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11. 发明申请

US20100075943A1 1-ADAMANTYLAZETIDIN-2-ONE DERIVATIVES AND DRUGS CONTAINING SAME 有权
标题翻译： 1-ADAMANTYLAZETIDIN-2-ONE衍生物和含有其的药物
公开(公告)号：US20100075943A1
公开(公告)日：2010-03-25
申请号：US12550206
申请日：2009-08-28
申请人： Hisashi Nakashima , Takahiro Mori , Takaaki Araki , Takahisa Ogamino , Kazutoyo Abe , Tadaaki Ohgiya , Ryoko Mori
发明人： Hisashi Nakashima , Takahiro Mori , Takaaki Araki , Takahisa Ogamino , Kazutoyo Abe , Tadaaki Ohgiya , Ryoko Mori
IPC分类号： A61K31/397 , C07D205/04 , A61P3/00
CPC分类号： C07D205/08 , A61K31/397 , C07D401/04 , C07D401/08 , C07D405/04
摘要： It is to provide a novel compound useful for preventing and/or treating diseases that involves 11β-hydroxysteroid dehydrogenase 1, particularly diabetes, insulin resistance, diabetes complication, obesity, dyslipidemia, hypertension, fatty liver, or metabolic syndrome. It is an 1-adamantyl azetidin-2-one derivative represented by the following general formula (1) or salt thereof, or their solvate. [wherein A ring represents C6-10 aryl group, 5- to 14-membered heteroaryl group, R1 is a hydrogen atom, halogen atom, C1-6 alkoxycarbonyl group, hydroxyl group, carboxyl group or carbamoyl group; R2 and R3 are the same or different and are a C1-6 alkyl group; R4, R5, and R6 are same or different, and are a hydrogen atom, halogen atom, C1-6 alkyl group, C1-6 alkoxy group, C6-10 aryl group, or R4 and R5, or R5 and R6 may together form a C1-3 alkylenedioxy group, R7 and R8 are the same of different and represent a hydrogen atom or C1-6 alkyl group, or may together form a C3-6 cyclic hydrocarbon group, n represents an integer of 0 or 1]
摘要翻译：提供一种可用于预防和/或治疗涉及11-羟基类固醇脱氢酶1，特别是糖尿病，胰岛素抵抗，糖尿病并发症，肥胖，血脂异常，高血压，脂肪肝或代谢综合征的疾病的新化合物。它是由以下通式（1）表示的1-金刚烷基氮杂环丁-2-酮衍生物或其盐或其溶剂合物。 [其中A环表示C6-10芳基，5〜14元杂芳基，R1表示氢原子，卤素原子，C1-6烷氧基羰基，羟基，羧基或氨基甲酰基。 R2和R3相同或不同，为C1-6烷基; R 4，R 5和R 6相同或不同，为氢原子，卤素原子，C 1-6烷基，C 1-6烷氧基，C 6-10芳基或R 4和R 5，或者R 5和R 6可以一起形成 C 1-3亚烷基二氧基，R 7和R 8相同，表示氢原子或C 1-6烷基，或一起形成C 3-6环烃基，n表示0或1的整数]

12. 发明授权

US5282363A Hydraulic circuit for running a crawler vehicle 失效
标题翻译：用于运行履带车的液压回路
公开(公告)号：US5282363A
公开(公告)日：1994-02-01
申请号：US815023
申请日：1991-12-31
申请人： Kazunori Ogawa , Takuma Endo , Hisashi Nakashima , Yoji Asano
发明人： Kazunori Ogawa , Takuma Endo , Hisashi Nakashima , Yoji Asano
IPC分类号： B62D11/08 , B60K17/10 , B62D11/02 , B62D11/18 , E02F9/12 , E02F9/22 , F15B11/044 , F16D31/02 , B62D11/00
CPC分类号： F16H61/4061 , B60K17/10 , B62D11/02 , B62D11/183 , E02F9/123 , E02F9/22 , E02F9/2253 , E02F9/2267 , E02F9/2275 , F15B11/0445 , F15B2211/20538 , F15B2211/20576 , F15B2211/3127 , F15B2211/327 , F15B2211/50527 , F15B2211/50545 , F15B2211/5154 , F15B2211/6051 , F15B2211/6355 , F15B2211/7058 , F15B2211/71
摘要： A hydraulic circuit for running a crawler vehicle which comprises a running frame portion provided with motors for running the crawler vehicle and an upper swivel portion turnably disposed on the running frame portion via a swivel joint. Electro-magnetic proportional flow directional control valve (a directional control valves) (15) for controlling the running motors are disposed between the swivel joint (41) and the running motors (19). The number of the high pressure passages in the swivel joint (41) can be reduced, because of increase of pressure resistance, the size of the swivel joint can be small, and accordingly, the hydraulic circuit for running a crawler vehicle can be inexpensive, and possibility for leakage of pressure oil becomes low.
摘要翻译：一种履带式履带车用液压回路，其特征在于，包括具有运行所述履带式车辆的电动机的行走机架部和经由旋转接头可转动地设置在所述行走架部上的上部旋转部。用于控制运行马达的电磁比例流量方向控制阀（方向控制阀）（15）设置在旋转接头（41）和行进马达（19）之间。旋转接头（41）中的高压通道的数量可以由于耐压性的提高而减小，所以旋转接头的尺寸可以小，因此，用于履带式履带式履带的液压回路便宜，并且压力油泄漏的可能性变低。

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