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11. 发明授权

US07192975B2 Arylimidazole derivatives, preparation and therapeutic used thereof 失效
标题翻译：芳基咪唑衍生物，其制备和治疗用途
公开(公告)号：US07192975B2
公开(公告)日：2007-03-20
申请号：US10517267
申请日：2003-07-24
申请人： Dennis Bigg , Anne-Marie Liberatore , Pierre-Etienne Chabrier De Lassauniere
发明人： Dennis Bigg , Anne-Marie Liberatore , Pierre-Etienne Chabrier De Lassauniere
IPC分类号： A61K31/4178 , C07D409/12
CPC分类号： C07D409/12 , C07D409/14
摘要： Compounds of the formula wherein the substituents are as defined in the specification which are useful for the treatment of pain.
摘要翻译：下式的化合物其中取代基如说明书中所定义，其可用于治疗疼痛。

12. 发明授权

US07956075B2 Derivatives of heterocycles with 5 members, their preparation and their use as medicaments 有权
标题翻译：具有5个成员的杂环衍生物，其制备及其作为药物的用途
公开(公告)号：US07956075B2
公开(公告)日：2011-06-07
申请号：US12001439
申请日：2007-12-11
申请人： Pierre-Etienne Chabrier De Lassauniere , Jeremiah Harnett , Dennis Bigg , Anne-Marie Liberatore , Jacques Pommier , Jacques Lannoy , Christophe Thurieau
发明人： Pierre-Etienne Chabrier De Lassauniere , Jeremiah Harnett , Dennis Bigg , Anne-Marie Liberatore , Jacques Pommier , Jacques Lannoy , Christophe Thurieau
IPC分类号： A61K31/425 , C07D277/28
CPC分类号： C07D277/28 , A61K31/417 , A61K31/4178 , A61K31/42 , A61K31/421 , A61K31/426 , A61K31/427 , A61K31/454 , A61K31/496 , C07D233/64 , C07D261/04 , C07D263/32 , C07D277/24 , C07D403/04 , C07D403/06 , C07D405/06 , C07D409/06 , C07D413/06 , C07D417/04 , C07D417/06
摘要： The invention relates to thiazole, oxazole, imidazole, isoxazole and isoxazoline derivatives of general formula (I) wherein Het is thiazole, oxazole, imidazole, isoxazole or isoxazoline, n is an integer from 0 to 6, A is notably selected from various optionally substituted aromatic radicals, B is notably hydrogen, alkyl or phenyl, R1 and R2 are notably independently hydrogen, alkyl or cycloalkyl and Ω is —NR46R47 or —OR48, R46 and R47 are notably independently hydrogen, alkyl, cycloalkyl or —(CH2)k—COOR51, R51 is notably alkyl or haloalkyl and R48 is notably hydrogen or alkyl. These compounds have advantageous pharmacological properties which allow their use in therapeutics, notably for treating neurodegenerative disorders or pain.
摘要翻译：本发明涉及噻唑，恶唑，咪唑，异恶唑和其中Het为噻唑，恶唑，咪唑，异恶唑或异恶唑啉的通式（I）的异恶唑啉衍生物，n为0至6的整数，A特别选自各种任选取代的芳基，B特别是氢，烷基或苯基，R 1和R 2特别独立地是氢，烷基或环烷基，和OHgr; 是-NR46R47或-OR48，R46和R47独特地是氢，烷基，环烷基或 - （CH2）k-COOR51，R51尤其是烷基或卤代烷基，R48特别是氢或烷基。这些化合物具有有利的药理学性质，其允许其用于治疗学，特别是用于治疗神经变性疾病或疼痛。

