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11. 发明授权

US08367099B2 Perforated fatty acid films 有权
标题翻译：穿孔脂肪酸膜
公开(公告)号：US08367099B2
公开(公告)日：2013-02-05
申请号：US11525390
申请日：2006-09-22
申请人： Steve A. Herweck , Thomas M. Swanick , Joseph Ferraro , Paul Martakos , Lisa Rogers , Theodore Karwoski , Keith M. Faucher , Philip McNamara , Roger Labrecque , Suzanne Conroy , Trevor Carlton
发明人： Steve A. Herweck , Thomas M. Swanick , Joseph Ferraro , Paul Martakos , Lisa Rogers , Theodore Karwoski , Keith M. Faucher , Philip McNamara , Roger Labrecque , Suzanne Conroy , Trevor Carlton
IPC分类号： A61L15/16
CPC分类号： B65B55/18 , A61B2017/00004 , A61B2017/320044 , A61B2090/0816 , A61F2/0059 , A61F2/0095 , A61L2/07 , A61L2/081 , A61L2/087 , A61L2/14 , A61L2/186 , A61L2/206 , A61L2/208 , A61L31/00 , A61L31/145 , A61L31/148 , A61L2202/24 , B26F1/18 , B29C39/02 , B65B31/04 , Y10T83/0481
摘要： A bio-absorbable stand-alone film is derived at least in part from fatty acids. The bio-absorbable stand-alone film can have anti-adhesive, anti-inflammatory, non-inflammatory, and wound healing properties, and can additionally include one or more therapeutic agents incorporated therein. The stand-alone film has one or more perforations or depressions formed therein. Corresponding methods of making the bio-absorbable stand-alone film with one or more perforations or depressions include molding, cutting, carving, puncturing or otherwise suitable methods to create the perforations or depressions in the bio-absorbable stand-alone film. The resulting stand-alone film is bioabsorbable.
摘要翻译：生物可吸收的独立膜至少部分地由脂肪酸衍生。生物吸收性独立膜可以具有抗粘连性，抗炎性，非炎性和伤口愈合性，并且还可以包括一种或多种掺入其中的治疗剂。独立膜具有形成在其中的一个或多个穿孔或凹陷。使具有一个或多个穿孔或凹陷的生物吸收性独立薄膜的相应方法包括成型，切割，雕刻，穿刺或以其它方式适当地在生物吸收性独立薄膜中产生穿孔或凹陷的方法。所得到的独立膜是生物可吸收的。

12. 发明申请

US20120315219A1 Drug Delivery Coating For Use With A Stent 有权
标题翻译：药物输送涂层用于支架
公开(公告)号：US20120315219A1
公开(公告)日：2012-12-13
申请号：US13593656
申请日：2012-08-24
申请人： Roger Labrecque , Geoffrey Moodie , Joseph Ferraro , Lisa Rogers , Paul Martakos , Theodore Karwoski , Steve A. Herweck
发明人： Roger Labrecque , Geoffrey Moodie , Joseph Ferraro , Lisa Rogers , Paul Martakos , Theodore Karwoski , Steve A. Herweck
IPC分类号： A61K9/00 , A61P29/00 , A61P7/02 , A61P3/00 , A61P35/00 , A61K49/00 , A61K38/14 , A61K31/727 , A61K31/44 , A61K31/4709 , A61K31/405 , A61K31/366 , A61K31/337 , A61K31/215 , A61K31/4353 , B05D3/00 , B05D5/00 , A61K31/7088
CPC分类号： A61L31/08 , A61F2/82 , A61F2/86 , A61F2250/0067 , A61K47/10 , A61K47/22 , A61K47/44 , A61L31/10 , A61L31/148 , A61L31/16 , A61L2300/22 , A61L2300/416 , A61L2300/428 , A61L2300/45 , A61L2300/606 , A61L2300/802 , A61L2420/02 , A61M25/0009 , A61M25/0045
摘要： A coated medical device and a method of providing a coating on an implantable medical device result in a medical device having a bio-absorbable coating. The coating includes a bio-absorbable carrier component. In addition to the bio-absorbable carrier component, a therapeutic agent component can also be provided. The coated medical device is implantable in a patient to effect controlled delivery of the coating, including the therapeutic agent, to the patient.
摘要翻译：涂覆的医疗装置和在可植入医疗装置上提供涂层的方法导致具有生物可吸收涂层的医疗装置。涂层包括生物吸收载体组分。除了生物可吸收载体组分之外，还可以提供治疗剂成分。涂覆的医疗装置可植入患者体内以实现对包括治疗剂在内的涂层的可控输送。

