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11. 发明申请

WO2006078633A1 VARIABLE RESISTANCE FLUID CONTROLLER 审中-公开
标题翻译：可变阻力流体控制器
公开(公告)号：WO2006078633A1
公开(公告)日：2006-07-27
申请号：PCT/US2006/001563
申请日：2006-01-18
申请人： WATERS INVESTMENTS LIMITED , GERHARDT, Geoff, C. , CHARLTON, Christopher, C.
发明人： GERHARDT, Geoff, C. , CHARLTON, Christopher, C.
IPC分类号： G01N30/06 , G01D11/02
CPC分类号： G01N30/34 , Y10T137/7737 , Y10T137/8597 , Y10T137/85986 , Y10T137/87346 , Y10T137/87539 , G01N30/6095
摘要： A fluid controller apparatus controls fluid flow, such as a solvent gradient flow, in a chromatography system. An apparatus includes a fluid-gradient controller having a fluid reservoir for containing a pump fluid and a pumping device connected to the fluid reservoir for receiving the pump fluid. The pumping device is in fluid communication with parallel-configured first and second solvent lines. The first and second solvent lines each contain a restrictor element and a solvent reservoir. During operation, the pumping device causes the pump fluid to flow through the first and second solvent lines in relation to their respective restriction devices. The pump fluid displaces solvent within the solvent reservoirs. The displaced solvent is mixed to form a solvent gradient.
摘要翻译：流体控制器装置在色谱系统中控制流体流，例如溶剂梯度流。一种装置包括具有用于容纳泵流体的流体储存器和连接到用于接收泵流体的流体储存器的泵送装置的流体梯度控制器。泵送装置与平行配置的第一和第二溶剂管线流体连通。第一和第二溶剂管线各自包含限流元件和溶剂储存器。在操作期间，泵送装置使泵流体相对于它们各自的限制装置流过第一和第二溶剂管线。泵流体置换溶剂容器内的溶剂。将置换的溶剂混合以形成溶剂梯度。

12. 发明申请

WO2005113457A2 CLOSED LOOP FLOW CONTROL OF A HPLC CONSTANT FLOW PUMP TO ENABLE LOW-FLOW OPERATION 审中-公开
标题翻译： HPLC恒定流量泵的闭环流量控制实现低流量操作
公开(公告)号：WO2005113457A2
公开(公告)日：2005-12-01
申请号：PCT/US2005/017923
申请日：2005-05-20
申请人： WATERS INVESTMENTS LIMITED , GERHARDT, Geoff, C. , LUONGO, Joseph, A.
发明人： GERHARDT, Geoff, C. , LUONGO, Joseph, A.
IPC分类号： C02F5/00
CPC分类号： B01D15/163 , B01L3/50273 , B01L2200/143 , B01L2400/086 , F04B13/02 , F04B23/04 , F04B2205/09 , G01N30/32 , G01N2030/324
摘要： A method and apparatus for monitoring and controlling nano-scale flow rate of fluid in the operating flow path of a HPLC system provide fluid flow without relying on complex calibration routines to compensate for solvent composition gradients typically used in HPLC. The apparatus and method are used to correct the flow output of a typical, analytical-scale (0.1-5 mL/min) HPLC pump to enable accurate anti precise flow delivery at capillary (
摘要翻译：用于监测和控制HPLC系统的操作流路中的流体的纳米级流速的方法和设备提供了流体流动而不依赖于复杂的校准例程来补偿通常用于 HPLC。该设备和方法用于校正典型的分析级（0.1-5mL / min）HPLC泵的流量输出以实现在毛细管（<0.1mL / min）和纳米级（ 1μL/ min）HPLC流速。

