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11. 发明申请

US20060154268A1 Circadian rhythm control gene cluster, DNA chip, and methods for using the DNA chip 审中-公开
标题翻译：昼夜节律控制基因簇，DNA芯片和使用DNA芯片的方法
公开(公告)号：US20060154268A1
公开(公告)日：2006-07-13
申请号：US11174992
申请日：2005-07-05
申请人： Takuro Yamamoto , Haruhiko Soma , Takayoshi Mamine , Toru Takumi , Yasukazu Nakahata
发明人： Takuro Yamamoto , Haruhiko Soma , Takayoshi Mamine , Toru Takumi , Yasukazu Nakahata
IPC分类号： C12Q1/68 , C07H21/04 , C12M1/34
CPC分类号： C07K14/4702
摘要： A circadian rhythm control gee cluster (Bmal1 gene, Npas2 gene, Rev-erbα, Dbp gene, Per3 gene, Per2 gene and Per1 gene) having a given expression timing and expression sequence under normal conditions is provided along with a DNA chip having, at least, the circadian control gene group sequentially arranged. There are also provided a method for predicting modulation in expression timing of the circadian rhythm control gene cluster, a method for detecting a circadian rhythm modulation, a method for selecting a circadian rhythm regulator, a method for screening a circadian rhythm regulator, and screening of a substance involving modulation of a circadian rhythm as a side effect, each using the DNA chip.
摘要翻译：在正常条件下具有给定表达时间和表达序列的昼夜节律控制gee簇（Bmal1基因，Npas2基因，Rev-erbalpha，Dbp基因，Per3基因，Per2基因和Per1基因）与DNA芯片一起提供，至少，昼夜节律控制基因组顺序排列。还提供了一种用于预测昼夜节律控制基因簇的表达定时中的调制的方法，用于检测昼夜节律调节的方法，选择昼夜节律调节剂的方法，筛选昼夜节律调节剂的方法，以及筛选一种涉及调节昼夜节律作为副作用的物质，每种都使用DNA芯片。

12. 发明授权

US4608695A Laser device formed with a stripe light emission region 失效
标题翻译：形成有条纹发光区域的激光装置
公开(公告)号：US4608695A
公开(公告)日：1986-08-26
申请号：US535788
申请日：1983-09-26
申请人： Tatsuji Oda , Takayoshi Mamine , Osamu Yoneyama
发明人： Tatsuji Oda , Takayoshi Mamine , Osamu Yoneyama
IPC分类号： H01S5/00 , H01S5/16 , H01S5/20 , H01S5/223 , H01S3/19
CPC分类号： H01S5/2232 , H01S5/16 , H01S5/20 , H01S5/2059
摘要： A semiconductor laser device having a stripe light emission region formed in an active layer, a bent portion formed in the active layer on a light end portion of the light emission region in a range of approximately the width of the light emission region, and a flat portion formed in the active layer the width of which is made larger than that of the light emission region inside of the end portion of the light emission region.
摘要翻译：具有形成在有源层中的条纹发光区域的半导体激光器件，形成在发光区域的光端部的有源层中的大致在发光区域的宽度范围内的弯曲部分，形成在有源层中的部分的宽度大于发光区域的端部内的发光区域的宽度。

