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11. 发明授权

US07910564B2 Genes of IL-12P40 subunit mutated for improving the activity of IL-12 and use thereof for DNA vaccine adjuvant 有权
标题翻译：为了改善IL-12的活性而突变的IL-12P40亚基的基因及其用于DNA疫苗佐剂的基因
公开(公告)号：US07910564B2
公开(公告)日：2011-03-22
申请号：US11832993
申请日：2007-08-02
申请人： Young Chul Sung , Sung Hee Lee , Sang Jun Ha , Man Ki Song , Jun Chang
发明人： Young Chul Sung , Sung Hee Lee , Sang Jun Ha , Man Ki Song , Jun Chang
IPC分类号： A61K48/00 , C07H19/00 , C07H21/00 , C07H21/02 , C07H21/04 , C12N15/00 , A01N63/00 , A01N65/00
CPC分类号： C07K14/005 , A61K39/39 , A61K2039/53 , A61K2039/55522 , A61K2039/57 , C12N2770/24222 , Y02A50/412
摘要： The present invention relates to the IL-12p40 subunit mutant gene which can produce IL-12 (interleukin 12) of human and mouse origin with high activity, the expression vector including above mutant gene and the use of them to DNA vaccine adjuvant. Particularly, it relates to IL-12p40 mutant gene which inhibits the secretion of IL-12p40 but normally secretes active IL- 12p70 by making mutation at Asn-222 (human) or Asn- 220 (mouse) amino acid of IL-12p40, which acts as a competitive inhibitor of active form of IL-12, IL-12p70. Therefore, the IL-12p40 mutant gene of the present invention can be useful for DNA vaccination and gene therapy against various diseases, for example, AIDS, hepatitis C or hepatitis B, cancer, influenza, tuberculosis and malaria, which essentially require cellular immune responses for their therapy.
摘要翻译：本发明涉及能够产生具有高活性的人和小鼠来源的IL-12（白细胞介素12）的IL-12p40亚基突变基因，包括上述突变基因的表达载体及其用于DNA疫苗佐剂。特别涉及抑制IL-12p40分泌的IL-12p40突变基因，通常在IL-12p40的Asn-222（人）或Asn-220（小鼠））氨基酸上突变而分泌活性的IL-12p70，作为IL-12，IL-12p70活性形式的竞争性抑制剂。因此，本发明的IL-12p40突变基因可用于针对各种疾病（例如艾滋病，丙型肝炎或乙型肝炎，癌症，流感，结核病和疟疾）的DNA疫苗接种和基因治疗，其基本上需要细胞免疫应答为他们的治疗。

12. 发明申请

US20060223165A1 Device for counting cells and method for manufacturing the same 审中-公开
标题翻译：用于计数细胞的装置及其制造方法
公开(公告)号：US20060223165A1
公开(公告)日：2006-10-05
申请号：US10565079
申请日：2004-07-13
申请人： Jun Chang , Seok Chung , Chanil Chung , Hyun Bang , Han Sang Jo
发明人： Jun Chang , Seok Chung , Chanil Chung , Hyun Bang , Han Sang Jo
IPC分类号： C12M1/34 , B44C3/08
CPC分类号： B82Y15/00 , G01N15/1456 , G01N33/49 , G01N2015/1486 , G02B21/34 , Y10T156/1039
摘要： Disclosed are a device for counting cells and a method for manufacturing the device. The device comprises a transparent upper substrate and a transparent lower substrate. Fine lattice patterns for counting cells are formed on the lower substrate. A space for filling the sample, including cells, is provided between the upper substrate and the lower substrate. A hole for injecting the samples into the space for filling the samples is provided in the upper substrate. The device is disposable, and the cost of manufacturing the device is low. It is easy to fill the samples into the filling space and to count cells by using the device. The upper substrate and the lower substrate are bonded, and thus, no cover is required.
摘要翻译：公开了一种用于计数细胞的装置及其制造方法。该装置包括透明上基板和透明下基板。在下基板上形成用于计数单元的细晶格图案。在上基板和下基板之间设置用于填充样品的空间，包括单元。用于将样品注入用于填充样品的空间中的孔设置在上基板中。该设备是一次性的，制造设备的成本低。通过使用该装置，可以容易地将样品填充到填充空间中并对细胞进行计数。上基板和下基板接合，因此不需要盖。

