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11. 发明专利

CA2568364A1 METHODS FOR PREPARING IMMUNOGENIC CONJUGATES 未知
公开(公告)号：CA2568364A1
公开(公告)日：2005-12-15
申请号：CA2568364
申请日：2005-06-03
申请人： US GOV HEALTH & HUMAN SERV
发明人： SHILOACH JOSEPH , ROBBINS JOHN B , LIU DARRELL T , LEPPLA STEPHEN H , SCHNEERSON RACHEL , KUBLER-KIELB JOANNA , MAJADLY FATHY
IPC分类号： A61K39/385 , A61K39/00 , A61K39/07 , A61K39/104 , A61K47/48

12. 发明专利

AU7826700A Vibrio cholerae O139 conjugate vaccines 未知
公开(公告)号：AU7826700A
公开(公告)日：2002-03-22
申请号：AU7826700
申请日：2000-09-01
申请人： US GOV HEALTH & HUMAN SERV
发明人： SZU SHOUSUN CHEN , KOSSACZKA ZUZANA , ROBBINS JOHN B
IPC分类号： A61K47/48
摘要： The disclosure pertains to conjugates of the capsular polysaccharide of Vibrio cholerae O139, or a structurally and/or immunologically related oligo- or poly-saccharide, and a carrier. These conjugates are useful as pharmaceutical compositions and/or vaccines to induce serum antibodies which have bactericidal (vibriocidal) activity against V. cholerae, in particular V. cholerae O139, and are useful to prevent, treat and/or reduce the severity of disease caused by V. cholerae infection, such as cholera. The present disclosure also relates to diagnostic tests for V. cholerae infection, and/or cholera caused by V. cholerae infection, using one or more of the oligo- or poly-saccharide-carrier conjugates or antibodies described above.

13. 发明专利

AU8575898A Vaccines against (escherichia coli) o157 infection 未知
公开(公告)号：AU8575898A
公开(公告)日：2000-02-14
申请号：AU8575898
申请日：1998-07-20
申请人： US GOV HEALTH & HUMAN SERV
发明人： SZU SHOUSUN C , ROBBINS JOHN B
IPC分类号： A61K39/02 , A61K39/108 , A61K39/385 , A61P31/04

14. 发明专利

CA2338093C VACCINES AGAINST ESCHERICHIA COLI O157 INFECTION 未知
公开(公告)号：CA2338093C
公开(公告)日：2010-11-30
申请号：CA2338093
申请日：1998-07-20
申请人： US GOV HEALTH & HUMAN SERV
发明人： SZU SHOUSUN C , ROBBINS JOHN B , KONADU EDWARD
IPC分类号： A61K39/385 , A61K39/02 , A61K39/108 , A61P31/04 , C07K14/25
摘要： This invention relates to conjugates of the O-specific polysaccharide of E. coli O157 with a carrier, and compositions thereof, and to methods of using of these conjugates and/or compositions thereof for eliciting an immunogenic response in mammals, including responses which provide protection against, or reduce the severity of, bacterial infections. More particularly it relates to the use of polysaccharides containing the tetrasaccharide repeat unit: (.fwdarw.3)-.alpha.-D-GalpNAc-(1.fwdarw.2)-.alpha.-D-PerpNAc-(1.fwdarw.3)-.alpha.-L-Fucp-(1.fwdarw.4)-.beta.-D-Glcp-(1.fwdarw., and conjugates thereof, to induce serum antibodies having bactericidal (killing) activity against hemolytic-uremic syndrome (HUS) causing E. coli, in particular E. coli O157. The conjugates, and compositions thereof, are useful as vaccines to induce serum antibodies which have bactericidal or bacteriostatic activity against E. coli, in particular E. coli O157, and are useful to prevent and/or treat illnesses caused by E. coli O157. The invention further relates to the antibodies which immunoreact with the O-specific polysaccharide of E. coli O157 and/or the carrier, that are induced by these conjugates and/or compositions thereof. The invention also relates to methods and kits using one or more of the polysaccharides, conjugates or antibodies described above.

15. 发明专利

AU2005249571B2 Methods for preparing immunogenic conjugates 未知
公开(公告)号：AU2005249571B2
公开(公告)日：2010-05-13
申请号：AU2005249571
申请日：2005-06-03
申请人： US GOV HEALTH & HUMAN SERV
发明人： KUBLER-KIELB JOANNA , LEPPLA STEPHEN H , SCHNEERSON RACHEL , ROBBINS JOHN B , LIU DARRELL T , SHILOACH JOSEPH , MAJADLY FATHY
IPC分类号： A61K39/00 , A61K39/07 , A61K39/104 , A61K39/385 , A61K47/48

16. 发明专利

AU2004252091A1 Poly-gamma-glutamic conjugates for eliciting immune responses directed against bacilli 未知
公开(公告)号：AU2004252091A1
公开(公告)日：2005-01-06
申请号：AU2004252091
申请日：2004-06-04
申请人： US GOV HEALTH & HUMAN SERV
发明人： SHILOACH JOSEPH , ROBBINS JOHN B , MAJADLY FATHY , SCHNEERSON RACHEL , KUBLER-KIELB JOANNA , LEPPLA STEPHEN , LIU DARRELL
IPC分类号： C07K14/32 , A61K38/00 , A61K39/00 , A61K39/07 , A61K47/48 , A61P31/04 , C07K16/12

