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11. 发明授权

US07199283B2 Geranylgeranyl pyrophosphate synthases 失效
公开(公告)号：US07199283B2
公开(公告)日：2007-04-03
申请号：US11032643
申请日：2005-01-10
申请人： Rebecca E. Cahoon , Mark E. Williams
发明人： Rebecca E. Cahoon , Mark E. Williams
IPC分类号： A01H1/00 , C07H21/04 , C07K14/415 , C12N5/14 , C12N9/00
CPC分类号： C12N9/1085 , C12N15/825 , C12N2799/021 , C12Q1/6895 , C12Y205/01029
摘要： This invention relates to an isolated nucleic acid fragment encoding a geranylgeranyl pyrophosphate synthase. The invention also relates to the construction of a chimeric gene encoding all or a portion of the geranylgeranyl pyrophosphate synthase, in sense or antisense orientation, wherein expression of the chimeric gene results in production of altered levels of the geranylgeranyl pyrophosphate synthase in a transformed host cell.

12. 发明授权

US5792846A Human calcium channel compositions and methods 失效
公开(公告)号：US5792846A
公开(公告)日：1998-08-11
申请号：US455543
申请日：1995-05-31
申请人： Michael M. Harpold , Steven B. Ellis , Mark E. Williams , Daniel H. Feldman , Ann F. McCue , Robert Brenner
发明人： Michael M. Harpold , Steven B. Ellis , Mark E. Williams , Daniel H. Feldman , Ann F. McCue , Robert Brenner
IPC分类号： A61K38/00 , C07K14/705 , C12N15/12 , C12Q1/68 , G01N33/564 , G01N33/68 , C07H21/04
CPC分类号： G01N33/6872 , C07K14/705 , C12Q1/6876 , C12Q1/6897 , G01N33/564 , G01N33/68 , G01N33/6893 , A61K38/00 , C12Q2600/158 , G01N2500/10
摘要： Isolated DNA encoding each of human calcium channel .alpha..sub.1 -, .alpha..sub.2 -, .beta.- and .gamma.-subunits, including subunits that arise as splice variants of primary transcripts, is provided. Cells and vectors containing the DNA and methods for identifying compounds that modulate the activity of human calcium channels are also provided.

13. 发明授权

US5631618A Magnetic arrays 失效
标题翻译：磁阵列
公开(公告)号：US5631618A
公开(公告)日：1997-05-20
申请号：US316278
申请日：1994-09-30
申请人： David L. Trumper , Won-jong Kim , Mark E. Williams
发明人： David L. Trumper , Won-jong Kim , Mark E. Williams
IPC分类号： G03F7/20 , H01F7/20 , H01F5/00
CPC分类号： G03F7/70758 , H01F7/20
摘要： Electromagnet arrays which can provide selected field patterns in either two or three dimensions, and in particular, which can provide single-sided field patterns in two or three dimensions. These features are achieved by providing arrays which have current densities that vary in the windings both parallel to the array and in the direction of array thickness.
摘要翻译：可以在两维或三维中提供所选择的场图案的电磁体阵列，特别地，其可以提供两维或三维的单面场图案。这些特征通过提供具有在阵列上平行的绕组和阵列厚度方向上变化的电流密度的阵列来实现。

14. 发明授权

US5570750A Rotary drill bit with improved shirttail and seal protection 失效
标题翻译：旋转钻头，具有改进的衬衫和密封保护
公开(公告)号：US5570750A
公开(公告)日：1996-11-05
申请号：US425917
申请日：1995-04-20
申请人： Mark E. Williams
发明人： Mark E. Williams
IPC分类号： E21B10/22 , E21B10/25 , E21B10/00
CPC分类号： E21B10/25 , E21B10/22
摘要： A rotary cone drill bit for forming a borehole having a bit body with an upper end portion adapted for connection to a drill string. A number of angularly-spaced support arms formed to extend from the bit body. Each support arm has an inside surface with a spindle connected thereto and an outer shirttail surface. A number of cutter cones equal to the number of support arms are rotatably mounted on respective spindles. Each of the cutter cones includes an internal cylindrical cavity for receiving the respective spindle. A gap with a generally cylindrical portion is formed between the spindle and the cavity with a seal element disposed within the gap. The gap has an opening contiguous with the bottom edge of the shirttail surface and extending outwardly from the spindle. A shirttail ring is disposed on the exterior of each spindle between the cutter cone and the inside surface of the respective support arm with a portion of the shirttail ring extending from the respective shirttail surface. A seal ring may be disposed on the exterior of the spindle adjacent to the shirttail ring. The seal ring cooperates with the sealing element to form a fluid barrier between the spindle and the cavity.
摘要翻译：一种用于形成钻孔的旋转锥形钻头，其具有适于连接到钻柱的上端部的钻头体。多个角度间隔的支撑臂形成为从钻头体延伸。每个支撑臂具有内表面，其中连接有主轴和外部衬衫表面。与支撑臂的数量相等的多个切割锥可旋转地安装在各自的主轴上。每个切割锥包括用于接收相应主轴的内圆柱形腔。在主轴和空腔之间形成具有大致圆柱形部分的间隙，其中密封元件设置在间隙内。间隙具有与底纹表面的底部边缘连续的开口并且从心轴向外延伸。在每个主轴的外部，在切割锥体和相应的支撑臂的内表面之间设置有一个衬衫戒指，一部分衬衫戒指环从相应的衬衫表面延伸。密封环可以布置在与衬衫尾环相邻的心轴的外部上。密封环与密封元件配合，以在主轴和空腔之间形成流体屏障。

