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11. 发明申请

WO2009005779A1 ATHERECTOMY DEVICES, SYSTEMS, AND METHODS 审中-公开
标题翻译： ATHERECTOMY设备，系统和方法
公开(公告)号：WO2009005779A1
公开(公告)日：2009-01-08
申请号：PCT/US2008/008140
申请日：2008-06-30
申请人： ATHEROMED, INC. , ESCUDERO, Paul , DANEK, Christopher, J. , TO, John , CHEE, Hiram , POMBO, August , SMITH, Torrey , HANN, Brenda
发明人： ESCUDERO, Paul , DANEK, Christopher, J. , TO, John , CHEE, Hiram , POMBO, August , SMITH, Torrey , HANN, Brenda
IPC分类号： A61B17/22
CPC分类号： A61B17/320758 , A61B2017/003 , A61B2017/00309 , A61B2017/00318 , A61B2017/00323 , A61B2017/00685 , A61B2017/22039 , A61B2017/22044 , A61B2017/22068 , A61B2017/22094 , A61B2017/320766 , A61B2017/320775
摘要： The devices and methods generally relate to treatment of occluded body lumens. In particular, the present devices and method relate to removal of the occluding material from the blood vessels as well as other body lumens.
摘要翻译：装置和方法通常涉及封闭体腔的治疗。特别地，本发明的装置和方法涉及从血管以及其它体腔去除闭塞材料。

12. 发明申请

WO2008005891A2 ATHERECTOMY DEVICES AND METHODS 审中-公开
公开(公告)号：WO2008005891A2
公开(公告)日：2008-01-10
申请号：PCT/US2007/072574
申请日：2007-06-29
申请人： ATHEROMED, INC. , TO, John , DANEK, Christopher James
发明人： TO, John , DANEK, Christopher James
IPC分类号： A61B17/3207
CPC分类号： A61B17/320783 , A61B17/22 , A61B17/32002 , A61B17/320708 , A61B17/320758 , A61B2017/003 , A61B2017/00318 , A61B2017/00331 , A61B2017/00685 , A61B2017/22038 , A61B2017/22039 , A61B2017/22041 , A61B2017/22044 , A61B2017/22068 , A61B2017/22094 , A61B2017/320032 , A61B2017/320716 , A61B2017/320741 , A61B2017/320775 , A61B2090/3735 , A61B2090/3784 , A61M25/0152 , A61M25/0155
摘要： The devices and methods generally relate to treatment of occluded body lumens. In particular, the present devices and method relate to removal of the occluding material from the blood vessels as well as other body lumens.

13. 发明申请

WO2014200737A1 MULTI-LUMEN-CATHETER RETRACTOR SYSTEM FOR A MINIMALLY-INVASIVE, OPERATIVE GASTROINTESTINAL TREATMENT 审中-公开
标题翻译：用于微型入路，手术胃肠道治疗的多用途导管系统
公开(公告)号：WO2014200737A1
公开(公告)日：2014-12-18
申请号：PCT/US2014/040429
申请日：2014-06-01
申请人： MACROPLATA INC. , PISKUN, Gregory , TO, John , FABRO, Mariel , TANG, Brian , KANTSEVOY, Sergey
发明人： PISKUN, Gregory , TO, John , FABRO, Mariel , TANG, Brian , KANTSEVOY, Sergey
IPC分类号： A61B1/00 , A61B1/018 , A61B17/02 , A61B17/34 , A61B1/31 , A61B1/32 , A61B17/00
CPC分类号： A61B17/0218 , A61B17/00234 , A61B2017/00331 , A61B2017/00557 , A61B2017/0225 , A61B2017/345
摘要： A system for performing minimally invasive procedures in a body lumen of a patient including a flexible catheter having a first lumen configured and dimensioned to receive an endoscope therethrough and a second lumen configured and dimensioned to receive a first flexible tube therethrough. The first flexible tube is movable through the second lumen and has a distal portion including a first curve extending in a first direction with respect to the longitudinal axis and a second curve extending in a second different direction with respect to the longitudinal axis. A retractor system is positioned at a distal portion of the catheter and is movable from a non-expanded insertion position to an expanded position forming an expanded cage to form a larger working space. The distal portion of the first flexible tube is movable within the expanded cage.
摘要翻译：一种用于在患者的体腔中执行微创手术的系统，包括柔性导管，所述柔性导管具有构造和尺寸以便容纳内窥镜的第一腔，以及构造和尺寸设计成容纳穿过其中的第一柔性管的第二腔。第一柔性管可移动穿过第二内腔，并且具有包括相对于纵向轴线在第一方向上延伸的第一曲线的远侧部分和相对于纵向轴线沿第二不同方向延伸的第二曲线。牵开器系统定位在导管的远端部分处，并且可从非扩张插入位置移动到扩展位置，形成扩张笼以形成更大的工作空间。第一柔性管的远侧部分可在扩展的笼内移动。

