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11. 发明申请

US20140330310A1 Patent Foramen Ovale (PFO) Closure Device with Radial and Circumferential Support 审中-公开
标题翻译：专利孔洞（PFO）带径向和圆周支撑的封闭装置
公开(公告)号：US20140330310A1
公开(公告)日：2014-11-06
申请号：US14334387
申请日：2014-07-17
申请人： W.L. Gore & Associates, Inc.
发明人： Andrzej J. Chanduszko
IPC分类号： A61B17/00 , A61B17/12
CPC分类号： A61B17/0057 , A61B17/12122 , A61B17/12172 , A61B2017/00004 , A61B2017/00575 , A61B2017/00592 , A61B2017/00606 , A61B2017/00619 , A61B2017/00867
摘要： The present invention provides a device for occluding an anatomical aperture, such as a septal defect or patent foramen ovale (PFO). The occluder includes two sides connected by an intermediate joint. Each of the sides includes at least one elongate element, which is arranged to form non-overlapping loops. Each loop has at least one radially-extending segment that is adjacent to a radially-extending segment of another loop. In at least some embodiments, at least one pair of adjacent radially-extending segments is connected. The loops of the device may be of various shapes, sizes, and configurations, and, in at least some embodiments, the loops have rounded peripheries. In some embodiments, at least one of the sides includes a tissue scaffold. When the occluder is deployed in vivo, the two sides are disposed on opposite sides of the septal tissue surrounding the aperture, thereby exerting a compressive force on the septal tissue that is distributed along both the outer periphery of the occluder and the radially-extending segments.
摘要翻译：本发明提供一种用于闭塞解剖孔的装置，例如间隔缺损或卵圆孔卵孔（PFO）。闭塞器包括通过中间接头连接的两侧。每个侧面包括至少一个细长元件，其被布置成形成非重叠的环。每个环具有至少一个径向延伸的段，其邻近另一环的径向延伸的段。在至少一些实施例中，连接至少一对相邻的径向延伸段。装置的环可以是各种形状，尺寸和构造，并且在至少一些实施例中，环具有圆形的周边。在一些实施例中，至少一个侧面包括组织支架。当闭塞器部署在体内时，两侧设置在围绕孔的间隔组织的相对侧上，从而对隔壁组织施加压缩力，该间隔组织沿封堵器的外周分布并且径向延伸段。

12. 发明申请

US20140031862A1 Delivery Systems and Methods for PFO Closure Device with Two Anchors 审中-公开
标题翻译：具有两个锚点的PFO封闭装置的输送系统和方法
公开(公告)号：US20140031862A1
公开(公告)日：2014-01-30
申请号：US14038584
申请日：2013-09-26
申请人： W.L. Gore & Associates, Inc.
发明人： Andrzej J. Chanduszko
IPC分类号： A61B17/00
CPC分类号： A61B17/0057 , A61B2017/00243 , A61B2017/00575 , A61B2017/00592 , A61B2017/00606 , A61B2017/00623 , A61B2017/00862 , A61B2017/00867
摘要： A device closes septal openings, such as a patent foramen ovale (PFO). The device includes two anchors and a flexible connector. Tension applied to one or more strings attached to the device causes the device to collapse into a reduced profile form for withdrawal into a delivery catheter, thereby facilitating retrieval of the device after insertion into a septal opening.
摘要翻译：器械关闭隔膜开口，例如卵圆孔卵孔（PFO）。该装置包括两个锚和一个柔性连接器。施加到附接到装置的一个或多个弦的张力导致装置折叠成缩小的轮廓形式以便退回到输送导管中，从而便于在插入间隔开口之后使装置回收。

