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11. 发明授权

US4026960A 2,7,10,15,18,23-Hexamethyltetra-cosane 失效
标题翻译： 2,7,10,15,18,23-六甲基四亚甲基
公开(公告)号：US4026960A
公开(公告)日：1977-05-31
申请号：US486782
申请日：1974-07-09
申请人： Takashi Nishida , Yoichi Ninagawa , Kazuo Itoi , Yoshiaki Omura , Yoshin Tamai , Takeo Hosogai , Yoshiji Fujita
发明人： Takashi Nishida , Yoichi Ninagawa , Kazuo Itoi , Yoshiaki Omura , Yoshin Tamai , Takeo Hosogai , Yoshiji Fujita
IPC分类号： A61K8/31 , A61Q19/00 , C07C1/00 , C07C1/22 , C07C1/24 , C07C9/12 , C07C9/14 , C07C9/22 , C07C11/02 , C07C27/00 , C07C29/17 , C07C29/42 , C07C31/125 , C07C33/048 , C07C67/00 , C10M169/00 , C07C9/16
CPC分类号： A61Q19/00 , A61K8/31 , C07C1/22 , C07C9/22 , C10M3/00 , C10M2203/02 , C10M2203/022 , C10M2203/024 , C10M2203/04 , C10N2240/06
摘要： 2,7,10,15,18,23-Hexamethyltetracosane is a novel compound. This compound is prepared [1] by hydrogenating 2,7,10,15,18,23-hexamethyltetracosa-1,6,18,23-tetraene-11,13-diyne-10,15-diol [itself a novel compound] or 2,7,10,15,18,23-hexamethyltetracosa-11,13-diyne-10,15-diol, dehydrating the hydrogenated intermediates, and thence hydrogenating the dehydrated precursors, or [2] by selectively, partially hydrogenating the said 10,15-diol compounds and thence hydrogenolyzing the precursor diols, or [3] by hydrogenolyzing the said 10,15-diol compounds, or [4] by hydrogenolyzing the hydrogenated intermediates of the reaction [1]. The compound, 3,6,11-trimethyl-undeca-6,11-dien-1-yl-3-ol, a starting material intermediate, is also a novel compound.
摘要翻译： 2,7,10,15,18,23 - 六甲基二十六烷是一种新型化合物。该化合物通过氢化2,7,10,15,18,23-六甲基二十四-1,6,18,23-四烯-11,13-二炔-10,15-二醇[本身为新化合物]制备[1] 或2,7,10,15,18,23-六甲基二十四碳-1,11,13-二炔-10,15-二醇，使氢化中间体脱水，然后氢化脱水前体，或[2]通过选择性地部分氢化所述然后通过氢化前体二醇，或[3]通过氢化所述10,15-二醇化合物或[4]，使反应的氢化中间体氢化[1]。化合物3,6,11-三甲基 - 十一碳烯-6,11-二烯-1-基-3-醇，起始材料中间体，也是一种新型化合物。

12. 发明授权

US4105700A Process for preparing stereospecific nerolidol and ester thereof 失效
标题翻译：立体特异性橙花叔醇及其酯的制备方法
公开(公告)号：US4105700A
公开(公告)日：1978-08-08
申请号：US778730
申请日：1977-03-17
申请人： Yoshiji Fujita , Yoshiaki Omura , Takashi Nishida , Kazuo Itoi
发明人： Yoshiji Fujita , Yoshiaki Omura , Takashi Nishida , Kazuo Itoi
IPC分类号： C07C29/42 , C07C51/38 , C07C29/24
CPC分类号： C07C45/71 , C07C29/42 , C07C45/82 , C07C51/38 , C07C67/03 , C07C67/08 , C07C67/27 , C07C67/333 , C07C67/54 , C07B2200/09
摘要： A process for obtaining a stereospecific nerolidol at the .DELTA..sup.6 -position thereof by rectifying a mixture of .DELTA..sup.6 -cis-nerolidol and .DELTA..sup.6 -trans-nerolidol in rectification column having from 10 to 100 theoretical plates with a reflux ratio of from 2 to 200 at a temperature below 230.degree. C. under reduced pressure to separate each stereospecific nerolidol from said mixture.
摘要翻译：在DELTA 6-位上通过将具有10-100理论塔板的精馏塔中的DELTA 6-顺式 - 橙花叔醇和DELTA 6-反式 - 200在低于230℃的温度下在减压下分离每个立体特异性橙花叔醇与所述混合物。

