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12. 发明授权

US09409905B2 Antibacterial compounds and methods for use 有权
标题翻译：抗菌化合物及使用方法
公开(公告)号：US09409905B2
公开(公告)日：2016-08-09
申请号：US14241506
申请日：2012-08-29
申请人： Arthur Branstrom , Vara Prasad Venkata Nagendra Josyula , Michael Andrew Arnold , Aleksey I. Gerasyuto , Gary Karp , Jiashi Wang , John David Baird , Guangming Chen , Olya Ginzburg , Jana Narasimhan , Srinivasa Peddi , Hongyan Qi , Sean Wesley Smith , Matthew G. Woll , Tianle Yang , Nanjing Zhang , Xiaoyan Zhang
发明人： Arthur Branstrom , Vara Prasad Venkata Nagendra Josyula , Michael Andrew Arnold , Aleksey I. Gerasyuto , Gary Karp , Jiashi Wang , John David Baird , Guangming Chen , Olya Ginzburg , Jana Narasimhan , Srinivasa Peddi , Hongyan Qi , Sean Wesley Smith , Matthew G. Woll , Tianle Yang , Nanjing Zhang , Xiaoyan Zhang
IPC分类号： C07D401/14 , C07D413/04 , C07D471/04 , C07D405/14 , C07D401/04 , A61K31/4709 , A61K31/5377 , A61K31/4439 , A61K45/06 , A61K31/437
CPC分类号： C07D471/04 , A61K31/437 , A61K31/4439 , A61K31/4709 , A61K31/5377 , A61K45/06 , C07D401/04 , C07D401/14 , C07D405/14 , C07D413/04 , Y02A50/406 , Y02A50/473 , Y02A50/475 , Y02A50/481
摘要： The present description relates to compounds and forms and pharmaceutical compositions thereof and methods for use thereof to treat or ameliorate bacterial infections caused by wild-type and multi-drug resistant Gram-negative and Gram-positive pathogens.
摘要翻译：本说明书涉及其化合物及其形式及其药物组合物及其用于治疗或改善由野生型和多药耐药革兰氏阴性和革兰氏阳性病原体引起的细菌感染的方法。

13. 发明申请

US20150080362A1 ANTIBACTERIAL COMPOUNDS AND METHODS FOR USE 有权
公开(公告)号：US20150080362A1
公开(公告)日：2015-03-19
申请号：US14241372
申请日：2012-08-29
申请人： Arthur Branstrom , Vara Prasad Venkata Nagendra Josyula , Michael Andrew Arnold , Aleksey I. Gerasyuto , Gary Karp , Jiashi Wang , Tamil Arasu , John David Baird , Wu Du , Olya Ginzburg , Yi Jin Kim Gorske , Jana Narasimhan , Srinivasa Peddi , Hongyan Qi , Sean Wesley Smith , Anthony Allan Turpoff , Richard Gerald Wilde , Tianle Yang , Nanjing Zhang , Xiaoyan Zhang
发明人： Arthur Branstrom , Vara Prasad Venkata Nagendra Josyula , Michael Andrew Arnold , Aleksey I. Gerasyuto , Gary Karp , Jiashi Wang , Tamil Arasu , John David Baird , Wu Du , Olya Ginzburg , Yi Jin Kim Gorske , Jana Narasimhan , Srinivasa Peddi , Hongyan Qi , Sean Wesley Smith , Anthony Allan Turpoff , Richard Gerald Wilde , Tianle Yang , Nanjing Zhang , Xiaoyan Zhang
IPC分类号： C07D515/04 , A61K31/4412 , C07D401/10 , A61K45/06 , A61K31/5377 , A61K31/4439 , C07D487/08 , A61K31/5383 , C07D213/80 , A61K31/4427
CPC分类号： C07D515/04 , A01N43/40 , A01N43/50 , A01N43/56 , A01N43/60 , A01N43/647 , A01N43/84 , A01N43/90 , A01N47/38 , A61K31/4412 , A61K31/4427 , A61K31/4439 , A61K31/496 , A61K31/5377 , A61K31/5383 , A61K45/06 , C07D213/80 , C07D401/10 , C07D487/08 , Y02A50/473 , Y02A50/475 , A61K2300/00
摘要： The present description relates to compounds and forms and pharmaceutical compositions thereof and methods for use thereof to treat or ameliorate bacterial infections caused by wild-type and multi-drug resistant Gram-negative and Gram-positive pathogens.

