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11. 发明申请

WO0104335A8 HUMAN-BOVINE CHIMERIC RESPIRATORY SYNCYTIAL VIRUS VACCINES 审中-公开
标题翻译：人类猪流感呼吸道感染病毒疫苗
公开(公告)号：WO0104335A8
公开(公告)日：2003-02-06
申请号：PCT/US0017755
申请日：2000-06-23
申请人： US GOV HEALTH & HUMAN SERV , BUCHHOLZ URSULA , COLLINS PETER L , MURPHY BRIAN R , WHITEHEAD STEPHEN S , KREMPL CHRISTINE D
发明人： BUCHHOLZ URSULA , COLLINS PETER L , MURPHY BRIAN R , WHITEHEAD STEPHEN S , KREMPL CHRISTINE D
IPC分类号： C12N15/09 , A61K39/00 , A61K39/12 , A61P11/00 , C07K14/14 , C12N7/00 , C12N7/04 , C12N15/86 , C12R1/93 , A61K38/17 , C12N15/62
CPC分类号： C12N7/00 , A61K39/00 , A61K39/12 , A61K39/155 , A61K2039/5254 , A61K2039/5256 , A61K2039/544 , C07K14/005 , C07K2319/00 , C12N15/86 , C12N2760/18522 , C12N2760/18534 , C12N2760/18543 , C12N2760/18561 , C12N2840/203
摘要： Chimeric human-bovine respiratory syncytial virus (RSV) are infectious and attenuated in humans and other mammals and useful in vaccine formulations for eliciting an anti-RSV immune response. Also provided are isolated polynucleotide molecules and vectors incorporating a chimeric RSV genome or antigenome which includes a partial or complete human or bovine RSV "background" genome or antigenome combined or integrated with one or more heterologous gene(s) or genome segment(s) of a different RSV strain. Chimeric human-bovine RSV of the invention include a partial or complete "background" RSV genome or antigenome derived from or patterned after a human or bovine RSV strain or subgroup virus combined with one or more heterologous gene(s) or genome segment(s) of a different RSV strain or subgroup virus to form the human-bovine chimeric RSV genome or antigenome. In preferred aspects of the invention, chimeric RSV incorporate a partial or complete bovine RSV background genome or antigenome combined with one or more heterologous gene(s) or genome segment(s) from a human RSV. Genes of interest include any of the NS1, NS2, N, P, M, SH, M2(ORF1), M2(ORF2), L, F or G genes or a genome segment including a protein or portion thereof. A variety of additional mutations and nucleotide modifications are provided within the human-bovine chimeric RSV of the invention to yield desired phenotypic and structural effects.
摘要翻译：嵌合人 - 牛呼吸道合胞病毒（RSV）在人类和其他哺乳动物中具有感染性和减毒性，并且可用于引发抗RSV免疫应答的疫苗制剂中。还提供了分离的多核苷酸分子和掺入嵌合RSV基因组或抗原组的载体，其包括部分或完整的人或牛RSV“背景”基因组或与一个或多个异源基因或基因组片段不同的RSV菌株。本发明的嵌合人类牛RSV包括部分或完整的“背景”RSV基因组或在与一个或多个异源基因或基因组片段组合的人或牛RSV病毒株或亚组病毒之后衍生或构图的部分或完整的“背景” 的不同RSV株或亚组病毒形成人 - 牛嵌合RSV基因组或抗原组。在本发明的优选方面，嵌合RSV包含与来自人RSV的一个或多个异源基因或基因组片段组合的部分或完整的牛RSV背景基因组或反向异构体。感兴趣的基因包括任何NS1，NS2，N，P，M，SH，M2（ORF1），M2（ORF2），L，F或G基因或包含蛋白质或其部分的基因组片段。在本发明的人 - 牛嵌合RSV内提供了多种额外的突变和核苷酸修饰，以产生所需的表型和结构效果。

