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11. 发明授权

US5587383A Imidazopyridine derivatives and their use 失效
公开(公告)号：US5587383A
公开(公告)日：1996-12-24
申请号：US387010
申请日：1995-02-10
申请人： Muneo Takatani , Yoshio Kozai , Kiminori Tomimatsu , Yumiko Shibouta
发明人： Muneo Takatani , Yoshio Kozai , Kiminori Tomimatsu , Yumiko Shibouta
IPC分类号： C07D471/04 , A61K31/435 , C07D471/02
CPC分类号： C07D471/04
摘要： A calmodulin inhibitory composition containing a compound of the formula (I): ##STR1## as well as an angiogenesis inhibitory composition containing a compound of the formula (1): ##STR2## are disclosed.

12. 发明授权

US5244908A Imidazopyridine derivatives and their pharmaceutical use 失效
标题翻译：咪唑吡啶衍生物及其药物用途
公开(公告)号：US5244908A
公开(公告)日：1993-09-14
申请号：US736957
申请日：1991-07-30
申请人： Muneo Takatani , Yoshio Kozai , Kiminori Tomimatsu , Yumiko Shibouta
发明人： Muneo Takatani , Yoshio Kozai , Kiminori Tomimatsu , Yumiko Shibouta
IPC分类号： C07D471/04
CPC分类号： C07D471/04
摘要： A calmodulin inhibitory composition containing a compound of the formula (I): ##STR1## as well as an angiogenesis inhibitory composition containing a compound of the formula (1): ##STR2## are disclosed.

13. 发明授权

US4921851A Cephem compounds, their production and use 失效
标题翻译：头孢烯化合物，其生产和使用
公开(公告)号：US4921851A
公开(公告)日：1990-05-01
申请号：US396758
申请日：1989-08-22
申请人： Shoji Kishimoto , Kiminori Tomimatsu , Akio Miyake , Yoshinobu Yoshimura
发明人： Shoji Kishimoto , Kiminori Tomimatsu , Akio Miyake , Yoshinobu Yoshimura
IPC分类号： C07D501/00 , C07D501/46 , C07D519/00
CPC分类号： C07D501/46 , C07D501/00 , C07D519/00
摘要： This invention relates to a compound of the formula: ##STR1## wherein Q is nitrogen or CH; R.sup.1 is hydrogen or a lower alkyl group which may be substituted; and ring A is a pyridine or pyridazine ring which is substituted at the ring-constituting carbon atom by a group of the formula:--E--(CH.sub.2).sub.n --R.sup.2in which E is sulfur or NH; R.sup.2 is an amino, carbamoylamino, formylamino, acetylamino, N-formimidoylamino, N-acetimidoylamino, lower alkylamino, hydroxyl or carbamoyloxy group; and n is an integer of 2 to 4, or a pharmaceutically acceptable salt thereof. The compound (I) or a pharmaceutically acceptable sale thereof has excellent antibacterial activity and is used as antibiotics.
摘要翻译：本发明涉及下式的化合物：其中Q是氮或CH; R1是氢或可被取代的低级烷基; 环A为吡啶或哒嗪环，其在环的构成碳原子上被下列基团取代：其中E为硫或NH的-E-（CH2）n-R2; R2是氨基，氨基甲酰基氨基，甲酰氨基，乙酰氨基，N-甲脒基氨基，N-亚氨代乙酰氨基，低级烷基氨基，羟基或氨基甲酰氧基; n为2〜4的整数，或其药学上可接受的盐。化合物（I）或其药学上可接受的销售具有优异的抗菌活性并用作抗生素。

14. 发明授权

US06881842B2 Process for producing tricyclic fused heterocyclic derivative 失效
标题翻译：三环稠合杂环衍生物的制备方法
公开(公告)号：US06881842B2
公开(公告)日：2005-04-19
申请号：US10381002
申请日：2001-09-20
申请人： Tadao Kawarasaki , Hideo Hashimoto , Kiminori Tomimatsu
发明人： Tadao Kawarasaki , Hideo Hashimoto , Kiminori Tomimatsu
IPC分类号： C07D455/04 , C07D471/06 , C07D487/06 , C07D401/06 , C07D401/14
CPC分类号： C07D471/06 , C07D455/04 , C07D487/06
摘要： A process for easily and industrially advantageously producing both a tricyclic fused heterocyclic derivative having acetylcholinesterase inhibitory activity and an intermediate for the derivative. The process for producing the target compounds comprises the following reaction.
摘要翻译：一种易于和工业上有利地生产具有乙酰胆碱酯酶抑制活性的三环稠合杂环衍生物和该衍生物的中间体的方法。制备目标化合物的方法包括以下反应。