13. 发明申请

WO2004059257A2 A SYSTEM AND METHOD OFMEASURING CONVECTION INDUCED IMPEDANCE GRADIENTS TO DETERMINE LIQUID FLOW RATES 审中-公开
标题翻译：测量流体流速的对流诱导阻抗等级的系统和方法
公开(公告)号：WO2004059257A2
公开(公告)日：2004-07-15
申请号：PCT/US2003/041348
申请日：2003-12-22
申请人： WATERS INVESTMENTS LIMITED , GERHARDT, Geoff, C. , FADGEN, Keith, E.
发明人： GERHARDT, Geoff, C. , FADGEN, Keith, E.
IPC分类号： G01F
CPC分类号： G01F1/6847 , G01N30/64 , G01N2030/324
摘要： A method and system for measuring the flow rate of a liquid or gas within a flow channel utilizing a centrally located excitation source and a plurality of sensor means. Said excitation means is comprised of a heating element coupled with an alternating current generator. Of the plurality of sensor means, at least one of said sensors is located in a position upstream of the excitation source location, and additionally a second of said plurality of sensors is located in a position downstream of the excitation source. Instantaneous fluid flow rate is calculated utilizing a high gain differential amplifier electrically coupled to said sensors, wherein the convectively induced inductive gradient of the flowing fluid is compared to the symmetrical zero flow induction gradient. Following such a comparison, a voltage signal proportional to the flow of fluid within the channel is derived.
摘要翻译：一种用于利用位于中心的激励源和多个传感器装置来测量流动通道内的液体或气体的流量的方法和系统。所述激励装置包括与交流发电机耦合的加热元件。在多个传感器装置中，至少一个所述传感器位于激励源位置的上游位置，并且所述多个传感器中的另一个位于激发源的下游位置。利用电耦合到所述传感器的高增益差分放大器来计算瞬时流体流速，其中流动流体的对流感应感应梯度与对称零流感应梯度进行比较。在进行这样的比较之后，导出与通道内的流体流量成比例的电压信号。

14. 发明申请

WO2006055675A1 DEVICE FOR PERFORMING SEPARATIONS AND METHODS OF MAKING AND USING SAME 审中-公开
标题翻译：用于执行分离的装置及其制造和使用方法
公开(公告)号：WO2006055675A1
公开(公告)日：2006-05-26
申请号：PCT/US2005/041615
申请日：2005-11-16
申请人： WATERS INVESTMENTS LIMITED , CHARLTON, Christopher, C. , GERHARDT, Geoff, C. , BENEVIDES, Christopher, C.
发明人： CHARLTON, Christopher, C. , GERHARDT, Geoff, C. , BENEVIDES, Christopher, C.
IPC分类号： B01D15/08
CPC分类号： G01N30/603 , B01D15/22 , B01J20/283
摘要： Embodiments of the present invention feature a device (11) for performing separations, methods of making and using such device (11). The device (11) includes a tubular member (13) having an exterior surface (17) and an interior surface (19). The interior surface (19) defines a chamber (25) having an outlet end (23) and an inlet end (21) for containing a separation media (15). The chamber (25) has a length dimension extending between the inlet end (21) and the outlet end (23), and at least one width dimension. A separation media (15) is constructed and arranged in a packing of particles in the chamber wherein the particles of the separation media (15) proximal to at least one of the inlet end (21) or outlet end (23) are fused to retain the separation media (15).
摘要翻译：本发明的实施例的特征在于用于执行分离的装置（11），以及制造和使用这种装置（11）的方法。装置（11）包括具有外表面（17）和内表面（19）的管状构件（13）。内表面（19）限定了具有出口端（23）和用于容纳分离介质（15）的入口端（21）的腔室（25）。腔室（25）具有在入口端（21）和出口端（23）之间延伸的长度尺寸和至少一个宽度尺寸。分离介质（15）被构造并布置在腔室中的颗粒填料中，其中分离介质（15）的接近入口端（21）或出口端（23）中的至少一个的颗粒被熔合以保持分离介质（15）。

15. 发明申请

WO2004025162A2 CAPILLARY INTERCONNECTION FITTING AND METHOD OF HOLDING CAPILLARY TUBING 审中-公开
标题翻译：毛细管连接配件及其保管方法
公开(公告)号：WO2004025162A2
公开(公告)日：2004-03-25
申请号：PCT/US2003/028128
申请日：2003-09-09
申请人： WATERS INVESTMENTS LIMITED , PLANT, Kenneth, R. , CORMIER, Sylvain, G. , GERHARDT, Geoff, C.
发明人： PLANT, Kenneth, R. , CORMIER, Sylvain, G. , GERHARDT, Geoff, C.
IPC分类号： F16L
CPC分类号： G01N30/6004 , G01N30/6034
摘要： The present invention is a capillary interconnection fitting and method of clamping a capillary in the fitting that separates a forward ferrule that holds the capillary from a secondary clamping device. The fitting comprises a sealing ferrule, a compression screw and a clamping device. The ferrule is fitted in a compression screw that mates to a fluidic component. The clamping device is decoupled from the ferrule and coupled to the compression screw.
摘要翻译：本发明是一种毛细管互连配件和夹紧毛细管的方法，该毛细管连接在将夹持毛细管的前套管与次夹紧装置分开的配件中。配件包括密封套圈，压缩螺钉和夹紧装置。套圈安装在与流体组件配合的压缩螺钉中。夹紧装置与套圈脱钩并联接到压紧螺钉。