17. 发明专利

ES2320998T3 COMPUESTOS QUE CONTIENEN COLESTEROL Y SU USO COMO INMUNOGENOS FRENTE A BORRELIA BURGDORFERI. 未知
公开(公告)号：ES2320998T3
公开(公告)日：2009-06-01
申请号：ES04758715
申请日：2004-04-02
申请人： US GOV HEALTH & HUMAN SERV
发明人： BEN-MENACHEM GIL , KUBLER-KIELB JOANNA , SCHNEERSON RACHEL , ROBBINS JOHN B , POZSGAY VINCE
IPC分类号： C07J9/00 , A61K31/56 , A61P31/00 , C07J20060101
摘要： Compuesto de fórmula A a continuación, o una sal o un complejo farmacéuticamente aceptables del mismo, en el que la fórmula A del compuesto comprende en la que R 1 se selecciona de azido, amino, amino sustituido, hidrazino, hidrazida, semicarbazida o carbohidrazida; R 2 se selecciona de una cadena de carbono saturada o insaturada que contiene de 1 a 25 átomos de carbono, o una cadena de carbono sustituida saturada o insaturada que contiene de 1 a 25 átomos de carbono; y L se selecciona de O, S o un radical alquileno.

18. 发明专利

AU2003200964A1 Lipooligosaccharide-Based Vaccine for Prevention of Moraxella (Branhamella) Catarrhalis Infections in Mammals 未知
公开(公告)号：AU2003200964A1
公开(公告)日：2003-06-12
申请号：AU2003200964
申请日：2003-02-21
申请人： US GOV HEALTH & HUMAN SERV
发明人： ROBBINS JOHN B , GU XIN-XING
IPC分类号： A61K39/02 , A61K39/116 , A61K39/295 , A61K39/385 , A61P27/16 , A61P31/04 , C08B37/00 , C12P19/04
摘要： A conjugate vaccine for Moraxella (Branhamella) catarrhalis comprising isolated lipooligosaccharide from which esterified fatty acids have been removed, to produce a detoxified lipooligosaccharide (dLOS), or from which lipid A has been removed, to produce a detoxified oligosaccharide (OS), which is linked to an immunogenic carrier. The vaccine is useful for preventing otitis media and respiratory infections caused by M. catarrhalis in mammals, including humans.

19. 发明专利

CA2714833A1 VACCINES AGAINST ESCHERICHIA COLI O157 INFECTION 未知
公开(公告)号：CA2714833A1
公开(公告)日：2000-02-03
申请号：CA2714833
申请日：1998-07-20
申请人： US GOV HEALTH & HUMAN SERV
发明人： KONADU EDWARD , SZU SHOUSUN C , ROBBINS JOHN B
IPC分类号： C07K16/12 , A61K39/02 , A61K39/108 , A61K39/116 , A61K39/385 , A61K39/40 , A61P31/04 , A61P37/04 , C07K14/25
摘要： This invention relates to conjugates of the O-specific polysaccharide of E. coli O157 with a carrier, and compositions thereof, and to methods of using of these conjugates and/or compositions thereof for eliciting an immunogenic response in mammals, including responses which provide protection against, or reduce the severity of, bacterial infections. More particularly it relates to the use of polysaccharides containing the tetrasaccharide repeat unit: (.fwdarw.3)-.alpha.-D-GalpNAc-(1.fwdarw.2)-.alpha.-D-PerpNAc-(1.fwdarw.3)-.alpha.-L-Fucp--(1.fwdarw.4)-.beta.-D-Glcp-(1.fwdarw., and conjugates thereof, to induce serum antibodies having bactericidal (killing) activity against hemolytic-uremic syndrome (HUS) causing E. coli, in particular E. coli O157. The conjugates, and compositions thereof, are useful as vaccines to induce serum antibodies which have bactericidal or bacteriostatic activity against E. coli, in particular E. coli O157, and are useful to prevent and/or treat illnesses caused by E. coli O157. The invention further relates to the antibodies which immunoreact with the O-specific polysaccharide of E. coli O157 and/or the carrier, that are induced by these conjugates and/or compositions thereof. The invention also relates to methods and kits using one or more of the polysaccharides, conjugates or antibodies described above.

20. 发明专利

AU2221299A Lipooligosaccharide-based vaccine for prevention of (moraxella) ((branhamella)) (catarrhalis) infections in mammals 未知
公开(公告)号：AU2221299A
公开(公告)日：1999-08-02
申请号：AU2221299
申请日：1999-01-12
申请人： US GOV HEALTH & HUMAN SERV
发明人： GU XIN-XING , ROBBINS JOHN B
IPC分类号： A61K39/02 , A61K39/116 , A61K39/295 , A61K39/385 , A61P27/16 , A61P31/04 , C08B37/00 , C12P19/04
摘要： A conjugate vaccine for Moraxella (Branhamella) catarrhalis comprising isolated lipooligosaccharide from which esterified fatty acids have been removed, to produce a detoxified lipooligosaccharide (dLOS), or from which lipid A has been removed, to produce a detoxified oligosaccharide (OS), which is linked to an immunogenic carrier. The vaccine is useful for preventing otitis media and respiratory infections caused by M. catarrhalis in mammals, including humans.

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