15. 发明授权

US08319010B2 Methods of producing maize plants having a high oil phenotype by detecting a marker locus genetically linked with a QTL6 region 有权
标题翻译：通过检测与QTL6区域遗传连锁的标记位点来生产具有高油表型的玉米植物的方法
公开(公告)号：US08319010B2
公开(公告)日：2012-11-27
申请号：US13157068
申请日：2011-06-09
申请人： William B. Allen , Bo Shen , Mitchell C. Tarczynski , Mark E. Williams , Peizhong Zheng , Gan-Yuan Zhong
发明人： William B. Allen , Bo Shen , Mitchell C. Tarczynski , Mark E. Williams , Peizhong Zheng , Gan-Yuan Zhong
IPC分类号： A01H1/00 , A01H5/00 , C12Q1/68
CPC分类号： A01H1/04 , C12N9/1029 , C12N15/8247 , C12Q1/6895 , C12Q2600/13 , C12Q2600/156 , C12Q2600/172 , Y10T436/104165
摘要： Compositions related to the quantitative trait locus 6 (QTL6) in maize and methods for their use are provided. The compositions are novel molecular marker loci that are genetically linked with QTL6 and which are associated with increased oil content and/or increased oleic acid content and/or an increased oleic acid/linoleic acid ratio of a plant or plant part thereof. These novel markers are characterized by the presence of at least one polymorphism relative to the corresponding marker locus from the QTL6 region of non-high-oil, non-high-oleic acid maize plants. In some embodiments, the novel marker loci comprise coding sequence for a maize DGAT1-2 polypeptide or biologically active variant thereof. The marker loci of the invention, and suitable fragments thereof, are useful in methods of the invention for manipulating oil and/or oleic acid content and/or oleic acid/lineolic acid ratio of a plant or plant part thereof, for marker-assisted selection of a plant, for example, a maize plant, or plant part thereof, having an increased oil content and/or increased oleic acid content and/or an increased oleic acid/linoleic acid ratio, and for marker-assisted breeding of the high oil and/or high oleic acid trait.
摘要翻译：提供了与玉米数量性状基因座6（QTL6）相关的成分及其使用方法。所述组合物是与QTL6遗传连锁的新型分子标记基因座，其与植物或植物部分的油含量增加和/或油酸含量增加和/或油酸/亚油酸含量增加相关。这些新型标记物的特征在于相对于非高油非高油酸玉米植物的QTL6区域的相应标记基因座存在至少一个多态性。在一些实施方案中，新的标记基因座包含玉米DGAT1-2多肽或其生物活性变体的编码序列。本发明的标记基因座及其合适的片段可用于本发明的操作用于标记辅助选择的植物或植物部分的油和/或油酸含量和/或油酸/线性酸比例的方法中具有增加的油含量和/或油酸含量增加和/或油酸/亚油酸比例增加的植物，例如玉米植物或其植物部分，以及高油的标记辅助育种和/或高油酸性状。