13. 发明授权

US08001922B2 Application of a coating on a medical device 有权
标题翻译：涂在医疗器械上的应用
公开(公告)号：US08001922B2
公开(公告)日：2011-08-23
申请号：US11238554
申请日：2005-09-28
申请人： Roger Labrecque , Geoffrey Moodie , Joseph Ferraro , Lisa Rogers , Paul Martakos , Theodore Karwoski , Steve A. Herweck , Suzanne Conroy , Brian Sunter , Georgette Henrich
发明人： Roger Labrecque , Geoffrey Moodie , Joseph Ferraro , Lisa Rogers , Paul Martakos , Theodore Karwoski , Steve A. Herweck , Suzanne Conroy , Brian Sunter , Georgette Henrich
IPC分类号： B05C1/00
CPC分类号： A61L31/08 , A61F2/82 , A61F2/86 , A61F2250/0067 , A61K47/10 , A61K47/22 , A61K47/44 , A61L31/10 , A61L31/148 , A61L31/16 , A61L2300/22 , A61L2300/416 , A61L2300/428 , A61L2300/45 , A61L2300/606 , A61L2300/802 , A61L2420/02 , A61M25/0009 , A61M25/0045
摘要： Devices for the provision of a coating on an implantable medical device are provided. The coating includes a bio-absorbable carrier component. In addition to the bio-absorbable carrier component, a therapeutic agent component can also be provided. The devices provide a coating having improved uniformity and coverage which in turn allow for greater control of the amount and dosage of the coating.
摘要翻译：提供了用于在可植入医疗装置上提供涂层的装置。涂层包括生物吸收载体组分。除了生物可吸收载体组分之外，还可以提供治疗剂成分。这些装置提供具有改进的均匀性和覆盖度的涂层，这又允许更大程度地控制涂层的量和剂量。

14. 发明申请

US20110144667A1 HERNIA PATCH 审中-公开
标题翻译：赫尼亚·帕特
公开(公告)号：US20110144667A1
公开(公告)日：2011-06-16
申请号：US12877919
申请日：2010-09-08
申请人： Anthony Richard Horton , Paul Martakos , Steve A. Herweck , Theodore Karwoski , Joseph F. Ferraro
发明人： Anthony Richard Horton , Paul Martakos , Steve A. Herweck , Theodore Karwoski , Joseph F. Ferraro
IPC分类号： A61B17/08
CPC分类号： A61F2/0063 , A61F2210/0004 , A61F2210/0076 , A61F2220/0008 , A61F2220/0075 , A61F2230/0004 , A61F2250/0018 , A61F2310/00389 , A61K31/20 , A61L31/10 , A61L31/14 , A61L31/148
摘要： A hernia patch supporting tissue in-growth conforms to a tissue wall upon surgical installation and fixation within a patient. The hernia patch can include a base and positioning straps. The base is formed of two layers that are affixed to each other around the perimeter of the patch, for example by stitching. A stabilizing washer is provided between the two layers, and the stitch is provided peripherally around the stabilizing washer, keeping the washer free-floating between the layers. The base, positioning straps, and stabilizing washer are formed of a structure that does not separate the layers of the implant or form a space in the form of a pocket, and promotes more uniform and confluent tissue incorporation or in-growth after implantation. The hernia patch may further include a hydrolysable bioabsorbable cross-linked coating of a fatty acid based material, such as an omega-3 fatty acid based material.
摘要翻译：支撑组织生长的疝补片在外科手术安装和固定在患者体内时符合组织壁。疝补片可以包括基部和定位带。底座由两层相互贴合，例如通过拼接而在贴片的周边彼此固定。在两层之间设有一个稳定的垫圈，并且在周向围绕稳定垫圈设置线圈，保持垫片在层之间自由浮动。基部，定位带和稳定垫圈由不分离植入物层或形成袋状空间的结构形成，并且在植入后促进更均匀和汇合的组织结合或生长。疝补片可以进一步包括基于脂肪酸的材料如ω-3脂肪酸基材料的可水解生物可吸收的交联涂层。

