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11. 发明授权

US07714017B2 Carboxylic acid peri-substituted bicyclics for occlusive artery disease 有权
标题翻译：用于闭塞性动脉疾病的羧酸邻位取代双环体
公开(公告)号：US07714017B2
公开(公告)日：2010-05-11
申请号：US11247431
申请日：2005-10-11
申请人： Jasbir Singh , Mark Gurney , Georgeta Hategan , Peng Yu , David Zembower , Nian Zhou , Alexandre Mikhaylovich Polozov , Wayne Edward Zeller
发明人： Jasbir Singh , Mark Gurney , Georgeta Hategan , Peng Yu , David Zembower , Nian Zhou , Alexandre Mikhaylovich Polozov , Wayne Edward Zeller
IPC分类号： A61K31/403 , A61K31/404 , A61K31/405 , C07D209/02 , C07D209/04 , A61K31/19 , A61K31/192 , C07C61/12
CPC分类号： C07D263/58 , C07D209/08 , C07D209/12 , C07D209/34 , C07D235/06 , C07D487/04 , C07D513/04
摘要： Peri-substituted, fused bicyclic ring carboxylic acids useful for the treatment or prophylaxis of a prostaglandin-mediated disease or condition are disclosed. The compounds are of the general formula A representative example is:
摘要翻译：公开了用于治疗或预防前列腺素介导的疾病或病症的环取代的稠合双环羧酸。化合物具有通式A的代表性实例是：

12. 发明申请

US20060142355A1 Carboxylic acid peri-substituted bicyclics for occlusive artery disease 有权
标题翻译：用于闭塞性动脉疾病的羧酸邻位取代双环
公开(公告)号：US20060142355A1
公开(公告)日：2006-06-29
申请号：US11247431
申请日：2005-10-11
申请人： Jasbir Singh , Mark Gurney , Georgeta Hategan , Peng Yu , David Zembower , Nian Zhou , Alexandre Polozov , Wayne Zeller
发明人： Jasbir Singh , Mark Gurney , Georgeta Hategan , Peng Yu , David Zembower , Nian Zhou , Alexandre Polozov , Wayne Zeller
IPC分类号： A61K31/43 , A61K31/4188 , A61K31/4162 , C07D498/02 , C07D487/02
CPC分类号： C07D263/58 , C07D209/08 , C07D209/12 , C07D209/34 , C07D235/06 , C07D487/04 , C07D513/04
摘要： Peri-substituted, fused bicyclic ring carboxylic acids useful for the treatment or prophylaxis of a prostaglandin-mediated disease or condition are disclosed. The compounds are of the general formula A representative example is:
摘要翻译：公开了用于治疗或预防前列腺素介导的疾病或病症的环取代的稠合双环羧酸。化合物具有通式A的代表性实例是：

13. 发明授权

US08927485B2 Site-specific modification of proteins through chemical modification enabling protein conjugates, protein dimer formation, and stapled peptides 有权
标题翻译：通过化学修饰实现蛋白质的位点特异性修饰，使蛋白质缀合物，蛋白质二聚体形成和装订肽
公开(公告)号：US08927485B2
公开(公告)日：2015-01-06
申请号：US13030772
申请日：2011-02-18
申请人： Alexander Krantz , Peng Yu
发明人： Alexander Krantz , Peng Yu
IPC分类号： A61K38/00 , C07K16/00 , C07K17/00 , C07K17/14 , C12P21/08 , A61K38/24 , A61K38/27 , C07K1/00 , C07K14/00 , A61K47/48
CPC分类号： A61K47/481 , A61K47/55
摘要： The present invention generally provides methods for the site-specific modification of peptides, polypeptides, and proteins, e.g., granulocyte macrophage colony-stimulating factor, human superoxide dismutase, annexin, leptin, antibodies and the like, cytokines and chemokines, at their N-termini and at sites at which unnatural aminoacids have been introduced along the protein framework. The modifications described herein can be used for the synthesis and application of the adducts in radio-labeling, molecular imaging and protein therapeutic applications, and the treatment of disorders such as rheumatoid arthritis, lupus erythematosus, psoriasis, multiple sclerosis, type-1 diabetes, Crohn's disease, and systemic sclerosis, Alzheimer disease, cancer, liver disease (e.g., alcoholic liver disease), and cachexia.
摘要翻译：本发明通常提供肽，多肽和蛋白质的位点特异性修饰的方法，例如粒细胞巨噬细胞集落刺激因子，人超氧化物歧化酶，膜联蛋白，瘦素，抗体等，细胞因子和趋化因子，并且沿着蛋白质框架引入非天然氨基酸的位点。本文所述的修饰可以用于加合物在放射性标记，分子成像和蛋白质治疗应用中的合成和应用，以及治疗疾病如类风湿性关节炎，红斑狼疮，牛皮癣，多发性硬化，1型糖尿病，克罗恩病和系统性硬化症，阿尔茨海默病，癌症，肝病（如酒精性肝病）和恶病质。

