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11. 发明申请

US20180200375A1 COMPOSITIONS AND METHODS RELATING TO SALTS OF SPECIALIZED PRO-RESOLVING MEDIATORS 审中-公开
公开(公告)号：US20180200375A1
公开(公告)日：2018-07-19
申请号：US15535936
申请日：2017-06-02
申请人： Thetis Pharmaceuticals LLC
发明人： Frank C. Sciavolino , Gary Mathias , Michael C. Van Zandt , Gunnar Erik Jagdmann, Jr. , Jessica J. Dworak
IPC分类号： A61K47/54 , A61K47/62 , A61P29/00 , A61P1/00
CPC分类号： A61K47/541 , A61K31/202 , A61K31/232 , A61K38/03 , A61K45/06 , A61K47/62 , A61K2800/00 , A61P1/00 , A61P1/04 , A61P1/06 , A61P1/12 , A61P29/00
摘要： The present invention relates to compounds of Formulas I-IV, which are salts of special lipid mediators of inflammation, compositions containing same, and methods of using same in the treatment of various diseases and disorders characterized by chronic or excessive inflammation, or both.

12. 发明授权

US09216951B2 Lipid-lowering antidiabetic agent 有权
标题翻译：降脂抗糖尿病药
公开(公告)号：US09216951B2
公开(公告)日：2015-12-22
申请号：US14524721
申请日：2014-10-27
申请人： Thetis Pharmaceuticals LLC
发明人： Banavara L. Mylari , Frank C. Sciavolino
IPC分类号： A61K31/665 , A61K31/35 , A01N57/00 , A01N43/16 , C07C279/04 , A61K31/202 , C07C279/26 , A61K31/155 , C07C57/03
CPC分类号： C07C279/04 , A61K31/155 , A61K31/202 , C07C57/03 , C07C279/26
摘要： A composition which includes a salt of metformin and the use of the composition for treatment of or use in prediabetes, diabetes, lowering triglycerides and/or other conditions in mammals.
摘要翻译：包含二甲双胍盐的组合物和该组合物用于治疗或用于哺乳动物中的糖尿病前期，糖尿病，降低甘油三酸酯和/或其它病症的用途。

13. 发明授权

US08901107B2 Lipid-lowering antidiabetic agent 有权
标题翻译：降脂抗糖尿病药
公开(公告)号：US08901107B2
公开(公告)日：2014-12-02
申请号：US13923829
申请日：2013-06-21
申请人： Thetis Pharmaceuticals LLC
发明人： Banavara L. Mylari , Frank C. Sciavolino
IPC分类号： A01N57/00 , A61K31/665 , A01N43/16 , A61K31/35 , C07C279/04 , A61K31/202 , C07C279/26 , A61K31/155 , C07C57/03
CPC分类号： C07C279/04 , A61K31/155 , A61K31/202 , C07C57/03 , C07C279/26
摘要： A composition which includes a salt of metformin and the use of the composition for treatment of or use in prediabetes, diabetes, lowering triglycerides and/or other conditions in mammals.
摘要翻译：包含二甲双胍盐的组合物和该组合物用于治疗或用于哺乳动物中的糖尿病前期，糖尿病，降低甘油三酸酯和/或其它病症的用途。

14. 发明授权

US11986512B2 Compositions and methods for cancer therapy 有权
公开(公告)号：US11986512B2
公开(公告)日：2024-05-21
申请号：US18049736
申请日：2022-10-26
申请人： Thetis Pharmaceuticals LLC , Beth Israel Deaconess Medical Center
发明人： Gary Mathias , Dipak Panigrahy , John Parkinson , Aaron Mathias , Frank C. Sciavolino
IPC分类号： A61K38/17 , A61K39/00 , A61K45/06 , A61P35/00 , C07K16/28
CPC分类号： A61K38/1793 , A61K45/06 , A61P35/00 , C07K16/2803 , C07K16/2818 , A61K2039/505
摘要： The present invention relates to compositions comprising resolvins and their use in methods of treating cancer.

15. 发明授权

US11925688B2 Compositions and methods relating to salts of specialized pro-resolving mediators 有权
公开(公告)号：US11925688B2
公开(公告)日：2024-03-12
申请号：US17449685
申请日：2021-10-01
申请人： Thetis Pharmaceuticals LLC
发明人： Frank C. Sciavolino , Gary Mathias , Michael C. Van Zandt , Gunnar Erik Jagdmann, Jr. , Jessica J. Dworak
IPC分类号： A61K47/54 , A61K31/202 , A61K31/232 , A61K38/03 , A61K45/06 , A61K47/62 , A61P1/00 , A61P1/04 , A61P1/06 , A61P1/12 , A61P29/00 , C07C59/42 , C07C229/26 , C07C237/12 , C07C237/22
CPC分类号： A61K47/541 , A61K31/202 , A61K31/232 , A61K38/03 , A61K45/06 , A61K47/62 , A61P1/00 , A61P1/04 , A61P1/06 , A61P1/12 , A61P29/00 , C07C59/42 , C07C229/26 , C07C237/12 , C07C237/22 , A61K2800/00
摘要： The present invention relates to compounds of Formulas I-IV, which are salts of special lipid mediators of inflammation, compositions containing same, and methods of using same in the treatment of various diseases and disorders characterized by chronic or excessive inflammation, or both.

