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11. 发明申请

US20090253723A1 PROTEIN KINASE INHIBITORS 有权
标题翻译：蛋白激酶抑制剂
公开(公告)号：US20090253723A1
公开(公告)日：2009-10-08
申请号：US12274834
申请日：2008-11-20
申请人： Nwe Y. Ba-Maung , Randy L. Bell , Richard F. Clark , Scott A. Erickson , Steve D. Fidanze , Robert D. Hubbard , Robert A. Mantei , George S. Sheppard , Bryan K. Sorensen , Gary T. Wang , Jieyi Wang
发明人： Nwe Y. Ba-Maung , Randy L. Bell , Richard F. Clark , Scott A. Erickson , Steve D. Fidanze , Robert D. Hubbard , Robert A. Mantei , George S. Sheppard , Bryan K. Sorensen , Gary T. Wang , Jieyi Wang
IPC分类号： A61K31/506 , C07D239/42 , A61P35/00
CPC分类号： C07D513/04
摘要： Compounds that inhibit protein kinases, compositions containing the compounds and methods of treating diseases using the compounds are disclosed.
摘要翻译：公开了抑制蛋白激酶的化合物，含有化合物的组合物和使用该化合物治疗疾病的方法。

12. 发明授权

US5516789A Lipoxygenase and cyclooxygenase inhibiting compounds 失效
标题翻译：脂氧合酶和环加氧酶抑制化合物
公开(公告)号：US5516789A
公开(公告)日：1996-05-14
申请号：US421125
申请日：1995-04-12
申请人： Clint D. W. Brooks , Andrew O. Stewart , Anwer Basha , Randy L. Bell
发明人： Clint D. W. Brooks , Andrew O. Stewart , Anwer Basha , Randy L. Bell
IPC分类号： C07C275/64 , C07D307/52 , C07D333/20 , C07D333/58 , C07D409/12 , A61K31/405 , C07D209/14
CPC分类号： C07D409/12 , C07C275/64 , C07D307/52 , C07D333/20 , C07D333/58
摘要： Compounds having the structure ##STR1## or a pharmaceutically acceptable salt thereof have activity as inhibitors of cylooxygenase and 5-lipoxygenase, reduce the biosynthesis of leukotrienes B.sub.4, C.sub.4, D.sub.4, and E.sub.4 and cylooxygenase products such as prostaglandins and thromboxane and are useful in the treatment of inflammatory and allergic disease states. The compounds have the structure indicated above wherein A is selected from (a) optinally substituted carbocyclic aryl, (b) optinally substituted furyl, (c) optinally substituted benzo[b]furyl, (d) optinally substituted thienyl, (e) optinally substituted pyridyloxy, (f) optinally substituted pyridylalkyl, (g) optinally substituted benzo[b]thienyl, (h) optinally substituted pyridyl, (i) optinally substituted quinolyl, and (j) optinally substituted indolyl; X is selected from (a) optionally substituted alkyl, (b) optinally substituted alkenyl, and (c) optinally substituted alkynyl; R.sup.1 and R.sup.2 are independently selected from hydrogen, hydroxy, and alkyl; and Z is a residue of a non-steroidal anti-inflammatory drug of the general formula Z--COOH.
摘要翻译：具有结构或其药学上可接受的盐的化合物具有作为环氧合酶和5-脂氧合酶抑制剂的活性，降低白细胞三烯B4，C4，D4和E4以及环加氧酶产物如前列腺素和血栓烷的生物合成，并且可用于治疗炎症和过敏性疾病状态。化合物具有上述结构，其中A选自（a）光学取代的碳环芳基，（b）光取代的呋喃基，（c）光取代的苯并[b]呋喃基，（d）最佳取代的噻吩基，（e）吡啶基氧基，（f）选择性取代的吡啶基烷基，（g）最佳取代的苯并[b]噻吩基，（h）最佳取代的吡啶基，（i）最佳取代的喹啉基和（j） X选自（a）任选取代的烷基，（b）光学取代的烯基和（c）最佳取代的炔基; R 1和R 2独立地选自氢，羟基和烷基; Z为通式Z-COOH的非甾体抗炎药物的残基。

13. 发明授权

US4714776A Antiallergic agents 失效
标题翻译：抗过敏剂
公开(公告)号：US4714776A
公开(公告)日：1987-12-22
申请号：US757686
申请日：1985-07-22
申请人： Randy L. Bell , George G. I. Moore
发明人： Randy L. Bell , George G. I. Moore
IPC分类号： A61K31/12 , A61K31/19 , A61K31/215 , A61K31/235 , A61K31/275 , A61P37/08 , A61P43/00 , C07C45/00 , C07C45/46 , C07C49/83 , C07C49/84 , C07C51/00 , C07C65/32 , C07C65/40 , C07C67/00 , C07C69/76 , C07C219/14 , C07C253/00 , C07C255/51 , C07C255/56
CPC分类号： C07C255/00 , C07C45/46 , C07C49/83 , C07C49/84 , C07C65/40
摘要： Novel antiallergic agents are described which are carboxy-substituted 3,5-di(tertiary-butyl)-4-hydroxybenzophenones. Pharmaceutical compositions containing and pharmacological methods for using such compounds are also described, as are synthetic intermediates for preparing such compounds.
摘要翻译：描述了新的抗过敏剂，其是羧基取代的3,5-二（叔丁基）-4-羟基二苯甲酮。还描述了含有药物组合物和使用这些化合物的药理学方法，以及用于制备这些化合物的合成中间体。

14. 发明授权

US4677113A Di-t-butylphenols substituted by a thenoyl group 失效
标题翻译：由噻吩甲酰基取代的二叔丁基酚
公开(公告)号：US4677113A
公开(公告)日：1987-06-30
申请号：US854846
申请日：1986-04-22
申请人： Randy L. Bell , George G. I. Moore
发明人： Randy L. Bell , George G. I. Moore
IPC分类号： A61K31/38 , A61K31/381 , A61P11/08 , A61P37/08 , A61P43/00 , C07D333/38 , C07D333/40
CPC分类号： C07D333/40 , C07D333/38
摘要： Novel compounds which are 2,6-di-t-butylphenols substituted on the 4 position by a thenoyl group, which thenoyl group is substituted by an acid group are useful as inhibitors of leukotriene synthesis and as antiallergic agents.
摘要翻译：作为噻吩甲酰基取代的苯甲酰基的4位上的2,6-二叔丁基酚的新型化合物，该噻吩甲酰基被酸基取代，可用作白三烯合成抑制剂和抗过敏剂。

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