12. 发明申请

WO0061737A3 Production of attenuated negative stranded RNA virus vaccines 审中-公开
标题翻译：减毒负链RNA病毒疫苗的生产
公开(公告)号：WO0061737A3
公开(公告)日：2001-08-23
申请号：PCT/US0009695
申请日：2000-04-12
申请人： US GOV HEALTH & HUMAN SERV
发明人： MURPHY BRIAN R , COLLINS PETER L , DURBIN ANNA P , SKIADOPOULOS MARIO H
IPC分类号： C12N15/09 , A61K39/155 , A61P31/14 , C07K14/115 , C07K14/135 , C12N7/00 , C12N7/04 , C12N15/00 , C12R1/93 , C12N15/86
CPC分类号： C07K14/005 , A61K2039/5254 , C12N7/00 , C12N2760/18622 , C12N2760/18643 , C12N2760/18661 , C12N2760/18822
摘要： Attenuated, recombinant negative stranded RNA viruses suitable for vaccine use are produced from one or more isolated polynucleotide molecules encoding the virus. A recombinant genome or antigenome of the subject virus is modified to encode a mutation within a recombinant protein of the virus at one or more amino acid positions(s) corresponding to a site of an attenuating mutation in a heterologous, mutant negative stranded RNA virus. A similar attenuating mutation as identified in the heterologous negative stranded RNA virus is thus incorporated at a corresponding site within the recombinant virus to confer an attenuated phenotype on the recombinant virus. The attenuating mutation incorporated in the recombinant virus may be identical or conservative in relation to the attenuating mutation identified in the heterologous, mutant virus. By the transfer of mutations into recombinant negative stranded RNA viruses in this manner, candidate vaccine viruses are engineered to elicit a desired immune response against a subject virus in a host susceptible to infection thereby.

13. 发明公开

EP1554301A4 DENGUE TETRAVALENT VACCINE CONTAINING A COMMON 30 NUCLEOTIDE DELETION IN THE 3'-UTR OF DENGUE TYPES 1,2,3, AND 4, OR ANTIGENIC CHIMERIC DENGUE VIRUSES 1,2,3, AND 4 有权转让
标题翻译：与通常30个核苷酸缺失IN 3“UTR登革类型1,2,3和4 OR嵌合抗原登革TETRA VALENTE登革疫苗病毒1,2,3和4
公开(公告)号：EP1554301A4
公开(公告)日：2006-11-08
申请号：EP03724319
申请日：2003-04-25
申请人： US GOV HEALTH & HUMAN SERV
发明人： WHITEHEAD STEPHEN S , MURPHY BRIAN R , MARKOFF LEWIS , FALGOUT BARRY , BLANEY JOSEPH , HANLEY KATHRYN
IPC分类号： C12N15/09 , A61K20060101 , A61K31/7088 , A61K38/00 , A61K39/00 , A61K39/12 , A61K39/295 , A61K39/42 , A61P31/14 , C07H21/00 , C07H21/04 , C12N7/00 , C12N7/04
CPC分类号： C12N7/00 , A61K39/12 , A61K2039/5254 , A61K2039/5256 , A61K2039/70 , C12N2770/24134 , C12N2770/24161
摘要： A rDEN3/4”30(ME), rDEN2/4”30(ME) or rDEN1/4”30(ME) recombinant chimeric dengue virus containing a 30 nucleotide deletion (”30) in a section of the 3' untranslated region of dengue type 4 genome, where said 30 nucleotide deletion corresponds to the TL2 stem-loop structure.
摘要翻译：甲RDEN3 / 4 “30（ME），rDEN2 / 4” 30（ME）或rDEN1 / 4 “30（ME）的重组嵌合登革病毒含有一个30个核苷酸缺失的3“非翻译的区域的截面（” 30）登革热4型基因组中，其中，所述30个核苷酸缺失对应于TL2茎 - 环结构。

