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11. 发明专利

CA2918585A1 CONSENSUS/ANCESTRAL IMMUNOGENS 未知
公开(公告)号：CA2918585A1
公开(公告)日：2005-03-31
申请号：CA2918585
申请日：2004-09-17
申请人： UNIV DUKE , UNIV CALIFORNIA , UNIV ALABAMA RES FOUND
发明人： KORBER BETTE T , HAHN BEATRICE H , SHAW GEORGE M , KOTHE DENISE , LI YING YING , DECKER JULIE , HAYNES BARTON F , GAO FENG , LIAO HUA-XIN
IPC分类号： C12N15/49 , A61K39/21 , A61P31/18 , A61P37/04 , C07H21/04 , C07K14/155 , C07K14/16 , C12N20060101 , C12N5/02 , C12N15/74
摘要： The present invention relates, in general, to an immunogen and, in particular, to an immunogen for inducing antibodies that neutralizes a wide spectrum of HIV primary isolates and/or to an immunogen that induces a T cell immune response. The invention also relates to a method of inducing anti-HIV antibodies, and/or to a method of inducing a T cell immune response, using such an immunogen. The invention further relates to nucleic acid sequences encoding the present immunogens.

12. 发明专利

AU2017200429A1 Consensus/Ancestral Immunogens 未知
公开(公告)号：AU2017200429A1
公开(公告)日：2017-02-16
申请号：AU2017200429
申请日：2017-01-20
申请人： UNIV OF ALABAMA AT BIRMINGHAM RES FOUND , UNIV DUKE , UNIV CALIFORNIA
发明人： HAYNES BARTON F , GAO FENG , DECKER JULIE , KORBER BETTE T , HAHN BEATRICE H , KOTHE DENISE , LI YING YING , SHAW GEORGE M , LIAO HUA-XIN
IPC分类号： A61K39/21 , C07H21/04 , C12N5/02 , C12N15/74
摘要： The present invention relates, in general, to an immunogen and, in particular, to an immunogen for inducing antibodies that neutralize a wide spectrum of HIV primary isolates and/or to an immunogen that induces a T cell immune response. The invention also relates to a method of inducing anti-HIV antibodies, and/or to a method of inducing a T cell immune response, using such an immunogen. The invention further relates to nucleic acid sequences encoding the present immunogens.

13. 发明专利

CA2539325C CONSENSUS/ANCESTRAL IMMUNOGENS 未知
公开(公告)号：CA2539325C
公开(公告)日：2016-03-22
申请号：CA2539325
申请日：2004-09-17
申请人： UNIV DUKE , UNIV ALABAMA RES FOUND , UNIV CALIFORNIA
发明人： KORBER BETTE T , HAHN BEATRICE H , SHAW GEORGE M , KOTHE DENISE , LI YING YING , DECKER JULIE , HAYNES BARTON F , GAO FENG , LIAO HUA-XIN
IPC分类号： C07K14/16 , A61K39/21 , A61P31/18 , A61P37/04 , C07H21/04 , C07K14/155 , C12N20060101 , C12N5/02 , C12N15/49 , C12N15/74 , C12N15/85
摘要： The present invention relates, in general, to an immunogen and, in particular, to an immunogen for inducing antibodies that neutralizes a wide spectrum of HIV primary isolates and/or to an immunogen that induces a T cell immune response. The invention also relates to a method of inducing anti-HIV antibodies, and/or to a method of inducing a T cell immune response, using such an immunogen. The invention further relates to nucleic acid sequences encoding the present immunogens.

