专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

11. 发明公开

EP3195191A2 SYSTEMS AND METHODS FOR CALCULATING IMMUNE SCORES 有权
标题翻译：用于计算免疫比例的系统和方法
公开(公告)号：EP3195191A2
公开(公告)日：2017-07-26
申请号：EP15767102.5
申请日：2015-09-03
申请人： Ventana Medical Systems, Inc.
发明人： BARNES, Michael , CHEN, Ting , CHEFD'HOTEL, Christophe , TUBBS, Alisa , ASCIERTO, Paolo A.
IPC分类号： G06K9/00 , G01N33/50 , G06T7/00
摘要： Embodiments disclosed herein are directed, among other things, to imaging systems, methods, and apparatuses for automatically identifying fields of view (FOVs) for regions in an image encompassing tumor are disclosed. In embodiments and in further aspects of the present invention, a computer-implemented method is disclosed for a tumor region based immune score computation. The method, in accordance with the present invention, involves identifying regions, for example, tumor areas or regions around a tumor area, partitioning a whole slide image or portion of a whole slide image into multiple regions related to the tumor, selecting FOVs within each identified region, and computing a number of cells present in each FOV. An immune score and/or immune-related score may be generated based on the cells counted in each FOV.
摘要翻译：公开了用于自动识别包含黑素瘤的图像中的区域的视野（FOV）的成像系统，方法和设备。在本发明的实施例和其他方面中，公开了一种用于基于肿瘤区域的免疫分数计算的计算机实现的方法。根据本发明，该方法涉及识别区域，例如肿瘤区域或肿瘤区域周围的区域，将整个载玻片图像或整个载玻片图像的一部分分成与肿瘤相关的多个区域，在每个区域内选择FOV 识别的区域，并计算每个FOV中存在的细胞的数量。基于在每个FOV中计数的细胞生成免疫分数和/或免疫相关分数。

12. 发明公开

EP3149700A1 AN IMAGE PROCESSING METHOD AND SYSTEM FOR ANALYZING A MULTI-CHANNEL IMAGE OBTAINED FROM A BIOLOGICAL TISSUE SAMPLE BEING STAINED BY MULTIPLE STAINS 有权
标题翻译：图像处理方法和系统进行分析多通道图像从一个平均值的多重染料着色的生物组织样本
公开(公告)号：EP3149700A1
公开(公告)日：2017-04-05
申请号：EP15726589.3
申请日：2015-05-29
申请人： Providence Health & Services - Oregon D/B/A , Ventana Medical Systems, Inc.
发明人： BARNES, Michael , CHEN, Ting , TUBBS, Alisa , BIFULCO, Carlo
IPC分类号： G06T5/00 , G06T7/00
CPC分类号： G06T7/0012 , G06T5/002 , G06T5/003 , G06T5/20 , G06T7/11 , G06T2207/10024 , G06T2207/10064 , G06T2207/30024 , G06T2207/30072
摘要： Systems and methods for automatic FOV selection in immunoscore computation that involve reading images for individual markers from an unmixed multiplex slide or single stain slides, and computing the tissue region mask from the individual marker image. The heat map of each marker is determined by applying the low pass filter on the individual marker image channel and selecting the top K highest intensity regions from the heat map as the candidate FOVs for each marker. The candidate FOVs from the individual marker images are merged together in the same coordinate system by either adding all of the FOVs together or by only adding the FOVs from the selected marker images depending on the user's choice, and registering all the individual marker images to a common coordinate system and transferring the FOVs back to the original images.
摘要翻译：系统和在immunoscore计算自动FOV选择方法并涉及读取用于各个标记图像从到未混合的多路滑动或单染色幻灯片，以及计算来自各个标记图像的组织区域掩模。每个标记的热图确定性通过施加各个标记图像通道上的低通滤波器，并从热图作为候补FOV每个标记选择前K最高强度区域开采。来自各个标记图像候选FOV由要么合并在一起相同的坐标系中加入所有的VOCs在一起或通过只从所选择的标记图像根据用户的选择添加的VOC，并注册所有单独的标记图像的公共坐标系和传递环的FOV回到原始图像。

