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11. 发明授权

US08671700B2 High pressure cryogenic fluid generator 有权
标题翻译：高压低温液体发生器
公开(公告)号：US08671700B2
公开(公告)日：2014-03-18
申请号：US12690866
申请日：2010-01-20
申请人： Thach Duong , Jay J. Eum
发明人： Thach Duong , Jay J. Eum
IPC分类号： F04B53/12 , F04B15/08
CPC分类号： F04B37/08 , F04B15/08 , F04B53/1012
摘要： The cryogenic fluid generator includes at least one pump assembly having an actuator mounted to a container assembly. A pump assembly housing includes a longitudinal positioning opening and a pressurization cavity at a distal end terminating with a pump assembly outlet. An internal check valve assembly includes a shaft positioned within an opening of the pump assembly housing that extends into the pressurization cavity. The shaft is attached to the actuator and includes a longitudinal guidance slot; a fluid passageway; and, an internal sealing surface. A positioning bar assembly is positioned within the guidance slot. A connecting rod is securely connected at a first end to the positioning bar assembly, the connecting rod being positioned within the fluid passageway and terminating with a flow inhibiting element. A seal is positioned between the pump assembly housing and the check valve to provide a closure for the pressurization cavity.
摘要翻译：低温流体发生器包括至少一个具有安装到容器组件的致动器的泵组件。泵组件壳体包括纵向定位开口和在终端具有泵组件出口的远端处的加压腔。内部止回阀组件包括位于泵组件壳体的开口内延伸进入加压腔的轴。轴连接到致动器并且包括纵向引导槽; 流体通道; 和内密封面。定位杆组件定位在引导槽内。连杆在第一端处牢固地连接到定位杆组件，连杆位于流体通道内并且终止于流动抑制元件。密封件定位在泵组件壳体和止回阀之间，以为加压腔提供封闭件。

12. 发明申请

US20120271292A1 CRYOSURGICAL PROBE WITH ADJUSTABLE SLIDING APPARATUS 审中-公开
标题翻译： CRYOSURGICAL探头与可调滑动装置
公开(公告)号：US20120271292A1
公开(公告)日：2012-10-25
申请号：US13539749
申请日：2012-07-02
申请人： Thach Duong , Jay J. Eum
发明人： Thach Duong , Jay J. Eum
IPC分类号： A61B18/02
CPC分类号： A61B18/02 , A61B2017/00274 , A61B2017/0046 , A61B2018/00547 , A61B2018/0262 , A61B2090/3925
摘要： A cryosurgical probe that includes a shaft for providing a heat exchange surface for cryogenic ablation, a housing, an insulation element slideably engaged with the shaft, and an adjustable sliding apparatus. The adjustable sliding apparatus includes a slider assembly attached to the insulation element for slideably guiding the insulation element within the shaft, and an actuation assembly operatively connected to the slider assembly for allowing a user to slide the slider assembly to provide a desired adjustment of the insulation element relative to the shaft.
摘要翻译：一种冷冻手术探针，其包括用于提供用于低温消融的热交换表面的轴，壳体，可滑动地与所述轴接合的绝缘元件以及可调滑动装置。可调滑动装置包括附接到绝缘元件的滑块组件，用于可滑动地将绝缘元件引导到轴内;以及致动组件，其可操作地连接到滑块组件，用于允许使用者滑动滑块组件以提供期望的绝缘调节元件相对于轴。

