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11. 发明专利

CA2612688A1 OSTEOGRAFT TREATMENT TO PROMOTE OSTEOINDUCTION AND OSTEOGRAFT INCORPORATION 未知
公开(公告)号：CA2612688A1
公开(公告)日：2007-01-04
申请号：CA2612688
申请日：2006-06-21
申请人： WARSAW ORTHOPEDIC INC
发明人： GROSS JEFFREY M , ZANELLA JOHN M , MCKAY WILLIAM F
IPC分类号： A61L27/54 , A61K9/00 , A61L27/12 , A61L27/20 , A61L27/22 , A61L27/36 , A61L27/56
摘要： The invention provides a bone implant, or osteograft, with improved retentio n of bioactive agents within the surface of the osteograft. Pits or pits forme d within the surface of the osteograft have porous plugs placed within them to retain fluid comprising bioactive agents. Pits can also be formed so that th e dimensions of the pits facilitate retention of fluid within a pit by hydrostatic attraction of fluid molecules within the pit.

12. 发明专利

AU2006262079A1 Osteograft treatment to promote osteoinduction and osteograft incorporation 未知
公开(公告)号：AU2006262079A1
公开(公告)日：2007-01-04
申请号：AU2006262079
申请日：2006-06-21
申请人： WARSAW ORTHOPEDIC INC
发明人： ZANELLA JOHN M , MCKAY WILLIAM F , GROSS JEFFREY M
IPC分类号： A61F2/28
摘要： The invention provides a bone implant, or osteograft, with improved retention of bioactive agents within the surface of the osteograft. Pits or pits formed within the surface of the osteograft have porous plugs placed within them to retain fluid comprising bioactive agents. Pits can also be formed so that the dimensions of the pits facilitate retention of fluid within a pit by hydrostatic attraction of fluid molecules within the pit.

13. 发明专利

CA2650648A1 VENTED DIRECTIONAL DELIVERY CANNULA WITH OPENINGS OF DIFFERENT SHAPE FOR USE WITH FLOWABLE MATERIALS AND METHOD FOR USE THEREOF 未知
公开(公告)号：CA2650648A1
公开(公告)日：2007-11-08
申请号：CA2650648
申请日：2007-04-19
申请人： WARSAW ORTHOPEDIC INC
发明人： SERBOUSEK JON C , GROSS JEFFREY M
IPC分类号： A61B17/88

14. 发明专利

AU2004275762A1 Reinforced fusion implant 未知
公开(公告)号：AU2004275762A1
公开(公告)日：2005-04-07
申请号：AU2004275762
申请日：2004-09-22
申请人： WARSAW ORTHOPEDIC INC
发明人： SIMONTON THOMAS A , GROSS JEFFREY M
IPC分类号： A61B17/70 , A61F2/00 , A61F2/02 , A61F2/28 , A61F2/30 , A61F2/44
摘要： The present invention provides a fusion implant for use between adjacent bony structures and related methods. The implant includes a body and at least one reinforcing member positionable within the body.

15. 发明申请

WO2011090628A2 BIDIRECTIONAL SELF-RETAINING SUTURES WITH LASER-MARKED AND/OR NON-LASER MARKED INDICIA AND METHODS 审中-公开
标题翻译：具有激光标记和/或非激光标记的指标的双向自保留方法和方法
公开(公告)号：WO2011090628A2
公开(公告)日：2011-07-28
申请号：PCT/US2010060889
申请日：2010-12-16
申请人： ANGIOTECH PHARM INC , GROSS JEFFREY M , D AGOSTINO WILLIAM L , AVELAR RUI , GORALTCHOUK ALEXEI , HERRMANN ROBERT A , LUSCOMBE BRIAN H
发明人： GROSS JEFFREY M , D AGOSTINO WILLIAM L , AVELAR RUI , GORALTCHOUK ALEXEI , HERRMANN ROBERT A , LUSCOMBE BRIAN H
IPC分类号： A61B17/04 , D02G3/34 , D02J3/00
CPC分类号： A61B17/06166 , A61B17/0469 , A61B34/30 , A61B90/90 , A61B90/92 , A61B90/94 , A61B90/98 , A61B2017/00115 , A61B2017/00526 , A61B2017/06009 , A61B2017/06014 , A61B2017/06057 , A61B2017/06176 , A61B2090/064 , A61B2090/0809 , A61B2090/365
摘要： A marked heterofunctional suture thread has two or more sections having different features. One or more sections of the suture thread are provided with laser-marked and non-laser marked indicia in order that they may be identified and differentiated from other sections. The suture thread may have retainers on the surface of one or more sections such that the suture thread can engage and retain tissue without knots. The markers may be used to indicate fixed features of a section of suture thread such as the presence and/orientation of retainers. In particular embodiments, laser-marked and non-laser marked indicia are used to identify the transition section of a bidirectional self-retaining suture.
摘要翻译：标记的异型功能缝合线具有两个或多个具有不同特征的部分。缝合线的一个或多个部分设置有激光标记和非激光标记的标记，以便它们可以被识别并且与其它部分区分开。缝合线可以在一个或多个部分的表面上具有保持器，使得缝合线可以接合并保持组织而没有结。标记可以用于指示缝合线的一部分的固定特征，例如保持器的存在和/取向。在特定实施例中，使用激光标记和非激光标记标记来识别双向自固位缝合线的过渡部分。

