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11. 发明申请

US20110230835A1 Implantation Device For Metabolite Sensors 有权
标题翻译：代谢传感器植入装置
公开(公告)号：US20110230835A1
公开(公告)日：2011-09-22
申请号：US13122110
申请日：2009-10-02
申请人： Achim Müller , Peter Herbrechtsmeier
发明人： Achim Müller , Peter Herbrechtsmeier
IPC分类号： A61M37/00
CPC分类号： A61B17/3468 , A61B5/0071 , A61B5/0075 , A61B5/0084 , A61B5/14532 , A61B2017/00535 , A61B2017/00539 , A61B2017/3447
摘要： The invention relates to an implantation device for implanting a sensor element for detecting at least one analyte in a bodily fluid or body tissue. The implantation device comprises at least one cannula for piercing a skin surface of a patient. The cannula has at least one holding area for holding the sensor element. The implantation device furthermore has at least one hydraulic container, connected to the cannula, for holding a hydraulic fluid and at least one pressure generation device. The pressure generation device is designed to apply pressure to the hydraulic fluid, wherein the sensor element can be transferred from the cannula into the body tissue using the hydraulic fluid.
摘要翻译：本发明涉及一种用于植入用于检测体液或身体组织中的至少一种分析物的传感器元件的植入装置。植入装置包括用于刺穿患者皮肤表面的至少一个套管。插管具有用于保持传感器元件的至少一个保持区域。植入装置还具有连接到套管的用于保持液压流体和至少一个压力产生装置的至少一个液压容器。压力产生装置被设计成对液压流体施加压力，其中传感器元件可以使用液压流体从插管转移到身体组织中。

12. 发明申请

US20100063371A1 DEVICE FOR MEASURING AN ANALYTE IN AN EYE FLUID 有权
标题翻译：用于测量眼液中分析物的装置
公开(公告)号：US20100063371A1
公开(公告)日：2010-03-11
申请号：US12374866
申请日：2007-07-23
申请人： Achim Müller , Peter Herbrechtsmeier , Klaus Haberstroh
发明人： Achim Müller , Peter Herbrechtsmeier , Klaus Haberstroh
IPC分类号： A61B5/1455
CPC分类号： A61B5/1455 , A61B5/14532 , A61B2560/0223
摘要： The invention proposes a manual measuring appliance (112) and an analytical measuring system (110) which can be used to measure at least one analyte in an eye fluid of an eye (114). The handheld measuring appliance (112) comprises a measuring system (120) and a positioning system (122). The measuring system (120) can measure at least one property of the at least one analyte and/or at least one analyte-dependent change of property of at least one ocular sensor (116) in the eye fluid, and this can be used to infer a concentration of the analyte in the eye fluid. The positioning system (122) is set up to measure a spatial positioning, wherein the spatial positioning comprises a distance between at least one measurement location in the eye (114) and the handheld measuring appliance (112) and also furthermore at least one further positioning co-ordinate. Furthermore, the handheld measuring appliance comprises a calibration system (128), wherein the calibration system (128) is set up to perform a comparison measurement of at least one analyte concentration in a body fluid and/or to adopt measurement data from a comparison measurement performed using a separate measuring appliance and to take them into account when determining the concentration of the at least one analyte.
摘要翻译：本发明提出了一种手动测量仪器（112）和分析测量系统（110），其可用于测量眼睛（114）的眼睛液体中的至少一种分析物。手持式测量仪器（112）包括测量系统（120）和定位系统（122）。测量系统（120）可以测量眼液中至少一种分析物的至少一种性质和/或至少一种分析物依赖的至少一种眼睛传感器（116）的性质变化，并且这可以用于推测眼液中分析物的浓度。定位系统（122）被设置为测量空间定位，其中空间定位包括眼睛（114）中的至少一个测量位置与手持式测量仪器（112）之间的距离，此外还包括至少一个另外的定位坐标。此外，手持式测量仪器包括校准系统（128），其中设置校准系统（128）以对体液中的至少一种分析物浓度进行比较测量和/或采用来自比较测量的测量数据使用单独的测量仪器执行，并在确定至少一种分析物的浓度时考虑它们。

