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11. 发明授权

US07632618B2 Polyhydroxyalkanoate-containing structure and manufacturing method thereof 失效
标题翻译：含聚羟基链烷酸酯的结构及其制造方法
公开(公告)号：US07632618B2
公开(公告)日：2009-12-15
申请号：US12177094
申请日：2008-07-21
申请人： Tsuyoshi Nomoto , Tetsuya Yano , Shinya Kozaki , Tsutomu Honma
发明人： Tsuyoshi Nomoto , Tetsuya Yano , Shinya Kozaki , Tsutomu Honma
IPC分类号： C03G9/00 , C08G63/06 , C12N11/14 , C12P7/40
CPC分类号： C12N9/1025 , C12N11/00 , C12P7/625 , Y10T428/2989
摘要： A method for manufacturing polyhydroxyalkanoate-containing structure, at least a part of a base material surface of the structure being coated with polyhydroxyalkanoate, the method comprises the steps of immobilizing a polyhydroxyalkanoate synthase on the base material surface, synthesizing, on the base material surface, polyhydroxyalkanoate using a 3-hydroxyacyl coenzyme A to become the substrate of the synthase and the synthase and coating at least a part of the base material surface with the synthesized polyhydroxyalkanoate, wherein the synthase contains an amino acid sequence capable of binding to the base material. A polyhydroxyalkanoate-containing structure, at least a part of a base material surface of the structure being coated with a polyhydroxyalkanoate, comprises the base material, a polyhydroxyalkanoate synthase immobilized on the base material surface, and the polyhydroxyalkanoate with which at least a part of the base material surface is coated, wherein the synthase contains an amino acid sequence capable of binding to the base material.
摘要翻译：一种制备聚羟基链烷酸酯结构的方法，所述结构的基材表面的至少一部分涂覆有聚羟基链烷酸酯，所述方法包括以下步骤：将聚羟基链烷酸酯合酶固定在基材表面上，在基材表面上合成，聚羟基链烷酸酯使用3-羟酰基辅酶A成为合成酶和合成酶的底物并用合成的聚羟基链烷酸酯涂覆至少一部分基材表面，其中合成酶含有能够与基材结合的氨基酸序列。一种含聚羟基链烷酸酯的结构，该结构的基材表面的至少一部分涂覆有聚羟基链烷酸酯，其包含基材，固定在基材表面上的聚羟基链烷酸酯合酶和至少一部分的聚羟基链烷酸酯基材表面被涂覆，其中合成酶含有能够结合基材的氨基酸序列。

12. 发明授权

US06853477B2 Particles for electrophoresis, a production method thereof and a display using the particles 失效
标题翻译：用于电泳的颗粒，其制备方法和使用该颗粒的显示器
公开(公告)号：US06853477B2
公开(公告)日：2005-02-08
申请号：US10133405
申请日：2002-04-29
申请人： Tsuyoshi Nomoto , Tetsuya Yano , Shinya Kozaki , Tsutomu Honma
发明人： Tsuyoshi Nomoto , Tetsuya Yano , Shinya Kozaki , Tsutomu Honma
IPC分类号： G02F1/167 , C08G63/06 , C08G63/688 , C09B67/08 , C09C3/10 , C12P7/62 , G02B26/00 , A61K9/50 , G09G3/34 , G03G74/04
CPC分类号： B82Y30/00 , C01P2004/01 , C01P2004/61 , C01P2004/64 , C01P2004/84 , C01P2006/60 , C01P2006/66 , C01P2006/90 , C08G63/06 , C08G63/6882 , C09B67/0013 , C09C3/10 , C12P7/625 , Y10T428/24331 , Y10T428/2998
摘要： Electrophoretic particles for electrophoretic display having excellent dispersibility and dispersion stability with time for insulating media, and being protected against coagulation, settling and the like, a process for production of the electrophoretic particles having high versatility for pigments to be used in response to a full-color display, and an electrophoretic display device using the electrophoretic particles that has an excellent memory property and is highly reliable are provided. The electrophoretic particles are formed using as at least a part of structure a pigment with at least a part of the surface covered with polyhydroxyalkanoate.
摘要翻译：用于电泳显示的电泳颗粒具有优异的分散性和分散稳定性以及绝缘介质随时间的分散稳定性，并且可防止凝结，沉降等。制备电子粒子的方法具有高反应性全色的颜料的通用性，并且提供了使用具有优异记忆性并且高度可靠的电泳粒子的电泳显示装置。电泳颗粒使用颜料的至少一部分结构形成，其中至少一部分表面被聚羟基链烷酸酯覆盖。

