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11. 发明授权

US07189695B2 Soluble zalpha11 cytokine receptors 有权
标题翻译：可溶性zalpha11细胞因子受体
公开(公告)号：US07189695B2
公开(公告)日：2007-03-13
申请号：US10872087
申请日：2004-06-18
申请人： Cindy A. Sprecher , Julia E. Novak , James W. West , Richard D. Holly , Andrew J. Nelson
发明人： Cindy A. Sprecher , Julia E. Novak , James W. West , Richard D. Holly , Andrew J. Nelson
IPC分类号： A61K38/17 , C07K14/435
CPC分类号： C07K16/2866 , A61K38/00 , C07K14/7155 , C07K2317/73 , C07K2319/00
摘要： Novel polypeptide combinations, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for soluble zalpha11 receptors that may be used as novel cytokine antagonists, and within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and in vivo. Ligand-binding receptor polypeptides can also be used to block zlapha11 Ligand activity in vitro and in vivo, and may be used in conjunction with zalpha11 Ligand and other cytokines to selectively stimulate the immune system. The present invention also includes methods for producing the protein, uses therefor and antibodies thereto.
摘要翻译：公开了可用作新型细胞因子拮抗剂的可溶性zalpha11受体的新型多肽组合，编码多肽的多核苷酸以及相关组合物和方法，以及用于检测刺激造血，淋巴和骨髓细胞增殖和/或发育的配体的方法体外和体内。配体结合受体多肽也可用于在体外和体内阻断zlapha11配体活性，并可与zalpha11配体和其他细胞因子结合使用以选择性刺激免疫系统。本发明还包括生产蛋白质的方法，用途及其抗体。

12. 发明授权

US07790862B2 IL-17 and IL-23 antagonists and methods of using the same 有权
标题翻译： IL-17和IL-23拮抗剂及其使用方法
公开(公告)号：US07790862B2
公开(公告)日：2010-09-07
申请号：US11762738
申请日：2007-06-13
申请人： Katherine E. Lewis , Scott R. Presnell , James W. West , Robert Mabry , Steven D. Levin
发明人： Katherine E. Lewis , Scott R. Presnell , James W. West , Robert Mabry , Steven D. Levin
IPC分类号： C12P21/08
CPC分类号： C07K16/244 , A61K2039/505 , A61K2039/507 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/622 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： The present invention relates to blocking, inhibiting, reducing, antagonizing or neutralizing the activity of IL-17, IL-23 via it's p19 subunit or both IL-17 and IL-23 (via p19). IL-17 and IL-23 are cytokines that are involved in inflammatory processes and human disease.
摘要翻译：本发明涉及通过其p19亚基或IL-17和IL-23（通过p19）阻断，抑制，降低，拮抗或中和IL-17，IL-23的活性。 IL-17和IL-23是涉及炎症过程和人类疾病的细胞因子。

13. 发明申请

US20120295310A1 NUCLEIC ACIDS ENCODING ANTI-IL-23 ANTIBODIES 审中-公开
标题翻译：核酸编码抗IL-23抗体
公开(公告)号：US20120295310A1
公开(公告)日：2012-11-22
申请号：US13528918
申请日：2012-06-21
申请人： Katherine E. Lewis , Scott R. Presnell , James W. West , Robert Mabry , Brent Meengs , Steven D. Levin
发明人： Katherine E. Lewis , Scott R. Presnell , James W. West , Robert Mabry , Brent Meengs , Steven D. Levin
IPC分类号： C12P21/02 , C12N5/16 , C12N1/19 , C12N15/13 , C12N5/10
CPC分类号： C07K16/244 , A61K2039/505 , A61K2039/507 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/622 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： The present invention relates to blocking, inhibiting, reducing, antagonizing or neutralizing the activity of IL-17, IL-23 via it's p19 subunit or both IL-17 and IL-23 (via p19). IL-17 and IL-23 are cytokines that are involved in inflammatory processes and human disease.
摘要翻译：本发明涉及通过其p19亚基或IL-17和IL-23（通过p19）阻断，抑制，降低，拮抗或中和IL-17，IL-23的活性。 IL-17和IL-23是涉及炎症过程和人类疾病的细胞因子。