13. 发明授权

US08623597B2 Bioassay method, bioassay device, and bioassay substrate 失效
标题翻译：生物测定法，生物测定装置和生物测定法
公开(公告)号：US08623597B2
公开(公告)日：2014-01-07
申请号：US10484134
申请日：2003-05-21
申请人： Takayoshi Mamine , Takuro Yamamoto
发明人： Takayoshi Mamine , Takuro Yamamoto
IPC分类号： C12Q1/68 , C12M1/00 , C12M1/34 , C12M3/00
CPC分类号： G01N33/543 , B01J2219/0036 , B01J2219/00362 , B01J2219/00378 , B01J2219/00527 , B01J2219/00536 , B01J2219/00576 , B01J2219/00585 , B01J2219/00596 , B01J2219/00653 , B01J2219/00659 , B01J2219/00677 , B01J2219/00722 , B01J2219/00725 , C40B40/06 , C40B40/10 , C40B60/14 , G01N33/54366 , G01N33/54373 , G01N33/54393
摘要： Disclosed is a bioassay method in which, by controlling the electric field formation in the reaction region where an interaction between substances, such as a hybridization, is performed, the efficiency of the interaction can be improved. Also disclosed is a bioassay apparatus in which the method can be favorably carried out. The method includes at least a step of turning on/off the electric field formation by the electric field-forming means E at a predetermined timing.
摘要翻译：公开了一种生物测定方法，其中通过控制在进行诸如杂交的物质之间的相互作用的反应区域中的电场形成，可以提高相互作用的效率。还公开了可以有利地进行该方法的生物测定装置。该方法至少包括在预定定时通过电场形成装置E接通/断开电场形成的步骤。

14. 发明授权

US07718129B2 Bioassay substrate and bioassay device and method 有权
标题翻译：生物测定底物和生物测定装置及方法
公开(公告)号：US07718129B2
公开(公告)日：2010-05-18
申请号：US10559745
申请日：2004-06-10
申请人： Takayoshi Mamine , Yasuhiro Sakamoto , Motohiro Furuki , Isamu Nakao
发明人： Takayoshi Mamine , Yasuhiro Sakamoto , Motohiro Furuki , Isamu Nakao
IPC分类号： G01N21/00
CPC分类号： G01N21/6452 , G01N21/6428 , G01N33/582 , G01N35/00069 , G01N2021/6482
摘要： A bioassay substrate (1) takes a flat-plate shape in which the principal surface similar to that of optical disc such as CD, etc. is circular. At the center of the substrate (1), there is formed a center hole (2) into which a chucking mechanism for rotation and holding is inserted. The substrate (1) is rotationally driven with the center hole (2) being as center. On the substrate (1), there are formed two regions of a recording region (3) and a reaction region (4) which are formed in concentrical form in a radial direction. The recording region (3) is a region where, similarly to the optical disk information recording medium, laser beams are irradiated so that recording/reproduction of information is optically performed. The reaction region (4) is a region serving as the filed of mutual reaction between probe DNA (nucleotide chain for detection) and sample DNA (marked or labeled nucleotide chain), in concrete terms, the field of hybridization reaction.
摘要翻译：生物测定基板（1）采用平板形状，其中与诸如CD等的光盘类似的主表面是圆形的。在基板（1）的中心形成有中心孔（2），插入有用于旋转和保持的夹紧机构。基板（1）以中心孔（2）为中心旋转驱动。在基板（1）上形成有径向形成为同心圆形的记录区域（3）和反应区域（4）的两个区域。记录区域（3）是类似于光盘信息记录介质照射激光束以便光学地执行信息的记录/再现的区域。反应区（4）是用作探针DNA（检测用核苷酸）与样品DNA（标记或标记核苷酸链）之间相互反应的领域的区域，具体来说是杂交反应场。

