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11. 发明授权

US09023382B2 Medicament carrier composition and method of forming a film therefrom 有权
标题翻译：药物载体组合物及其形成方法
公开(公告)号：US09023382B2
公开(公告)日：2015-05-05
申请号：US11916733
申请日：2006-04-24
申请人： Shaukat Ali , Anisul Quadir
发明人： Shaukat Ali , Anisul Quadir
IPC分类号： A61K9/70 , A61K31/79 , A61K31/192 , A61K31/135
CPC分类号： A61K31/192 , A61K9/7007 , A61K9/7015 , A61K9/7053 , A61K31/135
摘要： A medicament carrier composition includes a medicament and a polymer component including a polyvinylpyrrolidone having a weight average molecular weight of at least 700,000 g/mol. The medicament carrier composition has a viscosity of from 500 to 5,000 cps at 250 C, is substantially free of cellulose, and includes an auxiliary polymer. The medicament carrier composition is used to form a film that is also substantially free of cellulose. The film has a consistent thickness and size, and an increased flexibility and increased moisture resistance due to the polyvinylpyrrolidone. The medicament carrier composition is also used in a method of forming the film. The method includes the steps of providing the medicament and the polymer component. The method also includes the step of combining the polymer component and the medicament to form the medicament carrier composition. The method further includes the step of drying the medicament carrier composition to form the film.
摘要翻译：药物载体组合物包含药物和包含重均分子量至少为700,000g / mol的聚乙烯吡咯烷酮的聚合物组分。药物载体组合物在250℃下的粘度为500至5,000cps，基本上不含纤维素，并且包括辅助聚合物。药物载体组合物用于形成也基本上不含纤维素的膜。该膜具有一致的厚度和尺寸，以及由于聚乙烯吡咯烷酮而增加的柔性和增加的耐湿性。药物载体组合物也用于形成膜的方法。该方法包括提供药物和聚合物组分的步骤。该方法还包括组合聚合物组分和药物以形成药物载体组合物的步骤。该方法还包括干燥药物载体组合物以形成膜的步骤。

12. 发明申请

US20120269866A1 Gastroretentive Composition On The Basis Of A Water-Soluble Reaction Product From A Vinyl Group-Containing Precursor 有权
标题翻译：基于含乙烯基基团的前体的水溶性反应产物的胃结构
公开(公告)号：US20120269866A1
公开(公告)日：2012-10-25
申请号：US12667793
申请日：2007-12-26
申请人： Shaukat Ali , Carlos Santos , Anisul Quadir
发明人： Shaukat Ali , Carlos Santos , Anisul Quadir
IPC分类号： A61K31/192 , A61P29/00 , A61K47/34 , A61K9/00
CPC分类号： A61K9/0065
摘要： A gastroretentive composition comprises a mixture comprising an active ingredient component and an excipient component. The excipient component comprises a first water-soluble reaction product produced from a precursor comprising a vinyl group, and a copolymer of a polyalkylene glycol and a second water-soluble reaction product produced from a precursor comprising a vinyl group. A method of forming the gastroretentive composition comprises the steps of providing the active ingredient component and the excipient component, and mixing the active ingredient component and the excipient component to form a mixture. The mixture is aggregated to form an aggregation that is dry granulated to form a plurality of granules. The plurality of granules is processed to form the gastroretentive composition.
摘要翻译：胃滞留组合物包含包含活性成分组分和赋形剂组分的混合物。赋形剂组分包括由包含乙烯基的前体制备的第一水溶性反应产物和由包含乙烯基的前体制备的聚亚烷基二醇和第二水溶性反应产物的共聚物。形成胃滞留组合物的方法包括以下步骤：提供活性成分组分和赋形剂组分，并将活性成分组分和赋形剂组分混合以形成混合物。将混合物聚集形成干燥颗粒形成多个颗粒的聚集体。处理多个颗粒以形成胃滞留组合物。

13. 发明授权

US6120797A N-acyl phosphatidylethanolamine-mediated liposomal drug delivery 失效
标题翻译： N-酰基磷脂酰乙醇胺介导的脂质体药物递送
公开(公告)号：US6120797A
公开(公告)日：2000-09-19
申请号：US951056
申请日：1997-10-15
申请人： Paul R. Meers , Tong Shangguan , Shaukat Ali , Andrew Janoff , Charles Pak
发明人： Paul R. Meers , Tong Shangguan , Shaukat Ali , Andrew Janoff , Charles Pak
IPC分类号： A61K9/127
CPC分类号： A61K9/1271 , Y10S424/812 , Y10S436/829 , Y10T428/2984
摘要： This invention provides liposomes containing one or more N-acylated phosphatidylethanolamines, such liposomes being useful for localizing the delivery of bioactive agents to cells.
摘要翻译：本发明提供含有一种或多种N-酰化磷脂酰乙醇胺的脂质体，所述脂质体可用于将生物活性剂递送至细胞。