14. 发明授权

US08227579B2 IL-23 antagonists 有权
标题翻译： IL-23拮抗剂
公开(公告)号：US08227579B2
公开(公告)日：2012-07-24
申请号：US12870199
申请日：2010-08-27
申请人： Katherine E. Lewis , Scott R. Presnell , James W. West , Robert Mabry , Brent Meengs , Steven D. Levin
发明人： Katherine E. Lewis , Scott R. Presnell , James W. West , Robert Mabry , Brent Meengs , Steven D. Levin
IPC分类号： C12P21/08
CPC分类号： C07K16/244 , A61K2039/505 , A61K2039/507 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/622 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： The present invention relates to blocking, inhibiting, reducing, antagonizing or neutralizing the activity of IL-17, IL-23 via it's p19 subunit or both IL-17 and IL-23 (via p19). IL-17 and IL-23 are cytokines that are involved in inflammatory processes and human disease.
摘要翻译：本发明涉及通过其p19亚基或IL-17和IL-23（通过p19）阻断，抑制，降低，拮抗或中和IL-17，IL-23的活性。 IL-17和IL-23是涉及炎症过程和人类疾病的细胞因子。

15. 发明申请

US20090221802A1 SOLUBLE ZALPHA11 CYTOKINE RECEPTORS 有权
标题翻译：可溶性ZALPHA11细胞因子受体
公开(公告)号：US20090221802A1
公开(公告)日：2009-09-03
申请号：US11538359
申请日：2006-10-03
申请人： Cindy A. Sprecher , Julla E. Novak , James W. West , Scott R. Presnell , Richard D. Holly , Andrew J. Nelson
发明人： Cindy A. Sprecher , Julla E. Novak , James W. West , Scott R. Presnell , Richard D. Holly , Andrew J. Nelson
IPC分类号： C07K16/18 , C07K14/00
CPC分类号： C07K16/2866 , A61K38/00 , C07K14/7155 , C07K2317/73 , C07K2319/00
摘要： Novel polypeptide combinations, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for soluble zalpha11 receptors that may be used as novel cytokine antagonists, and within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and in vivo. Ligand-binding receptor polypeptides can also be used to block zalpha11 Ligand activity in vitro and in vivo, and may be used in conjunction with zalpha11 Ligand and other cytokines to selectively stimulate the immune system. The present invention also includes methods for producing the protein, uses therefor and antibodies thereto.
摘要翻译：公开了可用作新型细胞因子拮抗剂的可溶性zalpha11受体的新型多肽组合，编码多肽的多核苷酸以及相关组合物和方法，以及用于检测刺激造血，淋巴和骨髓细胞增殖和/或发育的配体的方法体外和体内。配体结合受体多肽也可用于在体外和体内阻断zalpha11配体活性，并可与zalpha11配体和其他细胞因子结合使用以选择性刺激免疫系统。本发明还包括生产蛋白质的方法，用途及其抗体。

16. 发明申请

US20110059087A1 IL-17 AND IL-23 ANTAGONISTS AND METHODS OF USING THE SAME 有权
标题翻译： IL-17和IL-23拮抗剂及其使用方法
公开(公告)号：US20110059087A1
公开(公告)日：2011-03-10
申请号：US12870199
申请日：2010-08-27
申请人： Katherine E. Lewis , Scott R. Presnell , James W. West , Robert Mabry , Brent Meengs , Steven D. Levin
发明人： Katherine E. Lewis , Scott R. Presnell , James W. West , Robert Mabry , Brent Meengs , Steven D. Levin
IPC分类号： A61K39/395 , C07K16/24 , C12N5/0783 , A61P25/28 , A61P1/00
CPC分类号： C07K16/244 , A61K2039/505 , A61K2039/507 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/622 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： The present invention relates to blocking, inhibiting, reducing, antagonizing or neutralizing the activity of IL-17, IL-23 via it's p19 subunit or both IL-17 and IL-23 (via p19). IL-17 and IL-23 are cytokines that are involved in inflammatory processes and human disease.
摘要翻译：本发明涉及通过其p19亚基或IL-17和IL-23（通过p19）阻断，抑制，降低，拮抗或中和IL-17，IL-23的活性。 IL-17和IL-23是涉及炎症过程和人类疾病的细胞因子。

