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11. 发明申请

US20090022695A1 METHOD FOR EXPANSION OF TUMOUR-REACTIVE T-LYMPHOCYTES FOR IMMUNOTHERAPY OF PATIENTS WITH SPECIFIC CANCER TYPES 有权
标题翻译：用于特异性癌症患者免疫的肿瘤反应性T淋巴细胞扩增的方法
公开(公告)号：US20090022695A1
公开(公告)日：2009-01-22
申请号：US12147752
申请日：2008-06-27
申请人： Ola Winqvist , Magnus Thorn
发明人： Ola Winqvist , Magnus Thorn
IPC分类号： A61K35/12 , C12N5/08
CPC分类号： A61K39/0011 , A61K2039/5158
摘要： Methods for treating a patient suffering from a neoplastic disease are disclosed and described. A number of diseases can be treated under the present methods, including without limitation gall bladder cancer, hepato cellular cancer, ovarian cancer, small intestine cancer, lung cancer, mesothelioma, breast cancer, kidney cancer, pancreas cancer, prostate cancer, carcinoid cancer, leiomyosarcoma, or metastasis thereof. A general method for providing such treatment may include: 1) identifying in a patient one or more sentinel and/or metinel lymph nodes draining the neoplasm; 2) resecting the one or more nodes and, optionally all or part of the tumour or metastasis; 3) isolating tumour-reactive T-lymphocytes from said lymph nodes; 4) in vitro expanding said tumour-reactive T-lymphocytes; and 5) administering the thus obtained tumour-reactive T-lymphocytes to the patient.
摘要翻译：公开和描述了治疗患有肿瘤疾病的患者的方法。可以根据本发明的方法治疗许多疾病，包括但不限于胆囊癌，肝细胞癌，卵巢癌，小肠癌，肺癌，间皮瘤，乳腺癌，肾癌，胰腺癌，前列腺癌，类癌，平滑肌肉瘤或其转移。提供这种治疗的一般方法可以包括：1）在患者身上识别排出赘生物的一个或多个哨兵和/或met淋巴结; 2）切除一个或多个节点，以及可选地全部或部分肿瘤或转移; 3）从所述淋巴结中分离肿瘤反应性T淋巴细胞; 4）体外扩增肿瘤反应性T淋巴细胞; 和5）将由此获得的肿瘤反应性T淋巴细胞给予患者。

12. 发明申请

US20070141026A1 Immunotherapy in cancer treatment 有权
标题翻译：癌症治疗中的免疫治疗
公开(公告)号：US20070141026A1
公开(公告)日：2007-06-21
申请号：US10530738
申请日：2003-10-08
申请人： Ola Winqvist , Magnus Thorn
发明人： Ola Winqvist , Magnus Thorn
IPC分类号： A61K38/20 , A61K38/19 , A61K39/395 , A61K35/14
CPC分类号： C12N5/0636 , A61K2039/5158 , C12N5/0651
摘要： The present invention relates to a novel method of cancer immuno-therapy and to a kit for use in this method. Specifically, the present invention relates to a novel method of collecting lymphocytes from sentinel lumph nodes and in vitro culture for the multiplication thereof lymphocytes.
摘要翻译：本发明涉及一种癌症免疫治疗的新方法以及用于该方法的试剂盒。具体地说，本发明涉及从前哨淋巴结收集淋巴细胞和体外培养用于增殖淋巴细胞的新方法。

13. 发明申请

US20110230396A1 ANTI-INFECTIVE COMPOUNDS AND USES THEREOF 审中-公开
标题翻译：抗感染化合物及其用途
公开(公告)号：US20110230396A1
公开(公告)日：2011-09-22
申请号：US13059997
申请日：2009-08-20
申请人： Ola Winqvist
发明人： Ola Winqvist
IPC分类号： A61K38/17 , A61P31/10
CPC分类号： A61K38/57
摘要： A medicament to prevent or cure fungal infections of the skin or body openings in an immunologically compromised person or animal can comprise Cystatin S, Cystatin SA, Cystatin SN, or similar agents.
摘要翻译：用于预防或治愈免疫受损害的人或动物中的皮肤或身体开口的真菌感染的药物可以包含半胱氨酸蛋白酶抑制剂S，半胱氨酸蛋白酶抑制剂SA，半胱氨酸蛋白酶抑制剂SN或类似药剂。

