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11. 发明申请

US20090053212A1 HUMANIZED ANTI-HUMAN OSTEOPONTIN ANTIBODY 失效
标题翻译：人类抗人类骨质疏松症抗体
公开(公告)号：US20090053212A1
公开(公告)日：2009-02-26
申请号：US11755671
申请日：2007-05-30
申请人： Nobuchika Yamamoto , Fumihiko Sakai , Hirofumi Higuchi , Masaharu Torikai , Toshihiro Nakashima
发明人： Nobuchika Yamamoto , Fumihiko Sakai , Hirofumi Higuchi , Masaharu Torikai , Toshihiro Nakashima
IPC分类号： A61K39/395 , C07K16/18 , C07H21/04 , C12N15/64 , A61P37/06 , C12N1/21 , C12P21/00
CPC分类号： C07K16/24 , A61K2039/505 , C07K2317/24 , C07K2317/56
摘要： The present invention provides a humanized anti-human osteopontin antibody having better activities (antigen binding activity, leukocyte migration inhibitory activity and the like) and/or stability (resistance to heat, low-pH conditions, denaturants and the like) than those of conventional anti-human osteopontin antibodies.
摘要翻译：本发明提供具有比常规的更好的活性（抗原结合活性，白细胞迁移抑制活性等）和/或稳定性（耐热，低pH条件，变性剂等）的人源化抗人骨桥蛋白抗体抗人骨桥蛋白抗体。

12. 发明申请

US20050199063A1 Electrostatically oscillated device 有权
标题翻译：静电摆动装置
公开(公告)号：US20050199063A1
公开(公告)日：2005-09-15
申请号：US11075708
申请日：2005-03-10
申请人： Hirofumi Higuchi
发明人： Hirofumi Higuchi
IPC分类号： B81B5/00 , G01C19/5762 , G01P15/08
CPC分类号： G01C19/5762
摘要： An oscillator is oscillatable in a predetermined direction. First and second driving electrodes are secured to the base and apply an electrostatic force to the oscillator to make drive oscillation of the oscillator in the predetermined direction. At the time of the drive oscillation of the oscillator, a predetermined electric charge is accumulated in the oscillator, and electric charges of opposite polarities are alternately and periodically accumulated in the first and second driving electrodes, respectively, to exert an attractive force between the oscillator and a corresponding one of the first and second driving electrodes and also to exert a repulsive force between the oscillator and the other one of the first and second driving electrodes, and vice versa.
摘要翻译：振荡器可在预定方向上振荡。第一驱动电极和第二驱动电极固定到基座并向振荡器施加静电力，以使振荡器在预定方向上的驱动振荡。在振荡器的驱动振荡时，在振荡器中累积预定的电荷，相反极性的电荷分别交替地周期地累积在第一和第二驱动电极中，以在振荡器之间施加吸引力以及第一和第二驱动电极中的相应一个，并且还在振荡器和第一和第二驱动电极中的另一个之间施加排斥力，反之亦然。

13. 发明授权

US5703272A Process for preparing a carboxylic acid ester 失效
标题翻译：羧酸酯的制备方法
公开(公告)号：US5703272A
公开(公告)日：1997-12-30
申请号：US707135
申请日：1996-09-03
申请人： Mariko Abe , Shuji Ebata , Takafumi Abe , Hirofumi Higuchi
发明人： Mariko Abe , Shuji Ebata , Takafumi Abe , Hirofumi Higuchi
IPC分类号： B01J21/06 , B01J21/08 , B01J37/03 , C07C67/08 , C07C69/02
CPC分类号： B01J21/063 , B01J21/08 , B01J37/03 , C07C67/08
摘要： A process for preparing a carboxylic acid ester which includes subjecting a carboxylic acid and an alcohol or a phenol to an esterification reaction in the presence of a silica-titania catalyst. The silica-titania catalyst is prepared by adding an acidic solution containing a silicon compound and a titanium compound dissolved therein to a solution of a basic compound to bring about co-precipitation, in which the acidic solution is a nitric acid-acidic solution or a sulfuric acid-acidic solution, a ratio of the amount (gram equivalent) of nitric acid or sulfuric acid to the amount (mol) of the silicon compound in the acidic solution is 0.5 to 50 and the amount of the titanium compound in the acidic solution is such that a ratio of titania (TiO.sub.2) in the silica-titania catalyst is 1 to 50% by weight.
摘要翻译：一种制备羧酸酯的方法，包括在二氧化硅 - 二氧化钛催化剂的存在下使羧酸和醇或酚进行酯化反应。二氧化硅 - 二氧化钛催化剂通过将含有硅化合物和溶解在其中的钛化合物的酸性溶液加入到碱性化合物的溶液中来进行共沉淀，其中酸性溶液是硝酸 - 酸性溶液或硫酸 - 酸性溶液，酸性溶液中的硝酸或硫酸的量（克当量）与硅化合物的量（摩尔）的比例为0.5〜50，酸性溶液中钛化合物的量使得二氧化硅 - 二氧化钛催化剂中的二氧化钛（TiO 2）的比例为1〜50重量％。