16. 发明申请

US20120102596A1 COMPOSITIONS RELATED TO THE QUANTITATIVE TRAIT LOCUS 6 (QTL6) IN MAIZE AND METHODS OF USE 有权
标题翻译：与量化条件6（QTL6）相关的组合物及其使用方法
公开(公告)号：US20120102596A1
公开(公告)日：2012-04-26
申请号：US13299763
申请日：2011-11-18
申请人： William B. Allen , Bo Shen , Mitchell C. Tarczynski , Mark E. Williams , Peizhong Zheng , Gan-Yuan Zhong
发明人： William B. Allen , Bo Shen , Mitchell C. Tarczynski , Mark E. Williams , Peizhong Zheng , Gan-Yuan Zhong
IPC分类号： C12N15/82 , C12Q1/68 , C12N15/63 , A01H5/00 , C12N9/10 , C12N15/54
CPC分类号： C12N15/8247 , C12N9/1029 , C12Q1/6895 , C12Q2600/13 , C12Q2600/156 , C12Q2600/172
摘要： Compositions related to the quantitative trait locus 6 (QTL6) in maize and methods for their use are provided. The compositions are novel molecular marker loci genetically linked with QTL6 and which are associated with increased oil content and/or increased oleic acid content and/or an increased oleic acid/linoleic acid ratio of a plant. These novel markers are characterized by the presence of at least one polymorphism relative to the corresponding marker locus from the QTL6 region of non-high-oil, non-high-oleic acid maize plants. In some embodiments, the novel marker loci comprise coding sequence for a maize DGAT1-2 polypeptide or biologically active variant thereof. The marker loci of the invention, and suitable fragments thereof, are useful in methods for manipulating oil and/or oleic acid content and/or oleic acid/linoleic acid ratio of a plant, for marker-assisted selection of a plant, and for marker-assisted breeding of the high oil and/or high oleic acid trait.
摘要翻译：提供了与玉米数量性状基因座6（QTL6）相关的成分及其使用方法。所述组合物是与QTL6遗传连锁的新型分子标记基因座，其与植物的油含量增加和/或油酸含量增加和/或油酸/亚油酸比例增加相关。这些新型标记物的特征在于相对于非高油非高油酸玉米植物的QTL6区域的相应标记基因座存在至少一个多态性。在一些实施方案中，新的标记基因座包含玉米DGAT1-2多肽或其生物活性变体的编码序列。本发明的标记基因座及其合适的片段可用于操作植物的油和/或油酸含量和/或油酸/亚油酸比例，用于植物的标记辅助选择和标记物的方法 - 高油和/或高油酸性状的辅助育种。

17. 发明申请

US20110264010A1 Systems, Devices, and Methods for Interpreting Movement 有权
公开(公告)号：US20110264010A1
公开(公告)日：2011-10-27
申请号：US13177144
申请日：2011-07-06
申请人： Mark E. Williams
发明人： Mark E. Williams
IPC分类号： A61B5/11
CPC分类号： A61B5/112 , A61B5/1038 , A61B5/1123 , A61B5/1124 , A61B5/165 , A61B5/4076 , A61B5/4082 , A61B5/4519 , A61B5/4528 , A61B5/7257 , A61B5/7275 , G06F19/00 , G06K9/00348
摘要： According to some exemplary embodiments, a method or system can involve associating a plurality of biokinetographic comparison results with a first specific dysfunction from a group of specific dysfunctions, each of the biokinetographic comparison results obtained from a comparison of a biokinetographic value to a standard for a corresponding biokinetographic variable.

18. 发明申请

US20110041207A1 COMPOSITIONS RELATED TO THE QUANTITATIVE TRAIT LOCUS 6 (QTL6) IN MAIZE AND METHODS OF USE 有权
标题翻译：与量化条件6（QTL6）相关的组合物及其使用方法
公开(公告)号：US20110041207A1
公开(公告)日：2011-02-17
申请号：US12875574
申请日：2010-09-03
申请人： William B. Allen , Bo Shen , Mitchell C. Tarczynski , Mark E. Williams , Peizhong Zheng , Gan-Yuan Zhong
发明人： William B. Allen , Bo Shen , Mitchell C. Tarczynski , Mark E. Williams , Peizhong Zheng , Gan-Yuan Zhong
IPC分类号： A01H1/02 , C12Q1/68 , A01H5/00 , A01H1/06
CPC分类号： C12N15/8247 , C12N9/1029 , C12Q1/6895 , C12Q2600/13 , C12Q2600/156 , C12Q2600/172
摘要： Compositions related to the quantitative trait locus 6 (QTL6) in maize and methods for their use are provided. The compositions are novel molecular marker loci that are genetically linked with QTL6 and which are associated with increased oil content and/or increased oleic acid content and/or an increased oleic acid/linoleic acid ratio of a plant or plant part thereof. These novel markers are characterized by the presence of at least one polymorphism relative to the corresponding marker locus from the QTL6 region of non-high-oil, non-high-oleic acid maize plants. In some embodiments, the novel marker loci comprise coding sequence for a maize DGAT1-2 polypeptide or biologically active variant thereof. The marker loci of the invention, and suitable fragments thereof, are useful in methods of the invention for manipulating oil and/or oleic acid content and/or oleic acid/linoleic acid ratio of a plant or plant part thereof, for marker-assisted selection of a plant, for example, a maize plant, or plant part thereof, having an increased oil content and/or increased oleic acid content and/or an increased oleic acid/linoleic acid ratio, and for marker-assisted breeding of the high oil and/or high oleic acid trait.
摘要翻译：提供了与玉米数量性状基因座6（QTL6）相关的成分及其使用方法。所述组合物是与QTL6遗传连锁的新型分子标记基因座，其与植物或植物部分的油含量增加和/或油酸含量增加和/或油酸/亚油酸含量增加相关。这些新型标记物的特征在于相对于非高油非高油酸玉米植物的QTL6区域的相应标记基因座存在至少一个多态性。在一些实施方案中，新的标记基因座包含玉米DGAT1-2多肽或其生物活性变体的编码序列。本发明的标记基因座及其合适的片段可用于本发明的用于操纵植物或植物部分的油和/或油酸含量和/或油酸/亚油酸比例的方法，用于标记辅助选择具有增加的油含量和/或油酸含量增加和/或油酸/亚油酸比例增加的植物，例如玉米植物或其植物部分，以及高油的标记辅助育种和/或高油酸性状。