15. 发明申请

US20090292111A1 ROR-alpha Promoting the Induction of Bmall 审中-公开
标题翻译： ROR-α促进Bmall的诱导
公开(公告)号：US20090292111A1
公开(公告)日：2009-11-26
申请号：US11909058
申请日：2006-03-27
申请人： Takuro Yamamoto , Takayoshi Mamine , Toru Takumi , Makoto Akashi
发明人： Takuro Yamamoto , Takayoshi Mamine , Toru Takumi , Makoto Akashi
IPC分类号： C07K16/00 , C07K14/00 , C07H21/02 , C07H21/04
CPC分类号： A61K31/7105 , A61K31/7088 , C07K14/4702 , C07K14/70567 , G01N33/743 , G01N2333/70567 , G01N2500/00
摘要： An object of the present invention is to clarify unelucidated aspects in the control mechanism of circadian rhythms. The present inventors have newly found that RORα (retinoic acid binding-receptor alpha; the same shall apply hereinafter) stimulates an induction of Bmal1 expression and also that the induction of Bmal1 expression is promoted under hypoxia. These findings strongly suggest the existence of a control mechanism of circadian rhythms that, when RORα expression is promoted under hypoxia or the like, an induction of Bmal1 expression is stimulated and, when the induction of Bmal1 expression is stimulated, binding between BMAL1 and CLOCK is stimulated and an induction of Per gene or Cry gene expression is stimulated. The present invention, therefore, has applicability as jet-lag regulating agents and anticancer agents.
摘要翻译：本发明的目的是澄清昼夜节律控制机制中的未消化方面。本发明人新发现，RORalpha（视黄酸结合受体α，以下相同）将刺激Bmal1表达的诱导，并且在缺氧下促进Bmal1表达的诱导。这些发现强烈地表明存在昼夜节律的控制机制，当在缺氧等下促进RORalpha表达时，刺激Bmal1表达的诱导，并且当刺激Bmal1表达的诱导时，BMAL1和CLOCK之间的结合是刺激并诱导Per基因或Cry基因表达。因此，本发明作为喷射滞后调节剂和抗癌剂具有适用性。

16. 发明申请

US20060128030A1 Bioassay substrate and bioassay device and method 有权
标题翻译：生物测定底物和生物测定装置及方法
公开(公告)号：US20060128030A1
公开(公告)日：2006-06-15
申请号：US10559745
申请日：2004-06-10
申请人： Takayoshi Mamine , Yasuhiro Sakamoto , Motohiro Furuki , Isamu Nakao
发明人： Takayoshi Mamine , Yasuhiro Sakamoto , Motohiro Furuki , Isamu Nakao
IPC分类号： G01N33/543 , C12M1/34
CPC分类号： G01N21/6452 , G01N21/6428 , G01N33/582 , G01N35/00069 , G01N2021/6482
摘要： A bioassay substrate (1) takes a flat-plate shape in which the principal surface similar to that of optical disc such as CD, etc. is circular. At the center of the substrate (1), there is formed a center hole (2) into which a chucking mechanism for rotation and holding is inserted. The substrate (1) is rotationally driven with the center hole (2) being as center. On the substrate (1), there are formed two regions of a recording region (3) and a reaction region (4) which are formed in concentrical form in a radial direction. The recording region (3) is a region where, similarly to the optical disk information recording medium, laser beams are irradiated so that recording/reproduction of information is optically performed. The reaction region (4) is a region serving as the filed of mutual reaction between probe DNA (nucleotide chain for detection) and sample DNA (marked or labeld nucleotide chain), in concrete terms, the field of hybridization reaction.
摘要翻译：生物测定基板（1）采用平板形状，其中与诸如CD等的光盘类似的主表面是圆形的。在基板（1）的中心形成有中心孔（2），插入有用于旋转和保持的夹紧机构。基板（1）以中心孔（2）为中心旋转驱动。在基板（1）上形成有径向形成为同心圆形的记录区域（3）和反应区域（4）的两个区域。记录区域（3）是类似于光盘信息记录介质照射激光束以便光学地执行信息的记录/再现的区域。反应区域（4）是用作探针DNA（检测用核苷酸链）和样品DNA（标记或者标记的核苷酸链）之间相互作用的区域的区域，具体来说是杂交反应场。