14. 发明专利

ES2533085T3 Desarrollo de mutaciones útiles para atenuar virus del dengue y virus del dengue quiméricos 未知
公开(公告)号：ES2533085T3
公开(公告)日：2015-04-07
申请号：ES10181804
申请日：2002-05-22
申请人： US GOV HEALTH & HUMAN SERV
发明人： WHITEHEAD STEPHEN S , MURPHY BRIAN R , HANLEY KATHRYN A , BLANEY JOSEPH E , LAI CHING-JUH
IPC分类号： C12Q1/70 , A61K39/12 , A61K39/193 , A61K39/295 , A61K39/42 , C07H21/02 , C07H21/04 , C07K1/00 , C07K14/00 , C07K17/00 , C12N7/00 , C12N7/01 , C12N7/04 , C12P19/34 , C12Q1/68 , G01N33/48 , G01N33/53
摘要： Un virus del dengue que comprende una mutación de glicina en la posición aminoacídica que corresponde a la posición aminoacídica 2664 de la SEQ ID NO: 19.

15. 发明专利

AU2011250694A8 Construction of West Nile virus and dengue virus chimeras for use in a live virus vaccine to prevent disease caused by West Nile virus 未知
公开(公告)号：AU2011250694A8
公开(公告)日：2013-09-12
申请号：AU2011250694
申请日：2011-11-10
申请人： US GOV HEALTH & HUMAN SERV , US ARMY
发明人： PLETNEV ALEXANDER G , PUTNAK JOSEPH R , CHANOCK ROBERT M , MURPHY BRIAN R , WHITEHEAD STEPHEN S , BLANEY SR JOSEPH E
IPC分类号： C12N15/09 , A61K31/7088 , A61K39/12 , A61K39/295 , A61P31/12 , C07K14/18 , C12N15/86
摘要： The present invention relates to attenuated, immunogenic West Nile virus chimeras built on a dengue virus backbone for the production of immunogenic, live, attenuated West Nile virus vaccines.

16. 发明专利

ES2317914T3 VACUNAS DE VIRUS SINCITIAL RESPIRATORIO QUE EXPRESAN ANTIGENOS PROTECTORES A PARTIR DE GENES PROXIMOS AL PROMOTOR. 未知
公开(公告)号：ES2317914T3
公开(公告)日：2009-05-01
申请号：ES01946696
申请日：2001-06-22
申请人： US GOV HEALTH & HUMAN SERV
发明人： KREMPL CHRISTINE D , COLLINS PETER L , MURPHY BRIAN R , BUCHHOLZ URSULA , WHITEHEAD STEPHEN S
IPC分类号： C12N7/00 , C12N15/09 , A61K39/12 , A61K39/155 , A61P31/14 , C12N7/02 , C12N7/04
摘要： Un virus sincitial respiratorio (RSV) recombinante e infeccioso, que comprende una proteína (N) principal de la nucleocápsida, una fosfoproteína (P) de la nucleocápsida, una proteína (L) polimerasa grande, un factor de prolongación de RNA-polimerasa, y un genoma o antigenoma del RSV recombinante parcial o completo, en donde un gen de glicoproteína en dicho genoma o antigenoma del RSV recombinante parcial o completo está desplazado posicionalmente a la posición 1, respecto al promotor.