14. 发明申请

WO2013192116A1 MULTI-LUMEN-CATHETER RETRACTOR SYSTEM FOR A MINIMALLY-INVASIVE, OPERATIVE GASTROINTESTINAL TREATMENT 审中-公开
标题翻译：用于微型入路，手术胃肠道治疗的多用途导管系统
公开(公告)号：WO2013192116A1
公开(公告)日：2013-12-27
申请号：PCT/US2013/046200
申请日：2013-06-17
申请人： MACROPLATA INC. , PISKUN, Gregory , TO, John , FABRO, Mariel , TANG, Brian , KANTSEVOY, Sergey
发明人： PISKUN, Gregory , TO, John , FABRO, Mariel , TANG, Brian , KANTSEVOY, Sergey
IPC分类号： A61B1/00 , A61B1/018 , A61B17/02 , A61B17/34
CPC分类号： A61B1/00087 , A61B1/00135 , A61B1/00154 , A61B1/31 , A61B17/0218 , A61B17/083 , A61B17/122 , A61B17/1285 , A61B17/3421 , A61B2017/00278 , A61B2017/00287 , A61B2017/00296 , A61B2017/00323 , A61B2017/00336 , A61B2017/00818 , A61B2017/00902 , A61B2017/2212 , A61B2017/2905 , A61B2017/3445 , A61B2017/3447 , A61B2017/345 , A61B2090/08021 , F04C2270/041
摘要： Improved methods and devices for performing an endoscopic surgery are provided. Systems are taught for operatively treating gastrointestinal disorders endoscopically in a stable, yet dynamic operative environment, and in a minimally-invasive manner. Such systems include, for example, an endoscopic surgical suite. The surgical suite can have a reversibly-expandable retractor that expands to provide a stable, operative environment within a subject. The expansion can be asymmetric around a stabilizer subsystem to maximize space for a tool and an endoscope to each be maneuvered independently to visualize a target tissue and treat the target tissue from outside the patient in a minimally invasive manner.
摘要翻译：提供了用于进行内窥镜手术的改进的方法和装置。所述系统被教导用于在稳定而又动态的手术环境中以微创方式内窥镜治疗胃肠道疾病。这样的系统包括例如内窥镜手术套件。外科手术套件可以具有可逆扩张的收缩器，其扩张以在受试者内提供稳定的手术环境。扩张可以在稳定器子系统周围是不对称的，以最大化工具和内窥镜的空间，每个人都可以独立地操纵以使目标组织可视化并且以微创方式从患者外部治疗目标组织。

