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11. 发明申请

US20100047243A1 NOVEL ANTIBODIES AGAINST IGF-IR 审中-公开
标题翻译：抗IGF-IR的新型抗体
公开(公告)号：US20100047243A1
公开(公告)日：2010-02-25
申请号：US12526966
申请日：2008-02-12
申请人： Michael Neil Burden , Jonathan Henry Ellis , Paul Andrew Hamblin , Alan Peter Lewis , Radba Shah
发明人： Michael Neil Burden , Jonathan Henry Ellis , Paul Andrew Hamblin , Alan Peter Lewis , Radba Shah
IPC分类号： A61K39/395 , C07K16/00 , C12N5/10 , C12P21/04
CPC分类号： C07K16/2863 , C07K2317/24 , C07K2317/73 , C07K2317/76
摘要： The present invention relates to antibodies or antigen binding fragments thereof which specifically binds to IGF-1R, specifically hIGF-1R. Also disclosed are antibody preparations comprising antibodies or antigen binding fragments of the invention. Methods of producing such antibodies or antigen binding fragments and uses thereof are also included within the scope of the present invention.
摘要翻译：本发明涉及特异性结合IGF-1R，特别是hIGF-1R的抗体或其抗原结合片段。还公开了包含本发明的抗体或抗原结合片段的抗体制剂。生产此类抗体或抗原结合片段的方法及其用途也包括在本发明的范围内。

12. 发明申请

US20120082682A1 IL-13 BINDING PROTEIN 有权
标题翻译： IL-13结合蛋白
公开(公告)号：US20120082682A1
公开(公告)日：2012-04-05
申请号：US13321982
申请日：2010-05-26
申请人： Claire Ashman , Jonathan Henry Ellis , Paul Andrew Hamblin , Alan Peter Lewis , Martin Anibal Orecchia
发明人： Claire Ashman , Jonathan Henry Ellis , Paul Andrew Hamblin , Alan Peter Lewis , Martin Anibal Orecchia
IPC分类号： A61K39/395 , A61P1/00 , A61P35/02 , A61P11/06 , C12N5/10 , C07K16/24
CPC分类号： C07K16/244 , A61K2039/505 , C07K16/247 , C07K16/468 , C07K2317/24 , C07K2317/565 , C07K2317/569 , C07K2317/73 , C07K2317/76 , Y02A50/41
摘要： The present invention relates to antigen binding proteins to human IL-13, including anti-IL-13 antibodies and anti-IL-3/anti-IL-4 mAbdAbs, pharmaceutical formulations containing them and to the use of such antigen binding proteins in the treatment and/or prophylaxis of inflammatory diseases such as asthma or IPF.
摘要翻译：本发明涉及抗人IL-13的抗原结合蛋白，包括抗IL-13抗体和抗IL-3 /抗-IL-4mAbdAb，含有它们的药物制剂以及该抗原结合蛋白在治疗和/或预防炎性疾病如哮喘或IPF。

13. 发明授权

US07780964B2 Immunoglobulins which bind NOGO 有权
标题翻译：结合NOGO的免疫球蛋白
公开(公告)号：US07780964B2
公开(公告)日：2010-08-24
申请号：US11177648
申请日：2005-07-06
申请人： Jonathan Henry Ellis , Paul Andrew Hamblin , Alan Peter Lewis , Paul Alexander Wilson
发明人： Jonathan Henry Ellis , Paul Andrew Hamblin , Alan Peter Lewis , Paul Alexander Wilson
IPC分类号： A61K39/395 , C07K21/08
CPC分类号： C07K16/18 , A61K2039/505 , C07K16/22 , C07K2317/24 , C07K2317/56 , C07K2317/76 , C12N5/0618 , C12N2501/70 , C12N2501/998
摘要： The present invention relates to antibodies to NOGO, pharmaceutical formulations containing them and to the use of such antibodies in the treatment and/or prophylaxis of neurological diseases/disorders.
摘要翻译：本发明涉及NOGO的抗体，含有它们的药物制剂以及这些抗体在治疗和/或预防神经疾病/病症中的用途。

14. 发明申请

US20090123479A1 IMMUNOGLOBULINS 审中-公开
标题翻译：免疫球蛋白
公开(公告)号：US20090123479A1
公开(公告)日：2009-05-14
申请号：US12245426
申请日：2008-10-03
申请人： Gary Peter Bembridge , Jane Elizabeth Clarkson , Jonathan Henry Ellis , Paul Andrew Hamblin , George Kopsidas , Alan Peter Lewis , Ruth McAdam
发明人： Gary Peter Bembridge , Jane Elizabeth Clarkson , Jonathan Henry Ellis , Paul Andrew Hamblin , George Kopsidas , Alan Peter Lewis , Ruth McAdam
IPC分类号： A61K39/395 , C07K16/00 , A61P29/00 , A61P37/00 , C12N5/00
CPC分类号： C07K16/244 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/76 , C07K2317/92
摘要： The present invention relates to antigen binding proteins to human IL-23, pharmaceutical formulations containing them and to the use of such antigen binding proteins in the treatment and/or prophylaxis of inflammatory diseases such as Rheumatoid Arthritis (RA).
摘要翻译：本发明涉及到人IL-23的抗原结合蛋白，含有它们的药物制剂以及这种抗原结合蛋白在治疗和/或预防炎性疾病如类风湿性关节炎（RA）中的用途。