13. 发明授权

US07291641B2 Derivatives of heterocycles with 5 members, their preparation and their use as medicaments 失效
标题翻译：具有5个成员的杂环衍生物，其制备及其作为药物的用途
公开(公告)号：US07291641B2
公开(公告)日：2007-11-06
申请号：US10915001
申请日：2004-08-10
申请人： Pierre-Etienne Chabrier De Lassauniere , Jermiah Harnett , Dennis Bigg , Ann-Marie Liberatore , Jacques Pommier , Jacques Lannoy , Christophe Thurieau , Zheng Xin Dong
发明人： Pierre-Etienne Chabrier De Lassauniere , Jermiah Harnett , Dennis Bigg , Ann-Marie Liberatore , Jacques Pommier , Jacques Lannoy , Christophe Thurieau , Zheng Xin Dong
IPC分类号： A61K31/417 , C07D233/61
CPC分类号： C07D233/64 , A61K31/417 , A61K31/4178 , A61K31/42 , A61K31/421 , A61K31/426 , A61K31/427 , A61K31/454 , A61K31/496 , C07D233/50 , C07D261/04 , C07D263/32 , C07D277/24 , C07D277/28 , C07D277/34 , C07D401/06 , C07D403/06 , C07D405/06 , C07D409/06 , C07D413/06 , C07D417/04 , C07D417/06 , C07D417/14
摘要： Thiaxozle, oxazole, imidazole, isoxazole and isoxazoline compounds of the formula wherein Het is thiazole, oxazole, imidazole, isoxazole or isoxazoline, n is an integer from 0 to 6, A is selected from the various optionally substituted aromatic radicals defined in the specification, B is hydrogen, alkyl or phenyl, R1 and R2 are independently hydrogen, alkyl or cycloalkyl or R1 and R2 taken together with the carbon atom which carries them, form a carbocycle with 3 to 7 members and Ω is —NH46R47 or —OR48, R46 and R47 are independently hydrogen, alkyl, cycloalkyl or —(CH2)kCOOR51, R51 is alkyl or haloalkyl and R48 is hydrogen or alkyl having advantageous pharmacological properties which allow their use in therapeutics, for treating neurodegenerative disorders or pain.
摘要翻译：噻唑，恶唑，咪唑，异恶唑和异恶唑啉化合物，其中Het是噻唑，恶唑，咪唑，异恶唑或异恶唑啉，n是0至6的整数，A选自说明书中定义的各种任选取代的芳族基， B是氢，烷基或苯基，R 1和R 2独立地是氢，烷基或环烷基或R 1和R 2 与携带它们的碳原子一起形成具有3至7个成员的碳环，并且Ω是-NH 46和/或 48，R 46和R 47独立地是氢，烷基，环烷基或 - （CH 2 CH 2） C 51，R 51是烷基或卤代烷基，R 48是具有有利药理学性质的氢或烷基，其允许它们用于治疗学用于治疗神经变性疾病或疼痛。

14. 发明申请

US20080207709A1 Thiazole Derivatives for Treating Dyskinesias Caused by a Chemical Treatment 有权
标题翻译：噻唑衍生物治疗由化学治疗引起的运动障碍
公开(公告)号：US20080207709A1
公开(公告)日：2008-08-28
申请号：US11995092
申请日：2006-07-07
申请人： Pierre-Etienne Chabrier De Lassauniere , Michel Auguet , Brigitte Spinnewyn
发明人： Pierre-Etienne Chabrier De Lassauniere , Michel Auguet , Brigitte Spinnewyn
IPC分类号： A61K31/425 , A61P43/00
CPC分类号： A61K31/426 , A61K31/198 , A61K31/427 , C07D277/28
摘要： The invention relates to the use of derivatives of thiazoles having general formula (I) for the preparation of a medicament for the treatment or prevention of dyskinesias caused by a chemical treatment. The invention also relates to a combination of thiazole derivatives having general formula (I) and at least one compound selected from among neuroleptics or products that act on the dopaminergic system for the treatment or prevention of dyskinesias caused by a chemical treatment.
摘要翻译：本发明涉及具有通式（I）的噻唑衍生物在制备用于治疗或预防由化学治疗引起的运动障碍的药物中的用途。本发明还涉及具有通式（I）的噻唑衍生物和选自神经安定药或作用于多巴胺能系统的产品的至少一种化合物的组合，用于治疗或预防由化学治疗引起的运动障碍。

15. 发明申请

US20070082013A1 Use of botulinum toxin for producing drug for preventing or treating final phase of lung troubles 审中-公开
标题翻译：使用肉毒杆菌毒素生产用于预防或治疗肺部疾病终末期的药物
公开(公告)号：US20070082013A1
公开(公告)日：2007-04-12
申请号：US10564825
申请日：2004-07-16
申请人： Pierre-Etienne Chabrier De Lassauniere
发明人： Pierre-Etienne Chabrier De Lassauniere
IPC分类号： A61K39/08
CPC分类号： A61K38/4893
摘要： The invention relates to the use of botulinum toxin for producing a drug for preventing or treating the final phase of lung troubles.
摘要翻译：本发明涉及肉毒杆菌毒素用于制备用于预防或治疗肺部疾病的最后阶段的药物的用途。