17. 发明申请

US20060127904A1 Hybridization sensing part, sensor chip, and hybridization method 审中-公开
标题翻译：杂交感测部分，传感器芯片和杂交方法
公开(公告)号：US20060127904A1
公开(公告)日：2006-06-15
申请号：US10525714
申请日：2003-08-20
申请人： Yuji Segawa , Takayoshi Mamine , Yasuhiro Sakamoto , Akira Yoshio , Takuro Yamamoto
发明人： Yuji Segawa , Takayoshi Mamine , Yasuhiro Sakamoto , Akira Yoshio , Takuro Yamamoto
IPC分类号： C12Q1/68 , C12M1/34
CPC分类号： B01J19/0046 , B01J2219/00436 , B01J2219/00529 , B01J2219/00576 , B01J2219/00596 , B01J2219/00608 , B01J2219/0061 , B01J2219/00612 , B01J2219/0063 , B01J2219/00653 , B01J2219/00713 , B01J2219/00722 , B01L3/502761 , B01L2200/0663 , B01L2300/0819 , B01L2400/0424 , B03C5/005 , B03C5/026 , G01N33/54373
摘要： The present invention provides a hybridization detector (1a) and the like that are improved in the hybridization efficiency by arraying nucleotide probes in a stretched form, a sensor chip including the hybridization detector (1a) or the like, and a method of hybridization using these detectors or the chip. The hybridization detector (la) and the like include a reaction region (R) for hybridization between the nucleotide probes (X) and target nucleotide sequences (Y) having a base sequence complementary to the nucleotide probes (X). The reaction region (R) has a configuration for stretching the nucleotide probes (X) by an electric field and immobilizing the nucleotide probes (X) on ends (E) of scanning electrodes (C) by dielectrophoresis.
摘要翻译：本发明提供了通过以拉伸形式排列核苷酸探针而提高杂交效率的杂交检测器（1a）等，包括杂交检测器（1a）的传感器芯片等，以及杂交方法使用这些探测器或芯片。杂交检测器（1a）等包括核苷酸探针（X）和碱基序列与核苷酸探针（X）互补的靶核苷酸序列（Y）之间进行杂交的反应区域（R）。反应区域（R）具有通过电场拉伸核苷酸探针（X）的构造，并且通过介电电泳将扫描电极（C）的端部（E）固定在核苷酸探针（X）上。

18. 发明申请

US20050069880A1 Bioassay method, bioassay device, and bioassay substrate 失效
标题翻译：生物测定法，生物测定装置和生物测定法
公开(公告)号：US20050069880A1
公开(公告)日：2005-03-31
申请号：US10484134
申请日：2003-05-21
申请人： Takayoshi Mamine , Takuro Yamamoto
发明人： Takayoshi Mamine , Takuro Yamamoto
IPC分类号： C12Q1/68 , C40B40/06 , C40B40/10 , C40B60/14 , G01N33/543
CPC分类号： G01N33/543 , B01J2219/0036 , B01J2219/00362 , B01J2219/00378 , B01J2219/00527 , B01J2219/00536 , B01J2219/00576 , B01J2219/00585 , B01J2219/00596 , B01J2219/00653 , B01J2219/00659 , B01J2219/00677 , B01J2219/00722 , B01J2219/00725 , C40B40/06 , C40B40/10 , C40B60/14 , G01N33/54366 , G01N33/54373 , G01N33/54393
摘要： Disclosed is a bioassay method in which, by controlling the electric field formation in the reaction region where an interaction between substances, such as a hybridization, is performed, the efficiency of the interaction can be improved. Also disclosed is a bioassay apparatus in which the method can be favorably carried out. In the method, an interaction between substances is detected by a detecting element 1 (10), the detecting element including at least a detection surface S (S′) which is surface-treated for immobilizing a detecting substance D, a reaction region R (R′) which provides a field for interaction between the detecting substance D immobilized on the detection surface S (S′) and a target substance T, and an electric field-forming means E which forms an electric field in the reaction region R (R′) by applying a potential difference in the reaction region R (R′), and the method includes at least a step of turning on/off the electric field formation by the electric field-forming means E at a predetermined timing.
摘要翻译：公开了一种生物测定方法，其中通过控制在进行诸如杂交的物质之间的相互作用的反应区域中的电场形成，可以提高相互作用的效率。还公开了可以有利地进行该方法的生物测定装置。在该方法中，通过检测元件1（10）检测物质之间的相互作用，检测元件至少包括用于固定检测物质D进行表面处理的检测表面S（S'），反应区域R（ R'），其提供固定在检测表面S（S'）上的检测物质D与目标物质T之间的相互作用的场和在反应区域R（R）中形成电场的电场形成装置E '）通过在反应区域R（R'）中施加电位差，并且该方法至少包括在预定的时刻由电场形成装置E接通/关闭电场形成的步骤。