15. 发明授权

US09394374B2 Antigen-binding proteins 有权
标题翻译：抗原结合蛋白
公开(公告)号：US09394374B2
公开(公告)日：2016-07-19
申请号：US13322224
申请日：2010-05-26
申请人： Paul Andrew Hamblin , Alan Peter Lewis , Martin Anibal Orecchia , Radha Shah Parmar
发明人： Paul Andrew Hamblin , Alan Peter Lewis , Martin Anibal Orecchia , Radha Shah Parmar
IPC分类号： C07K16/00 , C07K16/46 , C07K16/22 , C07K16/24 , C07K16/28
CPC分类号： C07K16/468 , C07K16/22 , C07K16/241 , C07K16/244 , C07K16/247 , C07K16/2863 , C07K16/2866 , C07K2317/31 , C07K2317/52 , C07K2317/569 , C07K2318/20 , C07K2319/30
摘要： The invention relates to linkers suitable for use in antigen-binding proteins, certain antigen binding proteins and methods of making such proteins and uses thereof.
摘要翻译：本发明涉及适用于抗原结合蛋白的接头，某些抗原结合蛋白及其制备方法。

16. 发明申请

US20140227259A1 MODIFIED PROTEINS AND PEPTIDES 审中-公开
标题翻译：改性蛋白和肽
公开(公告)号：US20140227259A1
公开(公告)日：2014-08-14
申请号：US14239196
申请日：2012-08-13
申请人： Claire Ashman , Mary Birchler , Rudolf M.T. De Wildt , Claire Holland , Alan Peter Lewis , Peter Morley , Thomas Sandal , Michael Steward
发明人： Claire Ashman , Mary Birchler , Rudolf M.T. De Wildt , Claire Holland , Alan Peter Lewis , Peter Morley , Thomas Sandal , Michael Steward
IPC分类号： C07K16/42
摘要： The present disclosure relates to modified proteins and peptides that have reduced ability to bind to pre-existing antibodies. Such modified protein/peptide molecules can comprise C-terminal additions, extensions or tags and/or certain amino acid substitutions. Such modified molecules (e.g., fusions and conjugates) comprise proteins, peptides, antigen binding molecules, antibodies or antibody fragments such as single variable domains. The disclosure further relates to uses and formulations of compositions comprising such modified C-terminally extended and/or amino acid substituted molecules and also to methods of production and expression of these.
摘要翻译：本公开涉及具有降低与先前存在的抗体结合的能力的修饰的蛋白质和肽。这种修饰的蛋白质/肽分子可以包含C-末端添加，延伸或标签和/或某些氨基酸取代。这样的修饰分子（例如，融合物和缀合物）包含蛋白质，肽，抗原结合分子，抗体或抗体片段，例如单可变结构域。本公开还涉及包含这种修饰的C-末端延伸和/或氨基酸取代的分子的组合物的用途和制剂，以及这些的生产和表达方法。

17. 发明申请

US20130310281A1 NOVEL ANTIGEN BINDING PROTEINS 审中-公开
标题翻译：新型抗原蛋白结合蛋白
公开(公告)号：US20130310281A1
公开(公告)日：2013-11-21
申请号：US13981972
申请日：2012-01-27
申请人： Emma R. Harding , Ekaterini Kotsopoulou , Alan Peter Lewis , Susannah Thornhill , Mark Uden
发明人： Emma R. Harding , Ekaterini Kotsopoulou , Alan Peter Lewis , Susannah Thornhill , Mark Uden
IPC分类号： C07K16/22
CPC分类号： C07K16/22 , C07K2317/569
摘要： The present invention provides novel antigen-binding proteins derived from human germline VH domains, having improved expression and improved biophysical characteristics.
摘要翻译：本发明提供了源自人种系VH结构域的新型抗原结合蛋白，具有改进的表达和改善的生物物理特性。

