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11. 发明授权

US5374429A Medical adhesive sheet and medical preparation 失效
标题翻译：医用胶片和医药准备
公开(公告)号：US5374429A
公开(公告)日：1994-12-20
申请号：US46962
申请日：1993-04-16
申请人： Takashi Kinoshita , Saburo Otsuka , Hitoshi Akemi , Kazuhiro Higashio
发明人： Takashi Kinoshita , Saburo Otsuka , Hitoshi Akemi , Kazuhiro Higashio
IPC分类号： A61F13/00 , A61F13/02 , A61K9/70 , A61L15/58 , B32B27/12
CPC分类号： A61K9/7061 , A61F13/023 , A61L15/58 , B32B27/12 , A61F2013/00578 , A61F2013/00604 , A61F2013/00744 , A61F2013/00906 , A61F2013/0091
摘要： A medical adhesive sheet comprising a support comprising a laminate of a polyester film having a thickness of from 0.5 to 6 .mu.m and a polyester nonwoven fabric having a basis weight of from 5 to 20 g/m.sup.2, and a pressure-sensitive adhesive layer laminated on the surface of the nonwoven fabric.
摘要翻译：一种医用胶粘片，其特征在于，具有由厚度为0.5〜6μm的聚酯薄膜和单位面积重量为5〜20g / m 2的聚酯无纺布构成的层压体的层叠体和叠层的粘合剂层在无纺织物的表面上。

12. 发明授权

US5204109A Percutaneous gel preparation 失效
标题翻译：经皮凝胶制备
公开(公告)号：US5204109A
公开(公告)日：1993-04-20
申请号：US855493
申请日：1992-03-23
申请人： Hitoshi Akemi , Saburo Otsuka , Takashi Kinoshita , Yoshifumi Hosaka , Yoshihisa Nakano
发明人： Hitoshi Akemi , Saburo Otsuka , Takashi Kinoshita , Yoshifumi Hosaka , Yoshihisa Nakano
IPC分类号： A61K9/70 , A61K31/34 , A61K31/565
CPC分类号： A61K9/7061 , A61K31/34 , A61K31/565
摘要： A percutaneous gel preparation is disclosed, which comprises a substrate having one surface thereof a crosslinked gel layer formed by crosslinking a composition comprising the following ingredients (a) to (c), the weight ratio of the ingredient (b) to the ingredient (c) being from 1.0/0.25 to 1.0/2.0:(a) isosorbide dinitrate;(b) an acrylate polymer; and(c) a liquid ingredient compatible with the ingredient (b).
摘要翻译：公开了一种经皮凝胶制剂，其包含其一个表面具有通过交联包含以下成分（a）至（c）的组合物，成分（b）与成分（c）的重量比）形成的交联凝胶层的基材）为1.0 / 0.25〜1.0 / 2.0：（a）硝酸异山梨酯; （b）丙烯酸酯聚合物; 和（c）与成分（b）相容的液体成分。

13. 发明授权

US08591939B2 Adhesive preparation containing fentanyl 有权
标题翻译：含芬太尼的粘合剂
公开(公告)号：US08591939B2
公开(公告)日：2013-11-26
申请号：US11196935
申请日：2005-08-04
申请人： Yuji Saeki , Masato Nishimura , Kensuke Matsuoka , Takateru Muraoka , Yoshifumi Hosaka , Mitsuhiko Hori , Kazuhisa Ninomiya , Hitoshi Akemi , Hidetoshi Kuroda
发明人： Yuji Saeki , Masato Nishimura , Kensuke Matsuoka , Takateru Muraoka , Yoshifumi Hosaka , Mitsuhiko Hori , Kazuhisa Ninomiya , Hitoshi Akemi , Hidetoshi Kuroda
IPC分类号： A61K31/445 , A61F13/02
CPC分类号： A61K9/7053 , A61K31/4468
摘要： The present invention provides a Fentanyl-containing percutaneously absorbable adhesive preparation, which is obtained from economic starting materials, has a constitution simpler than that of conventional ones, has sufficient skin permeability, and which permits control of skin permeability by changing the mixing ratio of two kinds of polyisobutylene having different molecular weights, a tackifier and an organic liquid. Specifically, the present invention provides a percutaneously absorbable adhesive preparation comprising a support and an adhesive layer laminated on one surface thereof, wherein the adhesive layer comprises Fentanyl, two kinds of polyisobutylene having different molecular weights, a tackifier and an organic liquid compatible with the aforementioned two kinds of polyisobutylene and the aforementioned tackifier.
摘要翻译：本发明提供了一种经济起始材料得到的含有芬太尼的经皮吸收性粘合剂制剂，其结构比以往更简单，具有足够的皮肤渗透性，并且通过改变两者的混合比可以控制皮肤渗透性种类具有不同分子量的聚异丁烯，增粘剂和有机液体。具体地说，本发明提供了一种经皮吸收性粘合剂制剂，其包含在其一个表面上层叠的载体和粘合剂层，其中所述粘合剂层包括芬太尼，两种具有不同分子量的聚异丁烯，增粘剂和与上述相容的有机液体两种聚异丁烯和上述增粘剂。