14. 发明专利

AU2004274937B9 Consensus/ancestral immunogens 未知
公开(公告)号：AU2004274937B9
公开(公告)日：2011-04-14
申请号：AU2004274937
申请日：2004-09-17
申请人： UNIV DUKE , UNIV CALIFORNIA , UNIV OF ALABAMA AT BIRMINGHAM RESEARCH FOUNDATION
发明人： LI YING YING , HAYNES BARTON F , KOTHE DENISE , KORBER BETTE T , DECKER JULIE , LIAO HUA-XIN , SHAW GEORGE M , GAO FENG , HAHN BEATRICE H
IPC分类号： A61K39/21 , C07H21/04 , C12N20060101 , C12N5/02 , C12N15/74
摘要： The present invention relates, in general, to an immunogen and, in particular, to an immunogen for inducing antibodies that neutralize a wide spectrum of HIV primary isolates and/or to an immunogen that induces a T cell immune response. The invention also relates to a method of inducing anti-HIV antibodies, and/or to a method of inducing a T cell immune response, using such an immunogen. The invention further relates to nucleic acid sequences encoding the present immunogens.

15. 发明专利

CA2539325A1 CONSENSUS/ANCESTRAL IMMUNOGENS 未知
公开(公告)号：CA2539325A1
公开(公告)日：2005-03-31
申请号：CA2539325
申请日：2004-09-17
申请人： UNIV DUKE , UNIV ALABAMA RES FOUND , UNIV CALIFORNIA
发明人： DECKER JULIE , HAYNES BARTON F , HAHN BEATRICE H , LIAO HUA-XIN , SHAW GEORGE M , KOTHE DENISE , GAO FENG , KORBER BETTE T , LI YING YING
IPC分类号： A61K39/21 , C07H21/04 , C12N20060101 , C12N5/02 , C12N15/74
摘要： The present invention relates, in general, to an immunogen and, in particula r, to an immunogen for inducing antibodies that neutralizes a wide spectrum of HIV primary isolates and/or to an immunogen that induces a T cell immune response. The invention also relates to a method of inducing anti-HIV antibodies, and/or to a method of inducing a T cell immune response, using such an immunogen. The invention further relates to nucleic acid sequences encoding the present immunogens.

16. 发明专利

AU1932100A Complete genome sequence of a simian immunodeficiency virus from a red-capped mangabey 未知
公开(公告)号：AU1932100A
公开(公告)日：2000-06-26
申请号：AU1932100
申请日：1999-12-03
申请人： UAB RESEARCH FOUNDATION
发明人： HAHN BEATRICE H , SHAW GEORGE M , GAO FENG , MARX PRESTON A , SMITH STEPHEN M , GEORGES-COURBOT MARIE CLAUDE , LU CHANG YONG
IPC分类号： A01N43/04 , A61K38/00 , C07H21/04 , C07K14/155 , C12N1/20 , C12N7/00 , C12N15/00 , C12P19/34 , C12Q1/70

17. 发明专利

AU1224100A Reference clones and sequences for non-subtype b isolates of human immunodeficiency virus type 未知
公开(公告)号：AU1224100A
公开(公告)日：2000-05-22
申请号：AU1224100
申请日：1999-10-25
申请人： UAB RESEARCH FOUNDATION THE
发明人： HAHN BEATRICE H , SHAW GEORGE M , GAO FENG
IPC分类号： A01N63/00 , A01N63/04 , A61K8/22 , A61K8/60 , A61K8/66 , A61Q5/00 , A61Q11/00 , A61Q17/00 , A61Q19/00 , C07H21/02 , C07K14/16 , C09D5/02 , C09D5/14 , C11D3/00 , C11D3/20 , C11D3/386 , C11D3/48 , C12Q1/68 , C12Q1/70 , C12N15/00 , C12N15/09 , C12N15/63 , C12N15/70 , C12N15/74 , C12N5/02 , C07H21/04
摘要： The nucleotide sequences of the genomes of eleven molecular clones for non-subtype B isolates of human immunodeficiency virus type 1 are disclosed. The invention relates to the nucleic acids and peptides encoded by and/or derived from these sequences and their use in diagnostic methods and as immunogens.