15. 发明申请

US20100004738A1 DRUG DELIVERY COATING FOR USE WITH A MEDICAL DEVICE AND METHODS OF TREATING VASCULAR INJURY 审中-公开
标题翻译：用于医疗设备的药物输送涂料和治疗血管损伤的方法
公开(公告)号：US20100004738A1
公开(公告)日：2010-01-07
申请号：US11919315
申请日：2006-04-28
申请人： Steve A. Herweck , Paul Martakos , Geoffrey Moodie , Theodore Karwoski , Trevor Carlton
发明人： Steve A. Herweck , Paul Martakos , Geoffrey Moodie , Theodore Karwoski , Trevor Carlton
IPC分类号： A61F2/82 , A61F2/00 , A61K31/439 , A61M25/00 , A61B17/03
CPC分类号： A61K31/436 , A61L27/54 , A61L29/16 , A61L31/16 , A61L2300/434 , A61L2300/45
摘要： The present inventions provide various embodiments of methods for one or more of treating vascular injury, neointima proliferation and/or local inflammation in a mammal by locally administering therapeutic compound comprising a mTOR targeting compound and a calcineurin inhibitor. In various aspects, the therapeutic compound comprises a bio-absorbable carrier component carrier component at least partially formed of a cellular uptake inhibitor and a cellular uptake enhancer, a mTOR targeting compound and a calcineurin inhibitor. In various aspects, the present invention provides for controlled delivery, which is at least partially characterized by total and relative amounts of a cellular uptake inhibitor and cellular uptake enhancer in a bio-absorbable carrier component.
摘要翻译：本发明提供了通过局部施用包含mTOR靶向化合物和钙调磷酸酶抑制剂的治疗化合物来治疗哺乳动物血管损伤，新内膜增生和/或局部炎症中的一种或多种的方法的各种实施方案。在各个方面，治疗化合物包括至少部分由细胞摄取抑制剂和细胞吸收增强剂，mTOR靶向化合物和钙调磷酸酶抑制剂形成的生物可吸收载体组分载体组分。在各个方面，本发明提供受控递送，其至少部分地表征为生物可吸收载体组分中的细胞摄取抑制剂和细胞摄取增强剂的总量和相对量。

16. 发明申请

US20080207756A1 Bio-absorbable oil suspension 审中-公开
标题翻译：生物吸收油悬浮液
公开(公告)号：US20080207756A1
公开(公告)日：2008-08-28
申请号：US11711389
申请日：2007-02-27
申请人： Steve A. Herweck , Theodore Karwoski , Paul Martakos
发明人： Steve A. Herweck , Theodore Karwoski , Paul Martakos
IPC分类号： A61K31/20 , A61P39/00
CPC分类号： A61K31/20
摘要： Exemplary embodiments of the invention provide a dispersing liquid for coating internal body tissues with a bio-absorbable oil, a method of making the dispersing liquid, methods of using the dispersing liquid and a kit for coating internal body tissues using the dispersing liquid. The dispersing liquid includes a suspension of a bio-absorbable oil suspended in a liquid carrier. The invention results in a uniform thin coating of bio-absorbable oil on internal body tissues.
摘要翻译：本发明的示例性实施方案提供了用生物可吸收油涂覆内部身体组织的分散液，制备分散液的方法，使用分散液的方法和使用分散液涂覆内部身体组织的试剂盒。分散液包括悬浮在液体载体中的生物可吸收油的悬浮液。本发明导致生物吸收油在内部身体组织上的均匀薄涂层。

17. 发明授权

US6042666A Prosthesis with in-wall modulation 失效
标题翻译：具有壁内调制的假体
公开(公告)号：US6042666A
公开(公告)日：2000-03-28
申请号：US105736
申请日：1998-06-26
申请人： Theodore Karwoski , Paul Martakos , Peter Gingras , Steve A. Herweck , Tom Swanick
发明人： Theodore Karwoski , Paul Martakos , Peter Gingras , Steve A. Herweck , Tom Swanick
IPC分类号： A61F2/00 , A61F2/06 , A61F2/10 , A61F2/24 , A61F2/88 , A61L27/16 , A61L27/34 , A61L27/40 , B32B31/00
CPC分类号： A61F2/07 , A61F2/06 , A61L27/16 , A61L27/34 , A61L27/40 , A61F2/105 , A61F2/2412 , A61F2/88 , A61F2002/072 , A61F2240/001
摘要： The wall of a prosthesis has a region which modulates communication through the porosity of the wall. The prosthesis is unitary, but may be assembled in successive bodies which are coalesced, so that the porous microstructure changes distinctly at stages through the thickness dimension of the wall. One embodiment is formed entirely of fluoropolymer, and has at least one surface adapted to support tissue regeneration and ingrowth. The modulation region is a stratum of high water entry pressure that reduces pulsatile hydraulic pressure transmission, or locally alters fluid-born-distribution of biological material through the wall and allows more natural gradients for tissue regeneration and growth in the outer region of the wall.
摘要翻译：假体的壁具有通过壁的孔隙调节连通的区域。假体是单一的，但是可以组合成连续的体，其被聚结，使得多孔微结构在阶段通过壁的厚度尺寸明显变化。一个实施方案完全由氟聚合物形成，并且具有适于支持组织再生和向内生长的至少一个表面。调制区域是高水入口压力的层次，可降低脉动式液压传递，或局部改变生物材料通过壁的流体出生分布，并允许更多的自然梯度用于组织再生和壁的外部区域的生长。