14. 发明申请

US20060034900A1 Adhesive preparation containing fentanyl 有权
公开(公告)号：US20060034900A1
公开(公告)日：2006-02-16
申请号：US11196935
申请日：2005-08-04
申请人： Yuji Saeki , Masato Nishimura , Kensuke Matsuoka , Takateru Muraoka , Yoshifumi Hosaka , Mitsuhiko Hori , Kazuhisa Ninomiya , Hitoshi Akemi , Hidetoshi Kuroda
发明人： Yuji Saeki , Masato Nishimura , Kensuke Matsuoka , Takateru Muraoka , Yoshifumi Hosaka , Mitsuhiko Hori , Kazuhisa Ninomiya , Hitoshi Akemi , Hidetoshi Kuroda
IPC分类号： A61K31/445 , A61F13/02
CPC分类号： A61K9/7053 , A61K31/4468
摘要： The present invention provides a Fentanyl-containing percutaneously absorbable adhesive preparation, which is obtained from economic starting materials, has a constitution simpler than that of conventional ones, has sufficient skin permeability, and which permits control of skin permeability by changing the mixing ratio of two kinds of polyisobutylene having different molecular weights, a tackifier and an organic liquid. Specifically, the present invention provides a percutaneously absorbable adhesive preparation comprising a support and an adhesive layer laminated on one surface thereof, wherein the adhesive layer comprises Fentanyl, two kinds of polyisobutylene having different molecular weights, a tackifier and an organic liquid compatible with the aforementioned two kinds of polyisobutylene and the aforementioned tackifier.

15. 发明授权

US07056526B2 Medical adhesive composition, medical adhesive tape using the same and tape preparation for percutaneous absorption 失效
公开(公告)号：US07056526B2
公开(公告)日：2006-06-06
申请号：US10230495
申请日：2002-08-29
申请人： Hidetoshi Kuroda , Takateru Muraoka , Keigo Inosaka , Hitoshi Akemi
发明人： Hidetoshi Kuroda , Takateru Muraoka , Keigo Inosaka , Hitoshi Akemi
IPC分类号： A61K9/70
CPC分类号： A61K9/7061 , A61L15/58 , Y10T428/28 , C08L39/06
摘要： The present invention provides a medical adhesive tape and a tape preparation for percutaneous absorption, both having an adhesive layer that resists glue remainder and stickiness upon peeling off of the tape even after adhesion to the human skin for a long time, and a medical adhesive composition to be used for such tapes. The medical adhesive composition of the present invention includes, as essential elements, (A) a copolymer containing (a) alkyl (meth)acrylate, wherein the alkyl moiety has 4 to 18 carbon atoms, in a proportion of not less than 50 wt % of the copolymer and (b) a carboxyl group-containing vinyl compound in a proportion of 0.1 wt %–10 wt % of the copolymer, (B) an alkoxide or a chelate compound of at least a metal selected from titanium, zirconium, zinc and aluminum, and (C) a polyol compound in a proportion of 0.2 wt %–5 wt % of the aforementioned medical adhesive composition. The medical adhesive tape of the present invention and tape preparation for percutaneous absorption are characterized in that the adhesive layer contains the above-mentioned medical adhesive composition of the present invention.