14. 发明授权

US5087750A Process for producing alpha-hydroxyisobutyric acid amide 失效
标题翻译：生产α-羟基丁酸酰胺的方法
公开(公告)号：US5087750A
公开(公告)日：1992-02-11
申请号：US586802
申请日：1990-09-24
申请人： Akitomo Uda , Shuji Ebata , Hirofumi Higuchi
发明人： Akitomo Uda , Shuji Ebata , Hirofumi Higuchi
IPC分类号： B01J23/34 , C07B61/00 , C07C231/06 , C07C235/06
CPC分类号： C07C231/065
摘要： A process for producing .alpha.-hydroisobutyric acid amide by a hydration reaction of acetonecyanohydrin in the presence of a catalyst containing manganese dioxide as a main component, and also in the presence of an oxidizing agent. In accordance with the process, the service life of the catalyst is increased, and the .alpha.-hydroxyisobutyric acid amide is produced in a high yield.

15. 发明授权

US5075493A Process for preparing .alpha., .beta.-unsaturated carboxylic acid ester 失效
标题翻译：制备（ALPHA），（BETA） - 饱和羧酸酯的方法
公开(公告)号：US5075493A
公开(公告)日：1991-12-24
申请号：US618040
申请日：1990-11-23
申请人： Yoshikazu Shima , Takafumi Abe , Hirofumi Higuchi , Koichi Kida
发明人： Yoshikazu Shima , Takafumi Abe , Hirofumi Higuchi , Koichi Kida
IPC分类号： B01J27/053 , B01J27/16 , B01J29/08 , C07B61/00 , C07C67/327 , C07C69/54
CPC分类号： C07C67/327
摘要： A process for producing .alpha., .beta.-unsaturated carboxylic acid ester which comprises catalytically reacting .alpha.-hydroxycarboxylic acid ester with crystalline aluminosilicate catalyst, and then catalytic reacting the resulting reaction product with solid acid catalyst.According to the process, .alpha., .beta.-unsaturated carboxylic acid ester of a high purity, and a high quality, without by-product, can be produced efficiently.

16. 发明授权

US5061675A Process for producing a denaturated manganese dioxide catalyst for the hydration reaction of cyanohydrins 失效
标题翻译：生产用于氰化氢水解反应的脱硫二氧化硅催化剂的方法
公开(公告)号：US5061675A
公开(公告)日：1991-10-29
申请号：US542835
申请日：1990-06-25
申请人： Shuji Ebata , Hiroyuki Hirayama , Hirofumi Higuchi , Koichi Kida
发明人： Shuji Ebata , Hiroyuki Hirayama , Hirofumi Higuchi , Koichi Kida
IPC分类号： B01J23/34 , C07B43/06 , C07C231/06
CPC分类号： B01J23/34 , C07C231/065
摘要： A process for producing a denatured manganese dioxide for the hydration reaction of cyanohydrins comprising reacting an aqueous permanganate salt solution and an aqueous manganese (II) compound in an acidic aqueous solution at a temperature of 70.degree. C. to 130.degree. C. is disclosed. The manganese dioxide catalyst obtained by the process exhibits a high activity over a long period in the preparation of an amide by the hydration of the corresponding cyanohydrin.

