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11. 发明申请

US20050032707A1 Novel peptides comprising furanoid sugar amino acids for the treatment of cancer 失效
标题翻译：包含呋喃糖类氨基酸的新型肽用于治疗癌症
公开(公告)号：US20050032707A1
公开(公告)日：2005-02-10
申请号：US10638107
申请日：2003-08-08
申请人： Sudhanand Prasad , Tushar Chakraborty , Archna Mathur , Manu Jaggi , Ajit Kunwar , Rama Mukherjee , Anand Burman
发明人： Sudhanand Prasad , Tushar Chakraborty , Archna Mathur , Manu Jaggi , Ajit Kunwar , Rama Mukherjee , Anand Burman
IPC分类号： A61K38/00 , C07K5/103 , C07K7/06 , C07K14/575 , A61K38/08
CPC分类号： C07K7/06 , A61K38/00 , C07K5/1013 , C07K14/57563
摘要： Anticancer peptides which incorporate furanoid sugar amino acids and compositions made using these peptides are described. Methods for synthesis of the peptides and for preparing the furanoid sugar amino acids are disclosed. The peptides and compositions made using the peptides have pharmacological applications of these peptides especially in the treatment and prevention of cancer and tumors.
摘要翻译：描述了掺入呋喃糖类氨基酸的抗癌肽和使用这些肽制备的组合物。公开了合成肽和制备呋喃糖基氨基酸的方法。使用肽制备的肽和组合物具有这些肽的药理学应用，特别是在治疗和预防癌症和肿瘤中。

12. 发明授权

US06596692B1 Substance P analogs for the treatment of cancer 失效
标题翻译：物质P类似物治疗癌症
公开(公告)号：US06596692B1
公开(公告)日：2003-07-22
申请号：US09629642
申请日：2000-07-31
申请人： Anand C. Burman , Sudhanand Prasad , Rama Mukherjee , Manu Jaggi , Anu T. Singh
发明人： Anand C. Burman , Sudhanand Prasad , Rama Mukherjee , Manu Jaggi , Anu T. Singh
IPC分类号： A61K3800
CPC分类号： C07K7/22 , A61K38/00
摘要： The present invention encompasses novel synthetic peptide analogs that are antagonists to Substance P, substance P like peptides and related peptides and are useful for the treatment of cancer. The invention particularly relates to the design and synthesis of the novel substance P antagonist analogs incorporating &agr;,&agr;-dialkylated amino acids in a site specific manner. The invention encompasses methods for the generation of these peptides, compositions containing these peptides and pharmacological applications of these peptides specifically in the treatment and prevention of cancer.
摘要翻译：本发明包括对物质P，物质P如肽和相关肽的拮抗剂的新型合成肽类似物，并且可用于治疗癌症。本发明特别涉及以特定方式结合α，α-二烷基化氨基酸的新物质P拮抗剂类似物的设计和合成。本发明包括用于产生这些肽的方法，含有这些肽的组合物和这些肽的药理学应用特异性地用于治疗和预防癌症。

13. 发明授权

US06492330B1 Antiangiogenic drugs 失效
标题翻译：抗血管生成药物
公开(公告)号：US06492330B1
公开(公告)日：2002-12-10
申请号：US09248381
申请日：1999-02-11
申请人： Rama Mukherjee , Manu Jaggi , Sudhanand Prasad , Anand C. Burman , Praveen Rajendran , Archana Mathur , Anu T. Singh
发明人： Rama Mukherjee , Manu Jaggi , Sudhanand Prasad , Anand C. Burman , Praveen Rajendran , Archana Mathur , Anu T. Singh
IPC分类号： A61K3800
CPC分类号： A61K38/31 , A61K38/08 , A61K38/10 , C07K7/086 , C07K7/22 , C07K14/57563 , C07K14/6555
摘要： The invention relates to the use of peptides individually or in combination, for treating and/or preventing angiogenesis. It also relates to the use of peptide analogs or a combination of peptides referred to as MuJ-7 as anticancer drugs in restricting the tumor growth and spread by inhibiting tumor angiogenesis. MuJ-7, in addition inhibits metastasis through its antiangiogenic activity in all cancers. The invention also relates to a pharmaceutical composition containing either individual peptides or in combination, and methods of treatment of human beings and animals for curing and/or preventing angiogenesis.
摘要翻译：本发明涉及肽单独或组合用于治疗和/或预防血管生成的用途。它还涉及肽类似物或被称为MuJ-7的肽的组合作为抗癌药物在限制肿瘤生长和通过抑制肿瘤血管生成而扩散的用途。 MuJ-7还通过其所有癌症中的抗血管生成活性抑制转移。本发明还涉及含有单个肽或组合的药物组合物，以及用于治疗和/或预防血管生成的人和动物的治疗方法。