13. 发明授权

US07399644B2 Immunoassay, reagent for immunoassay, and production method of the same 有权
标题翻译：免疫测定法，免疫测定用试剂及其制造方法
公开(公告)号：US07399644B2
公开(公告)日：2008-07-15
申请号：US10453483
申请日：2003-06-04
申请人： Tsutomu Honma , Tetsuya Yano , Tsuyoshi Nomoto , Shinya Kozaki
发明人： Tsutomu Honma , Tetsuya Yano , Tsuyoshi Nomoto , Shinya Kozaki
IPC分类号： G01N33/551 , G01N33/532 , G01N33/543 , G01N33/569 , G01N33/573 , C12Q1/70
CPC分类号： G01N33/54353 , C07K7/06 , G01N33/585
摘要： An assay method for determining presence of a target antibody or antigen in a specimen qualitatively or quantitatively by mixing the specimen with an antigen or antibody immunologically reactive with the target antibody or antigen, and assaying the level of the immunological agglutination reaction, wherein the reactive antigen or antibody is effectively immobilized on the carrier via an amino acid sequence capable of binding to the carrier.
摘要翻译：一种用于通过将标本与抗原或抗体与靶抗体或抗原免疫反应的抗原或抗体定性或定量地测定样品中目标抗体或抗原的存在以及测定免疫凝集反应的水平的测定方法，其中所述反应性抗原或抗体通过能够结合载体的氨基酸序列有效地固定在载体上。

14. 发明授权

US06916861B2 Pigment containing ink and production method thereof 失效
标题翻译：含油墨的颜料及其制备方法
公开(公告)号：US06916861B2
公开(公告)日：2005-07-12
申请号：US10133402
申请日：2002-04-29
申请人： Tsuyoshi Nomoto , Tetsuya Yano , Shinya Kozaki , Tsutomu Honma
发明人： Tsuyoshi Nomoto , Tetsuya Yano , Shinya Kozaki , Tsutomu Honma
IPC分类号： C12N15/09 , C08G63/688 , C09C3/10 , C09D11/00 , C12N9/24 , C12P7/62 , C12P11/00 , C12R1/01 , C12R1/38 , C12N7/62 , C03G9/00 , C03G17/00
CPC分类号： C09D11/322 , C08G63/6882 , C12P7/625 , C12P11/00 , Y10T428/254 , Y10T428/2991
摘要： A micro-capsulated pigment containing pigment ink being excellent in density, fineness, transparency, and coloring and color rendering properties required for ink solutions and having excellent dispersibility and dispersion stability with time due to the reduced particle size is provided. At least a color material with at least part of the surfaces of pigment particles covered with polyhydroxyalkanoate, and a medium for dispersion of the color material are used to obtain the pigment ink.
摘要翻译：提供了含有油墨溶液所需的密度，细度，透明度，着色和着色性优异的微胶囊颜料，并且由于粒径减小而具有优异的分散性和分散稳定性随着时间的推移。至少一种颜色材料，其颜料颗粒的至少一部分表面被聚羟基链烷酸酯覆盖，并且使用着色材料的分散介质来获得颜料墨。

15. 发明授权

US07615233B2 Particulate construct comprising polyhydroxyalkanoate and method for producing it 失效
标题翻译：包含聚羟基链烷酸酯的颗粒构造物及其生产方法
公开(公告)号：US07615233B2
公开(公告)日：2009-11-10
申请号：US10191563
申请日：2002-07-10
申请人： Tetsuya Yano , Tsuyoshi Nomoto , Shinya Kozaki , Tsutomu Honma
发明人： Tetsuya Yano , Tsuyoshi Nomoto , Shinya Kozaki , Tsutomu Honma
IPC分类号： A01N25/34
CPC分类号： A61K8/11 , A61K8/35 , A61K9/5031 , A61K47/6925 , A61K49/223 , A61K2800/412 , A61Q17/04 , B01J13/04 , B01J13/06 , B01J13/14 , Y02A50/473
摘要： The invention provides a particulate construct comprising a polyhydroxyalkanoate to serve as microcapsules containing a drug, and serving a slow releasing preparation not associated with a practically unacceptable initial burst release but showing a practically acceptable zero-order release for a certain period and a producing method for such particulate construct, and a slow releasing preparation of a high drug content capable of stably incorporating the drug in the particulate construct such as microcapsules, and a producing method for such preparation.
摘要翻译：本发明提供了一种包含聚羟基链烷酸酯的颗粒构造物，用作含有药物的微胶囊，并且用于与实际上不可接受的初始爆发释放无关的缓释制剂，但在一定时间内显示出实际可接受的零级释放，这种颗粒构造物，以及能够稳定地将药物并入微粒构造物如微胶囊中的高药物含量的缓释制剂及其制备方法。