17. 发明申请

US20140214209A1 COMPLEX DEVICE AND ROBOT HAND DRIVE CONTROL APPARATUS 有权
标题翻译：复杂装置和机器人手动控制装置
公开(公告)号：US20140214209A1
公开(公告)日：2014-07-31
申请号：US14343526
申请日：2012-08-28
申请人： Makiko Sugiura , Hirofumi Higuchi
发明人： Makiko Sugiura , Hirofumi Higuchi
IPC分类号： B25J9/16 , G01L1/16 , B06B1/06
CPC分类号： B25J9/1612 , B06B1/0674 , B25J13/082 , G01B17/00 , G01L1/16 , G01L1/162 , G01L1/255 , G01L5/226
摘要： A complex device includes: a substrate having a thick portion, a cavity and a membrane for bridging the cavity; and multiple piezoelectric elements having a lower electrode, a piezoelectric film and an upper electrode. A part of the piezoelectric elements has a projecting portion arranged on the upper electrode. The part of piezoelectric elements (30) provides a vertical pressure detection element. The piezoelectric elements further have an ultrasonic element other than the vertical pressure detection element. The ultrasonic element is arranged over at least the cavity of the substrate in a horizontal direction.
摘要翻译：复杂装置包括：具有厚部分的基底，用于桥接空腔的空腔和膜; 以及具有下电极，压电膜和上电极的多个压电元件。压电元件的一部分具有布置在上电极上的突出部分。压电元件（30）的一部分提供垂直压力检测元件。压电元件还具有除垂直压力检测元件之外的超声波元件。超声波元件在水平方向上至少布置在基板的空腔上。

18. 发明授权

US08715655B2 Human anti-α9 integrin antibody 有权
标题翻译：人抗α9整联蛋白抗体
公开(公告)号：US08715655B2
公开(公告)日：2014-05-06
申请号：US12810939
申请日：2008-12-26
申请人： Masaharu Torikai , Daisuke Ishikawa , Toshihiro Nakashima , Hirofumi Higuchi , Fumihiko Sakai , Nobuchika Yamamoto , Hirotada Fujita , Katsunari Taguchi
发明人： Masaharu Torikai , Daisuke Ishikawa , Toshihiro Nakashima , Hirofumi Higuchi , Fumihiko Sakai , Nobuchika Yamamoto , Hirotada Fujita , Katsunari Taguchi
IPC分类号： A61K39/395 , C07K16/00 , C07K16/46 , C07K16/28 , G01N33/53
CPC分类号： C07K16/2839 , A61K2039/505 , C07K2317/21 , C07K2317/34 , C07K2317/52 , C07K2317/622 , C07K2317/92 , C07K2319/00
摘要： The present invention provides a human anti-α9 integrin antibody or an antibody fragment which specifically recognize human α9 integrin and mouse α9 integrin, inhibit interaction with their ligands, particularly, the antibody or antibody fragment which recognize loop regions of human and mouse α9 integrins, a gene encoding the antibody or antibody fragment, a recombinant expression vector containing the gene, a transformant harboring the gene, production method of human anti-α9 integrin antibody or antibody fragment using the transformant, and an agent for the prophylaxis or treatment of rheumatoid arthritis which contains the antibody or antibody fragment.
摘要翻译：本发明提供一种人抗α9整联蛋白抗体或特异性识别人α9整联蛋白和小鼠α9整联蛋白的抗体片段，抑制与其配体的相互作用，特别是识别人和小鼠α9整联蛋白环区的抗体或抗体片段，编码抗体或抗体片段的基因，含有该基因的重组表达载体，携带该基因的转化体，使用该转化体的人抗-α9整联蛋白抗体的制备方法或抗体片段，以及预防或治疗类风湿性关节炎其含有抗体或抗体片段。

