2009-01-29
申请人： Wyeth LLC
发明人： KUMAR, Mahesh
IPC分类号： A61D7/00
CPC分类号： A61D1/025 , A61D7/04 , A61D2003/003 , A61M11/00 , A61M2205/13 , A61M2205/3379 , A61M2210/0606 , A61M2250/00
摘要： A system for vaccinating swine according to one embodiment includes a housing having an open first end and an open opposite second end. The housing has a pair of side walls that are angled and non-parallel to one another such that at the second end only a single piglet can exit at one time. The system also includes a vaccination station for individually vaccinating piglets. The vaccination station is located between the pair of side walls in a region thereof that is sized to only permit one piglet to stand between the side walls. The vaccination station includes at least one sensor that detects the presence of the one piglet within the vaccination station and at least one spray nozzle positioned within the vaccination station such that a vaccine dose discharged therefrom is directed upwardly into facial areas of the piglet effectively.
摘要翻译：根据一个实施例的用于接种猪的系统包括具有敞开的第一端和敞开的相对的第二端的壳体。壳体具有一对侧壁，它们彼此成角度且不平行，使得在第二端仅一只仔猪可以一次离开。该系统还包括一个单独接种仔猪的疫苗接种站。疫苗接种站位于其一部分侧壁之间，其尺寸仅允许一只小猪站在侧壁之间。疫苗接种站包括至少一个传感器，其检测疫苗接种站内的一只仔猪的存在以及位于接种站内的至少一个喷嘴，使得从其排出的疫苗剂量有效地向上指向小猪的面部区域。

20. 发明公开

EP2164510A1 EMULSION VACCINE COMPOSITIONS COMPRISING ANTIGEN AND ADJUVANT IN THE AQUEOUS PHASE 有权转让
标题翻译：乳液疫苗组合物的抗原和佐剂在水相中
公开(公告)号：EP2164510A1
公开(公告)日：2010-03-24
申请号：EP08771428.3
申请日：2008-06-19
申请人： Wyeth LLC
发明人： LUTZ, David Leon , RODENBERG, Jeffrey Harold , DIEHL, Evan James , KUMAR, Mahesh
IPC分类号： A61K39/00 , A61K39/145
CPC分类号： A61K39/145 , A61K9/107 , A61K39/00 , A61K39/12 , A61K39/39 , A61K2039/552 , A61K2039/55505 , A61K2039/55511 , A61K2039/55555 , A61K2039/55561 , A61K2039/55566 , A61K2039/55572 , C12N7/00 , C12N2760/16134 , C12N2760/16171
摘要： Emulsion vaccine formulations containing an antigen and an adjuvant in the aqueous phase are used for the vaccination of animals wherein the adjuvant is an acrylic polymer and/or dimethyl dioctadecyl ammonium bromide (DDA). These formulations can be prepared by mixing an aqueous phase containing the antigen and adjuvant with an oil phase in the presence of an emulsifier.

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