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11. 发明授权

US5986144A Triazole derivative, preparation process thereof and pharmaceutical comprising the same as an effective ingredient 失效
标题翻译：三唑衍生物，其制备方法和包含其作为有效成分的药物
公开(公告)号：US5986144A
公开(公告)日：1999-11-16
申请号：US311057
申请日：1999-05-14
申请人： Minoru Tokizawa , Sunao Takeda , Yasushi Kaneko , Hiromichi Eto , Kazuya Ishida , Kazunori Maebashi , Masaru Matsumoto , Takemitsu Asaoka , Susumu Sato , Hideaki Matsuda
发明人： Minoru Tokizawa , Sunao Takeda , Yasushi Kaneko , Hiromichi Eto , Kazuya Ishida , Kazunori Maebashi , Masaru Matsumoto , Takemitsu Asaoka , Susumu Sato , Hideaki Matsuda
IPC分类号： C07D249/08 , C07D303/34 , C07D521/00 , C07C323/07
CPC分类号： C07D231/12 , C07D233/56 , C07D249/08 , C07D303/34
摘要： Described is a triazole derivative represented by the formula (1) or salt thereof, preparation process thereof, preparation intermediates represented by the formulas (2) and (3), and a pharmaceutical comprising the compound represented by the formula (1) or salt thereof. wherein n stands for 0, 1 or 2, X.sup.1 represents H or F and Y.sup.1 and Y.sup.2 each independently represents H, halogen or CF.sub.3.
摘要翻译：描述由式（1）表示的三唑衍生物或其盐，其制备方法，由式（2）和（3）表示的制备中间体，以及包含式（1）表示的化合物或其盐的药物。其中n表示0,1或2，X 1表示H或F，Y 1和Y 2各自独立地表示H，卤素或CF 3。

12. 发明授权

US5699807A Blood pressure measuring system 失效
标题翻译：血压测量系统
公开(公告)号：US5699807A
公开(公告)日：1997-12-23
申请号：US507709
申请日：1995-07-26
申请人： Jun Motogi , Yoshio Sakai , Sunao Takeda
发明人： Jun Motogi , Yoshio Sakai , Sunao Takeda
IPC分类号： A61B5/022 , A61B5/02
CPC分类号： A61B5/02116 , A61B5/022 , A61B5/7239
摘要： A pressure sensor gathers discrete data representing the pulse amplitude of a pulse wave signal when a cuff pressure is increased and decreased. A RAM stores the discrete data of the pulse amplitude. A CPU processes the discrete data by using a spline function, to thereby generate the data representative of a smooth continuous line passing by points of the pulse amplitude of the discrete data. This process reduces a variation of the pulse amplitude of a pulse wave signal, to thereby minimize a variation of the blood pressure values. An inflection point of the smooth continuous line is used as a diastolic blood pressure value.
摘要翻译：当袖带压力增加和减小时，压力传感器收集表示脉搏波信号的脉冲幅度的离散数据。 RAM存储脉冲幅度的离散数据。 CPU通过使用样条函数处理离散数据，从而生成表示通过离散数据的脉冲幅度的点的平滑连续线的数据。该过程减少了脉搏波信号的脉冲幅度的变化，从而使血压值的变化最小化。平滑连续线的拐点被用作舒张血压值。

13. 发明授权

US09970872B2 Cell analyzer and cell analyzation method 有权
公开(公告)号：US09970872B2
公开(公告)日：2018-05-15
申请号：US13217338
申请日：2011-08-25
申请人： Takahiro Shioyama , Akane Suzuki , Sunao Takeda
发明人： Takahiro Shioyama , Akane Suzuki , Sunao Takeda
IPC分类号： G01N33/48 , G01N21/64 , G01N15/14 , G01N15/10
CPC分类号： G01N21/6428 , G01N15/1459 , G01N2015/1006 , G01N2015/1402 , G01N2015/1488
摘要： A cell analyzer includes: a measuring portion which measures cells that are nuclear stained; a displaying portion which displays a histogram of a fluorescence intensity by using a result of the measurement by the measuring portion; and a determining unit which obtains a number of strong-area cells that are distributed in an area where the fluorescence intensity is stronger than normal cells, and which determines a malignancy grade of cancer based on the number of strong-area cells and the histogram.