17. 发明授权

US08399219B2 Protease activatable interferon alpha proprotein 有权
标题翻译：蛋白酶活化的干扰素α前蛋白
公开(公告)号：US08399219B2
公开(公告)日：2013-03-19
申请号：US12711199
申请日：2010-02-23
申请人： Nancy E. Stagliano , James W. West , Kathryn Kamath , Paul H. Bessette , Jason Sagert
发明人： Nancy E. Stagliano , James W. West , Kathryn Kamath , Paul H. Bessette , Jason Sagert
IPC分类号： C12P21/04 , C12N5/10 , C12N15/00 , A61K38/21 , C07H21/04
CPC分类号： C07K14/56 , A61K38/00 , A61K47/64 , A61K47/65 , C07K14/00 , C07K14/555 , C07K14/565 , C07K14/57 , C07K14/705 , C07K16/00 , C07K19/00 , C07K2319/10 , C07K2319/31 , C07K2319/33 , C07K2319/50 , C07K2319/70 , C07K2319/90 , C12N15/1037 , G01N33/6866
摘要： The present disclosure provides for proprotein and activatable proprotein compositions. A proprotein contains a functional protein (i.e. a full length protein or functional fragment thereof) which is coupled to a peptide mask that inhibits the binding of the functional protein to its target or binding partner. An activatable proprotein contains a functional protein coupled to a peptide mask, and further coupled to an activatable linker, wherein in an non-activated state, the peptide mask inhibits binding of the functional protein to its target or binding partner and in an activated state the peptide mask does not inhibit binding of the functional protein to its target or binding partner. Proproteins can provide for reduced toxicity and adverse side effects that could otherwise result from binding of a functional protein at non-treatment sites if it were not inhibited from binding its binding partner. Proproteins can further provide improved biodistribution characteristics. Proproteins containing a peptide mask can display a longer in vivo or serum half-life than the corresponding functional protein not containing a peptide mask. The disclosure further provides methods of screening for, making, and using these proproteins.
摘要翻译：本公开内容提供了蛋白质和可激活的前蛋白组合物。前蛋白含有功能蛋白（即其全长蛋白质或其功能片段），其与抑制功能蛋白与其靶标或结合配偶体的结合的肽掩模偶联。可激活的蛋白质包含与肽掩模偶联的功能性蛋白质，并进一步与可活化接头偶联，其中在非活化状态下，肽掩模抑制功能性蛋白质与其靶标或结合配偶体的结合，并且在活化状态下肽掩模不抑制功能蛋白与其靶或结合配偶体的结合。前体蛋白可以提供如果不抑制结合其结合配偶体的功能性蛋白质在非处理部位的结合，则可以提供降低的毒性和不良副作用。前体蛋白可进一步提供改善的生物分布特征。含有肽掩模的前体蛋白可以显示比不含肽掩模的相应功能蛋白质更长的体内或血清半衰期。本公开进一步提供筛选，制备和使用这些蛋白质的方法。

18. 发明授权

US07470665B2 Methods for targeting cells that express fibroblast growth receptor-3 or -2 有权
标题翻译：靶向表达成纤维细胞生长受体-3或-2的细胞的方法
公开(公告)号：US07470665B2
公开(公告)日：2008-12-30
申请号：US10354859
申请日：2003-01-29
申请人： James W. West
发明人： James W. West
IPC分类号： A61K38/18 , C07K14/50 , C07K14/415 , C07K19/00
CPC分类号： C07K16/46
摘要： Fibroblast growth factor-18 (FGF-18) binds with FGF receptors-2 and -3. Compositions comprising an FGF-18 component can be used to target cells that express these receptors. Suitable targets include tumor cells that express constitutively activated forms of FGF receptors-2 and -3. For example, conjugates of FGF-18 and saporin can be used to target tumor cells that express FGF receptors-2 or -3, and to inhibit the proliferation of these cells.
摘要翻译：成纤维细胞生长因子-18（FGF-18）与FGF受体-2和-3结合。包含FGF-18组分的组合物可用于靶向表达这些受体的细胞。合适的靶标包括表达组成型活化形式的FGF受体-2和-3的肿瘤细胞。例如，FGF-18和saporin的缀合物可用于靶向表达FGF受体-2或-3的肿瘤细胞，并抑制这些细胞的增殖。

