专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

11. 发明专利

BRPI0410623A 未知
公开(公告)号：BRPI0410623A
公开(公告)日：2006-06-20
申请号：BRPI0410623
申请日：2004-05-26
申请人： SOD CONSEILS RECH APPLIC
发明人： BIGG DENNIS , LIBERATORE ANNE-MARIE , PONS DOMINIQUE
IPC分类号： A61K31/4164 , A61P35/00 , C07D233/54 , C07D233/64 , C07D401/12 , C07D403/10 , C07D403/12 , C07D405/10 , C07D405/12 , C07D409/10 , C07D409/12
摘要： Novel imidazole compounds of the formula wherein the substituents are as defined in the application having antitumoral activity and use thereof.

12. 发明专利

DK1349850T3 未知
公开(公告)号：DK1349850T3
公开(公告)日：2006-01-23
申请号：DK01989665
申请日：2001-12-27
申请人： SOD CONSEILS RECH APPLIC
发明人： BIGG DENNIS , POMMIER JACQUES , LIBERATORE ANNE-MARIE
IPC分类号： C07D401/04 , A61K31/415 , A61K31/445 , A61K31/454 , A61P1/04 , A61P9/06 , A61P9/10 , A61P25/00 , A61P25/02 , A61P25/04 , A61P25/06 , A61P25/08 , A61P25/16 , A61P25/24 , A61P25/28 , A61P43/00
摘要： The invention concerns novel sodium channel modulators derived from 2-piperidylimidazoles. The inventive compounds correspond to the general formula (I), wherein: R represents a hydrogen atom or an -X-Y-R radical wherein -X-Y represents a bond, a -CO-, -CO-O--CO-NH- or -CS-NH- radical and R represents an alkyl, haloalkyl, cycloalkyl, cycloalkylalkyl, aryl or aralkyl radical, said radicals being optionally substituted; R represents in particular an alkyl, cycloalkyl, cycloalkylalkyl or aryl radical optionally substituted; and R represents a hydrogen atom or an alkyl, cycloalkyl, cycloalkylalkyl, or aryl radical optionally substituted.

13. 发明专利

DE60113297D1 未知
公开(公告)号：DE60113297D1
公开(公告)日：2005-10-13
申请号：DE60113297
申请日：2001-12-27
申请人： SOD CONSEILS RECH APPLIC
发明人： BIGG DENNIS , POMMIER JACQUES , LIBERATORE ANNE-MARIE
IPC分类号： A61K31/415 , A61K31/445 , A61K31/454 , A61P1/04 , A61P9/06 , A61P9/10 , A61P25/00 , A61P25/02 , A61P25/04 , A61P25/06 , A61P25/08 , A61P25/16 , A61P25/24 , A61P25/28 , A61P43/00 , C07D401/04
摘要： The invention concerns novel sodium channel modulators derived from 2-piperidylimidazoles. The inventive compounds correspond to the general formula (I), wherein: R represents a hydrogen atom or an -X-Y-R radical wherein -X-Y represents a bond, a -CO-, -CO-O--CO-NH- or -CS-NH- radical and R represents an alkyl, haloalkyl, cycloalkyl, cycloalkylalkyl, aryl or aralkyl radical, said radicals being optionally substituted; R represents in particular an alkyl, cycloalkyl, cycloalkylalkyl or aryl radical optionally substituted; and R represents a hydrogen atom or an alkyl, cycloalkyl, cycloalkylalkyl, or aryl radical optionally substituted.

