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11. 发明授权

US07425533B2 Modified hirudin proteins and T-cell epitopes in hirudin 失效
标题翻译：水蛭素修饰水蛭素蛋白和T细胞表位
公开(公告)号：US07425533B2
公开(公告)日：2008-09-16
申请号：US10560918
申请日：2004-06-25
申请人： Matthew Baker , John Watkins
发明人： Matthew Baker , John Watkins
IPC分类号： C07K14/00
CPC分类号： C07K14/815
摘要： Modified forms of hirudin having improved properties are disclosed. The modified hirudin compounds are hirudin variants comprising amino acid substitutions in the sequence of hirudin. Peptide molecules consisting of the amino acid residue sequence CILGSDGEKNQCVTGEGTPKPESHNDGDFE (SEQ ID NO: 1) or a sequence consisting of at least 9 consecutive amino acid residues of SEQ ID NO: 1 having a potential MHC class II binding activity are disclosed. The peptide has a stimulation index of >1.8 in a biological assay of cellular proliferation, in which the index is defined as the value of cellular proliferation scored following stimulation by the peptide and divided by the value of cellular proliferation scored in control cells that have not been exposed to the peptide.
摘要翻译：公开了具有改进性能的水蛭素的修饰形式。修饰水蛭素化合物是水蛭素变体，其包含水蛭素序列中的氨基酸取代。公开了由氨基酸残基序列CILGSDGEKNQCVTGEGTPKPESHNDGDFE（SEQ ID NO：1）组成的肽分子或由具有潜在MHC II类结合活性的SEQ ID NO：1的至少9个连续氨基酸残基组成的序列。该肽在细胞增殖的生物测定中具有> 1.8的刺激指数，其中该指数被定义为在肽刺激后评分的细胞增殖值除以未分配的对照细胞中得到的细胞增殖的值暴露于肽。

12. 发明申请

US20060140929A1 Modified hirudin proteins and t-cell epitopes in hirudin 失效
标题翻译：水蛭素修饰水蛭蛋白和t-细胞表位
公开(公告)号：US20060140929A1
公开(公告)日：2006-06-29
申请号：US10560918
申请日：2004-06-25
申请人： Matthew Baker , John Watkins
发明人： Matthew Baker , John Watkins
IPC分类号： A61K38/48 , C07H21/04 , C12P21/06 , C12N9/48
CPC分类号： C07K14/815
摘要： The invention concerns hirudin and in particular modified forms of hirudin with improved properties. The improved proteins contain amino acid substitutions at specific positions. The invention provides modified hirudin with improved biological activity concomitant with reduced immunogenic potential in the protein. The improved proteins are intended for therapeutic use in the treatment of diseases in humans.
摘要翻译：本发明涉及水蛭素，特别是具有改进性质的水蛭素的修饰形式。改进的蛋白质在特定位置含有氨基酸取代。本发明提供了改进的水蛭素，其具有改善的生物活性，伴随着蛋白质中免疫原性的降低。改进的蛋白质用于治疗人类疾病的治疗用途。

13. 发明申请

US20130224405A1 ELECTROMAGNETIC META-MATERIALS 审中-公开
标题翻译：电磁元件
公开(公告)号：US20130224405A1
公开(公告)日：2013-08-29
申请号：US13403328
申请日：2012-02-23
申请人： Andy Nagerl , John Watkins
发明人： Andy Nagerl , John Watkins
IPC分类号： B32B3/12
CPC分类号： H05K7/14 , B32B3/12 , B32B3/28 , H05K1/0236 , H05K1/024 , H05K9/0086 , Y10T428/13 , Y10T428/24149 , Y10T428/24157
摘要： Apparatus including meta-materials and methods for making the apparatus are described. Circuit components, such as split ring resonators and/or spiral loops, may be formed on substrates to form the meta-materials. The meta-materials may be used in various types of apparatus. The methods of making the apparatus may include forming two and/or three-dimensional structures comprising the meta-materials.
摘要翻译：描述了包括用于制造该装置的超临界材料和方法的装置。可以在衬底上形成电路元件，例如开环谐振器和/或螺旋环，以形成超临界材料。超临界材料可用于各种类型的装置中。制造该装置的方法可以包括形成包括超临界材料的两个和/或三维结构。