13. 发明授权

US5319131A .alpha.-fluoroacrylic acid esters and polymers thereof 失效
标题翻译： α-氟丙烯酸酯及其聚合物
公开(公告)号：US5319131A
公开(公告)日：1994-06-07
申请号：US21282
申请日：1993-02-22
申请人： Rudolf Heumuller , Gunter Siegemund , Werner Groh , Gerhard Wieners , Peter Herbrechtsmeier
发明人： Rudolf Heumuller , Gunter Siegemund , Werner Groh , Gerhard Wieners , Peter Herbrechtsmeier
IPC分类号： C07C51/34 , C07C51/377 , C07C51/60 , C08F20/22 , C07C69/62
CPC分类号： C08F20/22 , C07C51/34 , C07C51/377 , C07C51/60
摘要： Esters of .alpha.-fluoroacrylic acid are accessible by hydrolysis of an .alpha.-hydroxymethyl-.alpha.-fluoromalonic acid ester, decarboxylation and dehydration of the hydrolysis product and subsequent esterification of the resulting .alpha.-fluoroacrylic acid with an alcohol. The esters are polymerizable and are suitable for use as a starting material for preparing fluoropolymers which in turn are usable as materials for manufacturing transparent articles. The polymers are high-molecular and non-crystalline and have softening temperatures of above 100.degree. C.
摘要翻译： α-氟代丙烯酸的酯可以通过α-羟甲基-α-氟丙酸酯的水解，水解产物的脱羧和脱水以及所得的α-氟丙烯酸与醇的酯化反应来获得。酯是可聚合的，并且适合用作制备含氟聚合物的起始原料，其可用作制造透明制品的材料。聚合物是高分子和非结晶的，并具有高于100℃的软化温度。

14. 发明授权

US5283303A Transplant thermoplastic molding compound made of 2,3-difluoroacrylic acid esters 失效
标题翻译：移植热塑性模塑料由2,3-二氟丙烯酸酯制成
公开(公告)号：US5283303A
公开(公告)日：1994-02-01
申请号：US941138
申请日：1992-11-03
申请人： Werner Groh , Peter Herbrechtsmeier , Rudolf Heumuller , Jurgen Theis , Gerhard Wieners
发明人： Werner Groh , Peter Herbrechtsmeier , Rudolf Heumuller , Jurgen Theis , Gerhard Wieners
IPC分类号： C08F20/02 , C08F16/14 , C08F20/10 , C08F20/22 , C08F214/26 , C08F216/14 , G02B1/04 , G02B6/00 , C08F18/20
CPC分类号： C08F20/22 , G02B1/046
摘要： A thermoplastic molding compound consisting of units of 2,3-difluoroacrylic acid esters or their deuterated derivatives, or containing units of these esters, is distinguished by a high glass transition temperature and a high transparency. It is therefore suitable for the manufacture of beam waveguides for long transmission distances and high continuous use temperatures.
摘要翻译：由2,3-二氟丙烯酸酯或它们的氘代衍生物或含有这些酯单元的单元构成的热塑性模塑料的特征在于高玻璃化转变温度和高透明度。因此，适用于制造长波长传输距离和高连续使用温度的光束波导。

15. 发明授权

US5132530A Light detector based on fluorescent dyes 失效
标题翻译：基于荧光灯的光检测器
公开(公告)号：US5132530A
公开(公告)日：1992-07-21
申请号：US762556
申请日：1991-09-18
申请人： Werner Groh , Jochen Coutandin , Peter Herbrechtsmeier , Jurgen Theis
发明人： Werner Groh , Jochen Coutandin , Peter Herbrechtsmeier , Jurgen Theis
IPC分类号： G01J1/02 , C09K11/00 , G01D5/26 , G02B6/00
CPC分类号： G01D5/268 , G01D5/26
摘要： A light detector consists of a plate-like light-absorbing body and at least one optical waveguide connected thereto. Both parts of the light detector contain a fluorescent dye, whereby the irradiated light is converted into a fluorescence radiation. This radiation is guided by total reflection to a light-sensitive semiconductor element and is measured there. The light detector is suitable as light barrier, fiber-optic revolution counter or UV detector.
摘要翻译：光检测器由板状光吸收体和与其连接的至少一个光波导构成。光检测器的两部分含有荧光染料，由此将照射的光转换成荧光辐射。该辐射由全反射引导到光敏半导体元件并在那里测量。光检测器适用于光阻，光纤转速计或UV检测器。