13. 发明授权

US4028385A Process for preparing stereospecific farnesylacetic acid and ester thereof 失效
标题翻译：制备立体特异性法呢基乙酸及其酯的方法
公开(公告)号：US4028385A
公开(公告)日：1977-06-07
申请号：US605455
申请日：1975-08-18
申请人： Yoshiji Fujita , Yoshiaki Omura , Takashi Nishida , Kazuo Itoi
发明人： Yoshiji Fujita , Yoshiaki Omura , Takashi Nishida , Kazuo Itoi
IPC分类号： C07C29/42 , C07C45/67 , C07C45/82 , C07C51/38 , C11C3/02 , C11C1/00
CPC分类号： C07C45/82 , C07C29/42 , C07C45/67 , C07C45/676 , C07C51/38 , C07C67/27 , C07C67/333 , C07C67/54 , C12C11/02 , C07B2200/09
摘要： A process for preparing stereospecific farnesylacetic acid and ester thereof by rectifying a mixture of .DELTA..sup.4,8 -trans- and .DELTA..sup.4 -cis-.DELTA..sup.8 -trans-farnesylacetic acids or esters thereof or .DELTA..sup.4,8 -trans- and .DELTA..sup.4 -cis-.DELTA..sup.8 -trans-farnesylacetic acid or esters thereof or a mixture of four isomers of the said farnesylacetic acids or esters thereof.
摘要翻译：通过将DELTA 4,8-反式和DELTA4-顺式-ΔTA-8-反 - 法呢基乙酸或其酯或DELTA 4,8-反式和DELTA4-反式 - 法呢基乙酸的混合物进行精馏来制备立体特异性法呢基乙酸及其酯的方法，顺-9-反 - 法呢基乙酸或其酯或所述法呢基乙酸或其酯的四种异构体的混合物。

14. 发明授权

US4025539A Process for preparing 2-substituted or unsubstituted geranyl acetic acids and esters thereof 失效
标题翻译：制备2-取代或未取代的香叶基乙酸及其酯的方法
公开(公告)号：US4025539A
公开(公告)日：1977-05-24
申请号：US633612
申请日：1975-11-20
申请人： Yoshiji Fujita , Yoshiaki Omura , Takashi Nishida , Kazuo Itoi
发明人： Yoshiji Fujita , Yoshiaki Omura , Takashi Nishida , Kazuo Itoi
IPC分类号： C07C69/587 , A61K31/22 , C07C20060101 , C07C67/03 , C07C67/26 , C07C69/52 , C07C69/54 , C07C69/608 , C07C69/618 , C07C69/74 , C07C69/76 , C07C229/30 , C07D295/14 , C09F3/02 , C09F5/00
CPC分类号： C07C403/02 , C07C227/18 , C07C67/27 , C07C2101/14
摘要： 2-Substituted or unsubstituted geranyl actic acid esters represented by the general formula [I], ##STR1## wherein R.sub.1 represents a hydrogen atom or a hydrocarbon and R.sub.5 is the same as R.sub.2, R.sub.3 or R.sub.4 hereinafter defined, are prepared by reacting linalool (II) with 2-substituted or unsubstituted ortho acetic acid ester derivatives represented by the general formula [III] ##STR2## wherein R.sub.2, R.sub.3 and R.sub.4, which are the same or different, each represents an alkyl group or a cycloalkyl group, in the presence of an acidic catalyst.
摘要翻译： 2-取代或未取代的由通式[I]表示的香叶基肌酸酯，其中R1表示氢原子或烃，R5与下文定义的R2，R3或R4相同，是通过使芳樟醇（II）与通式[III]表示的2-取代或未取代的邻乙酸酯衍生物反应，其中相同或不同的R 2，R 3和R 4各自表示烷基或环烷基，在酸性催化剂的存在下。

