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11. 发明申请

WO1998006848A1 GnRH-LEUKOTOXIN CHIMERAS 审中-公开
公开(公告)号：WO1998006848A1
公开(公告)日：1998-02-19
申请号：PCT/CA1997000559
申请日：1997-08-08
申请人： UNIVERSITY OF SASKATCHEWAN
发明人： UNIVERSITY OF SASKATCHEWAN , POTTER, Andrew, A. , MANNS, John, G.
IPC分类号： C12N15/16
CPC分类号： A61K39/0006 , A61K39/00 , A61K47/62 , A61K47/646 , A61K47/6829 , A61K47/6833 , A61K2039/6037 , C07K5/1008 , C07K5/1019 , C07K5/1021 , C07K5/1024 , C07K7/23 , C07K14/005 , C07K14/285 , C07K14/655 , C07K16/26 , C07K2319/00 , C12N2720/12322
摘要： New immunological carrier systems, DNA encoding the same, and the use of these systems, are disclosed. The carrier systems include chimeric proteins which include a leukotoxin polypeptide fused to one or more selected GnRH multimers which comprise at least one repeating GnRH decapeptide sequence, or at least one repeating unit of a sequence corresponding to at least one epitope of a selected GnRH molecule. Under the invention, the selected GnRH sequences may all be the same, or may correspond to different derivatives, analogues, variants or epitopes of GnRH so long as the GnRH sequences are capable of eliciting an immune response. The leukotoxin functions to increase the immunogenicity of the GnRH multimers fused thereto.
摘要翻译：公开了新的免疫载体系统，编码相同的DNA以及这些系统的使用。载体系统包括嵌合蛋白，其包含与一个或多个选定的GnRH多聚体融合的白细胞毒素多肽，所述GnRH多聚体包含至少一个重复的GnRH十肽序列，或至少一个对应于所选GnRH分子的至少一个表位的序列的重复单元。根据本发明，所选择的GnRH序列可以全部相同，或者可以对应于GnRH的不同衍生物，类似物，变体或表位，只要GnRH序列能够引发免疫应答即可。白细胞毒素用于增加与其融合的GnRH多聚体的免疫原性。

12. 发明申请

WO1992014152A1 ROTAVIRUS VP6 A DIAGNOSTIC AND TARGETING AGENT 审中-公开
标题翻译： ROTAVIRUS VP6诊断与治疗代理
公开(公告)号：WO1992014152A1
公开(公告)日：1992-08-20
申请号：PCT/CA1992000032
申请日：1992-01-29
申请人： UNIVERSITY OF SASKATCHEWAN
发明人： UNIVERSITY OF SASKATCHEWAN , REDMOND, Mark, J. , CAMPOS, Manuel , MATTE, Gilbert, G. , HAINES, Deborah, M.
IPC分类号： G01N33/569
CPC分类号： C07K14/005 , C12N2710/14143 , C12N2720/12322 , G01N33/5094 , G01N33/56966 , G01N33/56972 , G01N33/56983 , Y10S530/826
摘要： Advantage is taken of the ability of rotaviral VP6 protein to home to macrophage and monocytes to provide label to these cells in either an in vitro or in vivo environment. Further, the ability to couple label to the VP6 protein and to couple VP6 to a targeting agent provides a mechanism for conducting label (or an effector moiety) to any desired target.
摘要翻译：优点是轮状病毒VP6蛋白能够归巢于巨噬细胞和单核细胞，以在体外或体内环境中为这些细胞提供标记。此外，将标记物与VP6蛋白偶联并将VP6偶联至靶向剂的能力提供了将标记（或效应子部分）导入任何所需靶标的机制。

