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11. 发明申请

US20080006535A1 System for Controlling a Droplet Actuator 有权
标题翻译：控制滴液致动器的系统
公开(公告)号：US20080006535A1
公开(公告)日：2008-01-10
申请号：US11838388
申请日：2007-08-14
申请人： Philip Paik , Michael Pollack , Ryan Sturmer , Gregory Smith , Keith Brafford , Vamsee Pamula
发明人： Philip Paik , Michael Pollack , Ryan Sturmer , Gregory Smith , Keith Brafford , Vamsee Pamula
IPC分类号： G01N27/00
CPC分类号： B01L3/502792 , B01L2200/143 , B01L2300/027 , B01L2300/0816 , B01L2400/0427
摘要： Systems for controlling a droplet microactuator are provided. According to one embodiment, a system is provided and includes a controller, a droplet microactuator electronically coupled to the controller, and a display device displaying a user interface electronically coupled to the controller, wherein the system is programmed and configured to permit a user to effect a droplet manipulation by interacting with the user interface. According to another embodiment, a system is provided and includes a processor, a display device electronically coupled to the processor, and software loaded and/or stored in a storage device electronically coupled to the controller, a memory device electronically coupled to the controller, and/or the controller and programmed to display an interactive map of a droplet microactuator. According to yet another embodiment, a system is provided and includes a controller, a droplet microactuator electronically coupled to the controller, a display device displaying a user interface electronically coupled to the controller, and software for executing a protocol loaded and/or stored in a storage device electronically coupled to the controller, a memory device electronically coupled to the controller, and/or the controller.
摘要翻译：提供了用于控制液滴微致动器的系统。根据一个实施例，提供了一种系统，其包括电子耦合到控制器的控制器，液滴微致动器以及显示电子耦合到控制器的用户界面的显示设备，其中该系统被编程和配置为允许用户实现通过与用户界面交互来进行液滴操作。根据另一个实施例，提供了一种系统，包括处理器，电子耦合到处理器的显示设备，以及加载和/或存储在电子耦合到控制器的存储设备中的软件，电子耦合到控制器的存储设备，以及 /或控制器，并被编程以显示液滴微致动器的交互式地图。根据另一个实施例，提供了一种系统，其包括控制器，电子耦合到控制器的液滴微致动器，显示电子耦合到控制器的用户界面的显示设备，以及用于执行加载和/或存储在控制器中的协议的软件电子耦合到控制器的存储设备，电子耦合到控制器的存储设备和/或控制器。

12. 发明申请

US20110086377A1 Bead Manipulations on a Droplet Actuator 有权
标题翻译：水珠致动器上的珠粒操作
公开(公告)号：US20110086377A1
公开(公告)日：2011-04-14
申请号：US12673893
申请日：2008-08-25
申请人： Prasanna Thwar , Dwayne Allen , Philip Paik
发明人： Prasanna Thwar , Dwayne Allen , Philip Paik
IPC分类号： C12Q1/02 , C12N13/00 , C12N11/00 , C12N5/00 , C12M1/00 , C25B7/00
CPC分类号： B01L3/52 , B01L3/502761 , B01L3/502792 , B01L2200/0668 , B01L2300/0864 , B01L2300/089 , B01L2400/0415 , B01L2400/0424 , B01L2400/0427
摘要： A droplet actuator comprising: (a) a base substrate comprising electrodes configured for conducting droplet operations on a droplet operations surface thereof; (b) a droplet comprising one or more beads situated on the droplet operations surface; (c) a barrier arranged in relation to the droplet and the electrodes such that a droplet may be transported away from the beads using one or more droplet operations mediated by one or more of the electrodes while transport of the beads is restrained by a barrier. Related methods and kits are also provided.
摘要翻译：一种液滴致动器，包括：（a）基底基底，包括构造成用于在其液滴操作表面上进行液滴操作的电极; （b）包含位于所述液滴操作表面上的一个或多个珠粒的液滴; （c）相对于液滴和电极布置的屏障，使得可以使用由一个或多个电极介导的一个或多个液滴操作将液滴从珠流出，同时珠的传送被屏障限制。还提供了相关方法和试剂盒。

13. 发明申请

US20080038810A1 Droplet-based nucleic acid amplification device, system, and method 有权
标题翻译：基于液滴的核酸扩增装置，系统和方法
公开(公告)号：US20080038810A1
公开(公告)日：2008-02-14
申请号：US11639990
申请日：2006-12-15
申请人： Michael Pollack , Philip Paik , Vamsee Pamula
发明人： Michael Pollack , Philip Paik , Vamsee Pamula
IPC分类号： C12M1/00 , B23P17/00 , C12M1/34
CPC分类号： B01L3/502761 , B01L3/5025 , B01L3/502784 , B01L3/502792 , B01L7/52 , B01L7/525 , B01L2200/027 , B01L2200/0668 , B01L2200/0673 , B01L2200/147 , B01L2300/0819 , B01L2300/0861 , B01L2300/0864 , B01L2300/0867 , B01L2300/087 , B01L2300/089 , B01L2300/1827 , B01L2400/0406 , B01L2400/0415 , B01L2400/0427 , B01L2400/043 , B01L2400/0442 , B01L2400/0448 , B01L2400/0487 , G01N15/1484 , G01N2015/1006 , G01N2035/1046 , Y10T29/49002 , Y10T137/0318
摘要： The present invention relates to a droplet-based nucleic acid amplification device, system, and method. According to one embodiment, a droplet microactuator is provided and includes: (a) a substrate comprising electrodes for conducting droplet operations; and (b) one or more temperature control means arranged in proximity with one or more of the electrodes for heating and/or cooling a region of the droplet microactuator and arranged such that a droplet can be transported on the electrodes into the region for heating.
摘要翻译：本发明涉及一种基于液滴的核酸扩增装置，系统和方法。根据一个实施例，提供液滴微致动器，其包括：（a）包括用于进行液滴操作的电极的基板; 和（b）设置在一个或多个电极附近的一个或多个温度控制装置，用于加热和/或冷却液滴微致动器的区域，并且布置成使得液滴可以在电极上传送到加热区域中。

14. 发明申请

US20060054503A1 Methods for manipulating droplets by electrowetting-based techniques 有权
公开(公告)号：US20060054503A1
公开(公告)日：2006-03-16
申请号：US11077569
申请日：2005-03-10
申请人： Vamsee Pamula , Michael Pollack , Philip Paik , Hong Ren , Richard Fair
发明人： Vamsee Pamula , Michael Pollack , Philip Paik , Hong Ren , Richard Fair
IPC分类号： C07K1/26 , G01N27/447
CPC分类号： B01L3/50273 , B01F11/0071 , B01F13/0071 , B01F13/0076 , B01F13/0084 , B01L3/00 , B01L3/5027 , B01L3/502784 , B01L3/502792 , B01L2200/06 , B01L2200/0605 , B01L2200/10 , B01L2300/089 , B01L2300/161 , B01L2300/165 , B01L2400/0415 , B01L2400/0427 , B41J2002/14395 , C25B9/00 , G01N27/44791 , G02B26/005
摘要： Methods are provided for manipulating droplets. The methods include providing the droplet on a surface comprising an array of electrodes and a substantially co-planer array of reference elements, wherein the droplet is disposed on a first one of the electrodes, and the droplet at least partially overlaps a second one of the electrodes and an intervening one of the reference elements disposed between the first and second electrodes. The methods further include activating the first and second electrodes to spread at least a portion of the droplet across the second electrode and deactivating the first electrode to move the droplet from the first electrode to the second electrode.

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