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11. 发明专利

PL3432970T3 URZĄDZENIA DO DOSTARCZANIA LEKÓW IN VIVO 未知
公开(公告)号：PL3432970T3
公开(公告)日：2021-09-20
申请号：PL18705786
申请日：2018-02-01
申请人： TARIS BIOMEDICAL LLC
发明人： LEE HEEJIN , ABBATE EMILY , HOCKING SARAH , GIESING DENNIS
IPC分类号： A61M31/00 , A61K9/00

12. 发明专利

LT3432970T IN VIVO VAISTŲ VARTOJIMO ĮTAISAI 未知
公开(公告)号：LT3432970T
公开(公告)日：2021-05-10
申请号：LT18705786
申请日：2018-02-01
申请人： TARIS BIOMEDICAL LLC
发明人： LEE HEEJIN , ABBATE EMILY , HOCKING SARAH , GIESING DENNIS
IPC分类号： A61M31/00 , A61K9/00

13. 发明专利

DK3432970T3 IN VIVO LÆGEMIDDELLEVERINGSINDRETNINGER 未知
公开(公告)号：DK3432970T3
公开(公告)日：2021-05-10
申请号：DK18705786
申请日：2018-02-01
申请人： TARIS BIOMEDICAL LLC
发明人： HOCKING SARAH , GIESING DENNIS , LEE HEEJIN , ABBATE EMILY
IPC分类号： A61M31/00 , A61K9/00

14. 发明专利

PH12020550587A1 METHODS OF TREATMENT AND MAINTENANCE THERAPY FOR BLADDER CANCER USING GEMCITABINE 未知
公开(公告)号：PH12020550587A1
公开(公告)日：2021-04-26
申请号：PH12020550587
申请日：2020-05-08
申请人： TARIS BIOMEDICAL LLC
发明人： GIESING DENNIS , CUTIE CHRISTOPHER
IPC分类号： A61K31/7068 , A61K9/00 , A61M31/00 , A61P13/10 , A61P35/00
摘要： Provided are methods of treating urothelial carcinomas of the lower tract comprising administering comprising administering gemcitabine continuously and locally to the bladder of an individual in an induction therapy and/or maintenance therapy.

15. 发明专利

AU2019315957A1 Methods of treating overactive bladder using trospium 未知
公开(公告)号：AU2019315957A1
公开(公告)日：2021-02-18
申请号：AU2019315957
申请日：2019-07-31
申请人： TARIS BIOMEDICAL LLC
发明人： GIESING DENNIS
IPC分类号： A61K31/46 , A61P13/06 , A61P13/10
摘要： The present application provides methods of treating overactive bladder and methods of training or retraining bladder, prolonging symptom relief, improving the quality of life and/or neuronal remodeling in an individual having overactive bladder, by administering an effective amount of trospium locally to the bladder of the individual for at least about 24 hours.

16. 发明专利

AU2020217383A1 Drug delivery systems and methods for treatment of bladder cancer with gemcitabine 未知
公开(公告)号：AU2020217383A1
公开(公告)日：2020-09-03
申请号：AU2020217383
申请日：2020-08-12
申请人： TARIS BIOMEDICAL LLC
发明人： GIESING DENNIS , LEE HEEJIN , DANIEL KAREN
IPC分类号： A61K31/7068 , A61P35/00
摘要： Abstract Drug delivery devices and methods are provided for administering gemcitabine to a patient in need of treatment of bladder cancer by intravesically administering gemcitabine into the bladder of the patient to achieve a sustained concentration of the gemcitabine in urine in the bladder sufficient to produce a therapeutically effective concentration of the gemcitabine in the tissues of the bladder. In embodiments, the local administration into the patient's bladder is at a mean average amount of from 1mg/day to about 300 mg/day of the gemcitabine (FBE).

17. 发明专利

SG11201913251VA METHODS OF TREATING TUMOR METASTASIS 未知
公开(公告)号：SG11201913251VA
公开(公告)日：2020-01-30
申请号：SG11201913251V
申请日：2018-07-25
申请人： TARIS BIOMEDICAL LLC
发明人： GIESING DENNIS
IPC分类号： A61K31/7068 , A61M31/00 , A61P13/10 , A61P35/04
摘要： The present invention provides methods for treating or suppressing tumor metastasis at a site distinct from the bladder in an individual having a urothelial carcinoma of lower tract, comprising locally delivering to the bladder an effective amount of a chemotherapeutic agent (such as gemcitabine), wherein the chemotherapeutic agent is delivered continuously to the bladder for a sustained period of time (such as at least 24 hours).