14. 发明授权

US06608174B1 Radiolabeled vasoactive intestinal peptide analogs for diagnosis and radiotherapy 失效
标题翻译：放射性标记的血管活性肠肽类似物用于诊断和放射治疗
公开(公告)号：US06608174B1
公开(公告)日：2003-08-19
申请号：US09629632
申请日：2000-07-31
申请人： Anand C. Burman , Sudhanand Prasad , Rama Mukherjee , Sarjana Dutt , Rajan T. Sharma , Rinku Ahuja , Anil K. Mishra , Lazar T. Mathew
发明人： Anand C. Burman , Sudhanand Prasad , Rama Mukherjee , Sarjana Dutt , Rajan T. Sharma , Rinku Ahuja , Anil K. Mishra , Lazar T. Mathew
IPC分类号： A61K3816
CPC分类号： C07K14/57563 , A61K38/00 , A61K51/08
摘要： The present invention encompasses radiolabeled peptide analogs of vasoactive intestinal peptide (VIP) labeled with a radionuclide useful for imaging target sites within mammalian living systems. The invention particularly provides radiolabeled VIP derivatives that bind selectively to the VIP receptor on target cells. Specifically, the invention relates to the radiolabeling of VIP-receptor specific agents and their subsequent use for radiodiagnostic and radiotherapeutic purposes. The invention encompasses methods for radiolabeling these peptides with radio-nuclides and the use of these peptides as scintigraphic imaging agents. The radiolabeled VIP derivatives of the present invention exhibit pharmacological activity and therefore are useful as either imaging agent for visualization of VIP-receptor positive tumors and metastases, as a radiodiagnostic agent or as a radio-therapeutic agent for the treatment of such tumors in vivo by specifically targeting the cytotoxic radionuclide selectively to the tumor site in mammalian living systems.
摘要翻译：本发明包括用放射性核素标记的血管活性肠肽（VIP）的放射性标记肽类似物，其用于成像哺乳动物生物系统内的靶位点。本发明特别提供了放射性标记的VIP衍生物，其选择性地结合靶细胞上的VIP受体。具体地，本发明涉及VIP-受体特异性试剂的放射性标记及其随后用于放射诊断和放射治疗目的。本发明包括用放射性核素放射性标记这些肽的方法以及这些肽作为闪烁照相成像剂的用途。本发明的放射性标记的VIP衍生物显示药理活性，因此可用作VIP-受体阳性肿瘤和转移的可视化显像剂，作为放射诊断剂或作为放射治疗剂，用于通过特别是将细胞毒性放射性核素选择性地靶向哺乳动物生命系统中的肿瘤部位。