13. 发明授权

US07363071B2 Computer guided ablation of tissue using integrated ablative/temperature sensing devices 有权
标题翻译：使用集成烧蚀/温度感测装置的计算机引导消融组织
公开(公告)号：US07363071B2
公开(公告)日：2008-04-22
申请号：US10700326
申请日：2003-11-03
申请人： Sanford D. Damasco , Thach Duong , Jawahar M. Ali , David J. Battles , Paul W. Mikus , Jay J. Eum
发明人： Sanford D. Damasco , Thach Duong , Jawahar M. Ali , David J. Battles , Paul W. Mikus , Jay J. Eum
IPC分类号： A61B5/05
CPC分类号： A61B18/02 , A61B8/08 , A61B34/10 , A61B90/11 , A61B90/37 , A61B2017/00084 , A61B2017/00274 , A61B2017/3411 , A61B2018/00547 , A61B2090/378
摘要： The system for providing computer guided ablation of tissue of a patient includes an imaging device, an ablative surgical computer system, and a set of surgical devices. The imaging device receives imaging data from a treatment region of a patient, processes the imaging data and provides imaging output data and imaging signals. The imaging output data is available to an operator. The ablative surgical computer system includes a guidance module for processing the imaging signals and providing a treatment guidance plan to the operator; and, a treatment module for acquiring and processing surgical device output data, for optimally controlling treatment parameters and providing feedback information to the operator based on the treatment guidance plan. The set of surgical devices includes at least one integrated ablative/temperature sensing device including at least one ablative device for providing ablation of the treatment region based on the treatment parameters and operator input; and, at least one temperature sensing device for acquiring temperature data from the treatment region and providing a temperature sensing device output signal. The temperature sensing device output signal is a portion of the surgical device output data. The treatment guidance plan is utilized for placing the integrated ablative/temperature sensing device into the treatment region.
摘要翻译：用于提供患者组织的计算机引导消融的系统包括成像装置，烧蚀外科手术计算机系统和一组手术装置。成像装置从患者的治疗区域接收成像数据，处理成像数据并提供成像输出数据和成像信号。成像输出数据可供操作员使用。烧蚀手术计算机系统包括用于处理成像信号并向操作者提供治疗指导计划的引导模块; 以及用于获取和处理手术装置输出数据的治疗模块，用于根据治疗指导计划最佳地控制治疗参数并向操作者提供反馈信息。该组手术装置包括至少一个集成的烧蚀/温度感测装置，其包括至少一个消融装置，用于基于治疗参数和操作员输入提供治疗区域的消融; 以及至少一个用于从处理区域获取温度数据并提供温度感测装置输出信号的温度感测装置。温度感测装置输出信号是手术装置输出数据的一部分。治疗指导计划用于将整合的烧蚀/温度感测装置放置在治疗区域中。

14. 发明授权

US06972014B2 Open system heat exchange catheters and methods of use 有权
标题翻译：开放系统热交换导管及使用方法
公开(公告)号：US06972014B2
公开(公告)日：2005-12-06
申请号：US10336322
申请日：2003-01-04
申请人： Jay J. Eum , Thach Duong
发明人： Jay J. Eum , Thach Duong
IPC分类号： A61B18/00 , A61B18/02 , A61B18/04 , A61B18/18
CPC分类号： A61B18/02 , A61B2018/00041 , A61B2018/046
摘要： Various embodiments of open system heat exchange catheters and methods of use are disclosed. The various catheters can be used with various ablative surgical devices. One specific exemplary use is in conjunction with cryosurgical probes involving ablation of the prostate, in which the integrity of the urethra is desired to be maintained. Other uses involve various heating ablative devices. In one embodiment an injection tube assembly is used to provide heat exchange fluid through the urethra to the bladder where it is then expelled via a suprapubic suction tube. In other embodiments a coaxial tube assembly is utilized which defines a passageway for either expelling the bladder fluid or for providing access to an endoscope. In other embodiments a double lumen assembly is utilized that defines a passageway for expelling bladder fluid.
摘要翻译：公开了开放系统热交换导管和使用方法的各种实施例。各种导管可以与各种烧蚀手术装置一起使用。一个具体的示例性用途是结合涉及前列腺消融的冷冻手术探针，其中期望保持尿道的完整性。其他用途涉及各种加热烧蚀装置。在一个实施例中，注射管组件用于将热交换流体通过尿道提供给膀胱，然后通过耻骨上吸管将其排出。在其它实施例中，使用同轴管组件，其限定用于排出膀胱流体或用于提供对内窥镜的通路的通道。在其他实施例中，利用限定用于排出膀胱流体的通道的双腔组件。