14. 发明授权

US09291572B2 Method and apparatus for measuring pH of medium solution 有权
标题翻译：测量介质溶液pH值的方法和装置
公开(公告)号：US09291572B2
公开(公告)日：2016-03-22
申请号：US13441630
申请日：2012-04-06
申请人： Mitsuhiro Oura , Hirotsugu Kubo , Sunao Takeda , Teruo Okano , Tatsuya Shimizu
发明人： Mitsuhiro Oura , Hirotsugu Kubo , Sunao Takeda , Teruo Okano , Tatsuya Shimizu
IPC分类号： G01N21/31 , G06F19/00 , G01N21/80 , G01N31/22 , C12M1/34
CPC分类号： G01N21/80 , C12M41/26 , G01N31/221 , G01N2021/3148 , G01N2021/3181 , G01N2201/0627
摘要： A pH measuring method includes: illuminating a medium solution, which includes: a first material; and a second material, with a plurality of light beams, which includes: a first light beam, a wavelength of which corresponds to a first absorption peak; a second light beam, a wavelength of which corresponds to a second absorption peak or a second convergence point; a third light beam, a wavelength of which corresponds to a third absorption peak or a third convergence point; and a fourth light beam, a wavelength of the fourth light beam at which an absorbance of at least one of the first and second materials is converged irrespective of a pH; receiving transmitted or reflected light beams of the first to fourth light beams; measuring absorbances at the wavelengths of the received light beams respectively; and calculating a pH of the medium solution based on the absorbances.
摘要翻译： pH测量方法包括：照射介质溶液，其包括：第一材料; 以及具有多个光束的第二材料，其包括：第一光束，其波长对应于第一吸收峰; 第二光束，其波长对应于第二吸收峰或第二会聚点; 第三光束，其波长对应于第三吸收峰或第三会聚点; 以及第四光束，所述第四光束的波长，其中所述第一和第二材料中的至少一个的吸光度在不同pH下会聚; 接收第一至第四光束的透射或反射光束; 分别测量接收光束波长处的吸光度; 并基于吸光度计算介质溶液的pH。

15. 发明授权

US09017368B2 Blood pressure calculation method for non-invasive blood pressure measurement apparatus 有权
标题翻译：非侵入性血压测量仪的血压计算方法
公开(公告)号：US09017368B2
公开(公告)日：2015-04-28
申请号：US12263381
申请日：2008-10-31
申请人： Takashi Usuda , Sunao Takeda
发明人： Takashi Usuda , Sunao Takeda
IPC分类号： A61B5/02 , A61B5/021 , A61B5/022 , A61B5/00
CPC分类号： A61B5/022 , A61B5/02116 , A61B5/02225 , A61B5/7257
摘要： A method of calculating a blood pressure, includes: providing a non-invasive blood pressure measurement apparatus which includes a cuff being inflatable and deflatable and adapted to be fitted on a part of a living body and in which a plurality of calculation methods each of which has priority in accordance with a type of noise information are set; detecting, by the cuff, a signal waveform representing a change in an oscillation amplitude and a change in a cuff pressure; determining the type of the noise information contained in the detected signal waveform; deciding the blood pressure from at least one candidate value for the blood pressure, which is calculated by one of the calculation methods that has the priority with respect to the determined type of the noise information; and displaying the decided blood pressure.
摘要翻译：计算血压的方法包括：提供一种无创血压测量装置，其包括可充气和可放气并且适于安装在生物体的一部分上的袖带，并且其中多个计算方法各自按照一种噪声信息的优先级设置; 通过袖带检测表示振荡幅度的变化和袖带压的变化的信号波形; 确定检测信号波形中包含的噪声信息的类型; 从至少一个所述血压候选值决定血压，所述血压通过相对于所确定的噪声信息类型具有优先权的计算方法之一来计算; 并显示所确定的血压。