15. 发明申请

US20070093422A1 Drug comprising synthetic peptide analogs for the treatment of cancer 失效
标题翻译：包含用于治疗癌症的合成肽类似物的药物
公开(公告)号：US20070093422A1
公开(公告)日：2007-04-26
申请号：US11643342
申请日：2006-12-21
申请人： Rama Mukherjee , Anand Burman , Anu Singh , Manu Jaggi , Sudhanand Prasad , Sarjana Dutt
发明人： Rama Mukherjee , Anand Burman , Anu Singh , Manu Jaggi , Sudhanand Prasad , Sarjana Dutt
IPC分类号： A61K38/10 , C07K7/06
CPC分类号： A61K38/08 , A61K2300/00
摘要： The present invention relates to a combination of peptides that may be used for treatment of cancer. The peptide combination competes for the binding of specific neuropeptides at the plasma membrane and thereby alters the levels of key intracellular molecules implicated in cell proliferation, resulting in a broad spectrum of anticancer activity. The invention also relates to pharmaceutical compositions containing a combination of such peptide analogs.
摘要翻译：本发明涉及可用于治疗癌症的肽的组合。肽组合竞争在质膜上特异性神经肽的结合，从而改变涉及细胞增殖的关键细胞内分子的水平，导致广谱的抗癌活性。本发明还涉及含有这些肽类似物的组合的药物组合物。

16. 发明授权

US09907812B2 Conjugate-based antifungal and antibacterial prodrugs 有权
公开(公告)号：US09907812B2
公开(公告)日：2018-03-06
申请号：US14128281
申请日：2012-06-22
申请人： Abhijit S. Bapat , Gauthami Mahesh , Rajesh S. Gokhale , Sayali S. Shah , Shiladitya Sengupta , Sudhanand Prasad , Sumana Ghosh , Suresh R. Chawrai , Nidhi Arora , D. Sreedhar Reddy , Mallika Mishra , Kirti Bajaj
发明人： Abhijit S. Bapat , Gauthami Mahesh , Rajesh S. Gokhale , Sayali S. Shah , Shiladitya Sengupta , Sudhanand Prasad , Sumana Ghosh , Suresh R. Chawrai , Nidhi Arora , D. Sreedhar Reddy , Mallika Mishra , Kirti Bajaj
IPC分类号： A61K31/7056 , A61K47/48 , A61K31/085 , A61K31/496 , A61K8/37 , A61Q17/00 , A61K8/34 , A61K8/36 , A61K8/362 , A61K8/368 , A61K8/39 , A61K8/49 , A61Q5/00 , A61K8/60 , A61K8/81 , A61K8/02 , A01N37/46 , A61K47/60 , A61K47/54 , A61K47/55
CPC分类号： A61K31/7056 , A01N37/46 , A61K8/0241 , A61K8/347 , A61K8/361 , A61K8/362 , A61K8/368 , A61K8/37 , A61K8/375 , A61K8/39 , A61K8/49 , A61K8/4933 , A61K8/602 , A61K8/8129 , A61K31/085 , A61K31/496 , A61K47/54 , A61K47/542 , A61K47/552 , A61K47/60 , A61K2800/412 , A61K2800/413 , A61K2800/57 , A61Q5/006 , A61Q17/005
摘要： The invention provides conjugate-based antifungal or antibacterial prodrugs formed by coupling at least one anti-fungal agent or antibacterial agent with at least one linker and/or carrier. The prodrugs are of formula: (i) (AFA)m-X-(L)n; (ii) [(AFA)m′-X]p-L; (iii) AFA-[X-(L)n′]q; or (iv) (AFA)m″-X, wherein: AFA is an antifungal agent or an antibacterial agent; L is a carrier; X is a linker; m ranges from 1 to 10; n ranges from 2 to 10; m′ is 1 to 10; p is 1 to 10; n′ is 1 to 10; and q is 1 to 10, provided that q′ and n are not both 1; and m″ is 1 to 10. The invention also provides nanoparticles comprising the conjugate-based prodrugs. Additionally, the invention also provides non-conjugated antifungal and antibacterial agents in the form of nanoparticles.