19. 发明授权

US08413507B2 Semiconductor dynamic quantity sensor and method of manufacturing the same 有权
标题翻译：半导体动态量传感器及其制造方法
公开(公告)号：US08413507B2
公开(公告)日：2013-04-09
申请号：US12801405
申请日：2010-06-08
申请人： Tetsuo Fujii , Hisanori Yokura , Hirofumi Higuchi
发明人： Tetsuo Fujii , Hisanori Yokura , Hirofumi Higuchi
IPC分类号： G01C19/56 , G01P15/125
CPC分类号： H01L27/1203 , B81B2201/025 , B81B2201/0257 , B81B2201/0285 , B81B2201/047 , B81C1/00182 , G01C19/5755 , G01P15/0802 , G01P15/125 , G01P2015/0814 , H01L21/84
摘要： A semiconductor dynamic quantity sensor has a substrate including a semiconductor substrate, an insulation layer on a main surface of the semiconductor substrate, and a semiconductor layer on the insulation layer. The main surface has a projection that is trapezoidal or triangular in cross section. The semiconductor layer is divided by a through hole into a movable portion. A tip of the projection is located directly below the movable portion and spaced from the movable portion by a predetermined distance in a thickness direction of the substrate. A width of the tip of the projection is less than a width of the movable portion in a planar direction of the substrate. The distance between the tip of the projection and the movable portion is equal to a thickness of the insulation layer.
摘要翻译：半导体动态量传感器具有包括半导体衬底，半导体衬底的主表面上的绝缘层和绝缘层上的半导体层的衬底。主表面具有横截面为梯形或三角形的突起。半导体层由通孔分割成可动部。突出部的尖端位于可动部的正下方，与基板的厚度方向与可动部隔开预定的距离。突起的尖端的宽度小于基板的平面方向上的可动部的宽度。突起的尖端和可动部之间的距离等于绝缘层的厚度。

20. 发明申请

US20110059077A1 HUMANIZED ANTI-HUMAN ALPHA 9-INTEGRIN ANTIBODY 有权
标题翻译：人类抗人ALPHA 9整合抗体
公开(公告)号：US20110059077A1
公开(公告)日：2011-03-10
申请号：US12812341
申请日：2009-01-09
申请人： Kenji Uehara , Hirofumi Higuchi , Toshihiro Nakashima , Daisuke Ishikawa , Nobuchika Yamamoto , Hirotada Fujita , Fumihiko Sakai
发明人： Kenji Uehara , Hirofumi Higuchi , Toshihiro Nakashima , Daisuke Ishikawa , Nobuchika Yamamoto , Hirotada Fujita , Fumihiko Sakai
IPC分类号： C07K16/28 , C12N15/13 , C12N15/70 , C12N1/21 , C12P21/08 , A61K39/395
CPC分类号： C07K16/2839 , C07K2317/24 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C07K2317/94
摘要： The present invention provides a humanized anti-human α9 integrin antibody having improved activity and/or property as compared to a donor mouse anti-human α9 integrin antibody, namely, a humanized anti-human α9 integrin antibody containing a heavy-chain variable region consisting of the amino acid sequence shown by SEQ ID NO:11 and a light-chain variable region consisting of the amino acid sequence shown by SEQ ID NO:17, a humanized anti-human α9 integrin antibody containing a heavy-chain variable region consisting of the amino acid sequence shown by SEQ ID NO:13 and a light-chain variable region consisting of the amino acid sequence shown by SEQ ID NO:17, a humanized anti-human α9 integrin antibody containing a heavy-chain variable region consisting of the amino acid sequence shown by SEQ ID NO:15 and a light-chain variable region consisting of the amino acid sequence shown by SEQ ID NO:9, and a means for the prophylaxis or treatment of various diseases involving human α9 integrin in the pathogenesis, which uses the antibody.
摘要翻译：本发明提供与供体小鼠抗人α9整联蛋白抗体相比具有改善的活性和/或性质的人源化抗人α9整联蛋白抗体，即包含重链可变区的人源化抗人α9整联蛋白抗体，其包含的SEQ ID NO：11所示的氨基酸序列和由SEQ ID NO：17所示的氨基酸序列组成的轻链可变区，含有重链可变区的人源化抗人α9整联蛋白抗体由由SEQ ID NO：13所示的氨基酸序列和由SEQ ID NO：17所示的氨基酸序列组成的轻链可变区，包含由SEQ ID NO：17所示的重链可变区组成的人源化抗人α9整联蛋白抗体由SEQ ID NO：15所示的氨基酸序列和由SEQ ID NO：9所示的氨基酸序列组成的轻链可变区，以及用于预防或治疗涉及人α9整数的各种疾病的手段 rin在发病机制中，其使用抗体。

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