15. 发明授权

US06251905B1 Tricyclic compounds, their production and use 失效
标题翻译：三环化合物，其生产和使用
公开(公告)号：US06251905B1
公开(公告)日：2001-06-26
申请号：US09234876
申请日：1999-01-21
申请人： Muneo Takatani , Yumiko Shibouta , Kiminori Tomimatsu , Tetsuji Kawamoto
发明人： Muneo Takatani , Yumiko Shibouta , Kiminori Tomimatsu , Tetsuji Kawamoto
IPC分类号： C07D40106
CPC分类号： C07D471/16
摘要： Tricyclic compound of the formula: wherein ring A is a nitrogen-containing heterocyclic ring, having two nitrogen atoms as the hetero-atoms, which is optionally substituted with oxo or thioxo; ring Q may optionally be substituted; Y is an optionally substituted hydrocarbon group, an optionally substituted hydroxyl group or an optionally substituted mecapto group, excluding for methyl group as Y; R1 is a hydrogen atom, a halogen atom, an optionally substituted hydrocarbon group or an acyl group, or a salt thereof, having excellent PDGF-inhibiting activities, antihypertensive activities, activities of ameliorating renal diseases and activities of lowering lipid level.
摘要翻译：下式的三环化合物：其中环A是含氮杂环，具有两个氮原子作为杂原子，其任选被氧代或硫代取代; 环Q可任选被取代; Y是任选取代的烃基，任选取代的羟基或任选取代的mecapto基团，不包括甲基作为Y; R1是具有优异的PDGF抑制活性，抗高血压活性，改善肾脏疾病的活性和降低脂质水平的活性的氢原子，卤素原子，任选取代的烃基或酰基或其盐。

16. 发明授权

US4833134A Cephem compounds 失效
标题翻译：头孢烯化合物
公开(公告)号：US4833134A
公开(公告)日：1989-05-23
申请号：US84882
申请日：1987-08-13
申请人： Shoji Kishimoto , Kiminori Tomimatsu , Michiyuki Sendai
发明人： Shoji Kishimoto , Kiminori Tomimatsu , Michiyuki Sendai
IPC分类号： A61K31/545 , C07D501/38 , C07D501/46
CPC分类号： C07D501/46
摘要： Cephem compounds of the formula: ##STR1## wherein Q stands for a nitrogen atom or CH, R.sup.1 stands for a hydrogen atom or an optionally substituted lower alkyl group, R.sup.2 stands for a hydrogen atom or a lower alkyl group, A stands for a sulfur atom or NH, and n denotes an integral number ranging from 2 to 4, or salts thereof, and processes for producing them. The compounds (I) or salts thereof show not only excellent antibacterial activities against a wide range of pathogenic bacteria from gram-positive to gram-negative ones, including a variety of strains isolated clinically but also hydrophilic properties, and therefore they are excellent antibiotic substances having desirable water-solubility when used as injections.
摘要翻译：下式的头孢烯化合物：其中Q代表氮原子或CH，R1代表氢原子或任选取代的低级烷基，R2代表氢原子或低级烷基 A表示硫原子或NH，n表示2〜4的整数，或其盐，及其制造方法。化合物（I）或其盐不仅具有针对从革兰氏阳性至革兰氏阴性菌的广泛病原菌的优良抗菌活性，包括临床分离的各种菌株，而且亲水性，因此它们是优异的抗生素物质当用作注射剂时具有所需的水溶性。

17. 发明授权

US5958942A Tricyclic nitrogen ring compounds, their production and use 失效
标题翻译：三环氮环化合物，其生产和使用
公开(公告)号：US5958942A
公开(公告)日：1999-09-28
申请号：US783101
申请日：1997-01-14
申请人： Muneo Takatani , Yumiko Shibouta , Kiminori Tomimatsu , Tetsuji Kawamoto
发明人： Muneo Takatani , Yumiko Shibouta , Kiminori Tomimatsu , Tetsuji Kawamoto
IPC分类号： C07D471/16 , C07D471/04 , A61K31/44 , C07D401/06
CPC分类号： C07D471/16
摘要： Tricyclic compound of the formula: ##STR1## wherein ring A is a nitrogen-containing heterocyclic ring, having two nitrogen atoms as the hetero-atoms, which is optionally substituted with oxo or thioxo; ring Q may optionally be substituted; Y is an optionally substituted hydrocarbon group, an optionally substituted hydroxyl group or an optionally substituted mecapto group, excluding for methyl group as Y; R.sup.1 is a hydrogen atom, a halogen atom, an optionally substituted hydrocarbon group or an acyl group, or a salt thereof, having excellent PDGF-inhibiting activities, antihypertensive activities, activities of ameliorating renal diseases and activities of lowering lipid level.
摘要翻译：下式的三环化合物：其中环A是含氮杂环，具有两个氮原子作为杂原子，其任选被氧代或硫代基取代; 环Q可任选被取代; Y是任选取代的烃基，任选取代的羟基或任选取代的mecapto基团，不包括甲基作为Y; R1是具有优异的PDGF抑制活性，抗高血压活性，改善肾脏疾病的活性和降低脂质水平的活性的氢原子，卤素原子，任选取代的烃基或酰基或其盐。