14. 发明申请

US20110129532A1 METHOD AND MEANS FOR TREATING VIRAL DISEASE, IN PARTICULAR HIV/AIDS 审中-公开
标题翻译：治疗病毒，特别是艾滋病毒/艾滋病的方法和手段
公开(公告)号：US20110129532A1
公开(公告)日：2011-06-02
申请号：US12995062
申请日：2009-05-18
申请人： Ulf Ljungblad , Yen Backstroem Lundgren , Ola Winqvist
发明人： Ulf Ljungblad , Yen Backstroem Lundgren , Ola Winqvist
IPC分类号： A61K38/09 , A61P31/14 , A61P31/22 , A61K9/14 , A61P31/16 , A61P31/12 , A61P1/16 , A61P31/18
CPC分类号： A61K38/09 , A61K45/06 , Y02A50/385 , Y02A50/387 , Y02A50/393 , Y02A50/397 , Y02A50/409 , Y02A50/467 , A61K2300/00
摘要： A method of treating viral disease, in particular HIV/AIDS, comprises concomitant administration of GnRH or GnRH analog including pharmaceutically acceptable salts thereof in an amount sufficient to maintain in the patient an elevated unphysiological plasma level, in particular a castrating plasma level, of GnRH or GnRH analog, and of one or several natural, semi-synthetic or synthetic sexual hormones in a amount sufficient to compensate for the castration effect of GnRH or GnRH analog. Also disclosed is a corresponding pharmaceutical composition and a composition kit, and uses thereof.
摘要翻译：一种治疗病毒性疾病，特别是艾滋病毒/艾滋病的方法包括以足以维持患者体内GnRH或GnRH类似物（包括其药学上可接受的盐）的同时给药，其具有升高的非生理性血浆水平，特别是阉割血浆水平的GnRH 或GnRH类似物，以及一种或多种天然，半合成或合成性激素，其量足以补偿GnRH或GnRH类似物的去势效应。还公开了相应的药物组合物和组合物试剂盒及其用途。

15. 发明申请

US20110081649A1 DIAGNOSIS, STAGING AND MONITORING OF INFLAMMATORY BOWEL DISEASE 审中-公开
标题翻译：诊断病毒感染的诊断，分期和监测
公开(公告)号：US20110081649A1
公开(公告)日：2011-04-07
申请号：US12671318
申请日：2008-07-29
申请人： Magnus Thoern , Ola Winqvist
发明人： Magnus Thoern , Ola Winqvist
IPC分类号： C12Q1/68 , G01N33/567
CPC分类号： G01N33/6893 , G01N33/505 , G01N2333/705 , G01N2800/065 , G01N2800/52 , G01N2800/56
摘要： A method of differentiating between active and inactive IBD in a gastrointestinal mucosa sample or a sample from a sentinel lymph node draining gastrointestinal mucosa comprises preparing a suspension of single cells from the sample, analyzing the suspension for expression of the inflammation activation marker CD69 on CD4+ T helper cells using directly labelled fluorescent DC69 antibody; comparing the number of T helper cells expressing DC69 in the sample with that obtained from a corresponding sample of a healthy person, a significantly increased level of T helper cells expressing CDD69 signifying the presence of active IBD and a less than significantly increased level of T helper cells signifying the presence of inactive IBD. Also disclosed are methods of differentiating between ulcerative colitis (UC) and Crohn's disease (CD), of detecting UC and CD, and of determining the susceptibility of an IBD patient to steroid treatment.
摘要翻译：在胃肠粘膜样品或来自排泄胃肠粘膜的前哨淋巴结的样品中区分活性和无活性IBD的方法包括制备来自样品的单细胞悬浮液，分析悬浮液以在CD4 + T上表达炎症活化标记物CD69 使用直接标记荧光DC69抗体的辅助细胞; 将样品中表达DC69的T辅助细胞数与从健康人的相应样品获得的T辅助细胞的数量进行比较，表达CDD69的T辅助细胞水平显着增加，表示活动性IBD的存在和小于显着升高的T辅助细胞水平表示存在无活性IBD的细胞。还公开了区分溃疡性结肠炎（UC）和克罗恩病（CD），检测UC和CD以及确定IBD患者对类固醇治疗的敏感性的方法。