13. 发明申请

WO1992011494A1 TWO-PHASE FLOW HEAT EXCHANGE 审中-公开
标题翻译：两相流量热交换器
公开(公告)号：WO1992011494A1
公开(公告)日：1992-07-09
申请号：PCT/CA1991000438
申请日：1991-12-09
申请人： UNIVERSITY OF SASKATCHEWAN , REZKALLAH, Kamiel , BESANT, Robert, W.
发明人： UNIVERSITY OF SASKATCHEWAN
IPC分类号： F24F12/00
CPC分类号： F24F12/002 , F28D15/00 , F28F13/00 , Y02B30/563 , Y10S165/908
摘要： A heat exchange process and apparatus are especially suited for use in heat recovery applications, especially in a run-around heat exchanger. The run-around heat recovery system has two liquid to gas heat echangers (10, 12), one for heat transfer with stale air being exhausted and one for heat transfer with fresh air being taken in. The two heat exchangers (10, 12) are linked with a common coupling liquid so that heat may be extracted from one of the air flows and added to the other. To improve the heat transfer process, a gas is injected into the liquid just before it enters one or both of the heat exchangers. The resultant mixed phase flow produces a much higher heat transfer coefficient in the heat exchangers (10, 12), yielding a significant improvement in the system performance.
摘要翻译：热交换过程和设备特别适用于热回收应用，特别是在循环式热交换器中。循环热回收系统具有两个液 - 气换热器（10,12），一个用于传热，一个空气耗尽，一个用于带有新鲜空气的热传递。两个热交换器（10,12）与常见的耦合液体连接，使得可以从一个空气流中提取热量并加入另一个。为了改善传热过程，在进入一个或两个热交换器之前，气体被注入到液体中。所得混合相流在热交换器（10,12）中产生高得多的传热系数，从而显着提高了系统的性能。

14. 发明申请

WO1990015618A2 SRIF-RELATED PEPTIDES AND USES THEREOF 审中-公开
标题翻译： SRIF相关肽及其用途
公开(公告)号：WO1990015618A2
公开(公告)日：1990-12-27
申请号：PCT/CA1990000197
申请日：1990-06-21
申请人： UNIVERSITY OF SASKATCHEWAN
发明人： UNIVERSITY OF SASKATCHEWAN , LAARVELD, Bernard , KIRKWOOD, Roy, Neville , THACKER, Philip, Alfred , SORDILLO, Lorraine, M. , REDMOND, Mark
IPC分类号： A61K37/43
CPC分类号： C07K16/26 , A61K39/0005 , A61K2039/55505 , A61K2039/6081 , C07K2317/34
摘要： Compositions and methods for modulating SRIF activity as well as enhancing the reproductive performance and immunological function in vertebrates are disclosed. Compositions containing SRIF-related peptides or antibodies thereto can be administered to animals to modulate endogenous SRIF-like activity. The SRIF-related peptides can be linked to a carrier such as ovalbumin, and administered in an Al(OH)3 adjuvant, to enhance the immunogenicity of the SRIF-related peptides.

15. 发明申请

WO1996041879A1 CAMP FACTOR OF STREPTOCOCCUS UBERIS 审中-公开
标题翻译：拉格朗日的院长因素
公开(公告)号：WO1996041879A1
公开(公告)日：1996-12-27
申请号：PCT/CA1996000377
申请日：1996-06-07
申请人： UNIVERSITY OF SASKATCHEWAN
发明人： UNIVERSITY OF SASKATCHEWAN , JIANG, Min , POTTER, Andrew, A. , MACLACHLAN, Philip, Ronald
IPC分类号： C12N15/31
CPC分类号： C07K14/315 , A61K39/00 , Y10S930/29
摘要： The CAMP factor gen of Streptococcus uberis (S. uberis) is described, as well as the recombinant production of CAMP factor therefrom. CAMP factors can be used in vaccine compositions for the prevention and treatment of bacterial infections.
摘要翻译：描述了乳房链球菌（乳房链球菌）的CAMP因子基因，以及从其重组产生CAMP因子。 CAMP因子可用于预防和治疗细菌感染的疫苗组合物中。