15. 发明申请

WO2010042857A1 TETHER TENSIONING DEVICES AND RELATED METHODS 审中-公开
标题翻译： TETHER张力装置及相关方法
公开(公告)号：WO2010042857A1
公开(公告)日：2010-04-15
申请号：PCT/US2009/060227
申请日：2009-10-09
申请人： GUIDED DELIVERY SYSTEMS INC. , HERNLUND, Jonathan, D. , CALHOUN, Tenny, C. , TANG, Brian , TO, John , BOOTH, Clyde, Henry, III
发明人： HERNLUND, Jonathan, D. , CALHOUN, Tenny, C. , TANG, Brian , TO, John , BOOTH, Clyde, Henry, III
IPC分类号： A61B17/04 , A61B17/12
CPC分类号： A61B17/0487 , A61B17/0467 , A61B17/0485 , A61B2017/00243 , A61B2017/00783 , A61B2017/045 , A61B2017/0451 , A61B2017/048 , A61B2017/0488 , A61B2017/0496 , A61B2017/320052 , A61F2/2487
摘要： Devices, methods, and kits for tensioning tethers during a tissue modification procedure are described. In some variations, a tether coupled to anchors embedded in tissue may be tensioned to provide a cinching effect that tightens or compresses the tissue by bringing two pieces or sections of the tissue together. In certain variations, the tether may then be locked (e.g., to maintain the tension), and/or excess tether may be severed. The devices, methods, and/or kits may be used, for example, in minimally invasive procedures.
摘要翻译：描述了在组织修饰过程中张紧系链的装置，方法和试剂盒。在一些变型中，连接到嵌入在组织中的锚固件的系绳可以被张紧以提供通过将组织的两个或多个部分组合在一起而收紧或压缩组织的收紧效果。在某些变型中，系绳可以被锁定（例如，以维持张力），和/或可能切断多余的系绳。装置，方法和/或试剂盒可以用于例如微创手术。

16. 发明申请

WO2009054968A1 ATHERECTOMY DEVICES AND METHODS 审中-公开
公开(公告)号：WO2009054968A1
公开(公告)日：2009-04-30
申请号：PCT/US2008/012012
申请日：2008-10-22
申请人： ATHEROMED, INC. , ESCUDERO, Paul , TO, John , DANEK, Christopher J.
发明人： ESCUDERO, Paul , TO, John , DANEK, Christopher J.
IPC分类号： A61B17/22 , A61D1/02
CPC分类号： A61B17/320758 , A61B17/32075 , A61B17/320783 , A61B2017/00331 , A61B2017/00557 , A61B2017/00685 , A61B2017/22039 , A61B2017/22042 , A61B2017/22047 , A61B2017/22048 , A61B2017/22071 , A61B2017/22094 , A61B2017/22095 , A61B2017/320775
摘要： The devices and methods generally relate to treatment of occluded body lumens. In particular, the present devices and method relate to removal of the occluding material from the blood vessels as well as other body lumens.

17. 发明申请

WO2013081691A1 SAFE CUTTING HEADS AND SYSTEMS FOR FAST REMOVAL OF A TARGET TISSUE 审中-公开
标题翻译：安全切割头和系统快速去除目标组织
公开(公告)号：WO2013081691A1
公开(公告)日：2013-06-06
申请号：PCT/US2012/051952
申请日：2012-08-22
申请人： OUROBOROS MEDICAL, INC. , TO, John
发明人： TO, John
IPC分类号： A61B17/3205 , A61B17/3209 , A61B17/34 , A61B17/70
CPC分类号： A61B17/3205 , A61B17/320016 , A61B17/32002 , A61B2017/00261 , A61B2017/00738 , A61B2017/320064 , A61B2090/08021 , A61B2217/002 , A61F2/44 , A61F2002/444
摘要： A safe and efficient cutting heads for removing a target tissue from a subject during a surgical procedure are provided, the cutting heads composing a part of systems that address several problems, including clogging of state-of-the-art systems during removal of such tissue, for example. The target tissue can include any tissue that is accessible through a small surgical opening, for example, a joint tissue such as a meniscus or an intervertebral tissue, such as a nucleus pulposus. The devices can be referred to as orthopedic tissue removal devices having cutting heads associated with vacuum systems, making the systems useful in several procedures, including X-LIF (lateral approach to an intervertebral fusions) procedures, T-LIF (transforaminal approach to intervertebral fusions) procedures, P-LIF (posterior approach to intervertebral fusions), and a percutaneous, transforaminal approach (Kambin triangle access).
摘要翻译：提供了一种用于在外科手术过程中从被检体去除目标组织的安全且有效的切割头，所述切割头构成解决几个问题的系统的一部分，包括在移除这样的组织期间堵塞最先进的系统，例如。目标组织可包括通过小的外科手术开口可接近的任何组织，例如关节组织，例如弯月面或椎间组织，例如髓核。这些装置可以称为具有与真空系统相关联的切割头的整形外科组织去除装置，使得该系统在若干程序中有用，包括X-LIF（侧椎间融合术）方法，T-LIF（经椎间融合椎间融合术）程序，P-LIF（椎间融合的后路）和经皮，经椎间孔的方法（Kambin三角形通路）。