19. 发明授权

US07838263B2 Methods of identifying a plant with an Nsf1 locus 有权
标题翻译：鉴定具有Nsf1基因座的植物的方法
公开(公告)号：US07838263B2
公开(公告)日：2010-11-23
申请号：US11964871
申请日：2007-12-27
申请人： Thao Dam , Anthony D. Guida, Jr. , Christine B. Hazel , Bailin Li , Mark E. Williams
发明人： Thao Dam , Anthony D. Guida, Jr. , Christine B. Hazel , Bailin Li , Mark E. Williams
IPC分类号： C12Q1/26 , C12Q1/68
CPC分类号： C12N15/8278 , C12N15/8274
摘要： This invention relates to polynucleotide sequences encoding a gene that can confer resistance to at least one herbicide. It further relates to plants and seeds of plants carrying chimeric genes comprising said polynucleotide sequences, which enhance or confer resistance to at least one herbicide, and methods of making said plants and seeds. The invention further presents sequences that can be used as molecular markers that in turn can be used to identify the region of interest in corn lines resulting from new crosses and to quickly and efficiently select the best lines for breeding strategies by avoiding sensitive lines. Methods of identifying a plant with an Nsf1 locus using molecular markers are described.
摘要翻译：本发明涉及编码可赋予至少一种除草剂抗性的基因的多核苷酸序列。它进一步涉及携带包含所述多核苷酸序列的嵌合基因的植物和种子，其增强或赋予至少一种除草剂的抗性，以及制备所述植物和种子的方法。本发明还提供可用作分子标记的序列，其又可用于鉴定由新杂交产生的玉米品系中的感兴趣区域，并通过避免敏感品系快速有效地选择育种策略的最佳品系。描述了使用分子标记鉴定具有Nsf1基因座的植物的方法。

20. 发明授权

US07705200B2 Polynucleotide encoding a maize herbicide resistance gene and methods for use 有权
标题翻译：编码玉米除草剂抗性基因的多核苷酸及其使用方法
公开(公告)号：US07705200B2
公开(公告)日：2010-04-27
申请号：US12428648
申请日：2009-04-23
申请人： Thao Dam , Anthony D. Guida, Jr. , Christine B. Hazel , Bailin Li , Mark E. Williams
发明人： Thao Dam , Anthony D. Guida, Jr. , Christine B. Hazel , Bailin Li , Mark E. Williams
IPC分类号： C12N15/82 , A01H5/00 , A01N25/00
CPC分类号： C12N15/8278 , C12N15/8274
摘要： This invention relates to polynucleotide sequences encoding a gene that can confer resistance to at least one herbicide. It further relates to plants and seeds of plants carrying chimeric genes comprising said polynucleotide sequences, which enhance or confer resistance to at least one herbicide, and methods of making said plants and seeds. The invention further presents sequences that can be used as molecular markers that in turn can be used to identify the region of interest in corn lines resulting from new crosses and to quickly and efficiently select the best lines for breeding strategies by avoiding sensitive lines.
摘要翻译：本发明涉及编码可赋予至少一种除草剂抗性的基因的多核苷酸序列。它进一步涉及携带包含所述多核苷酸序列的嵌合基因的植物和种子，其增强或赋予至少一种除草剂的抗性，以及制备所述植物和种子的方法。本发明还提供可用作分子标记的序列，其又可用于鉴定由新杂交产生的玉米品系中的感兴趣区域，并通过避免敏感品系快速有效地选择育种策略的最佳品系。

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