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11. 发明申请

WO02052011A3 A NOVEL HUMAN LEUCINE-RICH REPEAT CONTAINING PROTEIN EXPRESSED PREDOMINATELY IN BONE MARROW, HLRRBM1 审中-公开
标题翻译： HLRRBM1中含有蛋白质的新型人类尿素重复蛋白
公开(公告)号：WO02052011A3
公开(公告)日：2003-09-12
申请号：PCT/US0149740
申请日：2001-12-20
申请人： SQUIBB BRISTOL MYERS CO
发明人： FEDER JOHN , RAMANATHAN CHANDRA , MINTIER GABE
IPC分类号： A61K38/00 , C07K14/47 , C07K16/18 , C12N15/12 , A61K38/17 , C12N15/11 , C12N15/63 , G01N33/50
CPC分类号： C07K14/47 , A61K38/00 , A61K2039/53 , C07K16/18
摘要： The present invention provides novel polynucleotides encoding HLRRBM1 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel HLRRBM1 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides, particularly immune diseases and/or disorders. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
摘要翻译：本发明提供了编码HLRRBM1多肽的新型多核苷酸，其片段及其同源物。还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。本发明还涉及将这些新型HLRRBM1多肽应用于诊断，治疗和/或预防与这些多肽，特别是免疫疾病和/或病症相关的各种疾病和/或病症的诊断和治疗方法。本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。

12. 发明申请

WO0244210A3 NOVEL HUMAN NUCLEIC ACID MOLECULES AND POLYPEPTIDES ENCODING A NOVEL HUMAN ION CHANNEL EXPRESSED IN SPINAL CORD AND BRAIN 审中-公开
标题翻译：新型人类核酸分子和多核苷酸编码在脊髓和脑中表达的新型人体离子通道
公开(公告)号：WO0244210A3
公开(公告)日：2003-11-06
申请号：PCT/US0145336
申请日：2001-11-30
申请人： SQUIBB BRISTOL MYERS CO
发明人： GAUGHAN GLEN , FEDER JOHN , NELSON THOMAS , MINTIER GABE , RAMANATHAN CHANDRA
IPC分类号： A01K67/027 , A61K38/00 , A61K45/00 , A61P1/00 , A61P1/16 , A61P3/10 , A61P3/12 , A61P3/14 , A61P9/00 , A61P9/06 , A61P13/12 , A61P25/00 , A61P25/04 , A61P25/16 , A61P25/22 , A61P25/24 , A61P25/28 , A61P37/00 , A61P43/00 , C07K14/705 , C07K16/28 , C07K19/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/12 , C12P21/02 , C12Q1/02 , C12Q1/68 , G01N33/15 , G01N33/50 , G01N33/53 , A61K38/17 , C12N15/62 , C12N15/63 , G01N33/68
CPC分类号： C07K14/705 , A61K38/00
摘要： The present invention relates to novel human nucleic acid molecules encoding novel human cation channels, and proteins and polypeptides encoded by such nucleic acid molecules. More specifically, the nucleic acid molecules of the invention include novel human genes, e.g., hVR1d.1 and hVR1d.2, that encode proteins or polypeptides that are expressed in spinal cord and brain tissues and display sequence homology and structural homology to the vanilloid and TRP (transient receptor potential) families of cation channel proteins. The proteins and polypeptides of the invention directed to this novel human cation channel may be therapeutically valuable targets for drug delivery in the treatment of human diseases that involve calcium, sodium, potassium or other ionic homeostatic dysfunction, such as central nervous system (CNS) disorders, e.g., degenerative neurological disorders such as Alzheimer's disease or Parkinson's disease, or other disorders such as chronic pain, anxiety and depression, stroke, cardiac disorders, e.g., arrhythmia, diabetes, hypercalcemia, hypocalcemia, hypercalciuria, hypocalciuria, or ion disorders associated with immunological disorders, gastro-intestinal (GI) tract disorders or renal or liver disease.
摘要翻译：本发明涉及编码新型人类阳离子通道的新型人核酸分子，以及由该核酸分子编码的蛋白质和多肽。更具体地，本发明的核酸分子包括编码在脊髓和脑组织中表达的蛋白质或多肽的新型人类基因，例如hVR1d.1和hVR1d.2，并显示与香草素的序列同源性和结构同源性， TRP（瞬时受体电位）家族的阳离子通道蛋白。针对这种新的人类阳离子通道的本发明的蛋白质和多肽可能是治疗涉及钙，钠，钾或其他离子平衡功能障碍的人类疾病的药物递送的治疗有价值的靶标，例如中枢神经系统（CNS）紊乱例如退行性神经障碍如阿尔茨海默病或帕金森病，或其他疾病如慢性疼痛，焦虑和抑郁，中风，心脏病，心律失常，糖尿病，高钙血症，低钙血症，高钙尿症，低钙血症或与免疫学障碍，胃肠（GI）道疾病或肾或肝脏疾病。