16. 发明申请

WO1995033365A1 BEAN HARVESTER 审中-公开
标题翻译：贝恩·哈维斯特
公开(公告)号：WO1995033365A1
公开(公告)日：1995-12-14
申请号：PCT/CA1995000324
申请日：1995-06-01
申请人： UNIVERSITY OF SASKATCHEWAN , ZYLA, Loyd, E. , KUSHWAHA, Lal, R. , REED, William, B.
发明人： UNIVERSITY OF SASKATCHEWAN
IPC分类号： A01D45/00
CPC分类号： A01D45/22 , A01D45/003 , A01D57/02
摘要： A crop harvester has bristle guards (39) mounted on the cutter bar (14) as crop lifters and to capture fruit lost by dehiscence during cutting. Each bristle guard is a set of laterally oriented bristles (44). Dehisced fruit is swept into the header by a pickup reel (16) having bristle bats (74). The bristles (76) are supported on the leading side by a strip (78) of flexible belting. The belting protects the bristle bats against being cut by the cutter bar. The crops are supported against being pushed forward by the bristle bats (74) of the reel. The reel diameter is reduced to about one-half normal and the reel index is increased to provide an aggressive reel operation, ensuring that plants are properly engaged in the bristle guards for cutting.
摘要翻译：作物收割机具有作为作物升降器安装在切割杆（14）上的刷毛防护件（39），并且在切割期间捕获由开裂损失的水果。每个刷毛防护罩是一组横向定向的刷毛（44）。旋开的水果被具有刷毛蝙蝠（74）的拾取卷轴（16）扫入头部。刷毛（76）由柔性带的带（78）支撑在前侧。皮带保护鬃毛蝙蝠不被切割杆切割。作物被支撑以被卷轴的刷毛蝙蝠（74）向前推动。卷轴直径减小到正常的大约一半，并且卷轴索引增加以提供积极的卷轴操作，确保植物适当地接合在刷毛防护件中用于切割。

17. 发明申请

WO1995016048A2 RECOMBINANT PROTEIN PRODUCTION IN BOVINE ADENOVIRUS EXPRESSION VECTOR SYSTEM 审中-公开
标题翻译：牛血清型表达载体系统中重组蛋白的生产
公开(公告)号：WO1995016048A2
公开(公告)日：1995-06-15
申请号：PCT/CA1994000678
申请日：1994-12-09
申请人： UNIVERSITY OF SASKATCHEWAN
发明人： UNIVERSITY OF SASKATCHEWAN , MITTAL, Suresh, K. , GRAHAM, Frank, L. , PREVEC, Ludvik , BABIUK, Lorne, A.
IPC分类号： C12N15/86
CPC分类号： C12N15/86 , A61K48/00 , C07K14/005 , C12N2710/10322 , C12N2710/10343 , C12N2710/10352
摘要： The present invention relates to novel live bovine adenovirus (BAV) expression vector systems in which part or all of one or both of the early region 1 (E1) and early region 3 (E3) genes are deleted and replaced by a foreign gene or fragment thereof and novel recombinant mammalian cell lines stably transformed with BAV E1 sequences, and therefore, express E1 gene products capable of allowing replication therein of a bovine adenovirus having an E1 deletion replaced by a heterologous nucleotide sequence encoding a foreign gene or fragment thereof and their use in production of (antigenic) polypeptides or fragments thereof for the purpose of live recombinant virus or subunit vaccine or for other therapies.
摘要翻译：本发明涉及新鲜活牛腺病毒（BAV）表达载体系统，其中早期区域1（E1）和早期区域3（E3）基因中的一个或两个的部分或全部被缺失并被外源基因或片段替代以及用BAV E1序列稳定转化的新型重组哺乳动物细胞系，因此表达能够允许其中复制具有E1缺失的牛腺病毒的E1基因产物，其被编码外来基因或其片段的异源核苷酸序列替代，并且其用途（抗原性）多肽或其片段的生产用于活重组病毒或亚单位疫苗或用于其它疗法。

18. 发明申请

WO1994005326A1 NOVEL BACTERIAL VACCINES USING VACCINE STRAINS OF PATHOGENIC BACTERIA 审中-公开
标题翻译：使用病原菌的疫苗菌株的新型细菌疫苗
公开(公告)号：WO1994005326A1
公开(公告)日：1994-03-17
申请号：PCT/CA1993000365
申请日：1993-09-03
申请人： UNIVERSITY OF SASKATCHEWAN
发明人： UNIVERSITY OF SASKATCHEWAN , ALLAN, Brenda, J. , POTTER, Andrew, A.
IPC分类号： A61K39/108
CPC分类号： C07K14/245 , A61K39/00
摘要： Vaccines are provided for vaccinating an animal against pathogenic bacteria, including E. coli. The invention also encompasses methods of preparing and methods of use of vaccine strains and compositions that result from or are used in these methods.
摘要翻译：提供疫苗以接种疫苗以对抗致病细菌，包括大肠杆菌。本发明还包括由这些方法产生或被使用的疫苗菌株和组合物的制备方法和使用方法。

