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11. 发明申请

WO2010090857A3 METHODS FOR AMPLIFYING HEPATITIS C VIRUS NUCLEIC ACIDS 审中-公开
标题翻译：用于放大丙型肝炎病毒核酸的方法
公开(公告)号：WO2010090857A3
公开(公告)日：2010-11-25
申请号：PCT/US2010021589
申请日：2010-01-21
申请人： VERTEX PHARMA , KWONG ANN D , FRANTZ JAMES DANIEL , BARTELS DOUGLAS J , LIN CHAO , SHAMES BENJAMIN , SEEPERSAUD SHEILA , LIPPKE JUDITH A , KIEFFER TARA L , ZHOU YI , ZHANG EILEEN Z , SULLIVAN JAMES C
发明人： KWONG ANN D , FRANTZ JAMES DANIEL , BARTELS DOUGLAS J , LIN CHAO , SHAMES BENJAMIN , SEEPERSAUD SHEILA , LIPPKE JUDITH A , KIEFFER TARA L , ZHOU YI , ZHANG EILEEN Z , SULLIVAN JAMES C
IPC分类号： C12Q1/68
CPC分类号： C12Q1/707 , C12Q1/6883
摘要： A method of amplifying an HCV nucleic acid in an HCV infected sample comprises amplifying a segment of a DNA template that is complementary to a genome of HCV RNA from the sample by a two-stage PCR, wherein a first stage PCR employs a first outer primer and a second outer primer, and a second stage PCR employs a first inner primer and a second inner primer. The nucleotide sequence of the first outer primer comprises a nucleotide sequence as set forth in SEQ ID NO: 2; or SEQ ID NO:9, wherein optionally 1, 2 or 3 nucleotides are other nucleotides than those of SEQ ID NO: 9. The nucleotide sequence of the second outer primer comprises a nucleotide sequence set forth in SEQ ID NO: 3 or 4; or a nucleotide sequence as set forth in SEQ ID NO: 10 or 11, wherein optionally 1, 2 or 3 nucleotides are other nucleotides than those of SEQ ID NO: 10 and 11. The nucleotide sequence of the first inner primer comprises a nucleotide sequence as set forth in SEQ ID NO: 5; or SEQ ID NO: 12, wherein optionally 1, 2 or 3 nucleotides are other nucleotides than those of SEQ ID NO: 12. The nucleotide sequence of the second inner primer comprises a nucleotide sequence as set forth in SEQ ID NO: 6 or 7; or a nucleotide sequence as set forth in SEQ ID NO: 13 or 14, wherein optionally 1, 2 or 3 nucleotides are other nucleotides than those of SEQ ID NO: 13 and 14.
摘要翻译：在HCV感染样品中扩增HCV核酸的方法包括通过两阶段PCR从样品中扩增与HCV RNA基因组互补的DNA模板的片段，其中第一阶段PCR使用第一外部引物和第二外引物，第二阶段PCR采用第一内引物和第二内引物。第一外引物的核苷酸序列包含SEQ ID NO：2所示的核苷酸序列; 或SEQ ID NO：9，其中任选地1,2或3个核苷酸是比SEQ ID NO：9的核苷酸更多的核苷酸。第二外部引物的核苷酸序列包含SEQ ID NO：3或4所示的核苷酸序列; 或如SEQ ID NO：10或11所示的核苷酸序列，其中任选1,2或3个核苷酸是与SEQ ID NO：10和11相同的其它核苷酸。第一内引物的核苷酸序列包含核苷酸序列如SEQ ID NO：5所示; 或SEQ ID NO：12，其中任选地1,2或3个核苷酸是与SEQ ID NO：12相同的其它核苷酸。第二内引物的核苷酸序列包含SEQ ID NO：6或7所示的核苷酸序列 ; 或如SEQ ID NO：13或14所示的核苷酸序列，其中任选地1,2或3个核苷酸是与SEQ ID NO：13和14相同的其它核苷酸。

12. 发明申请

WO2007144852A3 SYSTEM AND METHOD FOR IMPLEMENTING PROGRAM DELIVERY SERVICE 审中-公开
标题翻译：执行程序交付服务的系统和方法
公开(公告)号：WO2007144852A3
公开(公告)日：2008-02-21
申请号：PCT/IB2007052305
申请日：2007-06-15
申请人： UTSTARCOM TELECOM CO LTD , ZHOU YI , ZHANG ZHONG , LONG SHIZHU , FAN CUNZHI
发明人： ZHOU YI , ZHANG ZHONG , LONG SHIZHU , FAN CUNZHI
IPC分类号： H04N7/14 , G06F13/00 , H04L29/00
CPC分类号： H04L65/4084 , H04N7/165 , H04N21/25816 , H04N21/25875 , H04N21/4788 , H04N21/6334 , H04N21/6582
摘要： An apparatus and a method for implementing program service in a network interactive television system. In such apparatus and method, a valid user terminal is allowed to deliver programs to other valid users. This service is implemented by adding the following functional unit to a basic network interactive television system: a delivery service interface unit, a delivery service logic unit, and a delivery service data unit. The service flow related to program delivery is implemented by cooperation of these units with a terminal management unit, a system playing server, and user terminals.
摘要翻译：一种用于在网络交互式电视系统中实现节目服务的装置和方法。在这种装置和方法中，允许有效的用户终端向其他有效用户传递节目。该服务通过将以下功能单元添加到基本网络交互式电视系统来实现：传送服务接口单元，传送服务逻辑单元和传送服务数据单元。与节目传送相关的服务流程通过这些单元与终端管理单元，系统播放服务器和用户终端的协作来实现。