13. 发明公开

EP3111221A1 METHODS, KITS, AND SYSTEMS FOR SCORING THE IMMUNE RESPONSE TO CANCER BY SIMULTANEOUS DETECTION OF CD3, CD8, CD20 AND FOXP3 有权
标题翻译：方法，试剂盒和评估免疫反应，癌症由CD3，CD8，CD20和Foxp3同时检测，系统
公开(公告)号：EP3111221A1
公开(公告)日：2017-01-04
申请号：EP15706450.2
申请日：2015-02-20
申请人： Ventana Medical Systems, Inc.
发明人： SEBASTIAO, Noemi , DAY, William , OCHS, Robert , CHUKKA, Srinivas , MARTIN, Jim , BARNES, Michael , BREDNO, Joerg , CHEN, Ting , TUBBS, Alisa , NIE, Yao
IPC分类号： G01N33/574
CPC分类号： G01N33/5743 , G01N15/1463 , G01N33/566 , G01N33/574 , G01N33/57415 , G01N33/6875 , G01N35/00029 , G01N2015/008 , G01N2015/1006 , G01N2015/1486 , G01N2035/00138 , G01N2333/4703 , G01N2333/4739 , G01N2333/4742 , G01N2333/70503 , G01N2333/7051 , G01N2333/70517 , G06F19/20
摘要： This disclosure describes methods, kits, and systems for scoring the immune response to cancer through examination of tissue infiltrating lymphocytes (TILs). Methods of scoring the immune response in cancer using tissue infiltrating lymphocytes include detecting CD3, CD8, CD20, and FoxP3 within the sample and scoring the detection manually or scoring the digital images of the staining with the aid of image analysis and algorithms.
摘要翻译：本发明描述用于计分穿过组织浸润淋巴细胞（TIL的）的检查，以癌症的免疫应答的方法，试剂盒和系统。得分在使用组织浸润淋巴细胞癌症的免疫应答的方法包括检测CD3，CD8，CD20，和Foxp3样品内并手动得分检测或用图像分析和算法的帮助下得分染色的数字图像。

14. 发明公开

EP4220564A3 IMAGE PROCESSING SYSTEMS AND METHODS FOR DISPLAYING MULTIPLE IMAGES OF A BIOLOGICAL SPECIMEN 审中-实审
公开(公告)号：EP4220564A3
公开(公告)日：2023-08-30
申请号：EP22214786.0
申请日：2016-08-25
申请人： Ventana Medical Systems, Inc. , Providence Health & Services - Oregon
发明人： BARNES, Michael , CHEN, Ting , CHEFD´HOTEL, Christophe , TUBBS, Alisa , BIFULCO, Carlo
IPC分类号： G06T11/60
摘要： A system and method of displaying of multiple simultaneous views of a same region of a biological tissue sample. Logical instructions are executed by a processor to perform operations such as receiving a plurality of images of the biological tissue sample, converting the plurality of images to a common reference frame based on the individual metadata of each image, and arranging the plurality of images into a display pattern for simultaneous viewing of different aspects of the imaged biological tissue sample on a display screen. The plurality of images is produced by preprocessing images of the biological tissue sample. Each image shows a view mode of a same region of the biological tissue sample, and each image contains metadata that describe spatial orientation, such as the translation, rotation, and magnification, of the image to bring the plurality of images to a common view.