15. 发明授权

US06702846B2 Urological stent therapy system and method 失效
标题翻译：泌尿支架治疗系统及方法
公开(公告)号：US06702846B2
公开(公告)日：2004-03-09
申请号：US10091112
申请日：2002-02-28
申请人： Paul W. Mikus , William G. Moseley , Jay J. Eum
发明人： Paul W. Mikus , William G. Moseley , Jay J. Eum
IPC分类号： A61F206
CPC分类号： A61F2/88 , A61F2/95 , A61F2002/048 , A61F2002/9505 , A61F2002/9511 , A61F2002/9517 , A61F2250/0039 , A61M27/008
摘要： A stent system and method for use in the prostate gland. The stent is made of a shape memory alloy such as nitinol, and has a low temperature martensite state, with a martensite transition temperature below body temperature, and a high temperature austenite state, with an austenite transition temperature at or above body temperature, and a memorized shape in the high temperature austenite state which is a helical coil of diameter large enough to hold the prostatic urethra open. The stent is used to heat the prostate and is left in the prostatic urethra while the prostate heals. After the prostate is substantially healed, the stent is cooled to its martensite state and is easily removed from the urethra.
摘要翻译：用于前列腺的支架系统和方法。该支架由镍钛诺镍等形状记忆合金制成，具有马氏体转变温度低于体温的低温马氏体状态和奥氏体转变温度在体温以上的高温奥氏体状态，在高温奥氏体状态下记忆形状，其为直径足够大以容纳前列腺尿道打开的螺旋线圈。支架用于加热前列腺，并在前列腺治疗时留在前列腺尿道。在前列腺基本上愈合之后，支架被冷却到其马氏体状态，并且容易地从尿道中移出。

16. 发明授权

US6146378A Placement guide for ablation devices 有权
标题翻译：消融装置放置指南
公开(公告)号：US6146378A
公开(公告)日：2000-11-14
申请号：US272889
申请日：1999-03-19
申请人： Paul W. Mikus , Jay J. Eum
发明人： Paul W. Mikus , Jay J. Eum
IPC分类号： A61B19/00 , A61B1/00 , A61B17/00 , A61B17/32 , A61B17/34 , A61B17/42 , A61B18/02 , A61M25/08 , A61B18/18
CPC分类号： A61B18/02 , A61B2017/00292 , A61B2017/4216 , A61B2018/0212 , A61B2090/034 , A61B2090/0463 , A61B2090/378
摘要： A placement guide for positioning ablation devices within a human body is disclosed. The placement guide comprise an outer catheter and an inner tubular member disposed within a lumen of the outer catheter. When a stop on the inner tubular member engages a seat on the outer catheter, a distal projection of the inner tubular member extends from the distal end of the outer catheter. While monitoring the position of the inner tubular member through an endoscope inserted in its lumen, a clinician positions the distal projection within a human body for optimal ablation. After securing the outer catheter in position, the inner tubular member is withdrawn and replaced with an ablation device which is inserted distally within the outer catheter lumen until a stop on the ablation device engages the seat on the outer catheter wherein a distal projection of the ablation device extends from the distal end of the outer catheter. Because the distal projection of the inner tubular member has a length substantially identical to that of the inner tubular member, the ablation device may be positioned for optimal ablation.
摘要翻译：公开了一种用于将消融装置定位在人体内的放置引导件。放置引导件包括外导管和设置在外导管的内腔内的内管状构件。当内管状构件上的止动件与外导管上的座接合时，内管状构件的远端突出部从外导管的远端延伸。在通过插入其管腔中的内窥镜监测内管状构件的位置的同时，临床医生将远侧突出物定位在人体内以进行最佳消融。在将外导管固定就位之后，内管状构件被取出并且被切除装置替代，该消融装置向远端插入外导管内腔中直到消融装置上的止动件接合外导管上的座，其中消融的远侧突出部装置从外导管的远端延伸。因为内部管状构件的远侧突出部具有与内部管状构件的长度基本相同的长度，所以可以定位消融装置以实现最佳消融。