14. 发明授权

US08806451B2 Monad based cloud computing 有权
标题翻译：基于Monad的云计算
公开(公告)号：US08806451B2
公开(公告)日：2014-08-12
申请号：US13161787
申请日：2011-06-16
申请人： Zijian Zheng , Shengquan Yan , Peng Yu
发明人： Zijian Zheng , Shengquan Yan , Peng Yu
IPC分类号： G06F9/45 , G06F17/30 , G06F7/00 , G06F9/46
CPC分类号： G06F17/30539
摘要： Systems and methods are provided for using monads to facilitate complex computation tasks in a cloud computing environment. In particular, monads can be employed to facilitate creation and execution of data mining jobs for large data sets. Monads can allow for improved error handling for complex computation tasks. Monads can also facilitate identification of opportunities for improving the efficiency of complex computations.
摘要翻译：提供了系统和方法，以便在云计算环境中使用单极化来促进复杂的计算任务。特别地，可以采用单子来促进大数据集的数据挖掘作业的创建和执行。 Monads可以允许改进复杂计算任务的错误处理。 Monads也可以促进识别提高复杂计算效率的机会。

15. 发明申请

US20110263832A1 SITE-SPECIFIC MODIFICATION OF PROTEINS THROUGH CHEMICAL MODIFICATION ENABLING PROTEIN CONJUGATES, PROTEIN DIMER FORMATION, AND STAPLED PEPTIDES 有权
标题翻译：通过化学修饰使蛋白质的蛋白质特异性修饰使蛋白质结合蛋白，蛋白质二聚体形成和嵌段蛋白
公开(公告)号：US20110263832A1
公开(公告)日：2011-10-27
申请号：US13030772
申请日：2011-02-18
申请人： Alexander Krantz , Peng Yu
发明人： Alexander Krantz , Peng Yu
IPC分类号： C07K16/46 , C07K14/575
CPC分类号： A61K47/481 , A61K47/55
摘要： The present invention generally provides methods for the site-specific modification of peptides, polypeptides, and proteins, e.g., granulocyte macrophage colony-stimulating factor, human superoxide dismutase, annexin, leptin, antibodies and the like, cytokines and chemokines, at their N-termini and at sites at which unnatural aminoacids have been introduced along the protein framework. The modifications described herein can be used for the synthesis and application of the adducts in radio-labeling, molecular imaging and protein therapeutic applications, and the treatment of disorders such as rheumatoid arthritis, lupus erythematosus, psoriasis, multiple sclerosis, type-1 diabetes, Crohn's disease, and systemic sclerosis, Alzheimer disease, cancer, liver disease (e.g., alcoholic liver disease), and cachexia.
摘要翻译：本发明通常提供肽，多肽和蛋白质的位点特异性修饰的方法，例如粒细胞巨噬细胞集落刺激因子，人超氧化物歧化酶，膜联蛋白，瘦素，抗体等，细胞因子和趋化因子，并且沿着蛋白质框架引入非天然氨基酸的位点。本文所述的修饰可以用于加合物在放射性标记，分子成像和蛋白质治疗应用中的合成和应用，以及治疗疾病如类风湿性关节炎，红斑狼疮，牛皮癣，多发性硬化，1型糖尿病，克罗恩病和系统性硬化症，阿尔茨海默病，癌症，肝病（如酒精性肝病）和恶病质。

