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11. 发明申请

WO2009032198A1 CO-CRYSTALS AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME 审中-公开
标题翻译：包括其的CO晶体和药物组合物
公开(公告)号：WO2009032198A1
公开(公告)日：2009-03-12
申请号：PCT/US2008/010254
申请日：2008-08-29
申请人： VERTEX PHARMACEUTICALS INCORPORATED , ZHANG, Yuegang , CONNELY, Patrick, R. , JOHNSTON, Steve
发明人： ZHANG, Yuegang , CONNELY, Patrick, R. , JOHNSTON, Steve
IPC分类号： C07D403/12 , A61K31/454 , A61P1/16
CPC分类号： C07D403/12
摘要： The invention relates to co-crystals and compositions each comprising VX-950 and a co-crystal former selected from the group consisting of 3-methoxy-4-hydroxybenzoic acid, 2,4-dihydroxybenzoic acid, and 2,5-dihydroxybenzoic acid. Also within the scope of this invention are methods of making and using the same.
摘要翻译：本发明涉及共晶和组合物，其各自包含VX-950和选自3-甲氧基-4-羟基苯甲酸，2,4-二羟基苯甲酸和2,5-二羟基苯甲酸的共晶体形成剂。在本发明的范围内也是制造和使用本发明的方法。

12. 发明申请

WO2011133956A1 PHARMACEUTICAL COMPOSITIONS AND ADMINISTRATIONS THEREOF 审中-公开
标题翻译：药物组合物及其药理学
公开(公告)号：WO2011133956A1
公开(公告)日：2011-10-27
申请号：PCT/US2011/033693
申请日：2011-04-22
申请人： VERTEX PHARMACEUTICALS INCORPORATED , VAN GOOR, Fredrick, F. , ALARGOVA, Rossitza, Gueorguieva , ALCACIO, Tim, Edward , BINCH, Hayley, Marie , BOTFIELD, Martyn, Curtis , FANNING, Lev Tyler, Dewey , GROOTENHUIS, Peter Diederik, Jan , HURLEY, Dennis, James , KADIYALA, Irina, Nikolaevna , KAUSHIK, Ritu, Rohit , KESHAVARZ-SHOKRI, Ali , KRAWIEC, Mariusz , LEE, Elaine, Chungmin , LUISI, Brian , MEDEK, Ales , NUMA, Mehdi , SHETH, Urvi, Jagdishbhai , SILINA, Alina , VERWIJS, Marinus, Jacobus , YANG, Xiaoqing , YOUNG, Christopher Ryan , ZAMAN, Noreen, Tasneem , ZHANG, Beili , ZHANG, Yuegang , ZLOKARNIK, Gregor
发明人： VAN GOOR, Fredrick, F. , ALARGOVA, Rossitza, Gueorguieva , ALCACIO, Tim, Edward , BINCH, Hayley, Marie , BOTFIELD, Martyn, Curtis , FANNING, Lev Tyler, Dewey , GROOTENHUIS, Peter Diederik, Jan , HURLEY, Dennis, James , KADIYALA, Irina, Nikolaevna , KAUSHIK, Ritu, Rohit , KESHAVARZ-SHOKRI, Ali , KRAWIEC, Mariusz , LEE, Elaine, Chungmin , LUISI, Brian , MEDEK, Ales , NUMA, Mehdi , SHETH, Urvi, Jagdishbhai , SILINA, Alina , VERWIJS, Marinus, Jacobus , YANG, Xiaoqing , YOUNG, Christopher Ryan , ZAMAN, Noreen, Tasneem , ZHANG, Beili , ZHANG, Yuegang , ZLOKARNIK, Gregor
IPC分类号： A61K31/4704 , A61K31/404 , A61K31/443
CPC分类号： A61K31/4709 , A61K31/404 , A61K31/443 , A61K31/4704 , A61K45/06 , C07D405/12 , C12Q1/34 , G01N2500/04 , G01N2500/20 , A61K2300/00
摘要： The present invention relates to pharmaceutical compositions comprising a compound of Formula I in combination with one or both of a Compound of Formula II and/or a Compound of Formula III. The invention also relates to solid forms and to pharmaceutical formulations thereof, and to methods of using such compositions in the treatment of CFTR mediated diseases, particularly cystic fibrosis.(Formula I), (Formula II), (Formula III).
摘要翻译：本发明涉及药物组合物，其包含与式II化合物和/或式III化合物中的一种或两种结合的式I化合物。本发明还涉及固体形式及其药物制剂，以及使用这些组合物治疗CFTR介导的疾病，特别是囊性纤维化的方法（式I），（式II），（式III）。