16. 发明申请

US20100178321A1 PRESSURE-SENSITIVE ADHESIVE COMPOSITION APPLICABLE TO NAIL AND ADHESIVE AGENT FOR NAIL 审中-公开
标题翻译：适用于指甲和粘合剂的压敏粘合剂组合物
公开(公告)号：US20100178321A1
公开(公告)日：2010-07-15
申请号：US12729675
申请日：2010-03-23
申请人： Akinori HANATANI , Hitoshi Akemi
发明人： Akinori HANATANI , Hitoshi Akemi
IPC分类号： A61K8/89 , A61K9/70 , A61Q3/00
CPC分类号： A61K8/0208 , A61K8/02 , A61K8/891 , A61Q3/00 , C08L83/00 , C08L2666/02 , C09J183/04
摘要： The present invention aims at providing a pressure-sensitive adhesive composition applicable to nail, which shows superior adhesive performance (adhesive force, cohesion etc.), and superior drug releasability and drug stability, and an adhesive agent for nail, which uses this composition. The composition of the present invention contains a condensation polymer of a silicone resin and a silicone rubber. The composition of the present invention preferably contains not less than two kinds of condensation polymers having different resin/rubber ratios. The adhesive agent of the present invention has a support and an adhesive layer formed on one surface of the support, which contains the above-mentioned composition.
摘要翻译：本发明的目的在于提供一种适用于指甲的压敏粘合剂组合物，其具有优异的粘合性能（粘合力，内聚力等）和优异的药物释放性和药物稳定性，以及使用该组合物的指甲粘合剂。本发明的组合物含有有机硅树脂和硅橡胶的缩聚物。本发明的组合物优选含有不少于两种具有不同树脂/橡胶比的缩聚物。本发明的粘合剂具有形成在载体的一个表面上的载体和粘合剂层，其包含上述组合物。

17. 发明申请

US20100010043A1 PERCUTANEOUSLY ABSORBABLE PREPARATION 审中-公开
标题翻译： PERCUTANEOUSYOUSLY可吸收制剂
公开(公告)号：US20100010043A1
公开(公告)日：2010-01-14
申请号：US12475249
申请日：2009-05-29
申请人： Akinori Hanatani , Junichi Sekiya , Sachiko Terashi , Sumiyo Nishi , Hitoshi Akemi
发明人： Akinori Hanatani , Junichi Sekiya , Sachiko Terashi , Sumiyo Nishi , Hitoshi Akemi
IPC分类号： A61K31/445 , C07D211/08
CPC分类号： A61K31/4465 , A61K9/7053 , A61K9/7061
摘要： The present invention provides a percutaneously absorbable preparation comprising 2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxyindan-1-one and/or a hydrochloride thereof wherein the percuneously absorbable preoaration is able to administer to a patient such that Cmax per unit surface area of the percutaneously absorbable preparation is 0.025 to 0.5 ng/ml·cm2 in a plasma concentration profile.
摘要翻译：本发明提供了包含2 - [（1-苄基哌啶-4-基）甲基] -5,6-二甲氧基茚满-1-酮和/或其盐酸盐的经皮吸收制剂，其中可以吸收的预制剂能够施用于使得经皮吸收制剂的每单位表面积的C max在血浆浓度分布中为0.025至0.5ng / ml.cm 2。

18. 发明授权

US08394404B2 Adhesive material and adhesive preparation 有权
标题翻译：胶粘材料和粘合剂制备
公开(公告)号：US08394404B2
公开(公告)日：2013-03-12
申请号：US11196936
申请日：2005-08-04
申请人： Hitoshi Akemi , Kazuhisa Ninomiya , Hidetoshi Kuroda , Kensuke Matsuoka , Yuji Saeki , Masato Nishimura
发明人： Hitoshi Akemi , Kazuhisa Ninomiya , Hidetoshi Kuroda , Kensuke Matsuoka , Yuji Saeki , Masato Nishimura
IPC分类号： A61L15/16 , C08F136/00
CPC分类号： A61K9/7053
摘要： The present invention provides an adhesive material to be adhered to the skin etc., which maintains, for a certain time period after adhesion thereof to the skin surface, suitable adhesiveness that does not allow easy peeling or cause irritation to the skin, and which permits, when it is to be peeled off from the skin surface after the lapse of a desired certain time period, easy peeling without causing pain or physical irritation, and an adhesive preparation containing the adhesive material and a percutaneously absorbable drug in the adhesive layer. Specifically, the present invention provides an adhesive material containing a support and an adhesive layer laminated on one surface of the support, wherein the adhesive layer has an apparent viscosity at 30° C. of 0.2×104 to 10×104 Pa·s and comprises two kinds of synthetic rubbers having different flowability.
摘要翻译：本发明提供粘附到皮肤等上的粘合剂材料，其在粘附到皮肤表面上一段时间后保持适合的粘合性，其不容易剥离或对皮肤产生刺激，并且允许当在期望的特定时间段之后要从皮肤表面剥离时，易于剥离而不引起疼痛或身体刺激，以及在粘合剂层中含有粘合剂材料和经皮吸收药物的粘合剂。具体地说，本发明提供了一种粘合剂材料，其包含层叠在载体的一个表面上的载体和粘合剂层，其中所述粘合剂层在30℃下的表观粘度为0.2×10 4至10×10 4 Pa·s，并且包含两种具有不同流动性的合成橡胶。