16. 发明授权

US06770669B1 Amidine derivatives, preparation and use thereof as medicines 失效
标题翻译：脒衍生物，其制备和用途作为药物
公开(公告)号：US06770669B1
公开(公告)日：2004-08-03
申请号：US10111434
申请日：2002-04-23
申请人： Pierre-Etienne Chabrier De Lassauniere , Jeremiah Harnett
发明人： Pierre-Etienne Chabrier De Lassauniere , Jeremiah Harnett
IPC分类号： A61K3138
CPC分类号： C07D333/38
摘要： A seat adjustment mechanism is provided and includes an arm defining a first locking shoulder, a sector plate rotatably supported by the arm and defining a second locking shoulder having a lock recess, a locking member selectively engaging at least one of the first and second locking shoulders, a quadrant rotatably supported by the arm and slidably supporting the locking member for locking the quadrant in one of a first and second position relative to the arm and a cam plate rotatably supported by the quadrant for selectively engaging the locking member for locking the quadrant in one of the first and second positions. In the first position the locking member is biased against the first locking shoulder and in the second position the locking member is biased into the lock recess. A gear assembly is preferably provided and operably supported by the quadrant for actuation of the cam plate.
摘要翻译：提供座椅调节机构，并且包括限定第一锁定肩部的臂，由所述臂可旋转地支撑并限定具有锁定凹部的第二锁定肩部的扇形板，锁定构件，其选择性地接合所述第一和第二锁定肩部中的至少一个，由臂可旋转地支撑并且可滑动地支撑用于将所述象限锁定在相对于所述臂的第一和第二位置中的一个中的锁定元件的象限;以及由所述象限可旋转地支撑的凸轮板，用于选择性地接合所述锁定构件以锁定所述象限第一和第二职位之一。在第一位置，锁定构件被偏置抵靠第一锁定肩部，并且在第二位置，锁定构件被偏压到锁定凹部中。齿轮组件优选地设置并且可操作地由所述象限支撑以用于所述凸轮板的致动。

17. 发明授权

US09006274B2 Thiazole derivatives for treating dyskinesias caused by a chemical treatment 有权
标题翻译：噻唑衍生物，用于治疗由化学治疗引起的运动障碍
公开(公告)号：US09006274B2
公开(公告)日：2015-04-14
申请号：US11995092
申请日：2006-07-07
申请人： Pierre-Etienne Chabrier De Lassauniere , Michel Auguet , Brigitte Spinnewyn
发明人： Pierre-Etienne Chabrier De Lassauniere , Michel Auguet , Brigitte Spinnewyn
IPC分类号： A61K31/426 , A61K31/427
CPC分类号： A61K31/426 , A61K31/198 , A61K31/427 , C07D277/28
摘要： The invention relates to the use of derivatives of thiazoles having general formula (I) for the preparation of a medicament for the treatment or prevention of dyskinesias caused by a chemical treatment. The invention also relates to a combination of thiazole derivatives having general formula (I) and at least one compound selected from among neuroleptics or products that act on the dopaminergic system for the treatment or prevention of dyskinesias caused by a chemical treatment.
摘要翻译：本发明涉及具有通式（I）的噻唑衍生物在制备用于治疗或预防由化学治疗引起的运动障碍的药物中的用途。本发明还涉及具有通式（I）的噻唑衍生物和选自神经安定药或作用于多巴胺能系统的产品的至少一种化合物的组合，用于治疗或预防由化学治疗引起的运动障碍。