18. 发明申请

WO2006029029A3 COMPOSITIONS FOR DETECTION OF LATENT HIV REACTIVATION AND METHODS OF USING THE SAME 审中-公开
标题翻译：用于检测HIV阳性反应的组合物及其使用方法
公开(公告)号：WO2006029029A3
公开(公告)日：2009-05-07
申请号：PCT/US2005031432
申请日：2005-09-02
申请人： UAB RESEARCH FOUNDATION , KUTSCH OLAF , JONES JENNIFER , SHAW GEORGE M , LEVY DAVID N
发明人： KUTSCH OLAF , JONES JENNIFER , SHAW GEORGE M , LEVY DAVID N
IPC分类号： C12Q1/70 , C12Q1/66 , G01N33/00 , G01N33/53 , G01N33/567 , G01N33/574
CPC分类号： C12Q1/6897 , C12Q1/18 , G01N2333/16
摘要： Provided herein are compositions and methods that allow for the study of HIV latency and reactivation. Further provided are compositions and methods for in vitro screening of agents for their ability to reactivate, suppress reactivation or inhibit transcription of HIV. Compositions for and methods for activating a cell are also provided herein. Further provided herein are methods of treating a subject using agents that reactivate latent HIV infection or agents that inhibit HIV transcription. Also provided herein are methods of activating a latent microbiological entity in a subject. Further provided herein are methods for enhancing an immune response in a subject and compositions used as a vaccination adjuvant. Methods of making disclosed cells and compositions are also provided herein.
摘要翻译：本文提供了允许研究HIV潜伏期和再激活的组合物和方法。进一步提供的是用于体外筛选试剂以恢复，抑制再激活或抑制HIV转录的能力的组合物和方法。本文还提供了用于激活细胞的组合物和方法。本文还提供了使用重新激活潜伏HIV感染的药剂或抑制HIV转录的药物治疗受试者的方法。本文还提供了激活受试者中的潜在微生物实体的方法。本文还提供了用于增强受试者的免疫应答的方法和用作接种佐剂的组合物。本文还提供制备公开的细胞和组合物的方法。

19. 发明申请

WO2005111621A3 MOLECULAR SCAFFOLDS FOR HIV-1 EPITOPES 审中-公开
标题翻译： HIV-1抗原决定簇的分子标记
公开(公告)号：WO2005111621A3
公开(公告)日：2006-02-09
申请号：PCT/US2005011928
申请日：2005-04-08
申请人： UAB RESEARCH FOUNDATION , ADMINISTRATORS OF TULANE EDUCA , DECKER JULIE M , HAHN BEATRICE H , ROBINSON JAMES E , SHAW GEORGE M , BIBOLLETT-RUCHE FREDERIC
发明人： DECKER JULIE M , HAHN BEATRICE H , ROBINSON JAMES E , SHAW GEORGE M , BIBOLLETT-RUCHE FREDERIC
IPC分类号： G01N33/569 , C07K16/00 , C07K16/10 , C07K16/28
CPC分类号： G01N33/56988 , C07K16/1063 , C07K16/2812 , C07K2317/32 , C07K2317/34 , C07K2317/76 , G01N2469/20
摘要： Methods and compositions are provided for the use of an envelope polypeptide or a functional variant thereof from a lentivirus that is not HIV-1 as a molecular scaffold for HIV-1 epitopes. The HIV-1 epitopes can be recognized by HIV-1 binding antibodies, HIV-1 neutralizing antibodies and/or CD4-induced antibodies. Thus, methods are provided for detecting HIV-1 binding antibodies in a subject infected with HIV-1. Further provided are methods to determine an epitope for an HIV-1 binding antibody; methods to assay for an HIV-1 binding antibody; methods to identify a soluble CD4 mimic; methods to neutralize an non-HIV-1 virus; diagnostic assays to monitor HIV disease in a subject or to monitor the subject's response to immunization by a HIV vaccine; and methods to alter the neutralization potential of an HIV-1 derived CD4-induced antibody. Chimeric polypeptides, chimeric polynucleotides, kits, cells and viruses are also provided.
摘要翻译：提供了使用来自不是HIV-1作为HIV-1表位的分子支架的慢病毒的包膜多肽或其功能变体的方法和组合物。 HIV-1表位可被HIV-1结合抗体，HIV-1中和抗体和/或CD4诱导的抗体识别。因此，提供了用于检测感染HIV-1的受试者中的HIV-1结合抗体的方法。还提供了确定HIV-1结合抗体的表位的方法; 测定HIV-1结合抗体的方法; 识别可溶性CD4模拟物的方法; 中和非HIV-1病毒的方法; 用于监测受试者中艾滋病病毒的诊断测定或监测受试者对HIV疫苗免疫接种的反应; 以及改变HIV-1衍生的CD4诱导抗体的中和电位的方法。还提供了嵌合多肽，嵌合多核苷酸，试剂盒，细胞和病毒。