15. 发明公开

EP4187486A1 METHOD FOR CO-EXPRESSION ANALYSIS 审中-实审
公开(公告)号：EP4187486A1
公开(公告)日：2023-05-31
申请号：EP22212869.6
申请日：2015-12-30
申请人： Ventana Medical Systems, Inc.
发明人： BARNES, Michael , SINGH, Shalini , CHEN, Ting , CHEFD'HOTEL, Christophe , TUBBS, Alisa
IPC分类号： G06T7/00
摘要： Described herein are methods for co-expression analysis of multiple markers in a tissue sample comprising: computing a heat map of marker expression for each of a plurality of single marker channel images, wherein each of the plurality of single marker channel images comprise a single marker; identifying one or more candidate regions of interest in each heat map of marker expression; computing overlay masks comprising the identified one or more candidate regions of interest from each heat map of marker expression; determining one or more co-localized regions of interest from the overlay masks; mapping the one or more co-localized regions of interest to a same coordinate position in each of the plurality of single marker channel images; and estimating a number of cells in at least one of the determined one or more co-localized regions of interest in each of the plurality of single marker channel images.

16. 发明授权

EP3149700B1 AN IMAGE PROCESSING METHOD AND SYSTEM FOR ANALYZING A MULTI-CHANNEL IMAGE OBTAINED FROM A BIOLOGICAL TISSUE SAMPLE BEING STAINED BY MULTIPLE STAINS 有权
公开(公告)号：EP3149700B1
公开(公告)日：2018-12-12
申请号：EP15726589.3
申请日：2015-05-29
申请人： Providence Health & Services - Oregon D/B/A , Ventana Medical Systems, Inc.
发明人： BARNES, Michael , CHEN, Ting , TUBBS, Alisa , BIFULCO, Carlo
IPC分类号： G06T5/00 , G06T7/00
CPC分类号： G06T7/0012 , G06T5/002 , G06T5/003 , G06T5/20 , G06T7/11 , G06T2207/10024 , G06T2207/10064 , G06T2207/30024 , G06T2207/30072
摘要： Systems and methods for automatic FOV selection in immunoscore computation that involve reading images for individual markers from an unmixed multiplex slide or single stain slides, and computing the tissue region mask from the individual marker image. The heat map of each marker is determined by applying the low pass filter on the individual marker image channel and selecting the top K highest intensity regions from the heat map as the candidate FOVs for each marker. The candidate FOVs from the individual marker images are merged together in the same coordinate system by either adding all of the FOVs together or by only adding the FOVs from the selected marker images depending on the user's choice, and registering all the individual marker images to a common coordinate system and transferring the FOVs back to the original images.

17. 发明公开

EP3839812A2 SYSTEMS AND METHODS FOR GENERATING REGIONS IN AN IMAGE ENCOMPASSING TUMOR CELLS 审中-实审
公开(公告)号：EP3839812A2
公开(公告)日：2021-06-23
申请号：EP20202876.7
申请日：2015-09-03
申请人： Ventana Medical Systems, Inc.
发明人： BARNES, Michael , CHEN, Ting , CHEFD'HOTEL, Christophe , TUBBS, Alisa , ASCIERTO, Paolo A.
IPC分类号： G06K9/00 , G01N33/50 , G06T7/00 , G06T7/11
摘要： Imaging systems, methods, and apparatuses for automatically identifying fields of view (FOVs) for regions in an image encompassing melanoma is disclosed. In embodiments and in further aspects of the present invention, a computer-implemented method is disclosed for a tumor region based immune score computation. The method, in accordance with the present invention, involves identifying regions, for example, tumor areas or regions around a tumor area, partitioning a whole slide image or portion of a whole slide image into multiple regions related to the tumor, selecting FOVs within each identified region, and computing a number of cells present in each FOV. An immune score and/or immune-related score is generated based on the cells counted in each FOV.