13. 发明申请

WO2010090857A8 METHODS FOR AMPLIFYING HEPATITIS C VIRUS NUCLEIC ACIDS 审中-公开
标题翻译：用于放大丙型肝炎病毒核酸的方法
公开(公告)号：WO2010090857A8
公开(公告)日：2012-06-28
申请号：PCT/US2010021589
申请日：2010-01-21
申请人： VERTEX PHARMA , KWONG ANN D , FRANTZ JAMES DANIEL , BARTELS DOUGLAS J , LIN CHAO , SHAMES BENJAMIN , SEEPERSAUD SHEILA , LIPPKE JUDITH A , KIEFFER TARA L , ZHOU YI , ZHANG EILEEN Z , SULLIVAN JAMES C
发明人： KWONG ANN D , FRANTZ JAMES DANIEL , BARTELS DOUGLAS J , LIN CHAO , SHAMES BENJAMIN , SEEPERSAUD SHEILA , LIPPKE JUDITH A , KIEFFER TARA L , ZHOU YI , ZHANG EILEEN Z , SULLIVAN JAMES C
IPC分类号： C12Q1/68
CPC分类号： C12Q1/707 , C12Q1/6883
摘要： A method of amplifying an HCV nucleic acid in an HCV infected sample comprises amplifying a segment of a DNA template that is complementary to a genome of HCV RNA from the sample by a two-stage PCR, wherein a first stage PCR employs a first outer primer and a second outer primer, and a second stage PCR employs a first inner primer and a second inner primer. The nucleotide sequence of the first outer primer comprises a nucleotide sequence as set forth in SEQ ID NO: 2; or SEQ ID NO:9, wherein optionally 1, 2 or 3 nucleotides are other nucleotides than those of SEQ ID NO: 9. The nucleotide sequence of the second outer primer comprises a nucleotide sequence set forth in SEQ ID NO: 3 or 4; or a nucleotide sequence as set forth in SEQ ID NO: 10 or 11, wherein optionally 1, 2 or 3 nucleotides are other nucleotides than those of SEQ ID NO: 10 and 11. The nucleotide sequence of the first inner primer comprises a nucleotide sequence as set forth in SEQ ID NO: 5; or SEQ ID NO: 12, wherein optionally 1, 2 or 3 nucleotides are other nucleotides than those of SEQ ID NO: 12. The nucleotide sequence of the second inner primer comprises a nucleotide sequence as set forth in SEQ ID NO: 6 or 7; or a nucleotide sequence as set forth in SEQ ID NO: 13 or 14, wherein optionally 1, 2 or 3 nucleotides are other nucleotides than those of SEQ ID NO: 13 and 14.
摘要翻译：在HCV感染样品中扩增HCV核酸的方法包括通过两阶段PCR从样品中扩增与HCV RNA基因组互补的DNA模板的片段，其中第一阶段PCR使用第一外部引物和第二外引物，第二阶段PCR采用第一内引物和第二内引物。第一外引物的核苷酸序列包含SEQ ID NO：2所示的核苷酸序列; 或SEQ ID NO：9，其中任选地1,2或3个核苷酸是比SEQ ID NO：9的核苷酸更多的核苷酸。第二外部引物的核苷酸序列包含SEQ ID NO：3或4所示的核苷酸序列; 或如SEQ ID NO：10或11所示的核苷酸序列，其中任选1,2或3个核苷酸是与SEQ ID NO：10和11相同的其它核苷酸。第一内引物的核苷酸序列包含核苷酸序列如SEQ ID NO：5所示; 或SEQ ID NO：12，其中任选地1,2或3个核苷酸是与SEQ ID NO：12相同的其它核苷酸。第二内引物的核苷酸序列包含SEQ ID NO：6或7所示的核苷酸序列 ; 或如SEQ ID NO：13或14所示的核苷酸序列，其中任选地1,2或3个核苷酸是与SEQ ID NO：13和14相同的其它核苷酸。