16. 发明申请

WO2005053813A1 FLOW SENSING APPARATUS 审中-公开
标题翻译：流量感应装置
公开(公告)号：WO2005053813A1
公开(公告)日：2005-06-16
申请号：PCT/US2004/039415
申请日：2004-11-23
申请人： WATERS INVESTMENTS LIMITED , GERHARDT, Geoff, C. , LUONGO, Joseph, A. , FADGEN, Keith
发明人： GERHARDT, Geoff, C. , LUONGO, Joseph, A. , FADGEN, Keith
IPC分类号： B01D15/08
CPC分类号： G01F1/68 , G01F1/363 , G01N30/10 , G01N30/30 , G01N30/32 , G01N2030/324 , G01N2030/326 , G05D11/132
摘要： A method and apparatus for monitoring and controlling the nano-scale flow rate of fluid in the operating flow path of a HPLC system. A first flow sensor is disposed in a first flow path between a first flow-divider and a fluidic tee. A second flow sensor is disposed in a second flow path between a second flow-divider and the fluidic tee. A first recycle flow restrictor is disposed in the first recycle flow path in fluid communication with the first flow-divider. A second recycle flow restrictor is disposed in the second. The permeability of each recycle flow restrictor can be selected to produce a desired flow rate with each respective flow path. The output signals of the first and second flow sensors to control output of a pump within each flow path.
摘要翻译：一种用于监测和控制HPLC系统的操作流路中的流体的纳米流量的方法和装置。第一流量传感器设置在第一分流器和流体三通之间的第一流动路径中。第二流量传感器设置在第二分流器和流体三通之间的第二流动路径中。第一再循环流量限制器设置在与第一分流器流体连通的第一再循环流动路径中。第二个再循环流量限制器设置在第二个再循环流量限制器中。可以选择每个再循环流量限制器的渗透性，以产生每个相应流动路径的期望流量。第一和第二流量传感器的输出信号以控制每个流动路径内的泵的输出。

17. 发明申请

WO2004025153A2 FREEZE-THAW VALVE THAT SELF-LIMITS CRYOGENIC AGENT USAGE 审中-公开
标题翻译：冷冻阀可自动限制低温剂使用
公开(公告)号：WO2004025153A2
公开(公告)日：2004-03-25
申请号：PCT/US2003/028910
申请日：2003-09-15
申请人： WATERS INVESTMENTS LIMITED , GERHARDT, Geoff, C. , DOURDEVILLE, Theodore,
发明人： GERHARDT, Geoff, C. , DOURDEVILLE, Theodore,
IPC分类号： F16K
CPC分类号： F16K13/10 , F16K31/002 , Y10T137/0391 , Y10T137/2196 , Y10T137/4643 , Y10T137/6579
摘要： Methods and devices for the management of cryogenic agents within analytical systems using freeze thaw valving having an expansion chamber that limits the flow of the cryogenic agent. The expansion chamber is fitted with an expansion nozzle through which a cryogen flows and a porous frit that allows the cryogen to be exhausted. The porous frit initially allows a rapid flow of cryogen into the expansion chamber. This rapid flow lowers the temperature of the expansion chamber causing fluid contents within a freeze thaw segment to freeze. As the cryogen expands into the expansion chamber and turns into a solid, the porous frit is occluded causing the rapid flow to be restricted. The restriction of the cryogen flow by the occlusion of the porous frit allows the freeze thaw valve to use significantly less cryogen. Sublimation of the cryogen trapped within the porous frit provides sufficient cooling to maintain the valve in its closed position.
摘要翻译：使用具有限制低温剂流动的膨胀室的冻融阀在分析系统内管理低温剂的方法和装置。膨胀室配有膨胀喷嘴，冷却剂通过该喷嘴流动，允许冷冻剂排出的多孔玻璃料。多孔玻璃粉最初允许冷冻剂快速流入膨胀室。这种快速流动降低了膨胀室的温度，导致冻融段内的流体含量冻结。当冷冻剂膨胀到膨胀室中并变成固体时，多孔玻璃料被堵塞，导致快速流动受到限制。通过堵塞多孔玻璃料限制冷冻剂流允许冷冻解冻阀使用显着更少的冷冻剂。捕集在多孔玻璃料内的冷冻剂的升华提供足够的冷却以将阀保持在其关闭位置。

