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11. 发明申请

US20070077285A1 Adhesive skin patch 审中-公开
标题翻译：粘贴皮肤贴
公开(公告)号：US20070077285A1
公开(公告)日：2007-04-05
申请号：US10579913
申请日：2004-11-19
申请人： Hiroko Udagawa , Toshikazu Komoda , Masaru Hamabe
发明人： Hiroko Udagawa , Toshikazu Komoda , Masaru Hamabe
IPC分类号： A61K31/138 , A61K9/70
CPC分类号： A61K9/7061 , A61K31/137
摘要： The present invention provides an adhesive skin patch that permits excellent and prolonged percutaneous absorption of tulobuterol and that can be stably applied to the skin for a long period of time with less skin irritation. The adhesive skin patch comprises a base material and a medicated layer provided on one surface of the base material. The medicated layer contains 1 to 30% by weight of a resolvent, 40 to 98% by weight of a pressure-sensitive adhesive, and tulobuterol. The resolvent contains an aliphatic alcohol having a branched-chain structure or a double bond in its C8 to C30 carbon chain. The pressure-sensitive adhesive is a copolymer obtained by copolymerizing monomers containing 70% by weight or more of an alkyl(meth)acrylate whose alkyl group has 6 to 20 carbon atoms.
摘要翻译：本发明提供了一种粘合性皮肤贴剂，其可以优异地延长经皮肤吸收去胡萝特罗，并且可以长时间稳定地施用于皮肤，皮肤刺激较少。粘合性皮肤贴剂包括基材和设置在基材的一个表面上的药物层。含药层含有1至30重量％的溶剂，40至98重量％的压敏粘合剂和杜洛特罗。该溶剂含有在C8〜C30碳链中具有支链结构或双键的脂肪醇。压敏粘合剂是通过共聚含有70重量％以上的烷基具有6〜20个碳原子的（甲基）丙烯酸烷基酯的单体而得到的共聚物。

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