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    • 11. 发明申请
    • A BIOREACTOR
    • 一个生物学家
    • WO1996026264A1
    • 1996-08-29
    • PCT/GB1996000251
    • 1996-02-05
    • UNITED KINGDOM ATOMIC ENERGY AUTHORITYREED, Ian, Michael
    • UNITED KINGDOM ATOMIC ENERGY AUTHORITY
    • C12M03/06
    • C12M23/34C12M23/24C12M25/02C12M29/04C12M29/16
    • A bioreactor (10) suitable for cell lines such as hepatocytes which function best when attached to a surface consists of a stack of flexible membranes (22), which define several flow channels (25) between pairs of adjacent membranes (22). The channel width can therefore be adjusted, for example by fluid pressure, wide channels (25) aiding the loading of cells into the bioreactor (10), and narrower channels (25) providing less hold-up during use. Nutrient channels (20) may be defined by the same membranes (22), so nutrient channels (20) and flow channels (25) alternate up the stack. Hollow fibres (26) may be provided within the flow channels (25) for in situ oxygenation.
    • 适于细胞系的生物反应器(10),例如当连接到表面上时最好发挥作用的细胞系,其由在一对相邻膜(22)之间限定几个流动通道(25)的柔性膜堆叠组成。 因此,可以例如通过流体压力调节通道宽度,帮助将细胞负载到生物反应器(10)中的宽通道(25)和在使用期间提供更少的通道(25)提供更少的滞留。 营养通道(20)可以由相同的膜(22)定义,因此营养通道(20)和流动通道(25)在堆叠上交替。 中空纤维(26)可以设置在流动通道(25)内用于原位氧合。
    • 14. 发明申请
    • POWDER INHALER
    • 粉末吸入器
    • WO1992005825A1
    • 1992-04-16
    • PCT/GB1991001686
    • 1991-09-30
    • UNITED KINGDOM ATOMIC ENERGY AUTHORITYPRITCHARD, John, NigelMcAUGHEY, John, Jackson
    • UNITED KINGDOM ATOMIC ENERGY AUTHORITY
    • A61M15/00
    • A61M15/00A61M11/002A61M11/003A61M15/0086A61M2202/064
    • A dry powder inhaler (10) consists of a chamber (12) into which powder is introduced from a metering system, and a mouthpiece (26) through which a patient inhales, connected by a duct (16), so that air flows through the chamber carrying the powder into the patient's lungs. Within the duct is an impactor (25) consisting of a plate (27) spaced in front of a similary sized aperture, and between the chamber and the impactor plate is an orifice (18) narrower than the duct, so the air stream is diverted along S-shaped paths to avoid the plate. The presence of the impactor can improve the efficiency of delivery of a drug to the lungs, and decrease the unwanted dose to the mouth and throat, as the latter is principally due to agglomerates or larger particles which are intercepted or broken up by the impactor.
    • 干粉吸入器(10)包括从计量系统引入粉末的腔室(12)和患者通过管道(16)吸入的接口(26),使得空气流过 将粉末装入患者的肺部。 在管道内部是冲击器(25),其由在相似尺寸的孔的前面间隔开的板(27)组成,并且在腔室和冲击器板之间是比管道窄的孔口(18),因此气流被转向 沿S形路径避开板。 冲击器的存在可以提高药物向肺部递送的效率,并且减少对口腔和喉咙的不期望的剂量,因为后者主要是由于被冲击器拦截或分解的聚集体或更大的颗粒。