18. 发明申请

WO2008014306A2 COMPLIANT-SEAL CHECK VALVE 审中-公开
标题翻译：合格密封检查阀
公开(公告)号：WO2008014306A2
公开(公告)日：2008-01-31
申请号：PCT/US2007/074294
申请日：2007-07-25
申请人： WATERS INVESTMENTS LIMITED , CHARLTON, Christopher, B. , GERHARDT, Geoff, C. , DOURDEVILLE, Theodore
发明人： CHARLTON, Christopher, B. , GERHARDT, Geoff, C. , DOURDEVILLE, Theodore
IPC分类号： F04C14/24
CPC分类号： F16K15/021 , F04B53/1032 , Y10T137/7837 , Y10T137/7876 , Y10T137/7922 , Y10T137/7925
摘要： A check valve includes a valve seat and a compliant member that moves to seal the check valve by contacting the valve seat. A method for priming a chromatography solvent pump includes providing the check valve in fluid communication with an outlet of the pump, drawing fluid into the pump from a fluid source, and expelling the fluid from the pump through the valve, thus wetting the check valve. Another method for priming a chromatography solvent pump includes providing the check valve in fluid communication with an inlet of the pump, drawing fluid through the valve into the pump, and expelling the fluid from the pump.
摘要翻译：止回阀包括阀座和柔性构件，其通过接触阀座而移动以密封止回阀。用于启动色谱溶剂泵的方法包括提供止回阀与泵的出口流体连通，从流体源将流体引入泵中，并且将流体从泵排出通过阀，从而润湿止回阀。用于引发色谱溶剂泵的另一种方法包括提供止回阀与泵的入口流体连通，将流体通过阀吸入泵中，并从泵排出流体。

19. 发明申请

WO2007112224A2 CERAMIC-BASED CHROMATOGRAPHY APPARATUS AND METHODS FOR MAKING SAME 审中-公开
标题翻译：基于陶瓷的色谱装置及其制造方法
公开(公告)号：WO2007112224A2
公开(公告)日：2007-10-04
申请号：PCT/US2007/064267
申请日：2007-03-19
申请人： WATERS INVESTMENTS LIMITED , GERHARDT, Geoff, C. , MICHIENZI, Joseph , BENEVIDES, Christopher, C.
发明人： GERHARDT, Geoff, C. , MICHIENZI, Joseph , BENEVIDES, Christopher, C.
IPC分类号： B01D24/02
CPC分类号： G01N30/606 , G01N30/6026 , G01N30/6095
摘要： A high-performance liquid-chromatography apparatus includes a substrate that defines a separation column in fluidic communication with an inlet port of the processing unit. The processing unit is formed of sintered inorganic particles. The apparatus also includes a pump that delivers a solvent to the inlet port at a pressure sufficient for high-performance liquid-chromatography.
摘要翻译：高效液相色谱装置包括限定与处理单元的入口流体连通的分离塔的基板。处理单元由烧结无机颗粒形成。该设备还包括泵，其以足以用于高效液相色谱的压力将溶剂输送到入口。

20. 发明申请

WO2006078634A3 TEMPERATURE-CONTROLLED VARIABLE FLUIDIC RESISTANCE DEVICE 审中-公开
公开(公告)号：WO2006078634A3
公开(公告)日：2006-07-27
申请号：PCT/US2006/001564
申请日：2006-01-18
申请人： WATERS INVESTMENTS LIMITED , GERHARDT, Geoff, C. , CHARLTON, Christopher, C.
发明人： GERHARDT, Geoff, C. , CHARLTON, Christopher, C.
IPC分类号： F15C1/04
摘要： A thermally controlled variable restrictor device provides variable restriction of fluid flow by temperature-induced viscosity changes. The thermally controlled variable restrictor device allows fast variable fluid control by employing a thermo-electric heater-cooler in intimate contact with a fluid channel containing a fluid thereby effecting rapid viscosity changes in the flowing fluid. The permeability and flow rate of fluids through the variable restrictor device can be manipulated by changing the temperature of a restriction element.

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