18. 发明专利

SG11201907033SA IN VIVO DRUG DELIVERY DEVICES AND METHODS FOR DRUG DELIVERY 未知
公开(公告)号：SG11201907033SA
公开(公告)日：2019-08-27
申请号：SG11201907033S
申请日：2018-02-01
申请人： TARIS BIOMEDICAL LLC
发明人： LEE HEEJIN , ABBATE EMILY , HOCKING SARAH , GIESING DENNIS
IPC分类号： A61M31/00 , A61K9/00
摘要： /'.. ,- .-,, rs 1 I I I 1 r I 1 I i 07Mo° 64 60\ 0 0 oev: 52 54 50 62 54 _L.J. I I I 1 (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 09 August 2018 (09.08.2018) W I P0 I P C T o mono °nolo Ho Ho Ho Immo En oimIE (10) International Publication Number WO 2018/144738 Al (51) International Patent Classification: A61M 31/00 (2006.01) A61K 9/00 (2006.01) (21) International Application Number: PCT/US2018/016463 (22) International Filing Date: 01 February 2018 (01.02.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/453,333 01 February 2017 (01.02.2017) US 62/480,744 03 April 2017 (03.04.2017) US (71) Applicant: TARIS BIOMEDICAL LLC [US/US]; 113 Hartwell Avenue, Lexington, Massachusetts 02421 (US). (72) Inventors: LEE, Heejin; 1103 Albion Road, Bedford, Massachusetts 01730 (US). ABBATE, Emily; 6 Lone Star Drive, Nashua, New Hampshire 03062 (US). HOCKING, Sarah; 345 Washington Street, Winchester, Massachusetts 01890 (US). GIESING, Dennis; 4421 SW Gull Point Dri- ve, Lees Summit, Missouri 64082 (US). (74) Agent: FREDRICH, Stacy D. et al.; Eversheds Suther- land (US) LLP, 999 Peachtree Street, NE, Atlanta, Georgia 30309-3996 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Declarations under Rule 4.17: as to applicant's entitlement to apply for and be granted a patent (Rule 4.17(ii)) as to the applicant's entitlement to claim the priority of the earlier application (Rule 4.17(iii)) Published: — with international search report (Art. 21(3)) 1-1 GC N 1-1 00 O O 1-1 (54) Title: IN VIVO DRUG DELIVERY DEVICES AND METHODS FOR DRUG DELIVERY FIG. 2 (57) : Drug delivery devices and methods of administering drugs to patients are provided. A device (50) includes a reservoir (60) containing a drug (58). The reservoir (60) is defined by a wall (64) having a water-permeable portion, such that the water-permeable portion permits water to enter the device (50) and contact the drug (58). A restraining plug (56) closes off an opening of the device (50) such that transient microchannels (62) form between an elastic portion (54) of the device (50) and the restraining plug (56), upon the generation of a sufficient pressure within the reservoir (60), to release the drug (58) from the device (50). Methods of treating patients for neurogenic detrusor overactivity resulting from a spinal cord injury and/or for idiopathic overactive bladder and urinary incontinence are also described.

19. 发明专利

JOP20200124A1 طُرق لعلاج سرطان المثانة باستخدام جيمسيتابين وعلاج مدوامة لذلك 未知
公开(公告)号：JOP20200124A1
公开(公告)日：2019-05-08
申请号：JOP20200124
申请日：2020-05-20
申请人： TARIS BIOMEDICAL LLC
发明人： CUTIE CHRISTOPHER , GIESING DENNIS
摘要： يتوفربهذاالاختراعطرقلعلاجسرطاناتالظهارةالبولية،حيثتتألفهذهالطرقمنحقنجيمسيتابينموضعيًاوباستمرارفيمثانةالمريضكعلاجتحفيزو/أوعلاجمداومة. الشكل 1

20. 发明专利

SG11201809838VA METHOD OF TREATING LOWER TRACT UROTHELIAL CANCER 未知
公开(公告)号：SG11201809838VA
公开(公告)日：2018-12-28
申请号：SG11201809838V
申请日：2017-05-05
申请人： TARIS BIOMEDICAL LLC
发明人： GIESING DENNIS , CUTIE CHRISTOPHER , SARMA PURNANAND , LARRIVEE-ELKINS CHERYL , SEARCY CHRISTOPHER , AGARWAL VIKAS
IPC分类号： A61K31/7068 , A61K9/00 , A61M31/00 , A61P13/10
摘要： The present invention provides methods, devices, and kits related to treatment of urothelial carcinomas of the lower tract with antimetabolite (such as gemcitabine). In some aspects the methods, devices and kits relate to treatment of urothelial carcinomas of the lower tract with an antimetabolite (such as gemcitabine) and an immunomodulating agent.

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