15. 发明授权

US4603208A Certain polyprenyl intermediates 失效
标题翻译：某些聚异戊烯中间体
公开(公告)号：US4603208A
公开(公告)日：1986-07-29
申请号：US465483
申请日：1983-02-10
申请人： Takashi Onishi , Shigeaki Suzuki , Fumio Mori , Tetsuo Takigawa , Yoshiji Fujita , Masao Mizuno , Takashi Nishida
发明人： Takashi Onishi , Shigeaki Suzuki , Fumio Mori , Tetsuo Takigawa , Yoshiji Fujita , Masao Mizuno , Takashi Nishida
IPC分类号： C07C69/767 , C07C317/00 , C07C317/24 , C07D213/70 , C07D213/71 , C07D309/12 , C07D317/18 , C07D405/12 , C07D417/12 , C07F7/18 , C07C69/78 , C07C147/103
CPC分类号： C07D405/12 , C07C317/00 , C07C321/00 , C07D309/12 , C07D317/18 , C07D417/12 , C07F7/1852
摘要： Novel polyprenyl compounds have the general formula: ##STR1## represents a cis-isoprene unit, n is an integer of 11-19, Z.sup.1 is --CH.sub.2 OH or a functional precursor thereof, and either one of R.sup.1 and R.sup.2 is a hydrogen atom and the other is --S(O).sub.m R.sup.3 in which m is an integer of 0 (zero), 1 or 2 and R.sup.3 is a phenyl, naphthyl, pyridyl or thiazolinyl group or such group substituted with at least one lower alkyl and/or halogen substituent. The topic novel polyprenyl compounds can be synthesized from derivatives of the polyprenol which is obtainable from leaves of Ginkgo biloba or Cedrus deodara, among others, by extraction, if necessary followed by hydrolytic treatment. The novel polyprenyl compounds can be converted to mammalian dolichols or precursors thereof by reductive elimination of the --S(O).sub.m R.sup.3 group.
摘要翻译：新颖的聚异戊二烯化合物具有以下通式：其中n为11〜19的整数，Z 1为-CH 2 OH的整数，或其功能性前体，R 1和R 2中的任一个是氢原子，另一个是-S（O）m R 3，其中m是0（0），1或2的整数，并且R 3是苯基，萘基，吡啶基或噻唑啉基或该基团被至少一个低级烷基和/或卤素取代基取代。主题新颖的聚异戊二烯基化合物可以由聚乙二醇的衍生物合成，其可以通过提取，如果需要然后进行水解处理，可以从银杏叶或塞德斯酵母的叶获得。新的聚异戊烯基化合物可以通过-S（O）m R 3基团的还原性消除而转化为哺乳动物多烯醇或其前体。

16. 发明授权

US4659510A Trimethylcyclohexenyl compounds and aroma compositions containing the same 失效
标题翻译：三甲基环己烯化合物和含有它们的香气组合物
公开(公告)号：US4659510A
公开(公告)日：1987-04-21
申请号：US671194
申请日：1984-11-14
申请人： Takashi Ohnishi , Shigeaki Suzuki , Yoshiji Fujita , Takashi Nishida
发明人： Takashi Ohnishi , Shigeaki Suzuki , Yoshiji Fujita , Takashi Nishida
IPC分类号： A23L27/29 , C07C45/51 , C07C45/72 , C07C49/573 , C11B9/00 , A61K7/46 , C07C49/21
CPC分类号： C11B9/0034 , A23L27/29 , C07C45/511 , C07C45/72 , C07C49/573
摘要： Novel trimethylcyclohexenyl compounds of the 1,3,3-trimethyl-1-cyclohexene type having a 3-hydroxy-3-lower alkylpropionyl group at the 6-position of the cyclohexene are provided. These trimethylcyclohexenyl compounds have a floral note reminiscent of a variety of odors. There are also provided aroma compositions containing these compounds.
摘要翻译：提供了在环己烯的6位具有3-羟基-3-低级烷基丙酰基的1,3,3-三甲基-1-环己烯型的新型三甲基环己烯化合物。这些三甲基环己烯基化合物具有令人联想到各种气味的花香。还提供含有这些化合物的香气组合物。