16. 发明申请

US20090150337A1 INDEXING AND SEARCHING AUDIO USING TEXT INDEXERS 有权
标题翻译：使用文本索引进行索引和搜索音频
公开(公告)号：US20090150337A1
公开(公告)日：2009-06-11
申请号：US11952817
申请日：2007-12-07
申请人： Frank T.B. Seide , Peng Yu , Albert Joseph Kishan Thambiratnam
发明人： Frank T.B. Seide , Peng Yu , Albert Joseph Kishan Thambiratnam
IPC分类号： G06F17/30
CPC分类号： G06F17/30746 , G06F17/30778
摘要： A full-text lattice indexing and searching system and method for indexing word lattices using a text indexer to enable enhance searching of audio content. The system and method utilize a Time-Anchored Lattice Expansion (TALE) method that represents word lattices such that they can be indexed with existing text indexers with little or no modification. Embodiments of system and method include an indexing module for generating and indexing word lattices based on audio content and a searching module for allowing searching of a full-text index containing indexed word lattices. The indexing module includes a custom IFilter and a custom Wordbreaker. Embodiments of the searching module include an ExpandQuery function for decorating an input query and a custom Stemmer. Embodiments of the searching module also include a GenerateSnippets module that extracts information from the indexed word lattices to enable the creation of clickable snippets.
摘要翻译：一种全文格式索引和搜索系统和方法，用于使用文本索引器索引字格，以增强对音频内容的搜索。该系统和方法利用代表字格的时间锚定格子扩展（TALE）方法，使得它们可以用很少或没有修改的现有文本索引器进行索引。系统和方法的实施例包括用于基于音频内容生成和索引字格的索引模块和用于允许搜索包含索引的字格的全文索引的搜索模块。索引模块包括一个自定义的IFilter和一个自定义的Wordbreaker。搜索模块的实施例包括用于装饰输入查询和定制Stemmer的ExpandQuery函数。搜索模块的实施例还包括GenerateSnippets模块，该模块从索引的字格架提取信息，以创建可点击的片段。

17. 发明授权

US08476477B2 Process of oxidative conversion of methanol 有权
标题翻译：甲醇的氧化转化过程
公开(公告)号：US08476477B2
公开(公告)日：2013-07-02
申请号：US12713552
申请日：2010-02-26
申请人： Peng Yu , Jingsong Liu , Junfeng Rong , Changzhi Shi , Qiang Fu , Jin Wang , Wei Zhang , Xuhua Zhou
发明人： Peng Yu , Jingsong Liu , Junfeng Rong , Changzhi Shi , Qiang Fu , Jin Wang , Wei Zhang , Xuhua Zhou
IPC分类号： C07C41/50 , C07C43/315
CPC分类号： B01J29/166 , B01J29/48 , B01J2229/20 , B01J2229/42 , C07C41/50 , C07C43/30
摘要： A process for preparing polyoxymethylene dimethyl ethers from methanol is disclosed. For example, the process comprises contacting methanol with at least one oxidant in the presence of at least one catalyst wherein the at least one catalyst comprises at least one Group VIB metal component, such as in an amount of from about 0.5 to about 50 wt % (in terms of metal oxide) and at least one Group VIII metal component, such as in an amount of from about 0.2 to about 20 wt % (in terms of metal oxide), and at least one molecular sieve having acidic catalytic activity, such as in an amount of from about 40 to about 95 wt %, based on the total weight of the at least one catalyst for a time sufficient to obtain polyoxymethylene dimethyl ethers.
摘要翻译：公开了一种由甲醇制备聚甲醛二甲醚的方法。例如，该方法包括在至少一种催化剂存在下使甲醇与至少一种氧化剂接触，其中至少一种催化剂包含至少一种VIB族金属组分，例如约0.5至约50重量％（以金属氧化物计）和至少一种VIII族金属组分，例如约0.2至约20重量％（以金属氧化物计），和至少一种具有酸性催化活性的分子筛，例如其量为约40至约95重量％，基于至少一种催化剂的总重量足以获得聚甲醛二甲醚的时间。

18. 外观设计

USD897044S1 Nail dryer with magnifier 有权
公开(公告)号：USD897044S1
公开(公告)日：2020-09-22
申请号：US29663074
申请日：2018-09-12
申请人： Peng Yu
设计人： Peng Yu
摘要： FIG. 1 is a perspective view of a nail dryer with magnifier showing my new design;
FIG. 2 is a front elevational view thereof;
FIG. 3 is a rear elevational view thereof;
FIG. 4 is a left side elevational view thereof;
FIG. 5 is a right side elevational view thereof;
FIG. 6 is a top plan view thereof; and,
FIG. 7 is a bottom plan view thereof.
The broken lines illustrate portions of the nail dryer with magnifier and from no part of the claimed design.