16. 发明公开

EP2015827A4 VENTED DIRECTIONAL DELIVERY CANNULA 审中-公开
标题翻译： BELÜFTETEGERICHTETEABGABEKANÜLE
公开(公告)号：EP2015827A4
公开(公告)日：2009-05-06
申请号：EP07754348
申请日：2007-03-29
申请人： WARSAW ORTHOPEDIC INC
发明人： GROSS JEFFREY M , SERBOUSEK JON
IPC分类号： A61B17/88
CPC分类号： A61B17/8811
摘要： In one preferred aspect, a cannula is provided that has openings of different size to permit a surgeon to selectively control the distribution pattern of a flowable material through the cannula and into a patient. In another aspect, a cannula is provided that has openings of different shape to permit a surgeon to selectively control the distribution pattern of a flowable material through the cannula and into a patient. In another aspect, a method is provided for selectively controlling the distribution pattern of a flowable material through a cannula having openings of different size into a patient. In yet another aspect, a method is provided for selectively controlling the distribution pattern of a flowable material through a cannula having openings of different shape into a patient.
摘要翻译：在一个优选的方面，提供了具有不同尺寸的开口的套管，以允许外科医生选择性地控制可流动材料通过套管进入患者的分布模式。另一方面，提供了套管，其具有不同形状的开口以允许外科医生选择性地控制可流动材料通过套管进入患者的分布模式。另一方面，提供了一种用于选择性地控制通过具有不同尺寸开口的套管的可流动材料进入患者体内的分布模式的方法。在又一方面，提供了一种用于选择性地控制通过具有不同形状的开口的套管的可流动材料进入患者的分布模式的方法。

17. 发明申请

WO2011140282A2 LASER CUTTING SYSTEM AND METHODS FOR CREATING SELF-RETAINING SUTURES 审中-公开
标题翻译：激光切割系统和创建自我保护的方法
公开(公告)号：WO2011140282A2
公开(公告)日：2011-11-10
申请号：PCT/US2011035270
申请日：2011-05-04
申请人： ANGIOTECH PHARM INC , GROSS JEFFREY M , D AGOSTINO WILLIAM L , DRUBETSKY LEV , NAIMAGON ALEXANDER , CONNER JACOB D , WHITWORTH KEVIN R , WOOLSEY RYAN T , DICKEY FRED M
发明人： GROSS JEFFREY M , D AGOSTINO WILLIAM L , DRUBETSKY LEV , NAIMAGON ALEXANDER , CONNER JACOB D , WHITWORTH KEVIN R , WOOLSEY RYAN T , DICKEY FRED M
IPC分类号： A61B17/04 , A61B17/08 , D02J3/02 , D02J3/10
CPC分类号： A61B17/06166 , A61B17/0401 , A61B17/0644 , A61B2017/00526 , A61B2017/0417 , A61B2017/0427 , A61B2017/06038 , A61B2017/06176 , A61B2090/3937 , B23K26/032 , B23K26/0652 , B23K26/0665 , B23K26/083 , B23K26/1462 , B23K26/361 , B23K26/362 , B23K37/04
摘要： A laser-machining system and method is disclosed for forming retainers on a suture thread. The laser system is preferably a femtosecond laser system which is capable of creating submicron features on the suture thread while preserving strength of the suture thread. The laser-machining system enables creation of retainers and self-retaining suture systems in configurations which are difficult and/or impossible to achieve using mechanical cutting technology.
摘要翻译：公开了一种用于在缝合线上形成保持器的激光加工系统和方法。激光系统优选是飞秒激光系统，其能够在缝合线上产生亚微米特征，同时保持缝合线的强度。激光加工系统能够在使用机械切割技术难以和/或不可能实现的构造中创建保持器和自固位缝合系统。