17. 发明申请

US20140364595A1 CONJUGATE-BASED ANTIFUNGAL AND ANTIBACTERIAL PRODRUGS 有权
标题翻译：基于连接的抗真菌和抗菌素PRODRUGS
公开(公告)号：US20140364595A1
公开(公告)日：2014-12-11
申请号：US14128281
申请日：2012-06-22
申请人： Abhijit S. Bapat , Gauthami Mahesh , Rajesh S. Gokhale , Sayali S. Shah , Shiladitya Sengupta , Sudhanand Prasad , Sumana Ghosh , Suresh R. Chawrai , Nidhi Arora , D. Sreedhar Reddy , Malika Mishra , Kirti Bajaj
发明人： Abhijit S. Bapat , Gauthami Mahesh , Rajesh S. Gokhale , Sayali S. Shah , Shiladitya Sengupta , Sudhanand Prasad , Sumana Ghosh , Suresh R. Chawrai , Nidhi Arora , D. Sreedhar Reddy , Malika Mishra , Kirti Bajaj
IPC分类号： A61K31/7056 , A61K47/48 , A61K31/085 , A61K31/496
CPC分类号： A61K31/7056 , A01N37/46 , A61K8/0241 , A61K8/347 , A61K8/361 , A61K8/362 , A61K8/368 , A61K8/37 , A61K8/375 , A61K8/39 , A61K8/49 , A61K8/4933 , A61K8/602 , A61K8/8129 , A61K31/085 , A61K31/496 , A61K47/54 , A61K47/542 , A61K47/552 , A61K47/60 , A61K2800/412 , A61K2800/413 , A61K2800/57 , A61Q5/006 , A61Q17/005
摘要： The invention provides conjugate-based antifungal or antibacterial prodrugs formed by coupling at least one anti-fungal agent or antibacterial agent with at least one linker and/or carrier. The prodrugs are of formula: (i) (AFA)m-X-(L)n; (ii) [(AFA)m′-X]p-L; (iii) AFA-[X-(L)n′]q; or (iv) (AFA)m″-X, wherein: AFA is an antifungal agent or an antibacterial agent; L is a carrier; X is a linker; m ranges from 1 to 10; n ranges from 2 to 10; m′ is 1 to 10; p is 1 to 10; n′ is 1 to 10; and q is 1 to 10, provided that q′ and n are not both 1; and m″ is 1 to 10. The invention also provides nanoparticles comprising the conjugate-based prodrugs. Additionally, the invention also provides non-conjugated antifungal and antibacterial agents in the form of nanoparticles.
摘要翻译：本发明提供了通过将至少一种抗真菌剂或抗菌剂与至少一种接头和/或载体偶联而形成的基于缀合物的抗真菌或抗菌前药。前药具有下式：（i）（AFA）m-X-（L）n; （ii）[（AFA）m'-X] p-L; （iii）AFA- [X-（L）n'] q; 或（iv）（AFA）m“-X，其中：AFA是抗真菌剂或抗菌剂; L是载体; X是一个连接子; m范围从1到10; n范围从2到10; m'为1〜10; p为1〜10; n'为1〜10; q为1〜10，条件是q'和n不同时为1; 并且m“为1至10.本发明还提供了包含基于缀合物的前药的纳米颗粒。此外，本发明还提供纳米颗粒形式的非共轭抗真菌剂和抗菌剂。

18. 发明申请

US20110269680A1 GLP-1 ANALOGS AND USES THEREOF 审中-公开
标题翻译： GLP-1模拟物及其用途
公开(公告)号：US20110269680A1
公开(公告)日：2011-11-03
申请号：US13142516
申请日：2009-12-24
申请人： Rajesh Jain , Virender Kumar Vinayak , Sudhanand Prasad
发明人： Rajesh Jain , Virender Kumar Vinayak , Sudhanand Prasad
IPC分类号： A61K38/26 , A61P3/10 , C07K14/605
CPC分类号： C07K14/605 , A61K38/00
摘要： The present invention relates to a peptide selected from a group comprising GLP-1 analogs, its truncated forms, or pharmaceutically acceptable salts and derivatives thereof. The present invention further relates to a peptide selected from a group comprising GLP-1 analogs, its truncated forms, or pharmaceutically acceptable salts and derivatives thereof, wherein one or more aminoacids are substituted with a non-coded aminoacid.
摘要翻译：本发明涉及选自GLP-1类似物，其截短形式或其药学上可接受的盐和衍生物的组的肽。本发明还涉及一种选自包含GLP-1类似物，其截短形式或其药学上可接受的盐和衍生物的肽，其中一个或多个氨基酸被非编码氨基酸取代。

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