16. 发明申请

US20100015161A1 Composition Comprising In Vitro Expanded T-Lymphocytes and Vessel Formation Inhibitors Suitable in the Treatment of Cancer 审中-公开
标题翻译：包含体外扩增的T淋巴细胞和容器形成抑制剂的组合物适用于治疗癌症
公开(公告)号：US20100015161A1
公开(公告)日：2010-01-21
申请号：US12505156
申请日：2009-07-17
申请人： Ola Winqvist , Magnus Thörn
发明人： Ola Winqvist , Magnus Thörn
IPC分类号： A61K39/395 , A61K35/26 , A61P35/00
CPC分类号： C12N5/0636 , A61K2039/5158 , C12N5/0651 , C12N2501/23
摘要： Improved cancer therapy using a combination treatment with tumour-reactive T-lymphocytes obtained by an in vitro method for expansion and activation of tumour-reactive lymphocytes, in particular CD4+ helper and/or CD8+ T-lymphocytes and inhibitors of vessel formation inhibitors, notably inhibitors of VEGF.
摘要翻译：使用通过体外扩增和激活肿瘤反应性淋巴细胞，特别是CD4 +辅助和/或CD8 + T淋巴细胞和血管形成抑制剂抑制剂的体外方法获得的肿瘤反应性T淋巴细胞的组合治疗改进的癌症治疗，特别是抑制剂的VEGF。

17. 发明申请

US20090081175A1 Method for Treating Disseminated Cancer 有权
标题翻译：治疗弥漫性癌症的方法
公开(公告)号：US20090081175A1
公开(公告)日：2009-03-26
申请号：US12158687
申请日：2006-12-20
申请人： Ola Winqvist , Magnus Thorn
发明人： Ola Winqvist , Magnus Thorn
IPC分类号： A61K35/12 , A61P35/04
CPC分类号： C12N5/0636 , A61K39/0011 , A61K2039/5158 , C12N5/0651 , C12N2501/23 , C12N2501/24
摘要： The present invention discloses an immunotherapeutic method for treating a patient suffering from a disseminated cancer by administering expanded tumour-reactive CD4+ helper and/or CD8+ T-lymphocytes obtainable from one or more metastasis-draining lymph nodes (metinel nodes) draining a metastasis. The method comprises identification of one or more metinel lymph nodes in a patient, resection of the one or more nodes and, optionally all or part of the metastases, isolation of metastasis-reactive T-lymphocytes from said lymph nodes, in vitro expansion of said metastasis-reactive T-lymphocytes, and administration of the thus obtained T-lymphocytes to the patient, wherein the T-lymphocytes are CD4+ helper and/or CD8+ T-lymphocytes.
摘要翻译：本发明公开了一种免疫治疗方法，用于通过施用从一个或多个排泄转移的转移性淋巴结（metinel node）获得的扩增的肿瘤反应性CD4 +辅助细胞和/或CD8 + T淋巴细胞来治疗患有弥漫性癌症的患者。该方法包括鉴定患者中的一个或多个el淋巴结，切除一个或多个淋巴结，以及任选全部或部分转移，从所述淋巴结分离转移反应性T淋巴细胞，所述淋巴结的体外扩增转移反应性T淋巴细胞，以及由此获得的T淋巴细胞给予患者，其中T淋巴细胞是CD4 +辅助细胞和/或CD8 + T淋巴细胞。

18. 发明授权

US08877177B2 Chemokine containing apheresis column and methods of use 有权
标题翻译：含有单采血浆的趋化因子柱和使用方法
公开(公告)号：US08877177B2
公开(公告)日：2014-11-04
申请号：US13063038
申请日：2009-09-10
申请人： Ola Winqvist , Graham Cotton
发明人： Ola Winqvist , Graham Cotton
IPC分类号： A01N63/00 , A61M37/00 , B01J20/30 , B01J20/32 , B01J20/26 , B01J20/28 , C07K14/52 , C07K17/06 , C07K17/10 , A61M1/36
CPC分类号： A61M1/3679 , A61M1/3618 , B01J20/262 , B01J20/267 , B01J20/28004 , B01J20/28009 , B01J20/28016 , B01J20/3085 , B01J20/3212 , B01J20/3219 , B01J20/3242 , B01J20/3272 , B01J20/3274 , B01J2220/58 , C07K14/52 , C07K14/521 , C07K17/06 , C07K17/10
摘要： An apheresis column loaded with a solid support comprises one or more chemokines, in particular biotinylated chemokines, immobilized directly or indirectly on the support, in particular on a support carrying streptavidin. Also disclosed are uses of the column and the support and a method of depleting cells, in particular leukocytes, from the peripheral blood of a person suffering from an inflammatory condition such as Inflammatory Bowel Disease (IBD).
摘要翻译：负载有固体支持物的单采血液柱包含一个或多个趋化因子，特别是生物素化的趋化因子，其直接或间接地固定在载体上，特别是在携带链霉亲和素的载体上。还公开了柱和载体的使用以及从患有炎症性肠炎（IBD）的人的外周血中消耗细胞，特别是白细胞的方法。