16. 发明申请

US20090061498A1 POLYHYDROXYALKANOATE-CONTAINING STRUCTURE AND MANUFACTURING METHOD THEREOF 失效
标题翻译：含聚羟基烷酸钾的结构及其制造方法
公开(公告)号：US20090061498A1
公开(公告)日：2009-03-05
申请号：US12177094
申请日：2008-07-21
申请人： Tsuyoshi Nomoto , Tetsuya Yano , Shinya Kozaki , Tsutomu Honma
发明人： Tsuyoshi Nomoto , Tetsuya Yano , Shinya Kozaki , Tsutomu Honma
IPC分类号： C12N11/02 , C08K3/04 , G03G9/093 , C12N11/14
CPC分类号： C12N9/1025 , C12N11/00 , C12P7/625 , Y10T428/2989
摘要： A method for manufacturing polyhydroxyalkanoate-containing structure, at least a part of a base material surface of the structure being coated with polyhydroxyalkanoate, the method comprises the steps of immobilizing a polyhydroxyalkanoate synthase on the base material surface, synthesizing, on the base material surface, polyhydroxyalkanoate using a 3-hydroxyacyl coenzyme A to become the substrate of the synthase and the synthase and coating at least a part of the base material surface with the synthesized polyhydroxyalkanoate, wherein the synthase contains an amino acid sequence capable of binding to the base material. A polyhydroxyalkanoate-containing structure, at least a part of a base material surface of the structure being coated with a polyhydroxyalkanoate, comprises the base material, a polyhydroxyalkanoate synthase immobilized on the base material surface, and the polyhydroxyalkanoate with which at least a part of the base material surface is coated, wherein the synthase contains an amino acid sequence capable of binding to the base material.
摘要翻译：一种制备聚羟基链烷酸酯结构的方法，所述结构的基材表面的至少一部分涂覆有聚羟基链烷酸酯，所述方法包括将聚羟基链烷酸酯合酶固定在基材表面上，在基材表面上合成，聚羟基链烷酸酯使用3-羟酰基辅酶A成为合成酶和合成酶的底物并用合成的聚羟基链烷酸酯涂覆至少一部分基材表面，其中合成酶含有能够与基材结合的氨基酸序列。一种含聚羟基链烷酸酯的结构，该结构的基材表面的至少一部分涂覆有聚羟基链烷酸酯，其包含基材，固定在基材表面上的聚羟基链烷酸酯合酶和至少一部分的聚羟基链烷酸酯基材表面被涂覆，其中合成酶含有能够结合基材的氨基酸序列。