13. 发明申请

WO2009038683A2 SOLID FORMS OF N-[2,4-BIS(1,1-DIMETHYLETHYL)-5-HYDROXYPHENYL]-1,4-DIHYDRO-4-OXOQUINOLINE-3-CARBOXAMIDE 审中-公开
标题翻译： N- [2,4-BIS（1,1-二甲基乙基）-5-羟基苯基] -1,4-二氢-4-氧代喹啉-3-羧酰胺的固体形式
公开(公告)号：WO2009038683A2
公开(公告)日：2009-03-26
申请号：PCT/US2008/010728
申请日：2008-09-15
申请人： VERTEX PHARMACEUTICALS INCORPORATED , DEMATTEI, John , FENG, Yushi , HARRISON, Cristian , LOOKER, Adam , MUDUNURI, Praveen , ROEPER, Stefanie , ZHANG, Yuegang
发明人： DEMATTEI, John , FENG, Yushi , HARRISON, Cristian , LOOKER, Adam , MUDUNURI, Praveen , ROEPER, Stefanie , ZHANG, Yuegang
IPC分类号： A61K31/47 , C07D215/233 , A61P3/00 , A61P35/00 , A61P25/28 , A61P27/02 , A61P3/10
CPC分类号： C07D215/56 , A61K31/47 , A61K45/06 , C07D215/233
摘要： Solid forms of N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide are described herein, including crystalline forms thereof.
摘要翻译：本文描述了固体形式的N- [2,4-双（1,1-二甲基乙基）-5-羟基苯基] -1,4-二氢-4-氧代喹啉-3-甲酰胺，包括其结晶形式。

14. 发明申请

WO2005066367A2 METHODS OF PRODUCING CARBON NANOTUBES USING PEPTIDE OR NUCLEIC ACID MICROPATTERNING 审中-公开
标题翻译：使用肽或核酸微生物生产碳纳米管的方法
公开(公告)号：WO2005066367A2
公开(公告)日：2005-07-21
申请号：PCT/US2004/043364
申请日：2004-12-24
申请人： INTEL CORPORATION , SU, Xing , SUNDARARAJAN, Narayan , YAMAKAWA, Mineo , BERLIN, Andrew , SUN, Lei , ZHANG, Yuegang
发明人： SU, Xing , SUNDARARAJAN, Narayan , YAMAKAWA, Mineo , BERLIN, Andrew , SUN, Lei , ZHANG, Yuegang
IPC分类号： C12Q1/68
CPC分类号： B82Y40/00 , B82Y10/00 , B82Y30/00 , C01B32/162 , C01B2202/08 , C01B2202/36 , D01F9/127 , H01L51/0048 , H01L51/0052
摘要： The methods, apparatus and systems disclosed herein concern ordered arrays of carbon nanotubes. In particular embodiments of the invention, the nanotube arrays are formed by a method comprising attaching catalyst nanoparticles (140, 230) to polymer (120, 210) molecules, attaching the polymer (120, 210) molecules to a substrate, removing the polymer (120, 210) molecules and producing carbon nanotubes on the catalyst nanoparticles (140, 230). The polymer (120, 210) molecules alignment techniques. The nanotube arrays can be attached to selected areas (110, 310) of the substrate. Within the selected areas (110, 310), the nanotubes are distributed non-randomly. Other embodiments disclosed herein concern apparatus that include ordered arrays of nanotubes attached to a substrate and systems that include ordered arrays of carbon nanotubes attached to a substrate, produced by the claimed methods. In certain embodiments, provided herein are methods for aligning a molecular wire, by ligating the molecular wire to a double stranded DNA molecule.
摘要翻译：本文公开的方法，装置和系统涉及碳纳米管的有序阵列。在本发明的具体实施方案中，通过包括将催化剂纳米颗粒（140,230）附着到聚合物（120,210）分子上的方法形成纳米管阵列，将聚合物（120,210）分子连接到基底上，去除聚合物 120,210）分子并在催化剂纳米颗粒（140,230）上产生碳纳米管。聚合物（120,210）分子对齐技术。纳米管阵列可以附着到基板的选定区域（110,310）。在所选择的区域（110,310）内，纳米管是非随机分布的。本文公开的其它实施方案涉及包括连接到衬底的纳米管的有序阵列的装置以及包括通过所要求保护的方法产生的连接到衬底的碳纳米管的有序阵列的系统。在某些实施方案中，本文提供了通过将分子线连接到双链DNA分子来对齐分子线的方法。