16. 发明授权

US5032654A Transparent polymer material 失效
标题翻译：透明聚合物材料
公开(公告)号：US5032654A
公开(公告)日：1991-07-16
申请号：US113469
申请日：1987-10-23
申请人： Gerhard Wieners , Rudolf Heumuller , Jochen Coutandin , Werner Groh , Peter Herbrechtsmeier
发明人： Gerhard Wieners , Rudolf Heumuller , Jochen Coutandin , Werner Groh , Peter Herbrechtsmeier
IPC分类号： G02B6/00 , B29D11/00 , C08F2/02 , C08F20/22 , C08F220/22
CPC分类号： C08F20/22
摘要： A transparent material of very good heat resistance and very good light conductivity is essentially composed of a polymer derived mainly from bromophenyl acrylates or bromophenyl methacrylates.
摘要翻译：具有非常好的耐热性和非常好的光导率的透明材料基本上由主要由溴苯基丙烯酸酯或溴代苯基甲基丙烯酸酯衍生的聚合物组成。

17. 发明申请

US20140024060A1 USE OF HYDROGELS FOR BIOSENSORS HAVING ELEVATED SENSITIVITY 有权
标题翻译：对具有高灵敏度的生物传感器的水凝胶的使用
公开(公告)号：US20140024060A1
公开(公告)日：2014-01-23
申请号：US13994071
申请日：2011-12-13
申请人： Achim Müller , Peter Herbrechtsmeier , Monika Knuth , Katharina Nikolaus
发明人： Achim Müller , Peter Herbrechtsmeier , Monika Knuth , Katharina Nikolaus
IPC分类号： G01N33/53
CPC分类号： G01N33/5308 , G01N33/66
摘要： The present invention relates to measures for determining glucose and for diagnosing diseases based on impaired glucose metabolism. In particular the present invention relates to the use of a polymer-based hydrogel consisting of at least one water-soluble polymer in a sensor for enriching a dissolved glucose-binding protein, wherein the at least one water-soluble polymer is capable of interacting with the glucose-binding protein and wherein the glucose-binding protein is present in a complex with a ligand.
摘要翻译：本发明涉及用于测定葡萄糖和基于葡萄糖代谢受损的疾病诊断的措施。特别地，本发明涉及由至少一种水溶性聚合物组成的聚合物基水凝胶在传感器中用于富集溶解的葡萄糖结合蛋白的用途，其中所述至少一种水溶性聚合物能够与葡萄糖结合蛋白，并且其中所述葡萄糖结合蛋白存在于与配体的络合物中。

18. 发明授权

US08452363B2 Device for measuring an analyte in an eye fluid 有权
标题翻译：用于测量眼液中分析物的装置
公开(公告)号：US08452363B2
公开(公告)日：2013-05-28
申请号：US12374866
申请日：2007-07-23
申请人： Achim Müller , Peter Herbrechtsmeier , Klaus Haberstroh , Roman Gruler
发明人： Achim Müller , Peter Herbrechtsmeier , Klaus Haberstroh , Roman Gruler
IPC分类号： A61B5/00 , A61B3/00 , A61B3/10
CPC分类号： A61B5/1455 , A61B5/14532 , A61B2560/0223
摘要： The invention proposes a manual measuring appliance (112) and an analytical measuring system (110) which can be used to measure at least one analyte in an eye fluid of an eye (114). The handheld measuring appliance (112) comprises a measuring system (120) and a positioning system (122). The measuring system (120) can measure at least one property of the at least one analyte and/or at least one analyte-dependent change of property of at least one ocular sensor (116) in the eye fluid, and this can be used to infer a concentration of the analyte in the eye fluid. The positioning system (122) is set up to measure a spatial positioning, wherein the spatial positioning comprises a distance between at least one measurement location in the eye (114) and the handheld measuring appliance (112) and also furthermore at least one further positioning co-ordinate. Furthermore, the handheld measuring appliance comprises a calibration system (128), wherein the calibration system (128) is set up to perform a comparison measurement of at least one analyte concentration in a body fluid and/or to adopt measurement data from a comparison measurement performed using a separate measuring appliance and to take them into account when determining the concentration of the at least one analyte.
摘要翻译：本发明提出了一种手动测量仪器（112）和分析测量系统（110），其可用于测量眼睛（114）的眼睛液体中的至少一种分析物。手持式测量仪器（112）包括测量系统（120）和定位系统（122）。测量系统（120）可以测量眼液中至少一种分析物的至少一种性质和/或至少一种分析物依赖的至少一种眼睛传感器（116）的性质变化，并且这可以用于推断眼液中分析物的浓度。定位系统（122）被设置为测量空间定位，其中空间定位包括眼睛（114）中的至少一个测量位置与手持式测量仪器（112）之间的距离，此外还包括至少一个另外的定位坐标。此外，手持式测量仪器包括校准系统（128），其中设置校准系统（128）以对体液中的至少一种分析物浓度进行比较测量和/或采用来自比较测量的测量数据使用单独的测量仪器执行，并在确定至少一种分析物的浓度时考虑它们。