18. 发明授权

EP3111221B1 METHODS, KITS, AND SYSTEMS FOR SCORING THE IMMUNE RESPONSE TO CANCER BY SIMULTANEOUS DETECTION OF CD3, CD8, CD20 AND FOXP3. 有权
公开(公告)号：EP3111221B1
公开(公告)日：2018-10-10
申请号：EP15706450.2
申请日：2015-02-20
申请人： Ventana Medical Systems, Inc.
发明人： SEBASTIAO, Noemi , DAY, William , OCHS, Robert , CHUKKA, Srinivas , MARTIN, Jim , BARNES, Michael , BREDNO, Joerg , CHEN, Ting , TUBBS, Alisa , NIE, Yao
IPC分类号： G01N33/574
CPC分类号： G01N33/5743 , G01N15/1463 , G01N33/566 , G01N33/574 , G01N33/57415 , G01N33/6875 , G01N35/00029 , G01N2015/008 , G01N2015/1006 , G01N2015/1486 , G01N2035/00138 , G01N2333/4703 , G01N2333/4739 , G01N2333/4742 , G01N2333/70503 , G01N2333/7051 , G01N2333/70517 , G06F19/20
摘要： This disclosure describes methods, kits, and systems for scoring the immune response to cancer through examination of tissue infiltrating lymphocytes (TILs). Methods of scoring the immune response in cancer using tissue infiltrating lymphocytes include detecting CD3, CD8, CD20, and FoxP3 within the sample and scoring the detection manually or scoring the digital images of the staining with the aid of image analysis and algorithms.

19. 发明公开

EP3345161A1 IMAGE PROCESSING SYSTEMS AND METHODS FOR DISPLAYING MULTIPLE IMAGES OF A BIOLOGICAL SPECIMEN 有权
公开(公告)号：EP3345161A1
公开(公告)日：2018-07-11
申请号：EP16757236.1
申请日：2016-08-25
申请人： Ventana Medical Systems, Inc. , Providence Health & Services - Oregon
发明人： BARNES, Michael , CHEN, Ting , CHEFD'HOTEL, Christophe , TUBBS, Alisa , BIFULCO, Carlo
IPC分类号： G06T11/60 , G06F19/26
CPC分类号： G06T7/0016 , G06F3/04817 , G06F3/04883 , G06F19/26 , G06K9/469 , G06T3/0006 , G06T7/11 , G06T11/005 , G06T11/60 , G06T2200/24 , G06T2207/20192
摘要： A system and method of displaying of multiple simultaneous views of a same region of a biological tissue sample. Logical instructions are executed by a processor to perform operations such as receiving a plurality of images of the biological tissue sample, converting the plurality of images to a common reference frame based on the individual metadata of each image, and arranging the plurality of images into a display pattern for simultaneous viewing of different aspects of the imaged biological tissue sample on a display screen. The plurality of images is produced by preprocessing images of the biological tissue sample. Each image shows a view mode of a same region of the biological tissue sample, and each image contains metadata that describe spatial orientation, such as the translation, rotation, and magnification, of the image to bring the plurality of images to a common view.

20. 发明公开

EP4220564A2 IMAGE PROCESSING SYSTEMS AND METHODS FOR DISPLAYING MULTIPLE IMAGES OF A BIOLOGICAL SPECIMEN 审中-实审
公开(公告)号：EP4220564A2
公开(公告)日：2023-08-02
申请号：EP22214786.0
申请日：2016-08-25
申请人： Ventana Medical Systems, Inc. , Providence Health & Services - Oregon
发明人： BARNES, Michael , CHEN, Ting , CHEFD´HOTEL, Christophe , TUBBS, Alisa , BIFULCO, Carlo
IPC分类号： G06T11/60 , G16B45/00
摘要： A system and method of displaying of multiple simultaneous views of a same region of a biological tissue sample. Logical instructions are executed by a processor to perform operations such as receiving a plurality of images of the biological tissue sample, converting the plurality of images to a common reference frame based on the individual metadata of each image, and arranging the plurality of images into a display pattern for simultaneous viewing of different aspects of the imaged biological tissue sample on a display screen. The plurality of images is produced by preprocessing images of the biological tissue sample. Each image shows a view mode of a same region of the biological tissue sample, and each image contains metadata that describe spatial orientation, such as the translation, rotation, and magnification, of the image to bring the plurality of images to a common view.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式