17. 发明授权

US4270003A Hydroquinone derivatives and preparation thereof 失效
标题翻译：对苯二酚衍生物及其制备方法
公开(公告)号：US4270003A
公开(公告)日：1981-05-26
申请号：US62031
申请日：1979-07-30
申请人： Yoshiji Fujita , Takashi Ohnishi , Takashi Nishida
发明人： Yoshiji Fujita , Takashi Ohnishi , Takashi Nishida
IPC分类号： C07C37/62 , C07C43/225 , C07C317/18 , C07C147/08 , C07C43/20 , C07C43/205
CPC分类号： C07C317/18 , C07C41/22
摘要： The novel hydroquinone derivatives of the formula (I) are useful intermediates for the preparation of coenzyme Q, vitamin K and the polyprenyltrimethylquinones: ##STR1## wherein R.sup.1 is lower alkyl, lower alkoxy lower alkyl or methoxyethoxymethyl, R.sup.2 and R.sup.3 are each methyl or methoxy, or R.sup.2 and R.sup.3, taken together with the carbon atoms from which they depend, define a benzene ring, and R.sup.4 is a substituted or unsubstituted aromatic hydrocarbon. The compounds (I) are readily prepared either by reacting a Grignard reagent of the formula (II) with a halosulfone (III) in the presence of a copper compound, or by reacting a copper derivative (II') of the Grignard reagent (II) with a halo-sulfone (III), as follows: ##STR2## wherein R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are defined as above, and X is a halogen atom or a tosyl group.
摘要翻译：式（I）的新型氢醌衍生物是制备辅酶Q，维生素K和聚丙二酰基三甲基醌的有用的中间体：其中R 1是低级烷基，低级烷氧基低级烷基或甲氧基乙氧基甲基，R 2和R 3各自为甲基或甲氧基，或R 2和R 3与它们相应的碳原子一起定义苯环，并且R 4是取代或未取代的芳族烃。化合物（I）可以通过在铜化合物的存在下使式（II）的格氏试剂与卤代砜（III）反应，或者通过使格利雅试剂（II）的铜衍生物（II'））与卤代 - 砜（III）反应，如下：其中R 1，R 2，R 3和R 4如上定义，X为卤素原子或甲苯磺酰基。

18. 发明授权

US4215230A Production of ionones and irones by thermal rearrangement of propargylic alcohols 失效
标题翻译：通过炔丙醇的热重排生产紫罗兰酮和铁
公开(公告)号：US4215230A
公开(公告)日：1980-07-29
申请号：US908818
申请日：1978-05-23
申请人： Takashi Ohnishi , Yoshiji Fujita , Michihiro Ishiguro , Takashi Nishida
发明人： Takashi Ohnishi , Yoshiji Fujita , Michihiro Ishiguro , Takashi Nishida
IPC分类号： C07C33/05 , C07C33/14 , C07C45/45 , C07C49/543 , C07C403/00 , C07C45/00 , C07C33/02 , C07C33/04
CPC分类号： C07C49/543 , C07C29/42 , C07C33/14 , C07C403/08 , C07C45/455 , C07C2101/16
摘要： Ionones and irones are produced by thermal rearrangement of novel propargylic alcohols, as follows: ##STR1## wherein R.sup.1 is a lower alkyl group, R.sup.2 is hydrogen or methyl and the dotted lines in the product formula reflect the existence of a double bond at either one or the other of the positions indicated.
摘要翻译：紫罗兰酮和铁是通过新型炔丙醇的热重排产生的，如下：其中R1是低级烷基，R2是氢或甲基，并且产物式中的虚线反映了在任一种情况下存在双键或指示的其他职位。