19. 发明申请

US20100331634A1 HYDROGEL IMPLANT FOR SENSING METABOLITES IN BODY TISSUE 有权
标题翻译：用于感染身体组织中代谢物的HYDROGEL植入物
公开(公告)号：US20100331634A1
公开(公告)日：2010-12-30
申请号：US12601524
申请日：2008-05-23
申请人： Achim Müller , Peter Herbrechtsmeier , Monika Knuth , Katharina Nikolaus
发明人： Achim Müller , Peter Herbrechtsmeier , Monika Knuth , Katharina Nikolaus
IPC分类号： A61B5/145
CPC分类号： A61B5/1459 , A61B5/14532 , G01N21/77 , G01N2021/773 , G01N2021/7786
摘要： An implant (110) for detecting at least one analyte (126) in a body fluid, in particular an eye fluid, is proposed. The implant (110) is designed to be implanted in a tissue layer and/or a chamber of an eye of a patient, the implant (110) having a hydrogel matrix (110) with at least one hydrogel (114). The implant (110) also has sensor particles (116) dispersed in the hydrogel matrix (110), the sensor particles (116) having at least one sensor matrix (120) with a sensor matrix material (122) and at least one sensor material (124).
摘要翻译：提出了用于检测体液中的至少一种分析物（126）的植入物（110），特别是眼液。植入物（110）设计成植入患者眼睛的组织层和/或腔室中，植入物（110）具有至少一种水凝胶（114）的水凝胶基体（110）。植入物（110）还具有分散在水凝胶基质（110）中的传感器颗粒（116），传感器颗粒（116）具有至少一个具有传感器基体材料（122）的传感器矩阵（120）和至少一个传感器材料（124）。

20. 发明申请

US20080249381A1 Combined Apparatus For Measuring the Blood Glucose Level From an Ocular Fluid 审中-公开
标题翻译：用于从眼液测量血糖水平的组合仪器
公开(公告)号：US20080249381A1
公开(公告)日：2008-10-09
申请号：US11570628
申请日：2005-06-13
申请人： Achim Muller , Peter Herbrechtsmeier , Bernhard Seiferling , Wolfgang Hofmann
发明人： Achim Muller , Peter Herbrechtsmeier , Bernhard Seiferling , Wolfgang Hofmann
IPC分类号： A61B5/00
CPC分类号： A61B5/14532 , A61B5/0071 , A61B5/1455 , A61B5/1486 , A61B5/6821
摘要： A combined apparatus for measuring the blood glucose level from an ocular fluid comprises a hand-held fluorescence photometer (D1) for determining the glucose level of the ocular fluid and a device (D2) for the amperometric or photometric determination of the blood glucose level. The fluorescence photometer (D1) comprises: first irradiating means (7,8,10) for providing a pilot beam (1) for irradiation of the eye (3) in order to excite a first fluorescence comprising a first wavelength band; first detecting means (8,9,12,13) for measuring the intensity of the of the pupil fluorescence within the first wavelength band; second irradiating means (17,18,21) for providing a measurement beam (5) for irradiation of the eye in order to excite an ocular sensor (4) to emit a second fluorescence comprising a second wavelength band; second detecting means (18,19,20,22,23,24,25) for measuring the intensity of the second fluorescence within the second wavelength band. The first and second irradiating means are arranged such that the measurement beam irradiates the eye under a predetermined angle (a) between 0° and 90° and at a predetermined distance from the pilot beam.
摘要翻译：用于测量来自眼液的血糖水平的组合装置包括用于确定眼液的葡萄糖水平的手持荧光光度计（D 1）和用于血糖的电流或光度测定的装置（D 2）水平。荧光光度计（D 1）包括：第一照射装置（7,8,10），用于提供用于照射眼睛（3）的引导光束（1），以便激发包括第一波长带的第一荧光; 第一检测装置（8,9,12,13），用于测量第一波长带内的瞳孔荧光的强度; 第二照射装置（17,18,21），用于提供用于照射眼睛的测量光束（5），以激发眼睛传感器（4）以发射包括第二波长带的第二荧光; 用于测量第二波长带内的第二荧光的强度的第二检测装置（18,19,20,22,23,24,25）。第一和第二照射装置被布置成使得测量光束以0°至90°之间的预定角度（a）照射眼睛并且距离导向光束预定距离。

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