18. 发明申请

WO2010085457A1 DIAGNOSTIC CATHETERS, GUIDE CATHETERS, VISUALIZATION DEVICES AND CHORD MANIPULATION DEVICES, AND RELATED KITS AND METHODS 审中-公开
标题翻译：诊断导管，指导导管，可视化装置和手术操作装置及相关装置及方法
公开(公告)号：WO2010085457A1
公开(公告)日：2010-07-29
申请号：PCT/US2010/021440
申请日：2010-01-19
申请人： GUIDED DELIVERY SYSTEMS INC. , FABRO, Mariel , NAPP, Malte , STARKSEN, Niel, F. , ADAM, Charles, J. , TO, John
发明人： FABRO, Mariel , NAPP, Malte , STARKSEN, Niel, F. , ADAM, Charles, J. , TO, John
IPC分类号： A61M25/00
CPC分类号： A61B6/12 , A61B1/00078 , A61B1/3137 , A61B6/503 , A61B6/541 , A61B8/0883 , A61B8/12 , A61B17/320016 , A61B17/7208 , A61B2017/00243 , A61M25/0041 , A61M25/04 , G06F19/00
摘要： Described herein are devices, methods and kits for assessing and/or enhancing the accessibility of a subvalvular space of a heart, accessing the subvalvular space of the heart (e.g., to provide access for one or more other devices), and/or positioning one or more devices in the subvalvular space of the heart. The devices described herein may, for example, comprise catheters that may be used to manipulate one or more chordae tendineae, diagnostic catheters having different sizes and/or shapes (e.g., different curvatures), guide catheters having different sizes and/or shapes (e.g., different curvatures), and visualization catheters. In some variations, the devices, methods, and/or kits may be used to visualize a target site, such as a subannular groove of a heart valve. In certain variations, the devices, methods, and/or kits may be used to manipulate chordae tendineae to provide additional space in a ventricle of a heart (e.g., enhancing the accessibility of the ventricle).
摘要翻译：这里描述的是用于评估和/或增强心脏的亚阀瓣空间的可达性的装置，方法和试剂盒，其进入心脏的瓣膜下空间（例如，为一个或多个其它装置提供通路）和/或定位一个或更多的设备在心脏的小脑空间。本文描述的装置可以例如包括可用于操纵一个或多个腱索腱的导管，具有不同尺寸和/或形状（例如不同曲率）的诊断导管，具有不同尺寸和/或形状的导向导管（例如，，不同的曲率）和可视化导管。在一些变型中，可以使用装置，方法和/或试剂盒来可视化目标部位，例如心脏瓣膜的子宫沟槽。在某些变型中，装置，方法和/或试剂盒可用于操纵腱索腱索以在心脏的心室中提供额外的空间（例如，增强心室的可及性）。