18. 发明授权

US6010529A Expandable shielded vessel support 失效
标题翻译：可扩展屏蔽容器支架
公开(公告)号：US6010529A
公开(公告)日：2000-01-04
申请号：US759877
申请日：1996-12-03
申请人： Steve A. Herweck , Peter Gingras , Paul Martakos , Theodore Karwoski
发明人： Steve A. Herweck , Peter Gingras , Paul Martakos , Theodore Karwoski
IPC分类号： A61F2/00 , A61F2/06 , A61F2/10 , A61F2/24 , A61F2/88 , A61L31/04 , A61L31/10 , A61F2/04
CPC分类号： A61F2/07 , A61F2/06 , A61F2/88 , A61L31/04 , A61L31/10 , A61F2/105 , A61F2002/072 , A61F2240/001 , Y10S623/901
摘要： A radially expandable support body is enveloped within a cocoon. In a preferred construction, the support is a stent, and a tube of polymeric material, e.g. polytetrafluoroethylene (PTFE), passes through the interior of the stent body and is turned back upon itself over the stent to form a cuff. The assembly is then heated and the outer layer contacts and coalesces with the inner layer, closely surrounding the stent body within a folded envelope having a continuous and seamless end. In one embodiment, an end portion of the tube is expanded before folding back over the stent. The end portion, which becomes an exterior surface of the finished product, thus acquires a greater degree of porosity. Each end of the central tube may be so expanded, and folded back to seal all surfaces and both ends. The stent body itself may be a ring, or a short series of spaced-apart rings, or a wire or web, or a sheet possessing a number of apertures extending entirely through the sheet. The spaces or apertures are covered over or bridged by both the inner and outer polymer layers. The apertures, which may comprise under five to over eighty percent of the surface area of the stent, constitute regions or a grid of points through which the material is coalesced and continuously bonded, and around which strain is distributed by the support. These points or regions remain tacked together so expansion of the assembly does not delaminate the polymer or create flaps and pockets. In another embodiment, a two tube construction is cuffed and assembled into a similarly unitized and seamless stent. One tube is cuffed back, and the other tube covers the cuffed stent. In this embodiment both the tube thicknesses and porosities may differ substantially. For example the inner porosity may be selected to enhance blood flow or intimal regeneration, and the outer surface may have a porosity to encourage anchoring to external muscle tissue.
摘要翻译：径向可扩展的支撑体被包围在茧内。在优选的结构中，支撑件是支架，以及聚合物材料管，例如。聚四氟乙烯（PTFE）穿过支架主体的内部并在支架上自身转回以形成袖带。然后将组件加热并且外层与内层接触并聚结，在具有连续和无缝端部的折叠外壳内紧密地围绕支架主体。在一个实施例中，管的端部在折回到支架之前膨胀。成为成品的外表面的端部因此获得更大程度的孔隙率。中心管的每个端部可以如此膨胀，并且被折回以密封所有表面和两端。支架主体本身可以是一个环，或一系列间隔开的环，或者线或腹板，或者具有完全贯穿片材的多个孔的片。空间或孔被内聚合物层和外聚合物层覆盖或桥接。可以包括支架表面积的五到八十成以上的孔构成区域或网格，通过该点或网格将材料聚结并连续地结合，并且通过支撑分布在哪个应变附近。这些点或区域保持粘合在一起，因此组件的膨胀不会分解聚合物或产生襟翼和口袋。在另一个实施例中，将双管结构压合并组装成相似的单元化且无缝的支架。一根管子被套在后面，另一根管子覆盖着袖口支架。在该实施例中，管的厚度和孔隙度可能基本上不同。例如，可以选择内部孔隙率以增强血流或内膜再生，并且外表面可以具有孔隙度以促进锚定到外部肌肉组织。