13. 发明申请

US20130296925A1 Tubular Patent Foramen Ovale (PFO) Closure Device with Catch System 审中-公开
标题翻译：管状专利孔（OFO）（PFO）封闭装置
公开(公告)号：US20130296925A1
公开(公告)日：2013-11-07
申请号：US13934031
申请日：2013-07-02
申请人： W.L. Gore & Associates, Inc.
发明人： Andrzej J. Chanduszko , David J. Callaghan
IPC分类号： A61B17/00
CPC分类号： A61B17/0057 , A61B2017/00575 , A61B2017/00592 , A61B2017/00606 , A61B2017/00619 , A61B2017/00623
摘要： The present invention provides a device for occluding an anatomical aperture, such as an atrial septal defect (ASD) or a patent foramen ovale (PFO). The occluder includes two sides connected by a central tube. The occluder is formed from a tube, which is cut to produce struts in each side. Upon the application of force, the struts deform into loops. The loops may be of various shapes, sizes, and configurations, and, in at least some embodiments, the loops have rounded peripheries. In some embodiments, at least one of the sides includes a tissue scaffold. The occluder further includes a catch system that maintains its deployed state in vivo. When the occluder is deployed in vivo, the two sides are disposed on opposite sides of the septal tissue surrounding the aperture and the catch system is deployed so that the occluder exerts a compressive force on the septal tissue and closes the aperture.
摘要翻译：本发明提供一种用于闭塞解剖孔的装置，例如房间隔缺损（ASD）或卵圆孔卵孔（PFO）。封堵器包括通过中心管连接的两侧。封堵器由管子形成，其被切割以在每一侧产生支柱。施加力时，支柱变形成环。环可以是各种形状，尺寸和构造，并且在至少一些实施例中，环具有圆形的周边。在一些实施例中，至少一个侧面包括组织支架。闭塞器还包括在体内维持其部署状态的捕获系统。当闭塞器部署在体内时，两侧设置在围绕孔的间隔组织的相对侧上，并且捕获系统被展开，使得封堵器对隔膜组织施加压缩力并闭合孔。

14. 发明授权

US08568447B2 Delivery systems and methods for PFO closure device with two anchors 失效
标题翻译：具有两个锚点的PFO闭合装置的输送系统和方法
公开(公告)号：US08568447B2
公开(公告)日：2013-10-29
申请号：US13651643
申请日：2012-10-15
申请人： W.L. Gore & Associates, Inc.
发明人： Andrzej J. Chanduszko
IPC分类号： A61B17/08
CPC分类号： A61B17/0057 , A61B2017/00243 , A61B2017/00575 , A61B2017/00592 , A61B2017/00606 , A61B2017/00623 , A61B2017/00862 , A61B2017/00867
摘要： A device closes septal openings, such as a patent foramen ovale (PFO). The device includes two anchors and a flexible connector. Tension applied to one or more strings attached to the device causes the device to collapse into a reduced profile form for withdrawal into a delivery catheter, thereby facilitating retrieval of the device after insertion into a septal opening.
摘要翻译：器械关闭隔膜开口，例如卵圆孔卵孔（PFO）。该装置包括两个锚和一个柔性连接器。施加到附接到装置的一个或多个弦的张力导致装置折叠成缩小的轮廓形式以便退回到输送导管中，从而便于在插入间隔开口之后使装置回收。

15. 发明申请

US20130103034A1 Welding Systems Useful for Closure of Cardiac Openings 审中-公开
标题翻译：用于闭合心脏开口的焊接系统
公开(公告)号：US20130103034A1
公开(公告)日：2013-04-25
申请号：US13715831
申请日：2012-12-14
申请人： W.L. Gore & Associates, Inc.
发明人： Andrzej J. Chanduszko , David R. Widomski , Carol A. Devellian
IPC分类号： A61B18/14
CPC分类号： A61B18/1477 , A61B17/00491 , A61B17/0057 , A61B17/085 , A61B17/12122 , A61B17/12131 , A61B17/12136 , A61B17/12186 , A61B17/1219 , A61B17/12195 , A61B2017/00243 , A61B2017/005 , A61B2017/00504 , A61B2017/00513 , A61B2017/00557 , A61B2017/00575 , A61B2017/00592 , A61B2017/00606 , A61B2017/0061 , A61B2017/00623 , A61B2017/00632 , A61B2017/00867
摘要： A welding element is provided for applying heat, chemicals, pressure, or any combination thereof to tissues inside a patient's body, e.g., a patent foramen ovale. In one aspect, the welding element is connected to a radio frequency energy source and includes an electrode and a locator. The locator facilitates positioning of the welding element and is capable of moving from an open position to a clamping position. In another aspect, a needle is provided for transseptal puncturing before the application of heat. In yet another aspect, the welding element is configured as a coil. The welding element can be made of Nitinol.
摘要翻译：提供焊接元件，用于将热量，化学物质，压力或其任何组合施加到患者体内的组织，例如卵孔卵孔。一方面，焊接元件连接到射频能量源，并且包括电极和定位器。定位器便于焊接元件的定位，并且能够从打开位置移动到夹紧位置。另一方面，在施加热量之前提供穿刺针穿刺穿刺针。在另一方面，焊接元件被配置为线圈。焊接元件可以由镍钛诺（Nitinol）制成。

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