17. 发明授权

US08187260B1 Variable cryosurgical probe planning system 有权
标题翻译：可变冷冻手术探针计划系统
公开(公告)号：US08187260B1
公开(公告)日：2012-05-29
申请号：US11618492
申请日：2006-12-29
申请人： Shenghao Bao , Jay J. Eum
发明人： Shenghao Bao , Jay J. Eum
IPC分类号： A61B18/18 , A61B8/00
CPC分类号： A61B18/0218 , A61B5/0008 , A61B5/01 , A61B8/0841 , A61B8/085 , A61B8/0858 , A61B8/4254 , A61B8/4263 , A61B8/4416 , A61B8/5223 , A61B8/5238 , A61B8/5253 , A61B8/546 , A61B18/02 , A61B34/10 , A61B2017/00274 , A61B2018/00011 , A61B2018/00511 , A61B2018/00529 , A61B2018/00547 , A61B2018/00744 , A61B2018/00761 , A61B2018/00791 , A61B2018/00982 , A61B2034/104 , A61B2090/378
摘要： A cryosurgical system for assisting an operator in placing and operating cryosurgical probes in the prostate of a human patient. The cryosurgical system includes a computer system being programmed with software capable of performing the following steps: a) capturing a plurality of transverse views of the prostate; b) capturing a sagittal view of the prostate; c) outlining the capsule of the prostate, the urethra and the rectal wall of the patient with the assistance of the operator, utilizing the captured plurality of transverse views and the captured sagittal view; d) constructing a 3-dimensional model of the prostate, the urethra and the rectal wall utilizing the outlines of step c), above; and, e) utilizing the 3-dimensional model of the prostate, the urethra and the rectal wall to determine i) the number of cryosurgical probes to be utilized; ii) probe settings; and, iii) probe placement positions. The resultant ice thus produced by the cryosurgical probes is optimized for a specific patient.
摘要翻译：一种用于帮助操作者将冷冻手术探针置于和操作人类前列腺的冷冻手术系统。所述冷冻手术系统包括用软件编程的计算机系统，所述软件能够执行以下步骤：a）捕获前列腺的多个横向视图; b）捕获前列腺的矢状视图; c）在操作者的帮助下，使用所捕获的多个横向视图和所述被捕获的矢状视图概述前列腺的胶囊，患者的尿道和直肠壁; d）利用上述步骤c）的轮廓构建前列腺，尿道和直肠壁的3维模型; 和e）利用前列腺，尿道和直肠壁的三维模型来确定i）要使用的冷冻手术探针的数量; ii）探针设置; 和iii）探测放置位置。由冷冻手术探针产生的所得到的冰针对特定患者进行了优化。

18. 发明授权

US08740892B2 Expandable multi-tubular cryoprobe 有权
标题翻译：可扩展多管式冷冻探头
公开(公告)号：US08740892B2
公开(公告)日：2014-06-03
申请号：US12744033
申请日：2008-11-19
申请人： Alexei V. Babkin , Anatoly I. Efremov , Jay J. Eum
发明人： Alexei V. Babkin , Anatoly I. Efremov , Jay J. Eum
IPC分类号： A61B18/18
CPC分类号： A61B18/02 , A61B2018/0212 , A61B2018/0262
摘要： An expandable, flexible multi-tubular cryoprobe operational with a near critical cryogenic working fluid. The inlet fluid transfer micro-tubes utilized are formed of material that maintains flexibility in a full range of temperatures from −200° C. to ambient temperature. During operation, the cryoprobe is mechanically actuated to provide radial expansion of the inlet fluid transfer micro-tubes. Thus, enhanced thermal contact with target biological tissue to be treated is provided.
摘要翻译：可扩展的，灵活的多管式冷冻探头，可操作于近临界的低温工作液体。使用的入口流体转移微管由在-200℃至环境温度的全部温度范围内保持柔性的材料形成。在操作期间，冷冻探针机械致动以提供入口流体转移微管的径向膨胀。因此，提供了与要治疗的靶生物组织的热接触增强。