19. 发明申请

WO1993011660A2 MATURATION, DESICCATION AND ENCAPSULATION OF GYMNOSPERM SOMATIC EMBRYOS 审中-公开
标题翻译： GYMNOSPERM SOMATIC EMBRYOS的成熟，消除和包埋
公开(公告)号：WO1993011660A2
公开(公告)日：1993-06-24
申请号：PCT/CA1992000549
申请日：1992-12-18
申请人： UNIVERSITY OF SASKATCHEWAN , ATTREE, Stephen, M. , FOWKE, Lawrence, C.
发明人： UNIVERSITY OF SASKATCHEWAN
IPC分类号： A01H07/00
CPC分类号： A01H7/00 , A01H4/006
摘要： A desiccated mature gymnosperm somatic embryo characterized by having a moisture content which is lower than the moisture content of its corresponding zygotic embryo and a dry weight and per embryo lipid content which are higher than the lipid content and dry weight of its corresponding gymnosperm zygotic embryo. Preferred desiccated gymnosperm somatic embryos are conifer somatic embryos having a moisture content ranging between 10 and 55 %. Also within the scope of the invention is a method for producing desiccated somatic embryos. The method comprises developing immature embryos in a medium comprising at least one non-permeating water stress agent, a metabolizable carbon source and a growth regulator having an influence on embryo development for a period of time sufficient to yield the recovery of mature somatic embryos having a moisture content which is lower than the moisture content of corresponding zygotic embryos. The method can optionally include a secondary desiccation treatment to further reduce the moisture content of the embryos.
摘要翻译：一种干燥的成熟的裸子体细胞胚，其特征在于具有低于其相应的合子胚胎的水分含量的水分含量，并且干重和每个胚胎脂质含量高于其相应的子植体合子胚的脂质含量和干重。优选的干燥的裸子体细胞胚是水分含量在10％至55％之间的针叶树体细胞胚。还在本发明的范围内，是制造干燥体细胞胚的方法。该方法包括在包含至少一种不渗透水分胁迫剂，可代谢碳源和对胚胎发育影响的生长调节剂的培养基中培养未成熟胚，所述时间足以产生成熟体细胞胚的回收，所述成熟体细胞胚具有水分含量低于相应合子胚的含水量。该方法可以任选地包括二次干燥处理以进一步降低胚胎的水分含量。

20. 发明申请

WO1992014752A1 PRIMITIVE CELL COLONY STIMULATING FACTORS VECTORS, ANTIBODIES, AND METHODS OF USE 审中-公开
标题翻译：原始细胞群体刺激因子载体，抗体和使用方法
公开(公告)号：WO1992014752A1
公开(公告)日：1992-09-03
申请号：PCT/CA1992000069
申请日：1992-02-21
申请人： UNIVERSITY OF SASKATCHEWAN
发明人： UNIVERSITY OF SASKATCHEWAN , LAWMAN, Michael, J., P. , OHMANN, Helle, Bielefeldt , ATTAH-POKU, Samuel, K. , HEISE-QUALTIERE, Janette
IPC分类号： C07K07/08
CPC分类号： C07K14/53 , A61K38/00 , C07K16/243 , C07K2317/34
摘要： The present invention relates to novel primitive cell colony stimulating factors (PC-CSFs) and active fragments thereof, derived from non-adherent (NA) bone marrow cells. These factors are useful for treating disorders of the hematopoietic system. Antibodies directed against epitopes specific for PC-CSF can be used to purify PC-CSF, as well as for diagnosis of hematopoietic disorders.
摘要翻译：本发明涉及源于非粘附（NA）骨髓细胞的新颖的原始细胞集落刺激因子（PC-CSF）及其活性片段。这些因素对于治疗造血系统的病症是有用的。针对PC-CSF特异性表位的抗体可用于纯化PC-CSF，以及诊断造血障碍。

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