17. 发明授权

US06951745B2 Polyhydroxyalkanoate-containing structure and manufacturing method thereof 失效
标题翻译：含聚羟基链烷酸酯的结构及其制造方法
公开(公告)号：US06951745B2
公开(公告)日：2005-10-04
申请号：US10191540
申请日：2002-07-10
申请人： Tsuyoshi Nomoto , Tetsuya Yano , Shinya Kozaki , Tsutomu Honma
发明人： Tsuyoshi Nomoto , Tetsuya Yano , Shinya Kozaki , Tsutomu Honma
IPC分类号： G03G9/09 , B41M5/00 , C07K7/08 , C07K17/14 , C08G63/90 , C09C3/10 , C09D11/02 , C09D11/037 , C09D11/322 , C12N9/10 , C12N11/00 , C12N15/09 , C12P7/62 , G02B5/20 , G02B5/22 , G03G9/087 , C12P7/16 , C12P11/00
CPC分类号： C12N9/1025 , C12N11/00 , C12P7/625 , Y10T428/2989
摘要： A method for manufacturing polyhydroxyalkanoate-containing structure, at least a part of a base material surface of the structure being coated with polyhydroxyalkanoate, the method comprises the steps of immobilizing a polyhydroxyalkanoate synthase on the base material surface, synthesizing, on the base material surface, polyhydroxyalkanoate using a 3-hydroxyacyl coenzyme A to become the substrate of the synthase and the synthase and coating at least a part of the base material surface with the synthesized polyhydroxyalkanoate, wherein the synthase contains an amino acid sequence capable of binding to the base material. A polyhydroxyalkanoate-containing structure, at least a part of a base material surface of the structure being coated with a polyhydroxyalkanoate, comprises the base material, a polyhydroxyalkanoate synthase immobilized on the base material surface, and the polyhydroxyalkanoate with which at least a part of the base material surface is coated, wherein the synthase contains an amino acid sequence capable of binding to the base material.
摘要翻译：一种制备聚羟基链烷酸酯结构的方法，所述结构的基材表面的至少一部分涂覆有聚羟基链烷酸酯，所述方法包括将聚羟基链烷酸酯合酶固定在基材表面上，在基材表面上合成，聚羟基链烷酸酯使用3-羟酰基辅酶A成为合成酶和合成酶的底物并用合成的聚羟基链烷酸酯涂覆至少一部分基材表面，其中合成酶含有能够与基材结合的氨基酸序列。一种含聚羟基链烷酸酯的结构，该结构的基材表面的至少一部分涂覆有聚羟基链烷酸酯，其包含基材，固定在基材表面上的聚羟基链烷酸酯合酶和至少一部分的聚羟基链烷酸酯基材表面被涂覆，其中合成酶含有能够结合基材的氨基酸序列。

18. 发明申请

US20050208635A1 Polyhydroxyalkanoate-containing structure and manufacturing method thereof 审中-公开
公开(公告)号：US20050208635A1
公开(公告)日：2005-09-22
申请号：US11119889
申请日：2005-05-03
申请人： Tsuyoshi Nomoto , Tetsuya Yano , Shinya Kozaki , Tsutomu Honma
发明人： Tsuyoshi Nomoto , Tetsuya Yano , Shinya Kozaki , Tsutomu Honma
IPC分类号： G03G9/09 , B41M5/00 , C07K7/08 , C07K17/14 , C08G63/90 , C09C3/10 , C09D11/02 , C09D11/037 , C09D11/322 , C12N9/10 , C12N11/00 , C12N15/09 , C12P7/62 , G02B5/20 , G02B5/22 , G03G9/087 , G03G9/00
CPC分类号： C12N9/1025 , C12N11/00 , C12P7/625 , Y10T428/2989
摘要： A method for manufacturing polyhydroxyalkanoate-containing structure, at least a part of a base material surface of the structure being coated with polyhydroxyalkanoate, the method comprises the steps of immobilizing a polyhydroxyalkanoate synthase on the base material surface, synthesizing, on the base material surface, polyhydroxyalkanoate using a 3-hydroxyacyl coenzyme A to become the substrate of the synthase and the synthase and coating at least a part of the base material surface with the synthesized polyhydroxyalkanoate, wherein the synthase contains an amino acid sequence capable of binding to the base material. A polyhydroxyalkanoate-containing structure, at least a part of a base material surface of the structure being coated with a polyhydroxyalkanoate, comprises the base material, a polyhydroxyalkanoate synthase immobilized on the base material surface, and the polyhydroxyalkanoate with which at least a part of the base material surface is coated, wherein the synthase contains an amino acid sequence capable of binding to the base material.