16. 发明申请

US20230133085A1 COMPOSITIONS AND METHODS FOR CANCER THERAPY 有权
公开(公告)号：US20230133085A1
公开(公告)日：2023-05-04
申请号：US18049736
申请日：2022-10-26
申请人： Thetis Pharmaceuticals LLC , Beth Israel Deaconess Medical Center
发明人： Gary Mathias , Dipak Panigrahy , John Parkinson , Aaron Mathias , Frank C. Sciavolino
IPC分类号： A61K38/17 , C07K16/28 , A61K45/06 , A61P35/00
摘要： The present invention relates to compositions comprising resolvins and their use in methods of treating cancer.

17. 发明授权

US11191840B2 Compositions and methods relating to salts of specialized pro-resolving mediators 有权
公开(公告)号：US11191840B2
公开(公告)日：2021-12-07
申请号：US15733138
申请日：2018-11-28
申请人： Thetis Pharmaceuticals LLC
发明人： Frank C. Sciavolino , Gary Mathias , Michael C. Van Zandt , Gunnar Erik Jagdmann, Jr. , Jessica J. Dworak
IPC分类号： A61K47/54 , A61K47/62 , C07C59/42 , C07C229/26 , C07C237/12 , C07C237/22 , A61P1/06 , A61P1/12 , A61P29/00 , A61P1/04 , A61K31/202 , A61K31/232 , A61K38/03 , A61K45/06 , A61P1/00
摘要： The present invention relates to compounds of Formulas I-IV, which are salts of special lipid mediators of inflammation, compositions containing same, and methods of using same in the treatment of various diseases and disorders characterized by chronic or excessive inflammation, or both. Provided are pharmaceutical compositions adapted to deliver the compounds the lower gastrointestinal tract and methods of using same as monotherapy in the treatment of inflammatory diseases or disorders of the lower gastrointestinal tract, and in combination therapy with 5-aminosalicylate.

18. 发明授权

US09505709B2 Compositions and methods relating to ionic salts of peptides 有权
标题翻译：与肽的离子盐相关的组合物和方法
公开(公告)号：US09505709B2
公开(公告)日：2016-11-29
申请号：US14772320
申请日：2015-05-04
申请人： Thetis Pharmaceuticals LLC
发明人： Gary Mathias , Banavara L. Mylari , Frank C. Sciavolino
IPC分类号： C07C237/12 , C07C317/04 , C07C57/02 , C07D213/80 , A61K31/198 , A61K31/202 , A61P1/00 , A61P3/00 , A61P9/00 , A61P25/00 , A61P29/00 , C07K7/08 , C07C51/41 , C07C57/03 , C11C3/00
CPC分类号： C07K5/06086 , A23L33/12 , A23V2002/00 , C07C51/412 , C07C53/134 , C07C57/02 , C07C57/03 , C07C229/28 , C07C237/12 , C07C317/04 , C07C2601/14 , C07D213/80 , C07K5/06095 , C07K7/08 , C11C3/00
摘要： The present invention relates to compounds of Formula I, compositions containing same, and methods of use.
摘要翻译：本发明涉及式I化合物，含有其的组合物和使用方法。

19. 发明申请

US20150366980A1 Mineral Amino-Acid Complexes of Fatty Acids 有权
标题翻译：脂肪酸矿物氨基酸配合物
公开(公告)号：US20150366980A1
公开(公告)日：2015-12-24
申请号：US14504247
申请日：2014-10-01
申请人： Thetis Pharmaceuticals LLC
发明人： Frank C. Sciavolino , Gary Mathias
IPC分类号： A61K47/48 , A61K45/06 , A61K31/202
CPC分类号： A61K45/06 , A61K31/202 , A61K47/542 , C08F10/00
摘要： The present invention relates to compound of Formula III comprising an amino acid component, a divalent metal component, and a counter-ion component, compositions containing same, and methods of use.
摘要翻译：本发明涉及包含氨基酸组分，二价金属组分和抗衡离子组分的式III化合物，含有它们的组合物和使用方法。

20. 发明授权

US08765811B2 Tri-salt form of metformin 有权
标题翻译：三盐形式的二甲双胍
公开(公告)号：US08765811B2
公开(公告)日：2014-07-01
申请号：US13841970
申请日：2013-03-15
申请人： Thetis Pharmaceuticals LLC
发明人： Banavara L. Mylari , Frank C. Sciavolino
IPC分类号： C07C279/02
CPC分类号： A61K31/205 , C07C57/03 , C07C229/24 , C07C279/02 , C07C279/26
摘要： Provided herein are tri-salt compounds comprising a compound having two acidic functional groups and one basic functional groups (e.g., aspartate or glutamate), metformin, and polyunsaturated fatty acids, such as eicosapentaenoate or docosahexaenoate. The salts can be used in the treatment of diabetes, diabetes with concomitant dyslipidemia (e.g., high triglycerides) and diabetes exacerbated cardiovascular complications, such as cardiac arrhythmia, cardiac ischemia, myocardial infarction, cardiomyopathy, and stroke. The compounds of this invention are also useful in treating obesity.
摘要翻译：本文提供了三盐化合物，其包含具有两个酸性官能团和一个碱性官能团（例如天冬氨酸或谷氨酸盐），二甲双胍和多不饱和脂肪酸的化合物，例如二十碳五烯酸酯或二十二碳六烯酸酯。这些盐可以用于治疗糖尿病，伴有血脂异常的糖尿病（例如高甘油三酸酯）和糖尿病加重的心血管并发症，例如心律失常，心脏缺血，心肌梗塞，心肌病和中风。本发明的化合物也可用于治疗肥胖症。

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