14. 发明授权

US08452275B2 Methods and systems for increasing wireless traffic capacity in the vicinity of an event site 有权
标题翻译：增加事件现场附近无线通信容量的方法和系统
公开(公告)号：US08452275B2
公开(公告)日：2013-05-28
申请号：US11641031
申请日：2006-12-19
申请人： Alan Graves , Jeffrey Fitchett , Brian Vezza , John Watkins
发明人： Alan Graves , Jeffrey Fitchett , Brian Vezza , John Watkins
IPC分类号： H04W4/00
CPC分类号： H04W24/02 , H04W16/04 , H04W24/04
摘要： Network entity, method and computer-readable storage medium for use in a network that includes an arrangement of cell sites, each cell site being configured to provide wireless services to users within a respective coverage region. The network entity comprises an input configured to receive position information regarding occurrence of an event at an event site, and a processing entity configured to determine on a basis of the position information regarding occurrence of the event and policy information regarding the network, whether the event warrants coverage region reconfiguration and, if so, to generate a message commanding an adjustment to the coverage region of at least one cell site. An output is configured to release the message towards the at least one cell site, whereby application of the adjustment to the coverage region of the at least one cell site enables an increase in traffic to be accommodated in a vicinity of the event site.
摘要翻译：网络实体，方法和计算机可读存储介质，用于包括小区站点的布置的网络中，每个小区站点被配置为向相应覆盖区域内的用户提供无线服务。网络实体包括被配置为接收关于在事件站点处的事件的发生的位置信息的输入，以及被配置为基于关于事件的发生的位置信息和关于网络的策略信息确定事件的处理实体保证覆盖区重新配置，并且如果是，则生成指示对至少一个小区站点的覆盖区域的调整的消息。输出被配置为向所述至少一个小区站点释放消息，由此将所述调整应用于所述至少一个小区站点的覆盖区域能够增加要容纳在所述事件站点附近的业务量。

15. 发明授权

US06128193A Enhanced humidity control for small modules 失效
标题翻译：增强小型模块的湿度控制
公开(公告)号：US06128193A
公开(公告)日：2000-10-03
申请号：US82476
申请日：1998-05-21
申请人： John Seaborn Moss , John Watkins , Michal Stefan Tencer , Richard Pierre Hughes
发明人： John Seaborn Moss , John Watkins , Michal Stefan Tencer , Richard Pierre Hughes
IPC分类号： G05D22/00 , H05K5/06 , H05K5/02
CPC分类号： G05D22/00 , Y10S439/928
摘要： The present invention relates to two modules containing electronic equipment, one relatively small, and one relatively large, that will be physically connected and used for extended operation in an environment where the ambient atmosphere contains moisture filled air or some other specified environmental contaminant. An absorber such as desiccant of a prescribed amount is contained within at least the relatively large module to control the absolute humidity and/or environmental contaminants within each module during extended operation in the ambient environment. Permeable wall portions are placed in the region between the relatively small module and the relative large module to allow for moisture and/or other specified environmental contaminants to pass from the relatively small module to the relatively large module. As such, the lifespan of the small module can be extended.
摘要翻译：本发明涉及包含电子设备的两个模块，一个相对较小，一个相对较大的电子设备将被物理连接并用于在环境气氛包含湿气填充的空气或一些其它指定的环境污染物的环境中的延长操作。至少在相对大的模块中包含诸如规定量的干燥剂的吸收剂，以在周围环境中的延长操作期间控制每个模块内的绝对湿度和/或环境污染物。可渗透的壁部分放置在相对较小的模块和相对大的模块之间的区域中，以允许湿气和/或其它指定的环境污染物从相对较小的模块传递到相对较大的模块。因此，可以延长小型模块的使用寿命。

