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11. 发明授权

US07951334B2 Direct write nanolithographic deposition of nucleic acids from nanoscopic tips 有权
标题翻译：从纳米尖端直接写入纳米光刻的核酸
公开(公告)号：US07951334B2
公开(公告)日：2011-05-31
申请号：US12044738
申请日：2008-03-07
申请人： Chad A. Mirkin , Linette Demers , David S. Ginger
发明人： Chad A. Mirkin , Linette Demers , David S. Ginger
IPC分类号： B01L3/02
CPC分类号： G03F7/0002 , G01Q80/00 , Y10T436/2575
摘要： The use of direct-write nanolithography to generate anchored, nanoscale patterns of nucleic acid on different substrates is described, including electrically conductive and insulating substrates. Modification of nucleic acid, including oligonucleotides, with reactive groups such as thiol groups provides for patterning with use of appropriate scanning probe microscopic tips under appropriate conditions. The reactive groups provide for chemisorption or covalent bonding to the substrate surface. The resulting nucleic acid features, which exhibit good stability, can be hybridized with complementary nucleic acids and probed accordingly with use of, for example, nanoparticles functionalized with nucleic acids. Patterning can be controlled by selection of tip treatment, relative humidity, and nucleic acid structure.
摘要翻译：描述了使用直写式纳米光刻技术在不同基底上产生锚定的纳米级核酸图案，包括导电和绝缘基底。含有反应性基团如硫醇基团的核酸（包括寡核苷酸）的修饰使得在合适的条件下使用合适的扫描探针显微镜尖端进行图案化。反应性基团提供化学吸附或共价结合到基底表面。所得到的表现出良好稳定性的核酸特征可与互补核酸杂交，并使用例如用核酸官能化的纳米颗粒进行相应的探测。可以通过选择尖端处理，相对湿度和核酸结构来控制图案化。

12. 发明授权

US07361310B1 Direct write nanolithographic deposition of nucleic acids from nanoscopic tips 失效
标题翻译：从纳米尖端直接写入纳米光刻的核酸
公开(公告)号：US07361310B1
公开(公告)日：2008-04-22
申请号：US10307515
申请日：2002-12-02
申请人： Chad A. Mirkin , Linette Demers , David S. Ginger
发明人： Chad A. Mirkin , Linette Demers , David S. Ginger
IPC分类号： B01L3/02
CPC分类号： G03F7/0002 , G01Q80/00 , Y10T436/2575
摘要： The use of direct-write nanolithography to generate anchored, nanoscale patterns of nucleic acid on different substrates is described, including electrically conductive and insulating substrates. Modification of nucleic acid, including oligonucleotides, with reactive groups such as thiol groups provides for patterning with use of appropriate scanning probe microscopic tips under appropriate conditions. The reactive groups provide for chemisorption or covalent bonding to the substrate surface. The resulting nucleic acid features, which exhibit good stability, can be hybridized with complementary nucleic acids and probed accordingly with use of, for example, nanoparticles functionalized with nucleic acids. Patterning can be controlled by selection of tip treatment, relative humidity, and nucleic acid structure.
摘要翻译：描述了使用直写式纳米光刻技术在不同基底上产生锚定的纳米级核酸图案，包括导电和绝缘基底。含有反应性基团如硫醇基团的核酸（包括寡核苷酸）的修饰使得在合适的条件下使用合适的扫描探针显微镜尖端进行图案化。反应性基团提供化学吸附或共价结合到基底表面。所得到的表现出良好稳定性的核酸特征可与互补核酸杂交，并使用例如用核酸官能化的纳米颗粒进行相应的探测。可以通过选择尖端处理，相对湿度和核酸结构来控制图案化。

13. 发明授权

US07005378B2 Processes for fabricating conductive patterns using nanolithography as a patterning tool 失效
标题翻译：使用纳米光刻作为图案形成工具制造导电图案的工艺
公开(公告)号：US07005378B2
公开(公告)日：2006-02-28
申请号：US10647430
申请日：2003-08-26
申请人： Percy Vandorn Crocker, Jr. , Linette Demers , Nabil A. Amro
发明人： Percy Vandorn Crocker, Jr. , Linette Demers , Nabil A. Amro
IPC分类号： H01L21/44
CPC分类号： C23C18/06 , B82Y10/00 , B82Y40/00 , C23C18/08 , C23C18/161 , C23C18/1612 , C23C18/1658 , C23C18/1666 , C23C18/1667 , C23C18/1678 , G03F7/0002 , H01L21/288 , H01L21/76838 , H05K3/105 , H05K3/1241 , Y10S438/929
摘要： Nanolithographic deposition of metallic nanostructures using coated tips for use in microelectronics, catalysis, and diagnostics. AFM tips can be coated with metallic precursors and the precursors patterned on substrates. The patterned precursors can be converted to the metallic state with application of heat. High resolution and excellent alignment can be achieved.
摘要翻译：使用涂覆尖端的金属纳米结构的纳米光刻沉积用于微电子学，催化和诊断。 AFM尖端可以用金属前体涂覆，并且前体在基底上图案化。图案化的前体可以通过加热转化成金属状态。可以实现高分辨率和优异的对准。