16. 发明申请

US20070197893A1 Pressure Measuring Method, Pressure Measuring Device, And Tonometer 有权
标题翻译：压力测量方法，压力测量装置和压力计
公开(公告)号：US20070197893A1
公开(公告)日：2007-08-23
申请号：US11578910
申请日：2005-03-18
申请人： Makoto Nakai , Sunao Takeda , Akihiko Uchiyama , Kenji Yanashima , Akihiro Fujita , Itaru Yoshizawa
发明人： Makoto Nakai , Sunao Takeda , Akihiko Uchiyama , Kenji Yanashima , Akihiro Fujita , Itaru Yoshizawa
IPC分类号： A61B3/16
CPC分类号： G01L9/0022 , A61B3/16 , A61B5/0051 , G01L9/008
摘要： Provided are a pressure measuring method where a pressure is measured with a simple method and with high reproducibility and an intraocular pressure measuring device that is capable of measuring an intraocular pressure only by being made to come in contact with an eyelid and with which a subject himself/herself can perform intraocular pressure measurement. The intraocular pressure measuring device is constituted of a measurer (1), a piezo driver, a terminal base, an information processing device, and a resistor. The measurer (1) is constituted of a vibrator (11) such as a bimorph vibrator, four rubber bases (12), a case (13) vibratable with the vibrator (11) and the rubber bases (12) received in the case, and a contactor (14) coming in contact with an eyelid (16). In intraocular pressure measurement, the contactor (14) is made to come in contact with the eyelid (16). The vibrator (11) is constructed from a bimorph vibrator where an electric current varies according to the inner pressure of an object to be measured in contact with the vibrator with a contact AC voltage applied to the vibrator. A pressure such as an intraocular pressure of the object to be measured is measured by measuring an electric current value flowing in the vibrator.
摘要翻译：提供了一种压力测量方法，其中以简单的方法和高重现性测量压力，并且能够仅通过与眼睑接触并测量眼内压而能够测量眼内压的眼内压测量装置 /她自己可以进行眼压测量。眼压测量装置由测量器（1），压电驱动器，端子座，信息处理装置和电阻器构成。测量器（1）由诸如双压电晶片振动器的振动器（11），四个橡胶基座（12），可与振动器（11）振动的壳体（13）和容纳在壳体中的橡胶基座（12）构成，和与眼睑（16）接触的接触器（14）。在眼内压测量中，接触器（14）与眼睑（16）接触。振动器（11）由双压电晶片振子构成，其中电流根据施加到振动器的接触交流电压根据与振动器接触的被测量物体的内部压力而变化。通过测量在振动器中流动的电流值来测量被测量物体的眼压等压力。

17. 发明申请

US20070167852A1 Method and Apparatus for Measuring Blood Volume, and Vital Sign Monitor Using the Same 有权
标题翻译：用于测量血容量的方法和装置，以及使用其的生命体征监测器
公开(公告)号：US20070167852A1
公开(公告)日：2007-07-19
申请号：US11694657
申请日：2007-03-30
申请人： Yoshihiro Sugo , Takeshi Akiyama , Keisuke Uchida , Sunao Takeda
发明人： Yoshihiro Sugo , Takeshi Akiyama , Keisuke Uchida , Sunao Takeda
IPC分类号： A61B5/04
CPC分类号： A61B5/029 , A61B5/0245 , A61B5/0285
摘要： A first member is adapted to measure an electrocardiogram of a patient. A second member is adapted to measure a peripheral pulse wave of the patient. A first calculator calculates a pulse wave propagation time (PWTT) and a heart rate (HR) of the patient based on the electrocardiogram and the peripheral pulse wave. A second calculator calculates a cardiac output (CO) of the patient with an equation of CO=(αK·PWTT+βK)·HR, where α, β and K are coefficients inherent to the patient.
摘要翻译：第一构件适于测量患者的心电图。第二构件适于测量患者的外周脉搏波。第一计算器基于心电图和外周脉搏波计算患者的脉搏波传播时间（PWTT）和心率（HR）。第二计算器用CO =（αK.PWTT+βK）·HR等式计算患者的心输出量（CO），其中α，β和K是患者固有的系数。

18. 发明授权

US06958353B2 Imidazole derivatives or salts thereof and drugs containing the derivatives or the salts 失效
标题翻译：咪唑衍生物或其盐和含有衍生物或盐的药物
公开(公告)号：US06958353B2
公开(公告)日：2005-10-25
申请号：US10258610
申请日：2001-06-08
申请人： Fujiko Konno , Yoshihiro Nagao , Kazuo Isomae , Mari Ohtsuka , Yoshiyuki Takahashi , Fumio Ishii , Hiroyuki Hirota , Sunao Takeda , Noriyuki Kawamoto , Haruyoshi Honda , Susumu Sato
发明人： Fujiko Konno , Yoshihiro Nagao , Kazuo Isomae , Mari Ohtsuka , Yoshiyuki Takahashi , Fumio Ishii , Hiroyuki Hirota , Sunao Takeda , Noriyuki Kawamoto , Haruyoshi Honda , Susumu Sato
IPC分类号： A61P19/02 , A61P19/10 , A61P29/00 , A61P43/00 , C07D233/22 , C07D233/60 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/14 , C07D409/14 , C07D521/00 , A61K31/4178 , A61K31/444
CPC分类号： C07D401/14 , C07D231/12 , C07D233/22 , C07D233/56 , C07D249/08 , C07D401/12 , C07D403/12 , C07D405/14 , C07D409/14
摘要： The invention is directed to an imidazole derivative represented by formula (1): wherein each of R1 and R2 represents an aryl group, a heteroaryl group, etc.; each of A, X1, and X2 represents N or CH; each of Y and Z represents O, S, etc.; each of R3, R4, and R5 represents a hydrogen atom, an alkyl group, etc.; m is a number of 1 to 4; and n is a number of 0 to 4, or a salt thereof. The invention is also directed to a drug containing the derivative or the salt as an active ingredient. These compounds exert excellent effects of inhibiting production of NO and IL-6 and are useful for preventing or treating diseases induced by overproduction of NO and IL-6.
摘要翻译：本发明涉及由式（1）表示的咪唑衍生物：其中R 1和R 2各自表示芳基，杂芳基等; A，X 1和X 2各自表示N或CH; Y和Z各自表示O，S等; R 3，R 4和R 5各自表示氢原子，烷基等; m是1到4的数字; n为0〜4的数，或其盐。本发明还涉及含有衍生物或盐作为活性成分的药物。这些化合物具有抑制NO和IL-6产生的优异效果，可用于预防或治疗由过量产生NO和IL-6引起的疾病。