19. 发明授权

US07135540B2 Polyhydroxyalkanoate copolymer including unit having bromo group in side chain and method for producing the same 失效
标题翻译：聚羟基链烷酸酯共聚物，包括在侧链中具有溴基的单元及其制备方法
公开(公告)号：US07135540B2
公开(公告)日：2006-11-14
申请号：US10359600
申请日：2003-02-07
申请人： Tsutomu Honma , Shinya Kozaki , Takeshi Imamura , Takashi Kenmoku , Tatsuki Fukui , Etsuko Sugawa , Tetsuya Yano
发明人： Tsutomu Honma , Shinya Kozaki , Takeshi Imamura , Takashi Kenmoku , Tatsuki Fukui , Etsuko Sugawa , Tetsuya Yano
IPC分类号： C08G63/02
CPC分类号： C12P7/625 , C08G63/6822 , C08G63/6882 , C12P11/00
摘要： The invention provides a polyhydroxyalkanoate having a bromo group in a unit and being thermally stable and capable of arbitrarily controlling physical properties, and a producing method thereof. According to the invention, there are provided a polyhydroxyalkanoate copolymer including a 3-hydroxy-ω-bromoalkanoic acid unit represented by a formula—[OCH((CH2)nBr)CH2C(O)]— (n=1 to 8) (1) and a unit represented by a formula —[OCH((CH2)mR)CH2C(O)]— (2) within a same molecule, and a method for producing a polyhydroxyalkanoate copolymer by microorganisms, utilizing a ω-bromoalkanoic acid represented by a formula Br(CH2)pCH2CH2COOH (p=1 to 8) (20) and a compound represented by a formula R(CH2)qCH2CH2COOH (21) as raw materials.
摘要翻译：本发明提供一种具有溴基团并且是热稳定的并能够任意控制物理性能的聚羟基链烷酸酯及其制备方法。根据本发明，提供了一种包含由式 - [OCH（（CH 2）n）n Br表示的3-羟基-ω-溴代链烷酸单元的聚羟基链烷酸酯共聚物）CH 2 C（O）] - （n = 1-8）（1）和由式 - [OCH（（CH 2）2）（O）] - （2），以及通过微生物制备聚羟基链烷酸酯共聚物的方法，使用由以下化合物表示的ω-溴烷酸：式（Br 2 CH 2 CH 2 CH 2 CH 2 CH 2 CH 2 CH 2 COOH（p = 1〜8）（20 ）和由式R（CH 2 CH 2）q CH 2 CH 2 COOH（21）表示的化合物作为原料。

20. 发明授权

US07425432B2 Polyhydroxy alkanoate copolymer including within molecule unit having vinyl group or carboxyl group in side chain, and producing method therefor 有权
标题翻译：在侧链中具有乙烯基或羧基的分子单元内的聚羟基链烷酸酯共聚物及其制造方法
公开(公告)号：US07425432B2
公开(公告)日：2008-09-16
申请号：US10531689
申请日：2003-10-23
申请人： Takashi Kenmoku , Tetsuya Yano , Chieko Mihara , Shinya Kozaki , Tsutomu Honma , Tatsuki Fukui , Takeshi Imamura , Etsuko Sugawa
发明人： Takashi Kenmoku , Tetsuya Yano , Chieko Mihara , Shinya Kozaki , Tsutomu Honma , Tatsuki Fukui , Takeshi Imamura , Etsuko Sugawa
IPC分类号： C12P11/00 , C12P7/72 , C08G63/00 , C08G63/02 , C08G63/68
CPC分类号： C08G63/06 , C08G63/6882 , C12P7/625
摘要： The invention provides a PHA copolymer including at least a 3-hydroxy-ω-carboxyalkanoic acid represented by a formula (19) or (32) and simultaneously at least a unit represented by a formula (2) or a formula (3) in a molecule, a precursor PHA copolymer having a corresponding vinyl group or a corresponding alkoxycarbonyl group, a biosynthesis method thereof by microorganisms, and a method of producing a desired PHA copolymer from the precursor PHA copolymer: (wherein k, m, n are integers; R18 represents H, Na, K, R27? represents (A); R1 represents a substituent on a cyclohexyl group and represents H, CN, NO2, a halogen atom, CH3, C2H5, C3H7, CF3, C2F5, or C3F7; R includes a residue including a phenyl structure or a thienyl structure; these being independent for each unit).
摘要翻译：本发明提供一种PHA共聚物，其包含至少一种由式（19）或（32）表示的3-羟基-ω-羧基烷酸，同时至少由式（2）或式（3）表示的单元在分子，具有相应的乙烯基或相应的烷氧基羰基的前体PHA共聚物，微生物的生物合成方法以及由前体PHA共聚物制备所需PHA共聚物的方法（其中k，m，n为整数; R ＆lt; 18＆gt;＆gt;代表H，Na，K，R 27？表示（A）; R 1表示环己基上的取代基，代表H，CN ，NO 2 2，卤素原子，CH 3，C 2 H 5，C 3， H 3，CF 3，C 2 H 5，或C 3 H 3， R> R包括残基inc 提出苯基结构或噻吩基结构; 这些对于每个单元是独立的）。

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