14. 发明申请

WO2008137126A3 COMBINATION THERAPY FOR THE TREATMENT OF HCV INFECTION 审中-公开
标题翻译：用于治疗HCV感染的联合治疗
公开(公告)号：WO2008137126A3
公开(公告)日：2009-04-09
申请号：PCT/US2008005758
申请日：2008-05-05
申请人： VERTEX PHARMA , KWONG ANN , MANI NAGRAJ , ZHOU YI , LIN CHAO
发明人： KWONG ANN , MANI NAGRAJ , ZHOU YI , LIN CHAO
IPC分类号： A61K45/06 , A61K31/7068 , A61P31/12
CPC分类号： A61K31/497 , A61K31/7068 , A61K45/06 , A61K2300/00
摘要： The present invention relates to therapeutic combinations comprising a protease inhibitor and a polymerase inhibitor for the treatment of HCV. The present invention also relates to therapeutic combinations comprising VX-950 and a polymerase inhibitor. Also within the scope of the invention are methods using the therapeutic combinations of the present invention for treating HCV infection or alleviating one or more symptoms thereof in a patient. The present invention also provides kits comprising the combinations of the present invention.
摘要翻译：本发明涉及包含用于治疗HCV的蛋白酶抑制剂和聚合酶抑制剂的治疗组合。本发明还涉及包含VX-950和聚合酶抑制剂的治疗组合。也在本发明的范围内的方法是使用本发明的治疗组合治疗HCV感染或减轻患者中的一种或多种症状的方法。本发明还提供包含本发明组合的试剂盒。

15. 发明申请

WO2008020404A3 METHOD FOR REDUCING SYSTEM SIGNALLING INTERCHANGING PROCESSES FOR MULTIMEDIA SUBSYSTEM 审中-公开
标题翻译：一种减少多媒体子系统信号交互过程的方法
公开(公告)号：WO2008020404A3
公开(公告)日：2008-05-15
申请号：PCT/IB2007053241
申请日：2007-08-14
申请人： UTSTARCOM TELECOM CO LTD , ZHOU YI
发明人： ZHOU YI
IPC分类号： H04Q7/00
CPC分类号： H04L65/1016
摘要： The invention provides a method of signalling interchange in IMS, able to reduce the number of the signalling interchange and improve system stability. In the signalling interchange among a network element, SLF and HSS, the method comprises sequentially the following steps: the network element receiving a message containing a user ID; according to the user ID, the network element querying in its buffer storage HSS information corresponding to the user ID; and the network element building signalling interchange with a home HSS determined by the HSS information. Thus, by adding the buffer storage to network element, the method reduces the interchanging process that I-CSCF queries SLF about the subscriber's home HSS. Therefore, the method reduces performance loss due to the number of IMS signalling interchange and improves system stability without changing the existing IMS network infrastructure and influencing the IMS session and service processing mechanism.
摘要翻译：本发明提供了一种IMS中信令交互的方法，能够减少信令交换次数，提高系统稳定性。在网元，SLF和HSS之间的信令交换中，该方法依次包括以下步骤：网元接收包含用户标识的消息; 根据所述用户标识，所述网元向其缓存HSS中查询所述用户标识对应的信息; 并且网元建立信令与由HSS信息确定的归属HSS进行交换。因此，通过将缓冲存储添加到网元，该方法减少了I-CSCF查询关于订户的归属HSS的SLF的交换过程。因此，该方法降低了由于IMS信令交换数量造成的性能损失，并且在不改变现有IMS网络基础设施并影响IMS会话和业务处理机制的情况下提高了系统稳定性。

16. 发明申请

WO2006121767A3 4-AMINOQUINOLINE COMPOUNDS FOR TREATING VIRUS-RELATED CONDITIONS 审中-公开
标题翻译：用于治疗病毒相关条件的4-氨基喹啉化合物
公开(公告)号：WO2006121767A3
公开(公告)日：2007-11-08
申请号：PCT/US2006017200
申请日：2006-05-04
申请人： APATH LLC , OLIVO PAUL D , BUSCHER BENJAMIN A , DYALL JULIE , JOCKET-BALSAROTTI JENNIFER I , O'GUIN ANDREW K , ROTH ROBERT M , ZHOU YI , FRANKLIN GARY W , STARKEY GALE W
发明人： OLIVO PAUL D , BUSCHER BENJAMIN A , DYALL JULIE , JOCKET-BALSAROTTI JENNIFER I , O'GUIN ANDREW K , ROTH ROBERT M , ZHOU YI , FRANKLIN GARY W , STARKEY GALE W
IPC分类号： A61K31/4706
CPC分类号： A61K31/4706
摘要： This invention is directed to aminoquinoline compounds, pharmaceutical compositions of such compounds, kits comprising such compounds, and uses of such compounds for preparing medicaments and treating virus-related conditions in animals.
摘要翻译：本发明涉及氨基喹啉化合物，这种化合物的药物组合物，包含这些化合物的试剂盒，以及这些化合物用于制备药物和治疗动物病毒相关病症的用途。

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