19. 发明申请

US20050222514A1 Method and apparatus for measuring blood volume, and vital sign monitor using the same 有权
标题翻译：用于测量血容量的方法和装置，以及使用其的生命体征监测器
公开(公告)号：US20050222514A1
公开(公告)日：2005-10-06
申请号：US11094228
申请日：2005-03-31
申请人： Yoshihiro Sugo , Takeshi Akiyama , Keisuke Uchida , Sunao Takeda
发明人： Yoshihiro Sugo , Takeshi Akiyama , Keisuke Uchida , Sunao Takeda
IPC分类号： A61B5/02 , A61B5/0245 , A61B5/0285 , A61B5/029 , A61B5/04
CPC分类号： A61B5/029 , A61B5/0245 , A61B5/0285
摘要： A first member is adapted to measure an electrocardiogram of a patient. A second member is adapted to measure a peripheral pulse wave of the patient. A first calculator calculates a pulse wave propagation time (PWTT) and a heart rate (HR) of the patient based on the electrocardiogram and the peripheral pulse wave. A second calculator calculates a cardiac output (CO) of the patient with an equation of CO=(αK·PWTT+βK)·HR, where α, β and K are coefficients inherent to the patient.
摘要翻译：第一构件适于测量患者的心电图。第二构件适于测量患者的外周脉搏波。第一计算器基于心电图和外周脉搏波计算患者的脉搏波传播时间（PWTT）和心率（HR）。第二计算器用CO =（αK.PWTT+βK）·HR等式计算患者的心输出量（CO），其中α，β和K是患者固有的系数。

20. 发明授权

US06172266B2 Triazole derivative or slat thereof, preparation process thereof and pharmaceutical containing said compound as an effective ingredient 失效
标题翻译：三唑衍生物或其盐，其制备方法和含有所述化合物作为有效成分的药物
公开(公告)号：US06172266B2
公开(公告)日：2001-01-09
申请号：US09471286
申请日：1999-12-23
申请人： Sunao Takeda , Yasushi Kaneko , Minoru Tokizawa , Hiromichi Eto , Kazuya Ishida , Kazunori Maebashi , Masaru Matsumoto , Takemitsu Asaoka , Susumu Sato
发明人： Sunao Takeda , Yasushi Kaneko , Minoru Tokizawa , Hiromichi Eto , Kazuya Ishida , Kazunori Maebashi , Masaru Matsumoto , Takemitsu Asaoka , Susumu Sato
IPC分类号： C07C32307
CPC分类号： C07D231/12 , C07C323/22 , C07C2601/02 , C07D233/56 , C07D249/08 , C07D303/34
摘要： Described is a triazole derivative represented by the formula (1): wherein R1 represents a hydrogen atom, a lower alkyl group or an aralkyl group, X1 and X2 are the same or different and each independently represents a hydrogen atom, a halogen atom or a halogenoalkyl and n stands for an integer of 0 to 2, or salt thereof; a preparation process of said compound and a pharmaceutical comprising said compound as an effective ingredient. The compound as described above has high antimycotic activity and is useful for the prevention and treatment of mammalian mycotic infections.
摘要翻译：描述了由式（1）表示的三唑衍生物：其中R1表示氢原子，低级烷基或芳烷基，X1和X2相同或不同，并且各自独立地表示氢原子，卤素原子或卤代烷基，n表示0〜2的整数，或其盐; 所述化合物的制备方法和包含所述化合物作为有效成分的药物。如上所述的化合物具有高抗真菌活性，并且可用于预防和治疗哺乳动物真菌感染。

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