17. 发明专利

DE60136811D1 未知
公开(公告)号：DE60136811D1
公开(公告)日：2009-01-15
申请号：DE60136811
申请日：2001-06-22
申请人： US GOV HEALTH & HUMAN SERV
发明人： KREMPL CHRISTINE D , COLLINS PETER L , MURPHY BRIAN R , BUCHHOLZ URSULA , WHITEHEAD STEPHEN S
IPC分类号： C12N7/00 , C12N15/09 , A61K39/12 , A61K39/155 , A61P31/14 , C12N7/02 , C12N7/04
摘要： Recombinant respiratory syncytial virus (RSV) having the position of genes shifted within the genome or antigenome of the recombinant virus are infectious and attenuated in humans and other mammals. Gene shifted RSV are constructed by insertion, deletion or rearrangement of genes or genome segments within the recombinant genome or antigenome and are useful in vaccine formulations for eliciting an anti-RSV immune response. Also provided are isolated polynucleotide molecules and vectors incorporating a recombinant RSV genome or antigenome wherein a gene or gene segment is shifted to a more promoter-proximal or promoter-distal position within the genome or antigenome compared to a wild type position of the gene in the RSV gene map. Shifting the position of genes in this manner provides for a selected increase or decrease in expression of the gene, depending on the nature and degree of the positional shift. In one embodiment, RSV glycoproteins are upregulated by shifting one or more glycoprotein-encoding genes to a more promoter-proximal position. Genes of interest for manipulation to create gene position-shifted RSV include any of the NS1, NS2, N, P, M, SH, M2(ORF1), M2(ORF2), L, F or G genes or a genome segment that may be part of a gene or extragenic. A variety of additional mutations and nucleotide modifications are provided within the gene position-shifted RSV of the invention to yield desired phenotypic and structural effects.

18. 发明专利

CA2605878A1 ATTENUATED HUMAN PARAINFLUENZA VIRUS, METHODS AND USES THEREOF 未知
公开(公告)号：CA2605878A1
公开(公告)日：2007-10-25
申请号：CA2605878
申请日：2006-01-10
申请人： US GOV HEALTH & HUMAN SERV
发明人： COLLINS PETER L , NOLAN SHEILA , MURPHY BRIAN R , SKIADOPOULOS MARIO H
IPC分类号： C12N7/00

19. 发明专利

AU2006332044A1 Attenuated human parainfluenza virus, methods and uses thereof 未知
公开(公告)号：AU2006332044A1
公开(公告)日：2007-08-16
申请号：AU2006332044
申请日：2006-01-10
申请人： US GOV HEALTH & HUMAN SERV
发明人： MURPHY BRIAN R , COLLINS PETER L , SKIADOPOULOS MARIO H , NOLAN SHEILA
IPC分类号： C12N15/00

20. 发明专利

DE60033939D1 未知
公开(公告)号：DE60033939D1
公开(公告)日：2007-04-26
申请号：DE60033939
申请日：2000-07-06
申请人： US GOV HEALTH & HUMAN SERV
发明人： DURBIN ANNA P , COLLINS PETER L , MURPHY BRIAN R
IPC分类号： A61K48/00 , C12N15/09 , A61K9/12 , A61K39/00 , A61K39/102 , A61P31/16 , C07K14/115 , C12N7/00 , C12N7/04
摘要： Recombinant parainfluenza virus (PIV) are provided in which expression of the C, D and/or V translational open reading frame(s) (ORFs) is reduced or ablated to yield novel PIV vaccine candidates. Expression of the C, D and/or V ORF(s) is reduced or ablated by modifying a recombinant PIV genome or antigenome, for example by introduction of a stop codon, by a mutation in an RNA editing site, by a mutation that alters the amino acid specified by an initiation codon, or by a frame shift mutation in the targeted ORF(s). Alternatively, the C, D and/or V ORF(s) is deleted in whole or in part to render the protein(s) encoded thereby partially or entirely non-functional or to disrupt protein expression altogether. C, D and/or V ORF(s) deletion and knock out mutants possess highly desirable phenotypic characteristics for vaccine development. These deletion and knock out mutations changes specify one or more desired phenotypic changes in the resulting virus or subviral particle. Vaccine candidates are generated that show a change in viral growth characteristics, attenuation, plaque size, and/or a change in cytopathogenicity, among other novel phenotypes. A variety of additional mutations and nucleotide modifications are provided within the C, D and/or V ORF(s) deletion or ablation mutant PIV of the invention to yield desired phenotypic and structural effects.

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