14. 发明申请

US20090221655A1 ANTIBACTERIAL AGENTS 审中-公开
标题翻译：抗菌剂
公开(公告)号：US20090221655A1
公开(公告)日：2009-09-03
申请号：US12278006
申请日：2007-01-22
申请人： Vara Prasad Venkata Nagendra Josyula , Allison Laura Choy
发明人： Vara Prasad Venkata Nagendra Josyula , Allison Laura Choy
IPC分类号： A61K31/422 , C07D413/10 , A61P31/04
CPC分类号： C07D413/14 , C07D413/04
摘要： The present invention provides a compound of Formula (I) Or a pharmaceutically acceptable salt thereof wherein: W is CH2NHC(═Z)R1, C(═Z)NHR2, or CH2het; X is H, C1-6alkyl, or C2-6alkenyl; Y is H, or F; Z is O, or S; R1 is C1-6alkyl, NHC1-6alkyl, C3-7cycloalkyl, C2-6alkenyl, or OC1-4alkyl; R2 is H, C1-4alkyl, or —OC1-4alkyl; and het is a five-(5) or six-(6) membered heterocyclic ring having 1-4 heteroatoms selected from the group consisting of oxygen, sulfur, and nitrogen within the ring, wherein each carbon atom in het is optionally substituted with C1-4alkyl, C2-4alkenyl, C2-4alkynyl, halo, OR3, CN, NO2, NHR3R3, oxo, CF3, OCF3, C(═O)C1-4alkyl, OC(═O)C1-4alkyl, or C(═O)OR3; wherein R3 is H, or C1-4alkyl.
摘要翻译：本发明提供式（I）化合物或其药学上可接受的盐，其中：W是CH 2 NHC（-Z）R 1，C（-Z）NHR 2或CH 2 het; X是H，C 1-6烷基或C 2-6烯基; Y是H或F; Z是O或S; R 1是C 1-6烷基，NHC 1-6烷基，C 3-7环烷基，C 2-6烯基或OC 1-4烷基; R2是H，C1-4烷基或-OC1-4烷基; 并且het是在环内具有1-4个选自氧，硫和氮的1-4个杂原子的五（5）或六（6）元杂环，其中每个碳原子在任何位置任选被C1取代（O）C 1-4烷基，或C（-O（O）） - ， - （C 1-4）烷基，C 1-4烷基，C 2-4烯基，C 2-4炔基，卤素，OR 3，CN，NO 2，NHR 3 R 3，氧代，CF 3，OCF 3，C ）OR3; 其中R 3是H或C 1-4烷基。

15. 发明授权

US07435751B2 7-Fluoro-1,3-dihydro-indol-2-one oxazolidinones as antibacterial agents 失效
标题翻译： 7-氟-1,3-二氢 - 吲哚-2-酮恶唑烷酮作为抗菌剂
公开(公告)号：US07435751B2
公开(公告)日：2008-10-14
申请号：US11393961
申请日：2006-03-30
申请人： Vara Prasad Venkata Nagendra Josyula , Mikhail Gordeev , Gary Luehr
发明人： Vara Prasad Venkata Nagendra Josyula , Mikhail Gordeev , Gary Luehr
IPC分类号： A61K31/421 , A61K31/422 , C07D263/04 , C07D413/04
CPC分类号： C07D413/04
摘要： The present invention provides a compound of formula I or a pharmaceutically acceptable salt thereof wherein R1 is C1-4alkyl, optionally substituted with a fluoro atom, or R1 is a cyclopropyl or cyclopropylmethyl; and R2 is methyl or ethyl. These compounds are useful as antibacterial agents.
摘要翻译：本发明提供式I化合物或其药学上可接受的盐，其中R 1是任选被氟原子取代的C 1-4烷基，或R 0 > 1是环丙基或环丙基甲基; R 2是甲基或乙基。这些化合物可用作抗菌剂。

16. 发明授权

US07265140B2 Acyloxymethylcarbamate prodrugs of oxazolidinones 失效
标题翻译：氰甲氧基甲基氨基甲酸酯前药的恶唑烷酮
公开(公告)号：US07265140B2
公开(公告)日：2007-09-04
申请号：US10937187
申请日：2004-09-09
申请人： Vara Prasad Venkata Nagendra Josyula , Robert C. Gadwood , Lisa Marie Thomasco , Ji-Young Kim , Allison Laura Choy , Frederick Earl Boyer
发明人： Vara Prasad Venkata Nagendra Josyula , Robert C. Gadwood , Lisa Marie Thomasco , Ji-Young Kim , Allison Laura Choy , Frederick Earl Boyer
IPC分类号： A61K31/422 , C07D263/04
CPC分类号： C07D413/10 , C07D413/14
摘要： The present invention relates to acyloxymethylcarbamate oxazolidinones. The compounds of the present invention have potent activity with excellent oral bioavailability against Gram-positive and Gram-negative bacteria.
摘要翻译：本发明涉及酰氧基甲基氨基甲酸酯恶唑烷酮。本发明的化合物对革兰氏阳性和革兰氏阴性菌具有优异的口服生物利用度的有效活性。

17. 发明授权

US07141588B2 N-aryl-2-oxazolidinone-5-carboxamides and their derivatives 失效
标题翻译： N-芳基-2-恶唑烷酮-5-甲酰胺及其衍生物
公开(公告)号：US07141588B2
公开(公告)日：2006-11-28
申请号：US10646440
申请日：2003-08-22
申请人： Richard Charles Thomas , Toni-Jo Poel , Michael Robert Barbachyn , Mikhail Fedor Gordeev , Gary W. Luehr , Adam Renslo , Upinder Singh , Vara Prasad Venkata Nagendra Josyula
发明人： Richard Charles Thomas , Toni-Jo Poel , Michael Robert Barbachyn , Mikhail Fedor Gordeev , Gary W. Luehr , Adam Renslo , Upinder Singh , Vara Prasad Venkata Nagendra Josyula
IPC分类号： A61K31/44 , C07D223/02
CPC分类号： C07D263/20 , A61K31/4035 , A61K31/42 , A61K31/421 , A61K31/4245 , C07D263/58 , C07D413/04 , C07D413/10 , C07D417/04 , C07D417/10 , C07D471/04 , C07F9/65583
摘要： The present invention provides antibacterial agents having the formulae I, II, and III described herein.
摘要翻译：本发明提供具有本文所述的式I，II和III的抗菌剂。

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