16. 发明申请

US20080150360A1 System and Method for Providing Power Management in a Sensor Network 有权
标题翻译：在传感器网络中提供电源管理的系统和方法
公开(公告)号：US20080150360A1
公开(公告)日：2008-06-26
申请号：US11613313
申请日：2006-12-20
申请人： Brian Vezza , Kent Felske , Alan Graves , John Watkins , Guy Duxbury , Tom Chmara , Jeff Fitchett
发明人： Brian Vezza , Kent Felske , Alan Graves , John Watkins , Guy Duxbury , Tom Chmara , Jeff Fitchett
IPC分类号： H02J4/00
CPC分类号： H02J1/00 , G01D21/00 , H04L67/125 , Y10T307/406
摘要： The present invention relates to a system and method for providing power management to sensing nodes in a sensor network. A system may include a plurality of sensing nodes, each sensing node connected through a power management device to an external power source, such as a powered node of another network, for managing power from the external power source to the sensing node. Beneficially, a plurality of power management devices allow for a sensor network of fixed or mobile wireless sensing nodes or sensor gateways to make use of power from an external source such as an another network e.g. an existing emergency lighting system or other similar powered building system. Thus for example, a sensor or group of sensing nodes and their associated power management devices may be integral with or co-located in proximity to powered nodes of these other networks. An intelligent power management device connected to at least one of the sensing nodes may provide for power policy management to sensing nodes based on monitoring power conditions such as available power, power level status, and information obtained from the sensing nodes indicative of network conditions, detecting a change therein, and regulating power to the sensing node depending on the change
摘要翻译：本发明涉及一种用于提供电力管理以感测传感器网络中的节点的系统和方法。系统可以包括多个感测节点，每个感测节点通过电力管理设备连接到外部电源，例如另一网络的供电节点，用于管理从外部电源到感测节点的电力。有利的是，多个电力管理装置允许固定或移动无线传感节点或传感器网关的传感器网络利用来自诸如另一个网络的外部源的功率。现有的应急照明系统或其他类似的动力建筑系统。因此，例如，传感器或一组感测节点及其相关联的电力管理设备可以与这些其他网络的动力节点接近或与其相邻。连接到所述感测节点中的至少一个的智能电力管理装置可以基于监视功率条件（例如可用功率，功率电平状态以及从指示网络状况的感测节点获得的信息）来检测节点来提供电力策略管理，检测其中的变化，并且根据变化调节对感测节点的功率

17. 发明申请

US20060017032A1 Scissor thrust valve actuator 失效
公开(公告)号：US20060017032A1
公开(公告)日：2006-01-26
申请号：US10896579
申请日：2004-07-21
申请人： Kevin DeWall , John Watkins , Michael Nitzel
发明人： Kevin DeWall , John Watkins , Michael Nitzel
IPC分类号： F16K31/02
CPC分类号： F16K31/53 , F16K31/046 , Y10T137/8242
摘要： Apparatus for actuating a valve includes a support frame and at least one valve driving linkage arm, one end of which is rotatably connected to a valve stem of the valve and the other end of which is rotatably connected to a screw block. A motor connected to the frame is operatively connected to a motor driven shaft which is in threaded screw driving relationship with the screw block. The motor rotates the motor driven shaft which drives translational movement of the screw block which drives rotatable movement of the valve driving linkage arm which drives translational movement of the valve stem. The valve actuator may further include a sensory control element disposed in operative relationship with the valve stem, the sensory control element being adapted to provide control over the position of the valve stem by at least sensing the travel and/or position of the valve stem.