19. 发明授权

US07445772B2 Heterodimeric four helix bundle cytokines 有权
标题翻译：异二聚体四螺旋束细胞因子
公开(公告)号：US07445772B2
公开(公告)日：2008-11-04
申请号：US11675890
申请日：2007-02-16
申请人： James W. West , Stacey Tannheimer
发明人： James W. West , Stacey Tannheimer
IPC分类号： A61K38/19
CPC分类号： C07K14/5434 , A61K38/00 , C12N15/62 , Y10S514/885
摘要： Heterodimeric proteins comprising two helical bundle cytokines are disclosed. One of the polypeptides comprises zsig81 and a second polypeptide which comprises either p19 (aka IL-12A) or p35 (aka IL-12A). The proteins may be produced as fusion proteins or expressed as a single chain. The heterdimeric protein comprising zsig81 and p19 is designated zcyto33f2 and the heterodimeric protein comprising zsig81 and p35 is designated zcyto35f2. Zcyto33f2 and zcyto35f2 proteins are associated with epithelial cell types, including lung and gut epithelium, and may play a role in physiological conditions such as inflammation.
摘要翻译：公开了包含两个螺旋束细胞因子的异二聚体蛋白。多肽中的一种包含zsig81和包含p19（又名IL-12A）或p35（又名IL-12A）的第二多肽。蛋白质可以作为融合蛋白产生或表达为单链。包含zsig81和p19的杂二聚体蛋白质被命名为zcyto33f2，包含zsig81和p35的异二聚体蛋白质被命名为zcyto35f2。 Zcyto33f2和zcyto35f2蛋白与上皮细胞类型（包括肺和肠上皮）相关，并且可能在诸如炎症的生理条件中起作用。

20. 发明授权

US5748090A Optical flameout detector 失效
标题翻译：光学熄火检测器
公开(公告)号：US5748090A
公开(公告)日：1998-05-05
申请号：US892833
申请日：1997-07-16
申请人： Stephen E. Borg , James W. West , Robert M. Lawrence , Samuel E. Harper, Jr. , David W. Alderfer
发明人： Stephen E. Borg , James W. West , Robert M. Lawrence , Samuel E. Harper, Jr. , David W. Alderfer
IPC分类号： F23N5/08 , G08B17/12
CPC分类号： F23N5/082 , F23N2029/14
摘要： A device has been developed which monitors the presence of a flame within a combustion chamber. The optical flameout detection system responds to gross changes in combustor light intensity, which is monitored in two spectral bands. A photomultiplier tube makes optical measurements in the ultraviolet portion of the spectrum, and a silicon photodiode covers the visible region. The detectors, located outside the combustion chamber, receive the light energy radiated from the combustion process through fiber optic probes designed to operate in a high pressure environment. The optical fibers are aimed diagonally through the center of the injector at the combustion chamber wall downstream of the injector. The probed observe events occurring within a narrow conical-shaped field of view so that the system can quickly detect longitudinal movement of the flame front away from the injector. If a change in intensity of the flame is detected, the fuel supply to the combustion chamber is shut off, limiting the amount of unburned fuel in the combustion chamber which could reignite.
摘要翻译：已经开发了一种监测燃烧室内火焰存在的装置。光学熄火检测系统响应于在两个光谱带中监测的燃烧器光强度的总变化。光电倍增管在光谱的紫外部分进行光学测量，硅光电二极管覆盖可见光区域。位于燃烧室外的探测器通过被设计成在高压环境中工作的光纤探头接收从燃烧过程辐射的光能。在注射器下游的燃烧室壁处，光纤被对角地穿过喷射器的中心。探测到的观察事件发生在窄锥形视野内，使得系统可以快速检测火焰前端远离喷射器的纵向运动。如果检测到火焰的强度变化，则关闭燃烧室的燃料供给，从而限制燃烧室中可能重燃的未燃烧燃料的量。

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