14. 发明授权

US07842344B2 Peptide and protein arrays and direct-write lithographic printing of peptides and proteins 有权
标题翻译：肽和蛋白质阵列和肽和蛋白质的直写平版印刷
公开(公告)号：US07842344B2
公开(公告)日：2010-11-30
申请号：US10788414
申请日：2004-03-01
申请人： Chad A. Mirkin , Jung-Hyurk Lim , David S. Ginger , Jwa-Min Nam , Ki-Bum Lee , Linette Demers , Albena Ivanisevic
发明人： Chad A. Mirkin , Jung-Hyurk Lim , David S. Ginger , Jwa-Min Nam , Ki-Bum Lee , Linette Demers , Albena Ivanisevic
IPC分类号： B05D1/36
CPC分类号： G03B27/42 , Y10S977/857 , Y10S977/884 , Y10S977/885 , Y10S977/886
摘要： The present invention relates to the use of direct-write lithographic printing of proteins and peptides onto surfaces. In particular, the present invention relates to methods for creating protein and peptide arrays and compositions derived therefrom. Nanoscopic tips can be used to deposit the peptide or protein onto the surface to produce a pattern. The pattern can be dots or lines having dot diameter and line width of less than 1,000 nm. The tips and the substrate surfaces can be adapted for the peptide and protein lithography.
摘要翻译：本发明涉及将蛋白质和肽直接写入平版印刷在表面上的用途。特别地，本发明涉及用于产生蛋白质和肽阵列的方法和由其衍生的组合物。可以使用纳米尖端将肽或蛋白质沉积到表面上以产生图案。图案可以是点直径和线宽小于1,000nm的点或线。尖端和底物表面可适用于肽和蛋白质光刻。

15. 发明申请

US20080269073A1 DIRECT WRITE NANOLITHOGRAPHIC DEPOSITION OF NUCLEIC ACIDS FROM NANOSCOPIC TIPS 有权
标题翻译：来自纳米结构的核酸的直接写入纳米晶体沉积
公开(公告)号：US20080269073A1
公开(公告)日：2008-10-30
申请号：US12044738
申请日：2008-03-07
申请人： Chad A. Mirkin , Linette Demers , David S. Ginger
发明人： Chad A. Mirkin , Linette Demers , David S. Ginger
IPC分类号： C40B40/06 , C40B50/18
CPC分类号： G03F7/0002 , G01Q80/00 , Y10T436/2575
摘要： The use of direct-write nanolithography to generate anchored, nanoscale patterns of nucleic acid on different substrates is described, including electrically conductive and insulating substrates. Modification of nucleic acid, including oligonucleotides, with reactive groups such as thiol groups provides for patterning with use of appropriate scanning probe microscopic tips under appropriate conditions. The reactive groups provide for chemisorption or covalent bonding to the substrate surface. The resulting nucleic acid features, which exhibit good stability, can be hybridized with complementary nucleic acids and probed accordingly with use of, for example, nanoparticles functionalized with nucleic acids. Patterning can be controlled by selection of tip treatment, relative humidity, and nucleic acid structure.
摘要翻译：描述了使用直写式纳米光刻技术在不同基底上产生锚定的纳米级核酸图案，包括导电和绝缘基底。含有反应性基团如硫醇基团的核酸（包括寡核苷酸）的修饰使得在合适的条件下使用合适的扫描探针显微镜尖端进行图案化。反应性基团提供化学吸附或共价结合到基底表面。所得到的表现出良好稳定性的核酸特征可与互补核酸杂交，并使用例如用核酸官能化的纳米颗粒进行相应的探测。可以通过选择尖端处理，相对湿度和核酸结构来控制图案化。

16. 发明授权

US07098056B2 Apparatus, materials, and methods for fabrication and catalysis 失效
标题翻译：用于制造和催化的装置，材料和方法
公开(公告)号：US07098056B2
公开(公告)日：2006-08-29
申请号：US10637641
申请日：2003-08-11
申请人： Linette Demers
发明人： Linette Demers
IPC分类号： H01L21/00
CPC分类号： B82Y30/00 , D01F9/127 , D01F9/1278 , Y10S977/857
摘要： A method for producing carbon nanotubes, the method comprising: (a) providing a substrate with a top surface, (b) forming an island of catalyst material on the top surface using a tip having a patterning compound thereon, (c) heating the substrate and catalyst island, and (d) contacting the catalyst island with a carbon-containing gas for a period of time sufficient to form the nanotubes on the catalyst island.
摘要翻译：一种碳纳米管的制造方法，其特征在于，包括：（a）在基材上形成上表面，（b）在上表面上形成具有图形化合物的末端的催化剂材料岛，（c）和催化剂岛，和（d）使催化剂岛与含碳气体接触足以在催化剂岛上形成纳米管的时间。

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