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    • 17. 发明授权
    • System and method for securely affixing an element to a structure
    • 用于将元件牢固地固定到结构体的系统和方法
    • US4894269A
    • 1990-01-16
    • US127811
    • 1987-12-03
    • Michio Kimura
    • Michio Kimura
    • E04B1/41F16B13/14
    • E04B1/41F16B13/143Y10T428/15Y10T428/249997
    • A system for securely offixing to a structure at a recess therein comprises a container body filled with a main component and sealed with a cap formed in part by solidifying a hardening agent and an inorganic material with a solidifying agent. The cap may be formed by confining a hardening agent in a film or coated film of plastics. The container body is further subjected to flaw or strain working or otherwise formed to be weakened so as to break into small pieces when subjected to a force by the element. The main component and the hardening agent then react, within the recess, to securely affix the element to the structure. In another aspect of the invention, a method is provided for retaining the first component in its frangible container with a cap comprising the reactive or hardening agent for placement in a recess of the structure for forcible breakage of the container, a reaction and secure affixation by the reaction product.
    • 用于在其凹部处牢固地混合到结构体的系统包括填充有主要部件的容器主体,并且通过用固化剂固化硬化剂和无机材料部分地形成的帽密封。 帽可以通过将硬化剂限制在塑料的膜或涂膜中而形成。 容器主体进一步经受缺陷或应变加工或以其它方式形成为被削弱,以便当受到元件的力的影响时,该容器本体将被破碎成小块。 主要部件和硬化剂然后在凹槽内反应以将元件牢固地固定到结构上。 在本发明的另一方面,提供了一种用于将第一组分保持在其易碎容器中的方法,其具有包含反应性或硬化剂的帽,用于放置在结构的凹部中用于强制破坏容器,反应和固定的固定 反应产物。
    • 18. 发明授权
    • Novel N'-acylated phenyl-hydrazine and hydrozone derivatives
    • 新型N {40-酰基苯基 - 肼和水解产物
    • US3974145A
    • 1976-08-10
    • US439035
    • 1974-02-04
    • Michio KimuraShigeho InabaHisao Yamamoto
    • Michio KimuraShigeho InabaHisao Yamamoto
    • C07D209/60C07D209/70C07D307/54C07D317/66C07D317/68C07D319/18
    • C07D307/54C07D209/60C07D209/70C07D317/66C07D317/68C07D319/18
    • Novel indolylacetic acid derivatives, which have excellent anti-inflammatory, antipyretic and analgesic activities, represented by the formula, ##SPC1##Wherein X.sub.1 and X.sub.2 each is a member selected from the group consisting of oxygen and methylene; A is a member selected from the group consisting of unsubstituted saturated hydrocarbon chain having up to 5 carbon atoms, unsubstituted unsaturated hydrocarbon chain having up to 5 carbon atoms and substituted saturated or substituted ethylenically unsaturated hydrocarbon chain having up to 5 carbon atoms, in which the substituents are selected from the group consisting of halogen or phenyl, the hydrocarbon chain being straight or blanched one; m is 0 or 1; n is 1 or 2; R.sub.1 and R.sub.2 each is a member selected from the group consisting of hydrogen and alkyl having up to 4 carbon atoms; R.sub.3 is a member selected from the group consisting of alkyl having up to 4 carbon atoms, unsubstituted or a lower alkyl-, lower alkoxy-, lower alkylthio-, nitro-, cyano-, methylenedioxy-, ethylenedioxy- or halogen-substituted aryl, each of said alkyl, alkoxy and alkylthio substituents containing up to 4 carbon atoms, or unsubstituted, or halogen-, alkyl- or phenyl-substituted or benzene ring-condensed, saturated or unsaturated mono- or poly-aclicyclic group, or alkyl group substituted by said alicyclic group, or unsubstituted or methyl-, ethyl- or halogen-substituted 5- or 6-membered heterocyclic ring group containing oxygen, sulfur or nitrogen atom; R.sub.4 is a member selected from the group consisting of alkyl having up to 4 carbon atoms or hydrogen, or a group of M (wherein M is a cation).The indolylacetic acid of the formula (I) is prepared by reacting a compound of the formula, ##SPC2##Wherein X.sub.1, X.sub.2 and n are the same as defined above and B is a member selected from the group consisting of ##EQU1## and Z (wherein Z is a nitrogen protecting system comprising at least one readily removable group), with an acid halide represented by the formula,R.sub.3 --(A).sub.m --CO--hal (V)wherein R.sub.3, A and m are the same as defined above and hal is halogen, to obtain N.sup.1 -acylated compound of the formula, ##SPC3##Wherein X.sub.1, X.sub.2, R.sub.3, A, B, m and n are the same as defined above, then reacting the resultant N.sup.1 -acylated compound (II) with an aliphatic acid derivative represented by the formula, ##EQU2## wherein R.sub.1, R.sub.2 and R.sub.4 are the same as defined above.
    • 新型吲哚乙酸衍生物,其具有优异的抗炎,解热和止痛活性,由式WHEREIN X1和X2各自为选自氧和亚甲基的成员; A是选自具有至多5个碳原子的未取代的饱和烃链,具有至多5个碳原子的未取代的不饱和烃链和具有至多5个碳原子的取代的饱和或取代的烯属不饱和烃链的成员,其中 取代基选自卤素或苯基,烃链是直链或漂白的; m为0或1; n为1或2; R1和R2各自是选自氢和具有至多4个碳原子的烷基的成员; R3是选自具有至多4个碳原子的烷基,未取代的或低级烷基,低级烷氧基 - ,低级烷硫基 - ,硝基 - ,氰基 - ,亚甲二氧基 - ,亚乙二氧基或卤素取代的芳基的成员, 所述烷基,烷氧基和烷硫基取代基含有至多4个碳原子,或未取代的或卤素,烷基或苯基取代的或苯环稠合的饱和或不饱和的单 - 或多 - 酰基基团或烷基取代的 或含有氧,硫或氮原子的未取代或甲基,乙基或卤素取代的5元或6元杂环基; R4是选自具有至多4个碳原子的烷基或氢的成员,或一组M(其中M是阳离子)。