19. 发明授权

US06936045B2 Malleable cryosurgical probe 有权
标题翻译：可延展的冷冻手术探针
公开(公告)号：US06936045B2
公开(公告)日：2005-08-30
申请号：US09957337
申请日：2001-09-20
申请人： Xiaoyu Yu , Jay J. Eum , David J. Battles
发明人： Xiaoyu Yu , Jay J. Eum , David J. Battles
IPC分类号： A61B17/00 , A61B18/00 , A61B18/02
CPC分类号： A61B18/02 , A61B2017/00084 , A61B2017/00092 , A61B2017/00243 , A61B2018/00041 , A61B2018/00101 , A61B2018/0262
摘要： The malleable cryosurgical probe includes a cryostat assembly and a cryoprobe assembly. The cryostat assembly includes an elongated shaft assembly having at least one malleable segment thereof and a closed distal end. The shaft assembly includes at least one freezing portion, at least one thermally insulated portion and a thermally insulating element positioned about the thermally insulated portion. A cryostat is operably associated with the elongated shaft assembly. It includes a cryostat inlet for receiving gas entering the cryostat, a cryostat outlet and a heat exchanger positioned between the cryostat outlet and the cryostat inlet. The heat exchanger receives gas from the cryostat inlet and provides heat transfer between gas flowing within the cryostat and fluid exterior thereto. At least one Joule-Thomson nozzle is in fluid communication with the cryostat outlet. The at least one Joule-Thomson nozzle expands gas expelled therefrom. The expanded cold fluid communicates with the freezing portion to provide cooling thereof. The cryoprobe assembly includes a handle assembly for supporting the cryostat assembly and a fluid supply line assembly connectable to a fluid source at one end and to the cryostat inlet at a second end. The heat exchanger is positioned at a location longitudinally spaced from the freezing portion(s).
摘要翻译：可延展的冷冻手术探头包括低温恒温器组件和冷冻探针组件。低温恒温器组件包括细长轴组件，其具有至少一个可延展段和封闭的远端。轴组件包括至少一个冷冻部分，至少一个绝热部分和围绕该绝热部分定位的隔热元件。低温恒温器与细长轴组件可操作地相关联。其包括用于接收进入低温恒温器的气体的低温恒温器入口，低温恒温器出口和位于低温恒温器出口和低温恒温器入口之间的热交换器。热交换器从低温恒温器入口接收气体，并在低温恒温器内流动的气体和外部流体之间提供热传递。至少一个焦耳汤姆逊喷嘴与低温恒温器出口流体连通。至少一个焦耳汤姆逊喷嘴扩大从其排出的气体。膨胀的冷流体与冷冻部分连通以提供冷却。冷冻探头组件包括用于支撑低温恒温器组件的手柄组件和可在一端连接到流体源的流体供应管线组件和在第二端处连接到低温恒温器入口的流体供应管线组件。热交换器定位在与冷冻部分纵向间隔开的位置处。

20. 发明授权

US6162231A Stent insertion device 失效
标题翻译：支架插入装置
公开(公告)号：US6162231A
公开(公告)日：2000-12-19
申请号：US336974
申请日：1999-06-21
申请人： Paul W. Mikus , Jay J. Eum
发明人： Paul W. Mikus , Jay J. Eum
IPC分类号： A61F2/82 , A61F2/06 , A61F2/84 , A61M25/00 , A61M25/06 , A61M25/12 , A61M29/00 , A61F11/00
CPC分类号： A61M25/0662 , A61F2/95 , A61F2002/9517 , A61M25/0068 , A61M25/0668 , A61M29/00 , A61M2210/166
摘要： Two embodiments for a stent delivery device are disclosed. In the first embodiment, the stent delivery device comprises an outer sheath and an inner tubular member which distally ends in a tongue having an arcuate cross section. In a second embodiment, the stent delivery device further comprises a housing having a lumen extending longitudinally therethrough, the lumen holding the inner tubular member. A guide pin attached to the outer sheath is slidably disposed within the housing wherein the guide pin may be longitudinally displaced with respect to the lumen. In addition, an endoscope mounting plate may be slidably disposed along the housing. Detents may be used to releasably prevent a proximal displacement of the guide pin within the lumen of the housing as well as to releasably prevent the proximal displacement of the endoscope mounting plate with respect to the housing.
摘要翻译：公开了用于支架输送装置的两个实施例。在第一实施例中，支架输送装置包括外鞘和内管状构件，其以具有弓形横截面的舌头远端终止。在第二实施例中，支架输送装置还包括具有纵向延伸通过其延伸的内腔的壳体，所述内腔保持内管状构件。附接到外护套的引导销可滑动地设置在壳体内，其中引导销可以相对于内腔纵向移位。此外，内窥镜安装板可以沿壳体可滑动地设置。可以使用定位器来可释放地防止引导销在壳体的腔内的近端位移，并且可释放地防止内窥镜安装板相对于壳体的近侧位移。

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