13. 发明申请

WO0240670A3 A HUMAN G-PROTEIN COUPLED RECEPTOR, HGPRBMY8, EXPRESSED HIG HLY IN BRAIN 审中-公开
标题翻译：人类G蛋白偶联受体，HGPRBMY8，脑中表达的HLY
公开(公告)号：WO0240670A3
公开(公告)日：2003-04-03
申请号：PCT/US0143909
申请日：2001-11-14
申请人： SQUIBB BRISTOL MYERS CO
发明人： BATTAGLINO PETER , FEDER JOHN , MINTIER GABE , NELSON THOMAS , RAMANATHAN CHANDRA , WESTPHAL RYAN , CACACE ANGELA , BARBER LAUREN , HAWKEN DONALD , KORNACKER MICHAEL
IPC分类号： A61K38/00 , C07K14/705 , C12N1/21 , C12N15/12 , A61K38/17 , C07K16/28 , C12N5/10 , C12N15/62 , G01N33/68
CPC分类号： C07K14/705 , A61K38/00 , C07K2319/00
摘要： The present invention describes a newly discovered human G-protein coupled receptor and its encoding polynucleotide. Also described are expression vectors, host cells, agonists, antagonists, antisense molecules, and antibodies associated with the polynucleotide and/or polypeptide of the present invention. In addition, methods for treating, diagnosing, preventing, and screening for disorders associated with aberrant cell growth, neurological conditions, and diseases or disorders related to the brain are illustrated.
摘要翻译：本发明描述了新发现的人G-蛋白偶联受体及其编码多核苷酸。还描述了与本发明的多核苷酸和/或多肽相关的表达载体，宿主细胞，激动剂，拮抗剂，反义分子和抗体。此外，还说明了治疗，诊断，预防和筛选与异常细胞生长，神经病症以及与脑相关的疾病或病症相关疾病的方法。

14. 发明申请

WO0246414A3 HUMAN G-PROTEIN COUPLED RECEPTOR EXPRESSED HIGHLY IN KIDNEY 审中-公开
标题翻译：人类G蛋白偶联受体在KIDNEY高度表达
公开(公告)号：WO0246414A3
公开(公告)日：2003-03-27
申请号：PCT/US0146951
申请日：2001-12-07
申请人： SQUIBB BRISTOL MYERS CO
发明人： RAMANATHAN CHANDRA , FEDER JOHN , NELSON THOMAS , CACACE ANGELA , BARBER LAUREN , RYSEK ROLF-PETER
IPC分类号： C07K14/705 , C07K16/28 , C12N15/12 , C12Q1/68 , G01N33/50 , G01N33/566 , A61K38/17 , C07K14/72
CPC分类号： G01N33/566 , A61K2039/505 , C07K14/705 , C07K16/28 , C07K2319/30 , C12Q1/6883 , C12Q2600/156 , C12Q2600/158 , G01N33/5091 , G01N2333/726 , G01N2500/04
摘要： The present invention provides novel polynucleotides encoding HGPRBMY23 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel HGPRBMY23 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides, particularly renal diseases and/or disorders. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
摘要翻译：本发明提供了编码HGPRBMY23多肽的新型多核苷酸，其片段及其同源物。还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。本发明还涉及将这些新型HGPRBMY23多肽应用于诊断，治疗和/或预防与这些多肽，特别是肾脏疾病和/或病症相关的各种疾病和/或病症的诊断和治疗方法。本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。