13. 发明申请

US20060187442A1 Device for counting micro particles 有权
标题翻译：微粒计数装置
公开(公告)号：US20060187442A1
公开(公告)日：2006-08-24
申请号：US10565162
申请日：2004-07-13
申请人： Jun Chang , Chanil Chung , Dae Sung Hur , Alexey Dan Chin-Yu , Seok Chung , Jeong Ku Hwang , Seung Jeon
发明人： Jun Chang , Chanil Chung , Dae Sung Hur , Alexey Dan Chin-Yu , Seok Chung , Jeong Ku Hwang , Seung Jeon
IPC分类号： G01N33/48
CPC分类号： G01N15/1475 , B01L3/5027 , G01N15/147 , G01N21/6428 , G01N21/6458 , G01N2015/1486
摘要： A device for counting micro particles is presented. The device comprises a light source; a chip containing micro particles; an object lens; a CCD camera; a counting part; and a shifter for shifting the position of the chip. It is easy to count the number of micro particles, such as red blood cells or somatic cells, by using the device. The shifter shifts the position of the chip by a predetermined distance at every predetermined time interval in order that a certain area adjacent to the area photographed just before is shifted to the point where the light is incident. Therefore, sub-areas on the chip are photographed successively. The counting part counts the number of micro particles in each sub-area, and adds them together to calculate the total number of micro particles in the samples.
摘要翻译：提出了一种用于计数微粒的装置。该装置包括光源; 含有微粒的芯片; 物镜; CCD相机; 计数部分以及用于移动芯片的位置的移位器。通过使用该装置，容易计数微粒例如红细胞或体细胞的数量。移位器以每隔预定时间间隔将芯片的位置移动预定距离，以使与之前拍摄的区域相邻的某个区域移动到光入射点。因此，连续拍摄芯片上的子区域。计数部分计算每个子区域中的微粒数，并将它们相加在一起计算样品中的微粒总数。

14. 发明申请

US20060151839A1 Gate structure of semiconductor device and method for forming the same 失效
标题翻译：半导体器件的栅极结构及其形成方法
公开(公告)号：US20060151839A1
公开(公告)日：2006-07-13
申请号：US11268846
申请日：2005-11-08
申请人： Young Kim , Jun Chang , Min Lee , Yong Eun
发明人： Young Kim , Jun Chang , Min Lee , Yong Eun
IPC分类号： H01L29/78 , H01L21/4763
CPC分类号： H01L27/10876 , H01L21/2815 , H01L29/66636
摘要： Disclosed herein is a method for forming a gate structure of a semiconductor device. The method comprises forming a plurality of gates including a first gate dielectric film, a first gate conductive film, and a gate silicide film sequentially stacked on a silicon substrate having a field oxide film, forming a thermal oxide film on a side of the first gate conductive film, etching the silicon substrate exposed between the plurality of gates to a predetermined depth to form a plurality of trenches, forming a second gate oxide film on the interior wall of the trenches, and forming a second gate conductive film in a spacer shape on a predetermined region of the second gate oxide film, and on a side of the first gate conductive film, the gate silicide film, and the thermal oxide film.
摘要翻译：本文公开了一种用于形成半导体器件的栅极结构的方法。该方法包括形成多个栅极，其包括依次层叠在具有场氧化膜的硅基板上的第一栅极电介质膜，第一栅极导电膜和栅极硅化物膜，在第一栅极的一侧形成热氧化膜将暴露在所述多个栅极之间的硅衬底蚀刻到预定深度以形成多个沟槽，在所述沟槽的内壁上形成第二栅极氧化膜，并且形成间隔物形状的第二栅极导电膜第二栅极氧化膜的预定区域，以及第一栅极导电膜，栅极硅化物膜和热氧化物膜的一侧。

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