18. 发明授权

US5395839A Imidazopyridine derivatives and their use 失效
标题翻译：咪唑并吡啶衍生物及其用途
公开(公告)号：US5395839A
公开(公告)日：1995-03-07
申请号：US74292
申请日：1993-06-09
申请人： Takatani Muneo , Yoshio Kozai , Kiminori Tomimatsu , Yumiko Shibouta
发明人： Takatani Muneo , Yoshio Kozai , Kiminori Tomimatsu , Yumiko Shibouta
IPC分类号： C07D471/04 , A61K31/435
CPC分类号： C07D471/04
摘要： A calmodulin inhibitory composition containing a compound of the formula (I): ##STR1## as well as an angiogenesis inhibitory composition containing a compound of the formula (1): ##STR2## are disclosed.
摘要翻译：公开了一种含有式（I）化合物：（I）的钙调蛋白抑制组合物以及含有式（1）化合物的血管生成抑制组合物：IMAGE（1）。

19. 发明授权

US5389658A Pyridine derivatives, their production and use 失效
标题翻译：吡啶衍生物，其生产和使用
公开(公告)号：US5389658A
公开(公告)日：1995-02-14
申请号：US81181
申请日：1993-06-24
申请人： Muneo Takatani , Taketoshi Saijo , Kiminori Tomimatsu
发明人： Muneo Takatani , Taketoshi Saijo , Kiminori Tomimatsu
IPC分类号： C07D213/68 , C07D213/70 , C07D213/81 , C07D213/82 , C07D401/12 , C07D401/14 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D417/14 , A61K31/425
CPC分类号： C07D213/70 , C07D213/68 , C07D213/81 , C07D213/82 , C07D401/12 , C07D401/14 , C07D405/12 , C07D409/12 , C07D413/10 , C07D413/12 , C07D417/12 , C07D417/14
摘要： There is disclosed a pharmaceutical composition for providing antiinflammatory, antipyretic, analgesic, antiallergic, immunosuppressing or immunomodulating activity which comprises a pyridine derivative of the formula (I): ##STR1## wherein R is an optionally substituted pyridine ring, X is a oxygen atom or --S(O).sub.n --, wherein n is 0, 1 or 2, A is a bivalent C.sub.1-15 hydrocarbon residue whose branched moiety may have a substituent, Y is an oxygen or sulfur atom, R.sub.3 is a hydrogen atom or an optionally substituted hydrocarbon residue, R.sub.4 is an optionally substituted hydrocarbon residue or an optionally substituted monocyclic or bicyclic heterocyclic group, R.sub.3 and R.sub.4 may be joined together with the carbamoyl group or the thiocarbamoyl group to which they are attached to form an optionally substituted heterocyclic group, or R.sub.3 or R.sub.4 may be independently attached to A to form a ring, or a pharmaceutically acceptable salt or solvate thereof, and a pharmaceutically acceptable carrier or diluent.
摘要翻译：公开了一种用于提供抗炎，解热，止痛，抗过敏，免疫抑制或免疫调节活性的药物组合物，其包含式（I）的吡啶衍生物：其中R是任选取代的吡啶环，X是氧原子或-S（O）n - ，其中n为0,1或2，A为支链部分可具有取代基的二价C1-15烃基，Y为氧或硫原子，R3为氢原子或任选取代的烃残基，R4是任选取代的烃残基或任选取代的单环或双环杂环基，R 3和R 4可以与它们所连接的氨基甲酰基或硫代氨基甲酰基连接在一起形成任选取代的杂环基团或R 3或R 4可以独立地连接到A上以形成环，或其药学上可接受的盐或溶剂合物，以及药学上可接受的载体或稀释剂。

20. 发明授权

US4942159A Cephem compounds, their production and use 失效
标题翻译：头孢烯化合物，其生产和使用
公开(公告)号：US4942159A
公开(公告)日：1990-07-17
申请号：US235566
申请日：1988-08-24
申请人： Shoji Kishimoto , Kiminori Tomimatsu , Akio Miyake
发明人： Shoji Kishimoto , Kiminori Tomimatsu , Akio Miyake
IPC分类号： C07D501/46 , C07D519/00
CPC分类号： C07D501/46 , C07D519/00
摘要： Novel cephem compounds of the general formula: ##STR1## wherein R.sup.1 is a lower alkyl group, and salts and esters thereof, showing excellent and balanced antibacterial activity against a broad spectrum of bacteria, especially by rectal administration, and their production and use as antimicrobial agents are described.

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