15. 发明申请

WO02068471A3 NUCLEIC ACID MOLECULES AND POLYPEPTIDES FOR A HUMAN CATION CHANNEL POLYPEPTIDE 审中-公开
标题翻译：人体通道多肽的核酸分子和多肽
公开(公告)号：WO02068471A3
公开(公告)日：2003-05-01
申请号：PCT/US0150413
申请日：2001-12-21
申请人： SQUIBB BRISTOL MYERS CO
发明人： FEDER JOHN , MINTIER GABE , RAMANATHAN CHANDRA , WESTPHAL RYAN
IPC分类号： C07K14/705 , C12N15/12 , A01K67/027 , C07K16/28 , C12N15/62 , C12Q1/68 , G01N33/50 , G01N33/577
CPC分类号： C07K14/705 , A01K2217/05 , C07K2319/00
摘要： The present invention relates to novel human nucleic acid molecules encoding novel human cation channels, and proteins and polypeptides encoded by such nucleic acid molecules. More specifically, the nucleic acid molecules of the invention include the novel human gene designated HBMYCNG. The proteins and polypeptides of the invention represent a novel cation channel that may be therapeutically valuable targets for drug delivery in the treatment of human diseases which involve calcium, sodium, potassium or other ionic homeostatic dysfunction, such as central nervous system (CNS) disorders, e.g., stroke, anxiety and depression, or degenerative neurological disorders such as Alzheimer's disease or Parkinson's disease, or other disorders such as cardiac disorders, e.g., arrhythmia, diabetes, chronic pain, hypercalcemia, hypocalcemia, hypercalciuria, hypocalciuria, or ion disorders associated with immunological disorders, gasto-intestinal (GI) tract disorders, or renal or liver disease.
摘要翻译：本发明涉及编码新型人类阳离子通道的新型人核酸分子，以及由该核酸分子编码的蛋白质和多肽。更具体地，本发明的核酸分子包括命名为HBMYCNG的新型人基因。本发明的蛋白质和多肽代表一种新的阳离子通道，其可能是用于药物递送的治疗有价值的靶标，其用于治疗人类疾病，所述疾病涉及钙，钠，钾或其它离子稳态功能障碍，例如中枢神经系统（CNS）例如中风，焦虑和抑郁，或退行性神经障碍如阿尔茨海默病或帕金森病，或其他疾病如心脏病，例如心律失常，糖尿病，慢性疼痛，高钙血症，低钙血症，高钙尿症，低钙血症或与免疫学障碍，胃肠（GI）道疾病或肾或肝脏疾病。

16. 发明申请

WO02057460A3 POLYNUCLEOTIDES ENCODING HUMAN PHOSPHATASES 审中-公开
标题翻译：多核苷酸编码人类磷酸酶
公开(公告)号：WO02057460A3
公开(公告)日：2003-04-10
申请号：PCT/US0150459
申请日：2001-12-20
申请人： SQUIBB BRISTOL MYERS CO
发明人： JACKSON DONALD G , FEDER JOHN , NELSON THOMAS , MINTIER GABE , RAMANATHAN CHANDRA , LEE LIANA , SIEMERS NATHAN , BOL DAVID , SCHIEVEN GARY , FINGER JOSHUA , TODDERUD C GORDON , BASSOLINO DONNA , KRYSTEK STANLEY , MCATEE PATRICK , SUCHARD SUSAN , BANAS DANA
IPC分类号： A61K38/00 , A61K38/43 , A61K48/00 , A61P1/16 , A61P11/00 , A61P13/12 , A61P15/00 , A61P25/00 , A61P29/00 , A61P35/00 , A61P43/00 , C07K16/40 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/16 , C12N15/09 , C12N15/55 , C12P21/00 , C12Q1/02 , C12Q1/68 , G01N33/573 , G01N33/68 , G06F19/16 , A61K38/46 , C12N15/63 , C12Q1/42 , G06F17/50 , G06F19/00
CPC分类号： G06F19/16 , A61K38/00 , C07K2319/00 , C07K2319/30 , C12N9/16 , C12Q1/6883 , C12Q2600/158 , C12Y301/03048 , G01N33/573 , G01N33/6893 , G01N2333/916 , G01N2500/00 , G01N2500/04 , Y02A90/26
摘要： The present invention provides novel polynucleotides encoding human phosphatase polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel human phosphatase polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides, particularly cardiovascular diseases and/or disorders. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
摘要翻译：本发明提供编码人磷酸酶多肽，其片段和同源物的新型多核苷酸。还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。本发明还涉及将这些新型人磷酸酶多肽应用于诊断，治疗和/或预防与这些多肽，特别是心血管疾病和/或病症相关的各种疾病和/或病症的诊断和治疗方法。本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。