19. 发明授权

US08033395B2 Patch package structure 有权
标题翻译：贴片包装结构
公开(公告)号：US08033395B2
公开(公告)日：2011-10-11
申请号：US12314564
申请日：2008-12-12
申请人： Yoshihiro Iwao , Akinori Hanatani , Junichi Sekiya , Hitoshi Akemi
发明人： Yoshihiro Iwao , Akinori Hanatani , Junichi Sekiya , Hitoshi Akemi
IPC分类号： A61B19/02 , B65D73/00 , B65D65/26
CPC分类号： A61L15/24 , C08L33/20
摘要： The main object of the present invention is to provide a patch package structure including a patch containing a physiologically active ingredient and a package housing the patch, which is capable of stably retaining the physiologically active ingredient in the patch during preservation. This object can be achieved by employing the following constitution.To be specific, the present invention is a patch package structure including a patch 1 having an adhesive layer containing an organic liquid component, and a packaging member 51 housing the patch, wherein the packaging member 51 includes a first package 11, the first package 11 including an acrylonitrile resin layer 12, a moisture-absorbing layer 13 formed on the acrylonitrile resin layer 12, and a moisture impermeable layer 14 formed on the moisture-absorbing layer 13, and the acrylonitrile resin layer 12 is provided on the proximal side of the patch 1.
摘要翻译：本发明的主要目的是提供一种贴片包装结构，其包括含有生理活性成分的贴剂和容纳该贴剂的包装，其能够在保存期间稳定地保留贴剂中的生理活性成分。该目的可以通过采用以下结构来实现。具体而言，本发明是一种贴片包装结构，其包括具有含有有机液体成分的粘合剂层的贴片1和容纳该贴片的包装部件51，其中，包装部件51包括第一包装体11，第一包装体11 包括丙烯腈树脂层12，形成在丙烯腈树脂层12上的吸湿层13和形成在吸湿层13上的不透水层14和丙烯腈树脂层12设置在补丁1。

20. 发明授权

US07501358B2 Adhesive preparation 失效
标题翻译：粘合剂制备
公开(公告)号：US07501358B2
公开(公告)日：2009-03-10
申请号：US11402004
申请日：2006-04-12
申请人： Junichi Saito , Akinori Hanatani , Hitoshi Akemi
发明人： Junichi Saito , Akinori Hanatani , Hitoshi Akemi
IPC分类号： B32B27/04
CPC分类号： A61K9/7061 , Y10T442/20 , Y10T442/2738 , Y10T442/2754
摘要： The present invention provides an adhesive preparation superior in adhesion property, which does not peel off or fall off easily and which can be adhered for a long time. An adhesive preparation 10 has a support 1 made of a cloth, and a pressure sensitive adhesive layer 3 formed on one surface of the support 1, which contains a pressure sensitive adhesive and a drug. The ratio (CW/AW) of a mass (CW) per unit area of the support 1 and a mass (AW) per unit area of the pressure sensitive adhesive layer 3 is 1.0-5.0, an adhesive layer-free surface of the support 1 has a static friction coefficient of 0.25-0.75, and a 20% modulus (AM) in one direction of the adhesive preparation 10 and a 20% modulus (EM) in the direction perpendicular to that direction are each 0.5-1.5 N/cm, and the ratio thereof (AM/EM) is 0.5-2.0.
摘要翻译：本发明提供一种粘合性优异的粘合剂，其不会容易地剥离或脱落，并且可以长时间粘合。粘合剂10具有由布制成的支撑体1和形成在载体1的一个表面上的压敏粘合剂层3，该粘合剂层3含有压敏粘合剂和药物。支撑体1的每单位面积的质量（CW）的比（CW / AW）和压敏粘合剂层3的每单位面积的质量（AW）为1.0-5.0，载体的无粘合剂层的表面 1具有0.25-0.75的静摩擦系数，粘合剂10的一个方向上的20％模量（AM）和与该方向垂直的方向上的20％模量（EM）分别为0.5-1.5N / cm ，其比例（AM / EM）为0.5〜2.0。

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