19. 发明授权

US08449489B2 Method and means for treating inflammatory bowel disease 有权
标题翻译：治疗炎症性肠病的方法和手段
公开(公告)号：US08449489B2
公开(公告)日：2013-05-28
申请号：US12300501
申请日：2007-05-14
申请人： Magnus Thorn , Ola Winqvist
发明人： Magnus Thorn , Ola Winqvist
IPC分类号： A61M37/00 , A61K39/395
CPC分类号： C07K16/28 , A61M1/3679
摘要： A method of treating inflammatory bowel disease (IBD) comprises providing an intestinal biopsy sample obtained from inflamed tissue of a patient; mechanically treating the sample to obtain a cell suspension; identifying cell surface markers of activated leukocytes selected from T lymphocytes, neutrophil granulocytes, and eosinophil granulocytes in the suspension; raising antibodies against one of more of the activated cells and immobilizing them on a support; providing a column loaded with the support; diverting a portion of the patient's peripheral blood to make it pass through the column before re-infusing it to the patient to make the activated leukocytes couple with antibodies on the support, thereby eliminating them from the blood stream. Also disclosed are corresponding columns and supports, and their use in the method.
摘要翻译：治疗炎性肠病（IBD）的方法包括提供从患者的发炎组织获得的肠活检样品; 机械处理样品以获得细胞悬浮液; 鉴定悬浮液中选自T淋巴细胞，嗜中性粒细胞和嗜酸粒细胞粒细胞的活化白细胞的细胞表面标志物; 提高针对一种或多种活化细胞的抗体并将其固定在载体上; 提供装载有支撑件的柱子; 转移患者外周血的一部分使其通过柱，然后将其再次注入患者，使活化的白细胞与载体上的抗体偶联，从而从血液中除去它们。还公开了相应的列和支持，以及它们在该方法中的使用。

20. 发明授权

US08211424B2 Method for treating malignant melanoma 有权
标题翻译：恶性黑色素瘤治疗方法
公开(公告)号：US08211424B2
公开(公告)日：2012-07-03
申请号：US12158681
申请日：2006-12-20
申请人： Ola Winqvist , Magnus Thörn
发明人： Ola Winqvist , Magnus Thörn
IPC分类号： A01N63/02 , A61K35/02 , A61K35/26
CPC分类号： A61K39/0011 , A61K38/21 , A61K2039/5158 , C12N5/0636 , C12N2501/23 , G01N2333/57
摘要： The present invention discloses an immunotherapeutic method for treating patients suffering from malignant melanoma, by administering expanded tumour-reactive CD4+ helper and/or CD8+ T-lymphocytes obtainable from one or more sentinel or metinel lymph nodes draining a malignant melanoma or a metastasis arising from malignant melanoma. The present invention provides a new effective method for treating malignant melanoma and metastatic malignant melanoma, without adverse side effects associated with the known treatments. The method comprises identification of in a patient one or more sentinel and/or metinel lymph nodes draining a malignant melanoma or a metastasis there from, resection of the one or more nodes and, optionally all or part of the tumour or metastasis, isolation of tumour-reactive T-lymphocytes from said lymph nodes, in vitro expansion of said tumour-reactive T-lymphocytes, and administration of the thus obtained tumour-reactive T-lymphocytes to the patient, wherein the T-lymphocytes are CD4+ helper and/or CD8+ T-lymphocytes.
摘要翻译：本发明公开了一种用于治疗患有恶性黑色素瘤的患者的免疫治疗方法，其通过施用扩增的肿瘤反应性CD4 +辅助细胞和/或CD8 + T淋巴细胞，所述扩增的肿瘤反应性CD4 +辅助细胞和/或CD8 + T淋巴细胞可从排除恶性黑素瘤的一个或多个前哨淋巴结或met淋巴结或由恶性黑素瘤引起的转移黑色素瘤本发明提供了治疗恶性黑素瘤和转移性恶性黑素瘤的新型有效方法，其与已知治疗相关的无副作用。该方法包括在患者中识别排出恶性黑素瘤或其中的转移的一个或多个前哨淋巴结和/或met淋巴结，切除一个或多个淋巴结，以及任选全部或部分肿瘤或转移，分离肿瘤来自所述淋巴结的反应性T淋巴细胞，所述肿瘤反应性T淋巴细胞的体外扩增，以及由此获得的肿瘤反应性T淋巴细胞给予患者，其中T淋巴细胞是CD4 +辅助和/或CD8 + T淋巴细胞。

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