18. 发明申请

WO2012061658A3 DRUG-ELUTING SELF-RETAINING SUTURES AND METHODS RELATING THERETO 审中-公开
标题翻译：药物自我保留缝合和与其相关的方法
公开(公告)号：WO2012061658A3
公开(公告)日：2012-07-19
申请号：PCT/US2011059238
申请日：2011-11-03
申请人： ANGIOTECH PHARM INC , TISSUEGEN INC , GROSS JEFFREY M , DRUBETSKY LEV , NAIMAGON ALEXANDER , AVELAR RUI , D AGOSTINO WILLIAM L , NELSON KEVIN DON , CROW BRENT B , GRIFFIN NICKOLAS B
发明人： GROSS JEFFREY M , DRUBETSKY LEV , NAIMAGON ALEXANDER , AVELAR RUI , D AGOSTINO WILLIAM L , NELSON KEVIN DON , CROW BRENT B , GRIFFIN NICKOLAS B
IPC分类号： A61B17/04 , A61L17/14 , A61L27/54 , D02J3/00
CPC分类号： A61L17/005 , A61B17/0401 , A61B2017/00526 , A61B2017/00893 , A61B2017/06057 , A61B2017/0608 , A61B2017/06176 , A61L2300/414 , A61L2300/602 , A61L2430/32
摘要： A drug-eluting self-retaining suture comprises a filament, a plurality of retainers, and a drug impregnated in or coated on the filament. The shape and distribution of retainers modifies the in vivo release kinetics of the drug. The drug release kinetics may be modified uniformly or region by region. The self-retaining suture may for example be used for reattaching severed nerves and release nerve growth factor or other regeneration accelerating agents into the region of the nerve injury.
摘要翻译：药物洗脱自固位缝合线包括细丝，多个保持器以及浸渍或涂覆在细丝上的药物。保持器的形状和分布改变了药物的体内释放动力学。药物释放动力学可以被均匀地或逐区域地修改。自固定缝合线可以例如用于重新连接切断的神经并将神经生长因子或其他再生促进剂释放到神经损伤的区域中。

19. 发明申请

WO2011140283A2 SELF-RETAINING SYSTEMS HAVING LASER-CUT RETAINERS 审中-公开
标题翻译：具有激光切割保持器的自保留系统
公开(公告)号：WO2011140283A2
公开(公告)日：2011-11-10
申请号：PCT/US2011035271
申请日：2011-05-04
申请人： ANGIOTECH PHARM INC , GROSS JEFFREY M , D AGOSTINO WILLIAM L , DRUBETSKY LEV , NAIMAGON ALEXANDER
发明人： GROSS JEFFREY M , D AGOSTINO WILLIAM L , DRUBETSKY LEV , NAIMAGON ALEXANDER
IPC分类号： A61B17/04 , A61B17/08 , D02J3/02 , D02J3/10
CPC分类号： A61B17/06166 , A61B17/0401 , A61B17/0644 , A61B2017/00526 , A61B2017/0417 , A61B2017/0427 , A61B2017/06038 , A61B2017/06176 , A61B2090/3937 , B23K26/032 , B23K26/0652 , B23K26/0665 , B23K26/083 , B23K26/1462 , B23K26/361 , B23K26/362 , B23K37/04
摘要： Self-retaining suture systems including a suture thread bearing a plurality of laser-cut retainers are disclosed. A laser system allows the creation of retainers and self-retaining suture systems in configurations which are difficult and/or impossible to achieve using mechanical cutting technology.
摘要翻译：公开了包括具有多个激光切割保持器的缝合线的自固定缝线系统。激光系统允许在使用机械切割技术难以和/或不可能实现的构造中创建保持器和自固位缝合系统。

20. 发明申请

WO2005030099A3 REINFORCED FUSION IMPLANT 审中-公开
标题翻译：强化熔融植入物
公开(公告)号：WO2005030099A3
公开(公告)日：2005-07-28
申请号：PCT/US2004031089
申请日：2004-09-22
申请人： SDGI HOLDINGS INC , GROSS JEFFREY M , SIMONTON THOMAS A
发明人： GROSS JEFFREY M , SIMONTON THOMAS A
IPC分类号： A61B17/70 , A61F2/00 , A61F2/02 , A61F2/28 , A61F2/30 , A61F2/44
CPC分类号： A61F2/28 , A61B17/7059 , A61F2/447 , A61F2002/2817 , A61F2002/2835 , A61F2002/30014 , A61F2002/30016 , A61F2002/30057 , A61F2002/30062 , A61F2002/30332 , A61F2002/30448 , A61F2002/30449 , A61F2002/30461 , A61F2002/30472 , A61F2002/30604 , A61F2002/30784 , A61F2210/0004 , A61F2220/0033 , A61F2220/0041 , A61F2220/005 , A61F2220/0075 , A61F2250/0018 , A61F2250/0019 , A61F2310/00017 , A61F2310/00161 , A61F2310/00179 , A61F2310/00329 , A61F2310/00365
摘要： The present application provides a fusion implant (10) for use between adjacent bony structures and related methods. The implant includes a body (12) and at least one reinforcing member (24) positionable within the body.
摘要翻译：本申请提供了一种在相邻骨结构和相关方法之间使用的融合植入物（10）。植入物包括主体（12）和可定位在体内的至少一个加强构件（24）。

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