17. 发明申请

WO02074959A2 A NOVEL HUMAN LEUCINE-RICH REPEAT CONTAINING PROTEIN EXPRESSED PREDOMINATELY IN NERVOUS SYSTEM TISSUES, HLRRNS1 审中-公开
标题翻译：含有蛋白质的新型人类尿素重复蛋白在神经系统组织中预先表达，HLRRNS1
公开(公告)号：WO02074959A2
公开(公告)日：2002-09-26
申请号：PCT/US0150457
申请日：2001-12-20
申请人： SQUIBB BRISTOL MYERS CO
发明人： RAMANATHAN CHANDRA , FEDER JOHN , MINTIER GABE
IPC分类号： A61K38/00 , A61P25/00 , A61P35/00 , C07H21/04 , C07K14/435 , C07K14/72 , C12N5/06 , C12N15/12 , C12P21/02 , C12Q1/68 , A61K31/7088 , A61K38/17 , C07K14/47 , C07K16/18 , C12N15/63 , G01N33/50
CPC分类号： C07K14/723 , A61K38/00 , C12Q1/6883 , G01N2333/4709
摘要： The present invention provides novel polynucleotides encoding HLRRNS1 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel HLRRNS1 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides, particularly nervous system diseases and/or disorders. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
摘要翻译：本发明提供了编码HLRRNS1多肽的新型多核苷酸，其片段及其同源物。还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。本发明还涉及将这些新型HLRRNS1多肽应用于诊断，治疗和/或预防与这些多肽相关的各种疾病和/或病症，特别是神经系统疾病和/或病症的诊断和治疗方法。本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。

18. 发明公开

EP1481060A4 POLYNUCLEOTIDE ENCODING A NOVEL TRP CHANNEL FAMILY MEMBER, TRP-PLIK2, AND SPLICE VARIANTS THEREOF 审中-公开
标题翻译： TRP通道家族的多核苷酸编码的一个新成员，TRP-PLIK2和剪接变体
公开(公告)号：EP1481060A4
公开(公告)日：2005-08-10
申请号：EP02746429
申请日：2002-05-22
申请人： SQUIBB BRISTOL MYERS CO
发明人： LEE NING , CHEN JIAN , FEDER JOHN , WU SHUJIAN , CHANG HAN , LEE LIANA , BLANAR MICHAEL , BOL DAVID
IPC分类号： C07K14/705 , C12N15/12 , C07H21/04 , C07K14/00 , C12N15/00 , C12N15/63
CPC分类号： C07K14/705

19. 发明公开

EP1364000A4 POLYNUCLEOTIDES ENCODING A NOVEL METALLOPROTEASE, MP-1 审中-公开
标题翻译：新的金属蛋白酶MP-1编码多核苷酸
公开(公告)号：EP1364000A4
公开(公告)日：2004-12-15
申请号：EP02726565
申请日：2002-02-05
申请人： SQUIBB BRISTOL MYERS CO
发明人： CHEN JIAN , FEDER JOHN , NELSON THOMAS C , DUCLOS FRANCK , KRYSTEK STANLEY
IPC分类号： C12N9/64 , C12N9/50
CPC分类号： C12N9/6489 , C07K2299/00

20. 发明公开

EP1366147A4 POLYNUCLEOTIDE ENCODING A NOVEL HUMAN G-PROTEIN COUPLED RECEPTOR, HGPRBMY27 审中-公开
标题翻译：一种新的人G蛋白偶联受体，HGPRBMY27，多核苷酸编码
公开(公告)号：EP1366147A4
公开(公告)日：2004-11-17
申请号：EP02721268
申请日：2002-03-06
申请人： SQUIBB BRISTOL MYERS CO
发明人： RAMANATHAN CHANDRA , FEDER JOHN , MINTIER GABRIEL , CACACE ANGELA , BARBER LAUREN
IPC分类号： A61K38/00 , C07K14/705 , C12N15/12 , C12N1/12 , C12N5/06 , C12N15/63 , C12Q1/68
CPC分类号： C07K14/705 , A61K38/00

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