18. 发明授权

US5858725A Preparation of chimaeric antibodies using the recombinant PCR strategy 失效
标题翻译：使用重组PCR策略制备嵌合抗体
公开(公告)号：US5858725A
公开(公告)日：1999-01-12
申请号：US39198
申请日：1993-07-29
申请人： James Scott Crowe , Alan Peter Lewis
发明人： James Scott Crowe , Alan Peter Lewis
IPC分类号： C12N5/10 , C07K16/46 , C12N15/09 , C12N15/12 , C12P21/08 , C12Q1/68 , C12R1/91 , C07H21/04
CPC分类号： C07K16/464 , C12Q1/686 , C07K2317/24 , C07K2319/00 , C07K2319/02 , Y10S530/867
摘要： The invention relates to a method of producing a chimaeric antibody in which the CDR of a first antibody is spliced between the framework regions of a second antibody. The method is performed using a template comprising two framework regions, AB and CD, and between them, the CDR which is to be replaced by a donor CDR. Primers A and B are used to amplify the framework region AB, and primers C and D used to amplify the framework region CD. However, the primers B and C also contain, at their 5' ends, additional sequence corresponding to all or at least part of the donor CDR sequence. Primers B and C overlap by a length sufficient to permit annealing of their 5' ends to each other under conditions which allow a polymerase chain reaction to be performed and thereby incorporate all of the donor CDR sequence. The amplified regions AB and CD may undergo splice overlap extension to produce the chimaeric product in a single reaction.
摘要翻译： PCT No.PCT / GB91 / 01744 Sec。 371日期：1993年7月29日 102（e）日期1993年7月29日PCT 1990年10月8日PCT PCT。出版物WO92 / 07075 日期1992年4月30日本发明涉及一种生产嵌合抗体的方法，其中第一抗体的CDR在第二抗体的框架区域之间被剪接。该方法使用包含两个框架区AB和CD的模板进行，并且它们之间由供体CDR替代的CDR。引物A和B用于扩增框架区AB，引物C和D用于扩增框架区CD。然而，引物B和C在其5'末端还含有对应于全部或至少部分供体CDR序列的附加序列。引物B和C的重叠长度足以使其5'末端在允许进行聚合酶链反应并因此并入所有供体CDR序列的条件下彼此退火。扩增区域AB和CD可以经历拼接重叠延伸以在单个反应中产生嵌合产物。

19. 发明申请

US20140205604A1 ANTIGEN BINDING CONSTRUCTS 有权
标题翻译：抗原结合结构
公开(公告)号：US20140205604A1
公开(公告)日：2014-07-24
申请号：US14235330
申请日：2012-07-25
申请人： Claire Ashman , Ian Richard Catchpole , Zoe Hughes-Thomas , Alan Peter Lewis , Michael Steward
发明人： Claire Ashman , Ian Richard Catchpole , Zoe Hughes-Thomas , Alan Peter Lewis , Michael Steward
IPC分类号： C07K16/22
CPC分类号： C07K16/22 , A61K2039/505 , A61K2039/54 , A61K2039/70 , C07K16/46 , C07K2317/31 , C07K2317/33 , C07K2317/35 , C07K2317/52 , C07K2317/565 , C07K2317/569 , C07K2317/60 , C07K2317/64 , C07K2317/76 , C07K2317/92 , C07K2319/00
摘要： The present invention is directed to antigen binding constructs comprising one or two epitope binding domains separated by a single chain Fc region of an antibody, wherein each epitope binding domain in capable of binding to VEGF, to dimers comprising two antigen binding constructs of the invention, pharmaceutical compositions comprising said dimers and their use in the treatment of diseases associated with VEGF signalling, such as diabetic macular edema (DME), wet age-related macular degeneration (Wet AMD). diabetic retinopathy, retinal vein occlusion (RVO), and corneal neovascularisation, and polynucleotide sequences encoding said antigen binding constructs.
摘要翻译：本发明涉及包含由抗体的单链Fc区分离的一个或两个表位结合结构域的抗原结合构建体，其中能够结合VEGF的每个表位结合域与包含本发明的两个抗原结合构建体的二聚体，包含所述二聚体的药物组合物及其用于治疗与VEGF信号传导相关的疾病，例如糖尿病性黄斑水肿（DME），湿性年龄相关性黄斑变性（湿性AMD）的用途。糖尿病性视网膜病变，视网膜静脉阻塞（RVO）和角膜新生血管形成，以及编码所述抗原结合构建体的多核苷酸序列。

20. 发明申请

US20120070439A1 ANTIGEN-BINDING PROTEINS 有权
标题翻译：抗原结合蛋白
公开(公告)号：US20120070439A1
公开(公告)日：2012-03-22
申请号：US13322224
申请日：2010-05-26
申请人： Paul Andrew Hamblin , Alan Peter Lewis , Martin Anibal Orecchia , Radha Shah Parmar
发明人： Paul Andrew Hamblin , Alan Peter Lewis , Martin Anibal Orecchia , Radha Shah Parmar
IPC分类号： A61K39/395 , C12N15/13 , C12P21/00 , C12N5/10 , C12N1/19 , C07K16/46 , C12N1/21
CPC分类号： C07K16/468 , C07K16/22 , C07K16/241 , C07K16/244 , C07K16/247 , C07K16/2863 , C07K16/2866 , C07K2317/31 , C07K2317/52 , C07K2317/569 , C07K2318/20 , C07K2319/30
摘要： The invention relates to linkers suitable for use in antigen-binding proteins, certain antigen binding proteins and methods of making such proteins and uses thereof.
摘要翻译：本发明涉及适用于抗原结合蛋白的接头，某些抗原结合蛋白及其制备方法。

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