20. 发明申请

WO2006091455A2 MOLECULAR SCAFFOLDS FOR HIV-1 IMMUNOGENS 审中-公开
标题翻译： HIV-1免疫球蛋白的分子标记
公开(公告)号：WO2006091455A2
公开(公告)日：2006-08-31
申请号：PCT/US2006005363
申请日：2006-02-16
申请人： UAB RESEARCH FOUNDATION , SHAW GEORGE M , HAHN BEATRICE H , BIBOLLET-RUCHE FREDERIC
发明人： SHAW GEORGE M , HAHN BEATRICE H , BIBOLLET-RUCHE FREDERIC
CPC分类号： A61K39/21 , A61K39/12 , A61K39/385 , A61K2039/53 , A61K2039/6075 , A61K2039/64 , C07K14/005 , C07K2319/00 , C12N2740/15022 , C12N2740/16122 , C12N2740/16134
摘要： Methods and compositions are provided which employ chimeric polypeptides having at least one heterologous epitope for a human immunodeficiency virus type 1 (HIV-1) neutralizing antibody. These chimeric polypeptides behave as molecular scaffolds which are capable of presenting the various heterologous HTV-1 epitopes. The invention demonstrates that a heterologous epitope recognized by the HIV-1 neutralizing antibody can be more fully exposed to neutralizing antibodies when presented within the backbone of the chimeric polypeptide than when the epitope is presented within the context of an HIV-1 backbone. Polynucleotides encoding these chimeric polypeptides are also provided. Immunogenic compositions are provided which comprise a chimeric polypeptide having at least one heterologous epitope that interacts with an HIV-1 neutralizing antibody. Immuno genie compositions comprising chimeric polynucleotides encoding the chimeric polypeptides of the invention are also provided. Vaccines comprising such immunogenic compositions are also provided. Further provided are methods which employ the immunogenic compositions of the invention. Such methods include, for example, methods for eliciting an immune response in a subject, methods for generating antibodies specific for the chimeric polypeptide or the chimeric polypeptide, and methods for inhibiting or preventing infection by HIV-1 in a subject.
摘要翻译：提供了使用针对人免疫缺陷病毒1型（HIV-1）中和抗体具有至少一个异源表位的嵌合多肽的方法和组合物。这些嵌合多肽表现为能够呈递各种异源HTV-1表位的分子支架。本发明证明当HIV-1中和抗体在HIV-1主链的上下文中呈现时，HIV-1中和抗体识别的异源表位可以更好地暴露于中和抗体。还提供了编码这些嵌合多肽的多核苷酸。提供免疫原性组合物，其包含具有至少一种与HIV-1中和抗体相互作用的异源表位的嵌合多肽。还提供了包含编码本发明的嵌合多肽的嵌合多核苷酸的免疫精华组合物。还提供了包含这种免疫原性组合物的疫苗。还提供了采用本发明的免疫原性组合物的方法。这样的方法包括例如在受试者中引发免疫应答的方法，用于产生对嵌合多肽或嵌合多肽具有特异性的抗体的方法，以及用于抑制或预防受试者中HIV-1感染的方法。

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