15. 发明申请

WO2006135426A2 APPLICATION OF STATIC LIGHT TO A FLUID FLOW OF CNTs FOR PURPOSES OF SORTING THE CNTs 审中-公开
标题翻译：将静态光应用于碳纳米管的流体流中，用于分配CNT的用途
公开(公告)号：WO2006135426A2
公开(公告)日：2006-12-21
申请号：PCT/US2005/035403
申请日：2005-09-30
申请人： INTEL CORPORATION , ZHANG, Yuegang , LOPEZ, Herman , TAN, Shida
发明人： ZHANG, Yuegang , LOPEZ, Herman , TAN, Shida
IPC分类号： C01B31/02
CPC分类号： B07C5/344 , B82Y30/00 , B82Y40/00 , C01B32/172 , G01N2030/0035 , Y10S977/845
摘要： A method is described that comprises sorting carbon nanotubes (CNTs) within a fluidic flow for a targeted subset of CNTs. The sorting comprises attracting at least a portion of the CNTs within the fluidic flow in a direction of increasing intensity of an electric field component of a substantially stationary beam of light. The electric field component has a frequency that is less than one or more resonant frequencies of the CNTs within the portion.
摘要翻译：描述了一种方法，其包括在CNT的靶向子集的流体流中分选碳纳米管（CNT）。排序包括在基本上静止的光束的电场分量的强度增加的方向上吸引流体流中的至少一部分CNT _{。电场分量具有小于该部分内的CNT _{的一个或多个谐振频率的频率。}}

16. 发明申请

WO2005030640A1 SORTING OF SINGLE-WALLED CARBON NANOTUBES USING OPTICAL DIPOLE TRAPS 审中-公开
标题翻译：使用光学DIPOLE TRAPS分离单壁碳纳米管
公开(公告)号：WO2005030640A1
公开(公告)日：2005-04-07
申请号：PCT/US2004/031404
申请日：2004-09-23
申请人： INTEL CORPORATION , ZHANG, Yuegang , HANNAH, Eric , KOO, Tae-Woong
发明人： ZHANG, Yuegang , HANNAH, Eric , KOO, Tae-Woong
IPC分类号： C01B31/02
CPC分类号： B82Y30/00 , B07C5/12 , B82Y10/00 , B82Y40/00 , C01B32/172 , C01B2202/02 , Y10S977/845
摘要： In embodiments of the present invention, the electric field of a focused laser beam induces a dipole in a single-walled carbon nanotube. The single-walled carbon nanotube has one or more resonant frequencies. When the frequency of the laser beam is less than a resonance frequency of the single-walled carbon nanotube, the single-walled carbon nanotube may be trapped and the laser beam may move the single-walled carbon nanotube from a first microfluidic laminar flow to a second microfluidic laminar flow. When the frequency of the laser beam is higher than a resonant frequency of the single-walled carbon nanotube , the single-walled carbon nanotube may be repelled and the laser beam may not move the single-walled carbon nanotube.
摘要翻译：在本发明的实施例中，聚焦激光束的电场在单壁碳纳米管中诱导偶极子。单壁碳纳米管具有一个或多个谐振频率。当激光束的频率小于单壁碳纳米管的共振频率时，单层碳纳米管可能被捕获，并且激光束可以将单壁碳纳米管从第一微流体层流移动到第二微流体层流。当激光束的频率高于单壁碳纳米管的谐振频率时，单壁碳纳米管可能被排斥，激光束可能不会移动单壁碳纳米管。

