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11. 发明专利

AU784216B2 Production of attenuated, human-bovine chimeric respiratory syncytial virus vaccines 未知
公开(公告)号：AU784216B2
公开(公告)日：2006-02-23
申请号：AU5641500
申请日：2000-06-24
申请人： US GOV HEALTH & HUMAN SERV
发明人： BUCHHOLZ URSULA , COLLINS PETER L , MURPHY BRIAN R , WHITEHEAD STEPHEN S , KREMPL CHRISTINE D
IPC分类号： C12N15/09 , C12N15/86 , A61K38/17 , A61K39/00 , A61K39/12 , A61P11/00 , C07K14/14 , C12N7/00 , C12N7/04 , C12N15/62 , C12R1/93
摘要： Chimeric human-bovine respiratory syncytial virus (RSV) are infectious and attenuated in humans and other mammals and useful in vaccine formulations for eliciting an anti-RSV immune response. Also provided are isolated polynucleotide molecules and vectors incorporating a chimeric RSV genome or antigenome which includes a partial or complete human or bovine RSV “background” genome or antigenome combined or integrated with one or more heterologous gene(s) or genome segment(s) of a different RSV strain. In preferred aspects of the invention, chimeric RSV incorporate a partial or complete bovine RSV background genome or antigenome combined with one or more heterologous gene(s) or genome segment(s) from a human RSV. A variety of additional mutations and nucleotide modifications are provided within the human-bovine chimeric RSV of the invention to yield desired phenotypic and structural effects.

12. 发明专利

DE60041280D1 未知
公开(公告)号：DE60041280D1
公开(公告)日：2009-02-12
申请号：DE60041280
申请日：2000-06-23
申请人： US GOV HEALTH & HUMAN SERV
发明人： BUCHHOLZ URSULA , COLLINS PETER L , MURPHY BRIAN R , WHITEHEAD STEPHEN S , KREMPL CHRISTINE D
IPC分类号： C12N15/09 , C12N15/86 , A61K38/17 , A61K39/00 , A61K39/12 , A61P11/00 , C07K14/14 , C12N7/00 , C12N7/04 , C12N15/62 , C12R1/93
摘要： Chimeric human-bovine respiratory syncytial virus (RSV) are infectious and attenuated in humans and other mammals and useful in vaccine formulations for eliciting an anti-RSV immune response. Also provided are isolated polynucleotide molecules and vectors incorporating a chimeric RSV genome or antigenome which includes a partial or complete human or bovine RSV “background” genome or antigenome combined or integrated with one or more heterologous gene(s) or genome segment(s) of a different RSV strain. In preferred aspects of the invention, chimeric RSV incorporate a partial or complete bovine RSV background genome or antigenome combined with one or more heterologous gene(s) or genome segment(s) from a human RSV. A variety of additional mutations and nucleotide modifications are provided within the human-bovine chimeric RSV of the invention to yield desired phenotypic and structural effects.

13. 发明专利

AT416251T 未知
公开(公告)号：AT416251T
公开(公告)日：2008-12-15
申请号：AT01946696
申请日：2001-06-22
申请人： US GOV HEALTH & HUMAN SERV
发明人： KREMPL CHRISTINE D , COLLINS PETER L , MURPHY BRIAN , BUCHHOLZ URSULA , WHITEHEAD STEPHEN
IPC分类号： C12N7/00 , C12N15/09 , A61K39/12 , A61K39/155 , A61P31/14 , C12N7/02 , C12N7/04
摘要： Recombinant respiratory syncytial virus (RSV) having the position of genes shifted within the genome or antigenome of the recombinant virus are infectious and attenuated in humans and other mammals. Gene shifted RSV are constructed by insertion, deletion or rearrangement of genes or genome segments within the recombinant genome or antigenome and are useful in vaccine formulations for eliciting an anti-RSV immune response. Also provided are isolated polynucleotide molecules and vectors incorporating a recombinant RSV genome or antigenome wherein a gene or gene segment is shifted to a more promoter-proximal or promoter-distal position within the genome or antigenome compared to a wild type position of the gene in the RSV gene map. Shifting the position of genes in this manner provides for a selected increase or decrease in expression of the gene, depending on the nature and degree of the positional shift. In one embodiment, RSV glycoproteins are upregulated by shifting one or more glycoprotein-encoding genes to a more promoter-proximal position. Genes of interest for manipulation to create gene position-shifted RSV include any of the NS1, NS2, N, P, M, SH, M2(ORF1), M2(ORF2), L, F or G genes or a genome segment that may be part of a gene or extragenic. A variety of additional mutations and nucleotide modifications are provided within the gene position-shifted RSV of the invention to yield desired phenotypic and structural effects.

14. 发明专利

CA2378552A1 PRODUCTION OF ATTENUATED, HUMAN-BOVINE CHIMERIC RESPIRATORY SYNCYTIAL VIRUS VACCINES 未知
公开(公告)号：CA2378552A1
公开(公告)日：2001-01-18
申请号：CA2378552
申请日：2000-06-23
申请人： GOVERNMENT OF THE US DEP ART , BUCHHOLZ URSULA
发明人： COLLINS PETER L , MURPHY BRIAN R , WHITEHEAD STEPHEN S , KREMPL CHRISTINE D , BUCHHOLZ URSULA
IPC分类号： C12N15/09 , A61K39/00 , A61K39/12 , A61P11/00 , C07K14/14 , C12N7/00 , C12N7/04 , C12N15/86 , C12R1/93 , A61K38/17 , C12N15/62
摘要： Chimeric human-bovine respiratory syncytial virus (RSV) are infectious and attenuated in humans and other mammals and useful in vaccine formulations fo r eliciting an anti-RSV immune response. Also provided are isolated polynucleotide molecules and vectors incorporating a chimeric RSV genome or antigenome which includes a partial or complete human or bovine RSV "background" genome or antigenome combined or integrated with one or more heterologous gene(s) or genome segment(s) of a different RSV strain. Chimeri c human-bovine RSV of the invention include a partial or complete "background" RSV genome or antigenome derived from or patterned after a human or bovine R SV strain or subgroup virus combined with one or more heterologous gene(s) or genome segment(s) of a different RSV strain or subgroup virus to form the human-bovine chimeric RSV genome or antigenome. In preferred aspects of the invention, chimeric RSV incorporate a partial or complete bovine RSV background genome or antigenome combined with one or more heterologous gene( s) or genome segment(s) from a human RSV. Genes of interest include any of the NS1, NS2, N, P, M, SH, M2(ORF1), M2(ORF2), L, F or G genes or a genome segme nt including a protein or portion thereof. A variety of additional mutations an d nucleotide modifications are provided within the human-bovine chimeric RSV o f the invention to yield desired phenotypic and structural effects.

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