14. 发明授权

US09622966B2 Gastroretentive composition on the basis of a water-soluble reaction product from a vinyl group-containing precursor 有权
公开(公告)号：US09622966B2
公开(公告)日：2017-04-18
申请号：US12667793
申请日：2007-12-26
申请人： Shaukat Ali , Anisul Quadir
发明人： Shaukat Ali , Carlos Santos , Anisul Quadir
IPC分类号： A61K31/192 , A61K9/00
CPC分类号： A61K9/0065
摘要： A gastroretentive composition comprises a mixture comprising an active ingredient component and an excipient component. The excipient component comprises a first water-soluble reaction product produced from a precursor comprising a vinyl group, and a copolymer of a polyalkylene glycol and a second water-soluble reaction product produced from a precursor comprising a vinyl group. A method of forming the gastroretentive composition comprises the steps of providing the active ingredient component and the excipient component, and mixing the active ingredient component and the excipient component to form a mixture. The mixture is aggregated to form an aggregation that is dry granulated to form a plurality of granules. The plurality of granules is processed to form the gastroretentive composition.

15. 发明申请

US20130017241A1 Encapsulated Chlorine Dioxide Generator 审中-公开
标题翻译：封装二氧化氯发生器
公开(公告)号：US20130017241A1
公开(公告)日：2013-01-17
申请号：US13576611
申请日：2011-02-01
申请人： Kim Andrews , Shaukat Ali , Jesse Jefferis , James S. Dailey , Charles O. Onyiuke , Keith A. Hirsch
发明人： Kim Andrews , Shaukat Ali , Jesse Jefferis , James S. Dailey , Charles O. Onyiuke , Keith A. Hirsch
IPC分类号： A01N25/26 , A01P1/00 , B05D1/02 , A01N59/00
CPC分类号： C01B11/024
摘要： An encapsulated chlorine dioxide generator is provided. The encapsulated generator includes a core particle that includes a metal chlorite and a solid acid. The encapsulated generator also includes a protective layer that is disposed about at least a portion of the core particle. The protective layer includes a copolymer of polyvinyl alcohol and a polyalkylene glycol. The encapsulated generator is formed in a method including the steps of forming the core particle and disposing the protective layer about the core particle. The encapsulated generator is also used in a method of cleaning an environment. The method of cleaning the environment includes the steps of providing the encapsulated generator and forming chlorine dioxide from the encapsulated chlorine dioxide generator to clean the environment.
摘要翻译：提供了一种封装的二氧化氯发生器。包封的发生器包括包含金属亚氯酸盐和固体酸的核心颗粒。封装的发生器还包括围绕核心颗粒的至少一部分设置的保护层。保护层包括聚乙烯醇和聚亚烷基二醇的共聚物。密封发生器以包括以下步骤的方法形成，所述步骤包括形成核心颗粒并将保护层设置在芯颗粒周围。封装的发生器也用于清洁环境的方法。清洁环境的方法包括以下步骤：提供封装的发生器并从包封的二氧化氯发生器形成二氧化氯以清洁环境。

16. 发明申请

US20090053285A1 Medicament Carrier Composition and Method Of Forming A Film Therefrom 有权
标题翻译：药物载体组成及其形成方法
公开(公告)号：US20090053285A1
公开(公告)日：2009-02-26
申请号：US11916733
申请日：2006-04-24
申请人： Shaukat Ali , Anisul Quadir
发明人： Shaukat Ali , Anisul Quadir
IPC分类号： A61K47/32 , A61K31/192 , A61K31/135 , A61K9/70 , A61P29/00
CPC分类号： A61K31/192 , A61K9/7007 , A61K9/7015 , A61K9/7053 , A61K31/135
摘要： A medicament carrier composition includes a medicament and a polymer component including a polyvinylpyrrolidone having a weight average molecular weight of at least 700,000 g/mol. The medicament carrier composition has a viscosity of from 500 to 5,000 cps at 250 C, is substantially free of cellulose, and includes an auxiliary polymer. The medicament carrier composition is used to form a film that is also substantially free of cellulose. The film has a consistent thickness and size, and an increased flexibility and increased moisture resistance due to the polyvinylpyrrolidone. The medicament carrier composition is also used in a method of forming the film. The method includes the steps of providing the medicament and the polymer component. The method also includes the step of combining the polymer component and the medicament to form the medicament carrier composition. The method further includes the step of drying the medicament carrier composition to form the film.
摘要翻译：药物载体组合物包含药物和包含重均分子量至少为700,000g / mol的聚乙烯吡咯烷酮的聚合物组分。药物载体组合物在250℃下的粘度为500至5,000cps，基本上不含纤维素，并且包括辅助聚合物。药物载体组合物用于形成也基本上不含纤维素的膜。该膜具有一致的厚度和尺寸，以及由于聚乙烯吡咯烷酮而增加的柔性和增加的耐湿性。药物载体组合物也用于形成膜的方法。该方法包括提供药物和聚合物组分的步骤。该方法还包括组合聚合物组分和药物以形成药物载体组合物的步骤。该方法还包括干燥药物载体组合物以形成膜的步骤。

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