19. 发明申请

WO2009052438A2 DEVICES AND METHODS FOR TERMINATION 审中-公开
标题翻译：用于终止的设备和方法
公开(公告)号：WO2009052438A2
公开(公告)日：2009-04-23
申请号：PCT/US2008/080381
申请日：2008-10-17
申请人： GUIDED DELIVERY SYSTEMS INC. , SERINA, Eugene , CALHOUN, Tenny, C. , MEIER, Stephen , FABRO, Mariel , MIRCHANDANI, Tiffany, Huynh , TO, John , TANG, Brian
发明人： SERINA, Eugene , CALHOUN, Tenny, C. , MEIER, Stephen , FABRO, Mariel , MIRCHANDANI, Tiffany, Huynh , TO, John , TANG, Brian
IPC分类号： A61B17/04
CPC分类号： A61B17/0487 , A61B17/0467 , A61B17/0485 , A61B2017/00243 , A61B2017/00783 , A61B2017/0448 , A61B2017/045 , A61B2017/0454 , A61B2017/0456 , A61B2017/048 , A61B2017/0488 , A61B2017/0496 , A61B2017/320052
摘要： Devices and methods for locking and/or cutting tethers during a tissue modification procedure are described. In some variations, a tether may be used to tighten or compress tissue by bringing two pieces or sections of the tissue together. The tether, which may be under tension, may be locked to maintain the tension, and excess tether may be severed, using one or more of the devices and/or methods. The devices and/or methods may be used, for example, in minimally invasive procedures.
摘要翻译：描述了在组织修改过程中锁定和/或切割系绳的装置和方法。在一些变型中，系绳可以用于通过将组织的两个或多个部分组合在一起来收紧或压缩组织。可能处于张力下的系绳可以被锁定以保持张力，并且可以使用一种或多种装置和/或方法来切断多余的系绳。装置和/或方法可以用于例如微创程序。

20. 发明申请

WO2007021564A1 METHODS AND DEVICES FOR DEPLOYMENT OF TISSUE ANCHORS 审中-公开
标题翻译：用于部署组织锚固件的方法和装置
公开(公告)号：WO2007021564A1
公开(公告)日：2007-02-22
申请号：PCT/US2006/030260
申请日：2006-08-02
申请人： GUIDED DELIVERY SYSTEMS, INC. , TO, John , FABRO, Mariel , IM, Karl, S.
发明人： TO, John , FABRO, Mariel , IM, Karl, S.
IPC分类号： A61B17/04
CPC分类号： A61B17/068 , A61B17/0401 , A61B17/064 , A61B2017/00867 , A61B2017/0409 , A61F2/2445
摘要： Described here are devices, methods, and kits for deployment of tissue anchors. In some variations, the devices described here comprise a shaft defining a lumen for housing at least one anchor therein (the anchor having an eyelet) and a mechanism for deploying the anchor distally from the lumen, wherein the inner diameter of the lumen is the same size or smaller than the diameter of the eyelet of the anchor to be disposed therein when the anchor is in an expanded configuration. In some variations, the methods comprise loading an anchor within a lumen of a shaft (where the anchor comprises an eyelet and the shaft has a slot therethrough), passing a linking member through the slot and through the eyelet of the anchor, and deploying the anchor. Other methods comprise loading an anchor within a lumen of a shaft, and deploying the anchor distally from the lumen.
摘要翻译：这里描述的是用于部署组织锚的装置，方法和试剂盒。在一些变型中，这里描述的装置包括限定用于容纳其中的至少一个锚固件（具有孔眼）的内腔的轴和用于将锚固体从腔内向远侧展开的机构，其中内腔的内径相同当锚固件处于膨胀构型时，尺寸或小于待布置在其中的锚固件的孔眼的直径。在一些变型中，所述方法包括将锚固件装载在轴的内腔内（其中锚固件包括孔眼并且轴具有穿过其中的槽），使连接构件穿过狭槽并穿过锚固件的孔眼，并且将锚。其他方法包括将锚固件装载在轴的内腔内，并将锚固件从内腔远端展开。

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