19. 发明申请

US20130216479A1 SITE-SPECIFIC CHEMICAL MODIFICATION OF PROTEINS AT THEIR N-TERMINI, ENABLING THE FORMATION OF HOMOGENEOUS ADDUCTS 审中-公开
标题翻译：蛋白质在其N-末端的特异性化学修饰，启动均质添加物的形成
公开(公告)号：US20130216479A1
公开(公告)日：2013-08-22
申请号：US13854634
申请日：2013-04-01
申请人： Alexander Krantz , Peng Yu
发明人： Alexander Krantz , Peng Yu
IPC分类号： C07K1/107 , C07K14/47 , C07K14/575
CPC分类号： C07K1/1077 , C07K14/465 , C07K14/47 , C07K14/4721 , C07K14/535 , C07K14/575 , C07K14/5759 , C07K14/765 , C07K14/805 , C12N9/00 , C12N9/0089 , C12Y115/01001
摘要： Site-specific modifications of proteins at their N-termini are provided. In particular, a chemical modification of proteins at their N-termini via a transamination reaction to form homogeneous adducts such as, the corresponding oxime derivatives is provided. Methods of making and using the adducts in radio-labelling, molecular imaging applications, and treatment of disorders such as cancer, Crohn's disease, arthritis, atherothrombosis and plaque rupture are also provided.
摘要翻译：提供蛋白质在其N-末端的位点特异性修饰。特别地，提供了通过转氨基反应在其N-末端进行蛋白质的化学修饰以形成均匀的加合物，例如相应的肟衍生物。还提供了在放射性标记，分子成像应用中制备和使用加合物的方法以及诸如癌症，克罗恩病，关节炎，动脉粥样硬化血栓形成和斑块破裂等疾病的治疗方法。

20. 发明授权

US08060494B2 Indexing and searching audio using text indexers 有权
标题翻译：使用文本索引器索引和搜索音频
公开(公告)号：US08060494B2
公开(公告)日：2011-11-15
申请号：US11952817
申请日：2007-12-07
申请人： Frank T. B. Seide , Peng Yu , Albert Joseph Kishan Thambiratnam
发明人： Frank T. B. Seide , Peng Yu , Albert Joseph Kishan Thambiratnam
IPC分类号： G06F17/00
CPC分类号： G06F17/30746 , G06F17/30778
摘要： A full-text lattice indexing and searching system and method for indexing word lattices using a text indexer to enable enhance searching of audio content. The system and method utilize a Time-Anchored Lattice Expansion (TALE) method that represents word lattices such that they can be indexed with existing text indexers with little or no modification. Embodiments of system and method include an indexing module for generating and indexing word lattices based on audio content and a searching module for allowing searching of a full-text index containing indexed word lattices. The indexing module includes a custom IFilter and a custom Wordbreaker. Embodiments of the searching module include an ExpandQuery function for decorating an input query and a custom Stemmer. Embodiments of the searching module also include a GenerateSnippets module that extracts information from the indexed word lattices to enable the creation of clickable snippets.
摘要翻译：一种全文格式索引和搜索系统和方法，用于使用文本索引器索引字格，以增强对音频内容的搜索。该系统和方法利用代表字格的时间锚定格子扩展（TALE）方法，使得它们可以用很少或没有修改的现有文本索引器进行索引。系统和方法的实施例包括用于基于音频内容生成和索引字格的索引模块和用于允许搜索包含索引的字格的全文索引的搜索模块。索引模块包括一个自定义的IFilter和一个自定义的Wordbreaker。搜索模块的实施例包括用于装饰输入查询和定制Stemmer的ExpandQuery函数。搜索模块的实施例还包括GenerateSnippets模块，该模块从索引的字格架提取信息，以创建可点击的片段。

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