19. 发明授权

US08962023B2 UV cured gel and method of making 有权
标题翻译：紫外线固化凝胶及其制备方法
公开(公告)号：US08962023B2
公开(公告)日：2015-02-24
申请号：US11236943
申请日：2005-09-28
申请人： Roger Labrecque , Philip McNamara , Joseph Ferraro , Lisa Rogers , Paul Martakos , Theodore Karwoski , Steve A. Herweck , Keith Faucher , Thomas M. Swanick
发明人： Roger Labrecque , Philip McNamara , Joseph Ferraro , Lisa Rogers , Paul Martakos , Theodore Karwoski , Steve A. Herweck , Keith Faucher , Thomas M. Swanick
IPC分类号： A61K9/00 , A61L27/54 , A61F13/02 , A61K9/06 , A61K31/225 , A61K31/355 , A61K47/12 , A61K47/14 , A61L2/07 , A61L2/08 , A61L2/20 , A61L27/36 , A61L27/52 , A61L31/00 , A61L31/10 , A61L31/14 , A61F2/06 , B05D3/06
CPC分类号： A61K35/60 , A61F2/06 , A61F13/02 , A61F13/023 , A61F2250/0067 , A61K9/0024 , A61K9/06 , A61K31/225 , A61K31/355 , A61K38/13 , A61K47/12 , A61K47/14 , A61L2/07 , A61L2/081 , A61L2/087 , A61L2/206 , A61L2/208 , A61L27/36 , A61L27/3604 , A61L27/52 , A61L27/54 , A61L31/005 , A61L31/10 , A61L31/145 , A61L2202/24 , A61L2300/22 , A61L2300/252 , A61L2300/404 , A61L2300/41 , A61L2300/414 , A61L2300/42 , A61L2300/602 , B05D3/067
摘要： A method of UV curing and corresponding resulting non-polymeric cross-linked gel are provided. The cross-linked gel can be combined with a medical device structure. The cross-linked gel can provide anti-adhesion characteristics, in addition to improved healing and anti-inflammatory response. The cross-linked gel is generally formed of a naturally occurring oil, or an oil composition formed in part of a naturally occurring oil, that is at least partially cured forming a cross-linked gel derived from at least one fatty acid compound. In addition, the oil composition can include a therapeutic agent component, such as a drug or other bioactive agent. The curing method can vary the application of UV light in both intensity and duration to achieve a desired amount of cross-linking forming the gel.
摘要翻译：提供UV固化方法和相应的所得非聚合交联凝胶。交联凝胶可以与医疗装置结构组合。除了改善愈合和抗炎反应之外，交联凝胶还可提供抗粘附特性。交联凝胶通常由天然存在的油或部分天然存在的油形成的油组合物形成，其至少部分固化形成由至少一种脂肪酸化合物衍生的交联凝胶。此外，油组合物可以包括治疗剂组分，例如药物或其它生物活性剂。固化方法可以改变UV光在强度和持续时间上的应用，以实现形成凝胶的所需量的交联。

20. 发明授权

US08795703B2 Stand-alone film and methods for making the same 有权
标题翻译：独立电影和制作相同的方法
公开(公告)号：US08795703B2
公开(公告)日：2014-08-05
申请号：US11237264
申请日：2005-09-28
申请人： Thomas M. Swanick , Joseph Ferraro , Paul Martakos , Lisa Rogers , Theodore Karwoski , Steve A. Herweck , Keith Faucher , Philip McNamara
发明人： Thomas M. Swanick , Joseph Ferraro , Paul Martakos , Lisa Rogers , Theodore Karwoski , Steve A. Herweck , Keith Faucher , Philip McNamara
IPC分类号： A61F2/00 , A61K9/14 , A61K35/60
CPC分类号： A61K35/60 , A61F2/06 , A61F13/02 , A61F13/023 , A61F2250/0067 , A61K9/0024 , A61K9/06 , A61K31/225 , A61K31/355 , A61K38/13 , A61K47/12 , A61K47/14 , A61L2/07 , A61L2/081 , A61L2/087 , A61L2/206 , A61L2/208 , A61L27/36 , A61L27/3604 , A61L27/52 , A61L27/54 , A61L31/005 , A61L31/10 , A61L31/145 , A61L2202/24 , A61L2300/22 , A61L2300/252 , A61L2300/404 , A61L2300/41 , A61L2300/414 , A61L2300/42 , A61L2300/602 , B05D3/067
摘要： A stand-alone film is derived at least in part from fatty acids. The stand-alone film can have anti-adhesive, anti-inflammatory, non-inflammatory, and wound healing properties, and can additionally include one or more therapeutic agents incorporated therein. Corresponding methods of making the stand-alone film include molding, casting, or otherwise applying a liquid or gel to a substrate, and curing or otherwise treating to form the stand-alone film. The resulting stand-alone film is bioabsorbable.
摘要翻译：至少部分地从脂肪酸衍生独立的膜。独立膜可以具有抗粘连，抗炎，非炎性和伤口愈合性质，并且还可以包括一种或多种掺入其中的治疗剂。制造独立膜的相应方法包括将液体或凝胶成型，铸造或以其它方式施加到基底，以及固化或以其他方式处理以形成独立的膜。所得到的独立膜是生物可吸收的。

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