19. 发明授权

US4203780A Fe Ion implantation into semiconductor substrate for reduced lifetime sensitivity to temperature 失效
标题翻译： Fe离子注入半导体衬底，降低寿命对温度的敏感性
公开(公告)号：US4203780A
公开(公告)日：1980-05-20
申请号：US936104
申请日：1978-08-23
申请人： Takeshi Matsushita , Takayoshi Mamine , Hisao Hayashi , Kazuo Nishiyama
发明人： Takeshi Matsushita , Takayoshi Mamine , Hisao Hayashi , Kazuo Nishiyama
IPC分类号： H01L21/22 , H01L29/167 , H01L21/263
CPC分类号： H01L29/167 , H01L21/221 , Y10S438/917
摘要： A method of an iron Fe ion implantation into a semiconductor substrate of an N-type conductivity is disclosed. The method comprises the steps of implanting Fe ions into an N-type semiconductor substrate from its one surface with the dose amount of 10.sup.10 to 10.sup.15 cm.sup.-2 and heat-treating the semiconductor substrate with Fe ions at 850.degree. to 1250.degree. C. to control the lifetime of the minority carrier in the substrate and hence to reduce the temperature dependency of the lifetime.
摘要翻译：公开了将铁Fe离子注入到N型电导率的半导体衬底中的方法。该方法包括以下步骤：从其一个表面将剂量为1010至1015cm -2的Fe离子注入到N型半导体衬底中，并用850°至1250℃的Fe离子对半导体衬底进行热处理，控制底物中少数载体的寿命，从而降低寿命的温度依赖性。

20. 发明授权

US4015280A Multi-layer semiconductor photovoltaic device 失效
标题翻译：多层半导体光电器件
公开(公告)号：US4015280A
公开(公告)日：1977-03-29
申请号：US622500
申请日：1975-10-15
申请人： Takeshi Matsushita , Takayoshi Mamine
发明人： Takeshi Matsushita , Takayoshi Mamine
IPC分类号： H01L31/04 , H01L31/068 , H01L31/0687 , H01L31/10
CPC分类号： H01L31/0687 , Y02E10/544
摘要： A semiconductor photovoltaic device is comprised of 2n layers of alternating p-type and n-type material having respective PN junctions between adjacent layers, wherein n is an integer greater than 1. Each layer has a thickness which is less than the diffusion length of a minority carrier therein. The PN junctions are excited by light which is incident on the device to thereby cause majority carriers to be accumulated in the respective layers so as to forward bias all of the PN junctions. As a result of this forward biasing, minority carriers are injected across a first PN junction fr0m one layer into an adjacent layer and then traverse the next PN junction into the next succeeding layer. The photovoltaic device thus is adapted to supply a voltage and a current to a load.
摘要翻译：半导体光伏器件由2n层交替的p型和n型材料构成，在相邻层之间具有相应的PN结，其中n是大于1的整数。每个层的厚度小于a的扩散长度少数载体。 PN结被入射到器件上的光激发，从而使多数载流子累积在各层中，以便对所有PN结进行正向偏置。作为这种向前偏置的结果，少数载流子跨越第一PN结fr0m注入相邻层中，然后穿过下一个PN结进入下一个后续层。因此，光伏器件适于向负载提供电压和电流。

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