17. 发明申请

WO2016057730A1 CO-CRYSTALS OF MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR 审中-公开
标题翻译： CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR的调节剂的共晶体
公开(公告)号：WO2016057730A1
公开(公告)日：2016-04-14
申请号：PCT/US2015/054577
申请日：2015-10-07
申请人： STROHMEIER, Mark , CAESAR, JR., John P. , CONNELLY, Patrick Raymond , FAWAZ, Majed , LUSS-LUSIS, Eduard , MCCLAIN, Brian R. , MEDEK, Ales , MIAO, Hai , NTI-ADDAE, Kwame Wiredu , YIN, Ping , ZHANG, Yuegang
发明人： STROHMEIER, Mark , CAESAR, JR., John P. , CONNELLY, Patrick Raymond , FAWAZ, Majed , LUSS-LUSIS, Eduard , MCCLAIN, Brian R. , MEDEK, Ales , MIAO, Hai , NTI-ADDAE, Kwame Wiredu , YIN, Ping , ZHANG, Yuegang
IPC分类号： C07D215/56
CPC分类号： C07D215/56 , A61K31/225 , A61K31/47 , A61K45/06 , C07B2200/13 , C07C69/18 , C07C69/30 , C07C69/34 , C07C69/58 , C07C69/587
摘要： The present disclosure relates to co-crystals comprising N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide (Compound 1) and a co-former and methods for their preparation. The present disclosure further relates to pharmaceutical compositions comprising the co-crystal forms, as well as methods of treatment therewith and kits.
摘要翻译：本公开内容涉及包含N- [2,4-双（1,1-二甲基乙基）-5-羟基苯基] -1,4-二氢-4-氧代喹啉-3-甲酰胺（化合物1）和共 - 成型机及其制备方法。本公开还涉及包含共晶形式的药物组合物，以及其治疗方法和试剂盒。

18. 发明申请

WO2011133953A1 PHARMACEUTICAL COMPOSITIONS AND ADMINISTRATIONS THEREOF 审中-公开
标题翻译：药物组合物及其药理学
公开(公告)号：WO2011133953A1
公开(公告)日：2011-10-27
申请号：PCT/US2011/033689
申请日：2011-04-22
申请人： VERTEX PHARMACEUTICALS INCORPORATED , VAN GOOR, Fredrick, F. , ALARGOVA, Rossitza, Gueorguieva , ALCACIO, Tim, Edward , AREKAR, Sneha, G. , BINCH, Hayley, Marie , BOTFIELD, Martyn, Curtis , FANNING, Lev, Tyler Dewey , GROOTENHUIS, Peter, Diederik Jan , HURLEY, Dennis, James , JOHNSTON, Steven, C. , KADIYALA, Irina, Nikolaevna , KAUSHIK, Ritu, Rohit , KESHAVARZ-SHOKRI, Ali , KRAWIEC, Mariusz , LEE, Elaine, Chungmin , LUISI, Brian , MEDEK, Ales , MUDUNURI, Praveen , NUMA, Mehdi , SHETH, Urvi Jagdishbhai , SILINA, Alina , SULLIVAN, Mark Jeffrey , VERWIJS, Marinus Jacobus , YANG, Xiaoqing , YOUNG, Christopher Ryan , ZAMAN, Noreen Tasneem , ZHANG, Beili , ZHANG, Yuegang , ZLOKARNIK, Gregor
发明人： VAN GOOR, Fredrick, F. , ALARGOVA, Rossitza, Gueorguieva , ALCACIO, Tim, Edward , AREKAR, Sneha, G. , BINCH, Hayley, Marie , BOTFIELD, Martyn, Curtis , FANNING, Lev, Tyler Dewey , GROOTENHUIS, Peter, Diederik Jan , HURLEY, Dennis, James , JOHNSTON, Steven, C. , KADIYALA, Irina, Nikolaevna , KAUSHIK, Ritu, Rohit , KESHAVARZ-SHOKRI, Ali , KRAWIEC, Mariusz , LEE, Elaine, Chungmin , LUISI, Brian , MEDEK, Ales , MUDUNURI, Praveen , NUMA, Mehdi , SHETH, Urvi Jagdishbhai , SILINA, Alina , SULLIVAN, Mark Jeffrey , VERWIJS, Marinus Jacobus , YANG, Xiaoqing , YOUNG, Christopher Ryan , ZAMAN, Noreen Tasneem , ZHANG, Beili , ZHANG, Yuegang , ZLOKARNIK, Gregor
IPC分类号： A61K31/4704 , A61K31/404 , A61K31/443
CPC分类号： A61K31/4709 , A61K31/404 , A61K31/443 , A61K31/4433 , A61K31/47 , A61K31/4704 , G01N33/6872 , G01N2333/4703 , A61K2300/00
摘要： The present invention relates to pharmaceutical compositions comprising a compound of Formulas I and II, optionally in combination with a Compound of Formula III and/or a Compound of Formula IV. The invention also relates to solid forms and to pharmaceutical formulations thereof, and to methods of using such compositions in the treatment of CFTR mediated diseases, particularly cystic fibrosis.
摘要翻译：本发明涉及包含式I和II化合物，任选与式III化合物和/或式IV化合物组合的药物组合物。本发明还涉及固体形式及其药物制剂，以及使用这些组合物治疗CFTR介导的疾病，特别是囊性纤维化的方法。