19. 发明授权

US4303588A Farnesylacetic acid amides 失效
标题翻译：法呢基乙酸酰胺
公开(公告)号：US4303588A
公开(公告)日：1981-12-01
申请号：US132408
申请日：1980-03-21
申请人： Susumu Okabe , Yoshiaki Omura , Yoichi Ninagawa , Yoshiji Fujita
发明人： Susumu Okabe , Yoshiaki Omura , Yoichi Ninagawa , Yoshiji Fujita
IPC分类号： A01N37/20 , A61K31/16 , A61K31/40 , A61K31/495 , A61P1/04 , C07C233/38 , C07D211/26 , C07D211/58 , C07D295/13 , C11C3/00 , C07D211/22
CPC分类号： C07D295/13 , C07D211/26 , C07D211/58
摘要： Novel farnesylacetic acid amide compounds represented by general formula ##STR1## wherein A is alkylene of at least 2 carbon atoms, R.sup.1 is H or lower alkyl, and R.sup.2 and R.sup.3 are each independently H, alkyl, cycloalkyl, alkenyl, aryl or aralkyl, or either one of R.sup.2 and R.sup.3 is such a group that forms, together with A, a piperidine or pyrrolidine ring which contains as constituent thereof the nitrogen atom lying therebetween, or R.sup.2 and R.sup.3 combinedly represent a group which forms, together with the nitrogen atom to which they are bonded, a piperidine, pyrrolidine or piperazine ring; and salts thereof have antiulcerogenic and antibacterial activities.
摘要翻译：由通式表示的新型法呢基酰胺化合物，其中A为至少2个碳原子的亚烷基，R 1为H或低级烷基，R 2和R 3各自独立地为H，烷基，环烷基，烯基，芳基或芳烷基，或 R 2和R 3中的任一个是与A一起形成哌啶或吡咯烷环的基团，其中含有位于其间的氮原子作为其组成，或者R 2和R 3组合地表示与氮原子一起形成的基团它们是键合的，哌啶，吡咯烷或哌嗪环; 及其盐具有抗溃疡和抗菌活性。

20. 发明授权

US4289786A Farnesylacetic acid ester derivatives 失效
标题翻译：法呢基乙酸酯衍生物
公开(公告)号：US4289786A
公开(公告)日：1981-09-15
申请号：US96570
申请日：1979-11-21
申请人： Susumu Okabe , Yoshiaki Omura , Yoichi Ninagawa , Yoshiji Fujita
发明人： Susumu Okabe , Yoshiaki Omura , Yoichi Ninagawa , Yoshiji Fujita
IPC分类号： A61K31/215 , A61K31/22 , A61K31/445 , A61P1/04 , C07C67/00 , C07C213/00 , C07C219/08 , C07C219/10 , C07D211/22 , C07D211/42 , C07D211/46 , C07D295/088 , A61K31/23 , C09F5/08
CPC分类号： C07D295/088 , C07D211/22 , C07D211/42 , C07D211/46 , Y10S514/925
摘要： Novel farnesylacetic acid ester derivatives containing an amine nitrogen in the alcohol residue thereof and represented by the following general formula exhibit high levels of antiulcerogenic activity and very low levels of toxicity: ##STR1## wherein A is an alkylene radical containing at least 2 carbon atoms; R.sup.1 is H, alkyl, cycloalkyl, aryl, aralkyl or alkenyl; R.sup.2 and R.sup.3 are independently H, alkyl, aryl, aralkyl or alkenyl or one of R.sup.2 and R.sup.3 forms, together with A, a piperidine, pyrrolidine, tetrahydropyrimidine or piperazine ring which contains the nitrogen atom lying therebetween or R.sup.2 and R.sup.3 combine to form, together with the adjacent nitrogen atom, a piperazine ring; provided that the total number of carbon atoms contained in A, R.sup.1, R.sup.2 and R.sup.3 is at least 5.
摘要翻译：在其醇残基中含有胺氮并由下列通式表示的新型法呢基乙酸酯衍生物具有高水平的抗致癌活性和非常低的毒性水平：其中A是含有至少2个碳原子的亚烷基; R1是H，烷基，环烷基，芳基，芳烷基或烯基; R2和R3独立地是H，烷基，芳基，芳烷基或烯基或R2和R3中的一个与A，哌啶，吡咯烷，四氢嘧啶或哌嗪环一起形成，其中氮原子位于其间或R2和R3结合形成，与相邻的氮原子一起形成哌嗪环; 条件是A，R1，R2和R3中含有的碳原子总数至少为5。

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