18. 发明申请

US20090270400A1 PAINKILLING ASSOCIATION COMPRISING A DIHYDROIMIDAZOPYRAZINE DERIVATIVE 审中-公开
标题翻译：包含二氢咪唑并吡啶衍生物的结合协会
公开(公告)号：US20090270400A1
公开(公告)日：2009-10-29
申请号：US11722070
申请日：2005-12-16
申请人： Michel Auguet , Christine Favre , Gregoire Prevost , Pierre-Etienne Chabrier De Lassauniere
发明人： Michel Auguet , Christine Favre , Gregoire Prevost , Pierre-Etienne Chabrier De Lassauniere
IPC分类号： A61K31/495
CPC分类号： A61K45/06 , A61K31/4985 , A61K2300/00
摘要： The invention relates to a product comprising (1R)-1-[(({2R)-2-amino-3-[(8S)-8-(cyclohexylmethyl) -2-phenyl-5,6-dihydroimidazo [1,2-a]pyrazin-7(8H)-yl]-3-oxopropyl}dithio)methyl]-2-[(8S)-8-(cyclohexylmethyl) -2-phenyl-5,6-dihydrolmidazo[1,2-a]pyrazin-7(8H)-yl]-2-oxoethylamine in association with an analgesic agent selected from morphine, the similar or a morphine derivative, sodium channel inhibitors, non-steroidal antiflammatory agents (AINS), glutamatergic system inhibitors, tricycle antidepressants and gabaergic derivatives for simultaneous therapeutic use which is separated or out over the time for pain treatment or prevention.
摘要翻译：本发明涉及包含（1R）-1 - [（（（2R）-2-氨基-3 - [（8S）-8-（环己基甲基）-2-苯基-5,6-二氢咪唑并[1,2 -a]吡嗪-7（8H） - 基] -3-氧代丙基}二硫基）甲基] -2 - [（8S）-8-（环己基甲基）-2-苯基-5,6-二氢咪唑并[1,2-a ]吡嗪-7（8H） - 基] -2-氧代乙胺与选自吗啡，类似或吗啡衍生物，钠通道抑制剂，非甾体抗炎剂（AINS），谷氨酸能系统抑制剂，三轮车抗抑郁药和用于同时治疗的gabaergic衍生物，其用于疼痛治疗或预防的时间分离或排出。

19. 发明授权

US09176119B2 Method for quantifying a cholinergic neurotoxin in a sample 有权
标题翻译：用于定量样品中胆碱能神经毒素的方法
公开(公告)号：US09176119B2
公开(公告)日：2015-11-03
申请号：US12065523
申请日：2006-08-11
申请人： José-Antonio Camara-Ferrer , Michael Auguet , Pierre-Etienne Chabrier De Lassauniere
发明人： José-Antonio Camara-Ferrer , Michael Auguet , Pierre-Etienne Chabrier De Lassauniere
IPC分类号： A61K49/00 , A61K49/06 , G01N33/50
CPC分类号： G01N33/5088 , G01N2333/33 , G01N2333/4603
摘要： The invention relates to a method for determining the kinetics of action of a cholinergic neurotoxin as well as a method for determining the quantity of neurotoxin in a sample.
摘要翻译：本发明涉及一种用于测定胆碱能神经毒素作用动力学的方法以及用于测定样品中神经毒素数量的方法。

20. 发明授权

US09080220B2 Simultaneous, separate or sequential therapeutic use of at least one botulinum neurotoxin and of at least one opiate derivative 有权
标题翻译：至少一种肉毒杆菌神经毒素和至少一种阿片衍生物的同时，单独或连续的治疗用途
公开(公告)号：US09080220B2
公开(公告)日：2015-07-14
申请号：US12305191
申请日：2007-06-11
申请人： Michel Auguet , Christine Favre , Pierre-Etienne Chabrier De Lassauniere
发明人： Michel Auguet , Christine Favre , Pierre-Etienne Chabrier De Lassauniere
IPC分类号： A61K38/48 , A61K39/08 , A61K9/00 , A61K31/485 , A61K45/06
CPC分类号： C12Y304/24069 , A61K31/485 , A61K38/4893 , A61K45/06 , A61K2300/00
摘要： The present invention relates to a composition comprising: at least one botulinum neurotoxin, and at least one opiate derivative or its salt. The invention also relates to a product comprising at least one botulinum neurotoxin and at least one opiate derivative or its salt, as a combination product for simultaneous, separate or sequential therapeutic use in the treatment or prevention of pain and of neuromuscular disorders.
摘要翻译：本发明涉及一种组合物，其包含：至少一种肉毒杆菌神经毒素和至少一种阿片剂衍生物或其盐。本发明还涉及包含至少一种肉毒杆菌神经毒素和至少一种阿片剂衍生物或其盐作为用于治疗或预防疼痛和神经肌肉疾病的同时，分开或顺序治疗用途的组合产品的产品。

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