18. 发明申请

US20050223222A1 Systems and methods for preserving confidentiality of sensitive information in a point-of-care communications environment 有权
标题翻译：在保护点通信环境中保护敏感信息的机密性的系统和方法
公开(公告)号：US20050223222A1
公开(公告)日：2005-10-06
申请号：US10813358
申请日：2004-03-31
申请人： Alan Graves , Jeffrey Fitchett , John Watkins
发明人： Alan Graves , Jeffrey Fitchett , John Watkins
IPC分类号： H04L9/08 , H04L9/32 , H04L29/06
CPC分类号： H04L63/0428 , H04L9/0894 , H04L63/08 , H04L2209/80 , H04L2209/88
摘要： A data processing apparatus comprises a memory store; a data bus connected to the memory store, the data bus being adapted for transporting data to and from the memory store; a processing entity operative to release read and write commands towards the memory store, the write command being accompanied by first data intended to be written to the memory store; and an encryption module communicatively coupled to the processing entity and to the data bus. Upon the processing entity releasing a write command accompanied by said first data, the encryption module encrypts, in accordance with an encryption key, said first data and send an encrypted version of said first data onto the data bus for writing into the memory store. The reverse operation is performed upon the processing entity releasing a read command.
摘要翻译：数据处理装置包括存储器存储器; 连接到存储器存储器的数据总线，数据总线适于将数据传送到存储器存储器和从存储器存储器传送数据; 处理实体，其用于释放对存储器存储器的读取和写入命令，所述写入命令伴随着要写入存储器存储器的第一数据; 以及通信地耦合到处理实体和数据总线的加密模块。在处理实体释放伴随有所述第一数据的写入命令时，加密模块根据加密密钥对所述第一数据进行加密，并将所述第一数据的加密版本发送到数据总线上以写入存储器存储器。在处理实体释放读取命令时执行相反的操作。

19. 发明授权

US6041369A Reducing two variables in alternate clock cycles during data transmission for monitoring when a data burst is close to completion 失效
标题翻译：在数据传输期间，在替代时钟周期中减少两个变量，以便在数据突发完成时进行监视
公开(公告)号：US6041369A
公开(公告)日：2000-03-21
申请号：US93595
申请日：1998-06-09
申请人： John Watkins
发明人： John Watkins
IPC分类号： G06F13/28 , G06F12/00
CPC分类号： G06F13/28
摘要： An improved apparatus and method for monitoring and controlling when a data phase in a burst transmission of data is about to end. The apparatus described interleaves dual adder circuits such that each dual adder circuit has more time to process incoming data. Distribution of the processing allows slower, lower cost components to be used in high speed applications. The described apparatus and method are particularly useful in peripheral component interconnect applications.
摘要翻译：一种改进的装置和方法，用于监视和控制数据的突发传输中的数据相位何时即将结束。所描述的装置交织双加法器电路，使得每个双加法器电路具有更多的时间来处理输入数据。处理的分布允许在高速应用中使用更慢，更低成本的组件。所描述的装置和方法在外围组件互连应用中特别有用。

20. 发明授权

US4923572A Image transfer tool 失效
标题翻译：图像传输工具
公开(公告)号：US4923572A
公开(公告)日：1990-05-08
申请号：US251174
申请日：1988-09-29
申请人： John Watkins , Ramon Magee , Arthur Doerflinger
发明人： John Watkins , Ramon Magee , Arthur Doerflinger
IPC分类号： B29C59/04 , B29C59/00 , C25D1/00
CPC分类号： B29C59/002
摘要： A generally cylindrical image embossing tool which can be used for embossing a web of material in continuous manner is made by placing an image or pattern which is to be replicated onto an embossable material maintained in the form of a cylinder. An electroform in generally cylindrical form corresponding to the image or pattern to be replicated is formed from the imaged embossable material and the electroform is supported on a rigid cylindrical support to form the image transfer tool.A novel imaging tool has a curved stamping surface carrying an embossed image or pattern. The radius of curvature of the stamping surface matches the radius of curvature of a cylindrical surface which is to be stamped so as to transfer the image or pattern which is to be replicated.
摘要翻译：通常将可复制的图像或图案放置在以圆柱体形式保持的可压纹材料上的情况下，可以用于连续地压印材料网的大致圆柱形图像压印工具。对应于要复制的图像或图案的大致圆柱形的电铸从成像的可压纹材料形成，并且电铸支撑在刚性圆柱形支撑件上以形成图像转印工具。一种新颖的成像工具具有带有压花图像或图案的弯曲的冲压表面。冲压表面的曲率半径与待冲压的圆柱形表面的曲率半径匹配，以便传送要复制的图像或图案。

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