19. 发明申请

WO2009076200A2 SOLID FORMS OF 1-ETHYL-3-(5-(5-FLUOROPYRIDIN-3-YL)-7-(PYRIMIDIN-2-YL)-1H-BENZO[D]IMIDAZOL-2-YL)UREA 审中-公开
标题翻译： 1-乙基-3-（5-（5-氟吡啶-3-基）-7-（嘧啶-2-基）-1H-苯并[d]咪唑-2-基）脲的固体形式
公开(公告)号：WO2009076200A2
公开(公告)日：2009-06-18
申请号：PCT/US2008/085673
申请日：2008-12-05
申请人： VERTEX PHARMACEUTICALS INCORPORATED , MACIKENAS, Dainius , ALARGOVA, Rossitza , KADIYALA, Irina , LE TIRAN, Arnaud , ZHANG, Yuegang
发明人： ALARGOVA, Rossitza , KADIYALA, Irina , LE TIRAN, Arnaud , ZHANG, Yuegang
IPC分类号： C07D403/14
CPC分类号： C07D401/14
摘要： Solid forms of crystalline1-ethyl-3-(5-(5-fluoropyridin-3-yl)-7-(pyrimidin-2-yl)- 1H-benzo[d]imidazol-2-yl)urea, compositions containing solid forms of crystalline 1- ethyl-3-(5-(5-fluoropyridin-3-yl)-7-(pyrimidin-2-yl)-1H-benzo[d]imidazol-2-yl)urea and methods of using the same are described.
摘要翻译：结晶1-乙基-3-（5-（5-氟吡啶-3-基）-7-（嘧啶-2-基）-1H-苯并[d]咪唑-2-基）（5-（5-氟吡啶-3-基）-7-（嘧啶-2-基）-1H-苯并[d]咪唑-2-基）固体形式的组合物）尿素及其使用方法进行了描述。

20. 发明申请

WO2006127018A3 REAL-TIME MONITORING OPTICALLY TRAPPED CARBON NANOTUBES 审中-公开
公开(公告)号：WO2006127018A3
公开(公告)日：2006-11-30
申请号：PCT/US2005/021626
申请日：2005-06-17
申请人： INTEL CORPORATION , TAN, Shida , ZHANG, Yuegang
发明人： TAN, Shida , ZHANG, Yuegang
IPC分类号： B23K26/14 , C01B31/02 , D01F9/12
摘要： An embodiment of the present invention is a technique to monitor carbon nanotubes (CNTs). A carbon nanotube (CNT) is manipulated in a fluid by a laser beam. An illuminating light from a light source is aligned along axis of the CNT to produce an optical response from the CNT. The CNT is monitored using an optical sensor according to the optical response.

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