14. 发明专利

AU783129B2 5-membered heterocycle derivatives, production thereof and use thereof as medicaments 未知
公开(公告)号：AU783129B2
公开(公告)日：2005-09-29
申请号：AU7796500
申请日：2000-10-10
申请人： SOD CONSEILS RECH APPLIC
发明人： LASSAUNIERE PIERRE-ETIENNE CHA , HARNETT JEREMIAH , BIGG DENNIS , POMMIER JACQUES , LANNOY JACQUES , LIBERATORE ANNE-MARIE , THURIEAU CHRISTOPHE
IPC分类号： A61K31/417 , A61K31/4178 , A61K31/42 , A61K31/421 , A61K31/426 , A61K31/427 , A61K31/454 , A61K31/496 , A61K31/506 , A61K31/5415 , A61P1/00 , A61P1/04 , A61P1/14 , A61P3/04 , A61P3/10 , A61P25/00 , A61P25/02 , A61P25/04 , A61P25/06 , A61P25/08 , A61P25/14 , A61P25/16 , A61P25/18 , A61P25/24 , A61P25/28 , A61P29/00 , A61P29/02 , A61P31/12 , A61P31/18 , A61P33/00 , A61P37/06 , A61P39/02 , A61P39/06 , A61P43/00 , C07D233/54 , C07D233/64 , C07D261/04 , C07D261/08 , C07D263/32 , C07D277/24 , C07D277/28 , C07D403/04 , C07D403/06 , C07D403/14 , C07D405/06 , C07D409/06 , C07D413/06 , C07D417/04 , C07D417/06 , A61K31/4164
摘要： Five-membered heterocycles (III) in racemic or enantiomeric form, and their mixtures and their salts are new. Five-membered heterocycles of formula (III) in racemic or enantiomeric form, and their mixtures and their salts are new: [Image] Het : 5-membered heterocycle with 2 heteroatoms, such that (III) is of formula (IIIa) - (IIId); A : alkyl, cycloalkyl, cycloalkylalkyl or a group of formula (A1), (A2), (A3), (A4) or (A5); R 3> : H, OH, alkoxy, or alkyl; R 4> - R 8> : H, halogen, OH, alkyl, alkoxy, CN, NO 2, or NR 1> 0>R 1> 1>; R 1> 0> and R 1> : H, alkyl, or -COR 1> 2>, or together with the N atom they form a 4-7 membered heterocycle with 1-3 heteroatoms; R 1> 2> : H, alkyl, alkoxy or NR 1> 3>R 1> 4>; R 1> 3> and R 1> 4> : H, alkyl; or R 1> 3> and R 1> 4> together with N atom : 4-7 membered heterocycle with 1-3 heteroatoms; R 9> : H, alkyl, or -COR 1> 5>; R 1> 5> : H, alkyl, alkoxy, or -NR 1> 6>R 1> 7>; R 1> 6> and R 1> 7> : H, alkyl, or together with the N atom they form a 4-7 membered heterocycle with 1-3 heteroatoms; W' is either not present or it : a bond, -O-, -S-, or -NR 1> 8>-; R 1> 8> : H or alkyl; Q : H, -OR 2> 2>, -SR 2> 2>, -NR 2> 3>R 2> 4>, phenyl (optionally substituted by halogen, OH, CN, NO 2, alkyl, alkoxy, -NR 1> 0>R 1> 1>, methylene dioxy or ethylene dioxy), or -COPh, -SO 2Ph, -CH 2Ph (these being optionally substituted on the aromatic ring by alkyl, alkoxy or halogen); R 2> 2> : H, alkyl, or aryl (optionally substituted by alkyl, OH, halogen, NO 2, or alkoxy); R 2> 3> and R 2> 4> : H, alkyl, or -COR 2> 5>; R 2> 5> : alkyl; R 1> 9>, R 2> 0> and R 2> 1> : H, halogen, OH, -SR 2> 6>, alkyl, cycloalkyl, alkenyl, alkoxy, CN, NO 2, -SO 2-NHR 4> 9>, -CONHR 5> 5>, -S(O) q-R 5> 6>, -NH(CO)R 5> 7>, -CF 3, -OCF 3, or -NR 2> 7>R 2> 8>; R 2> 6> : H or alkyl; R 2> 7> and R 2> 8> : H, alkyl, -COR 2> 9>, or together with the N atom they form a 4-7 membered heterocycle with 1-3 heteroatoms; R 4> 9> and R 5> 0> : H, alkyl or alkylcarbonyl; q : 0, 1, or 2; R 5> 6> and R 5> 7> : H, alkyl or alkoxy; R 2> 9> : H, alkyl, alkoxy or -NR 3> 0>R 3> 1>; R 3> 0> and R 3> 1> : H, alkyl, or together with the N atom they form a 4-7 membered heterocycle with 1-3 heteroatoms; R 3> 2> : H or alkyl; T' : methylene or ethylene; R 3> 3> : H, alkyl, - -NR 3> 4>R 3> 5>, or - -CHR 3> 6>R 3> 7>; : 1-6C alkylene; R 3> 4> and R 3> 5> : H or alkyl; R 3> 6> and R 3> 7> : H, carbocyclic or heterocyclic aryl, (optionally substituted by alkyl, OH, halogen, NO 2, alkoxy, or NR 1> 0>R 1> 1>); X : S or -NR 3> 8>; R 3> 8> : H, alkyl, cyanoalkyl, aralkyl, alkylcarbonyl, or aralkylcarbonyl; Y' : O or S; R 1> : H, alkyl, aminoalkyl, alkoxyalkyl, cycloalkyl, cycloalkylalkyl, trifluoromethyl alkyl, alkenyl, allenyl, allenylalkyl, allynyl, cyanoalkyl, -(CH 2) g-Z 1>R 3> 9>, -(CH 2) g-COR 4> 0>, -(CH 2) g-NHCOR 70>, aryl, aralkyl, arylcarbonyl, heteroaryl alkyl, aralkylcarbonyl, (aryl groups in these being optionally substituted by alkyl, halogen, alkoxy, nitro, CN, cyanoalkyl, amino, alkylamino, dialkylamino, -(CH 2) k-Z 2>R 3> 9> or -(CH 2) k-COR 4> 0>); and R 2> : H, alkyl, aminoalkyl, alkoxyalkyl, cycloalkyl, trifluoromethyl alkyl, -(CH 2) g-NHCOR 7> 1> (aryl and heteroaryl groups being optionally substituted by halogen, alkyl, alkoxy, OH, CN, NO 2, amino, mono- or dialkylamino); or R 1> and R 2> may together form : a 3-7 membered carbocycle; Z 1> and Z 2> : a bond, -O-, -NR 4> 1>-, or -S-; R 3> 9> and R 4> 1> : H, alkyl, alkenyl, alkynyl, or cyanoalkyl; R 4> 0> : H, alkyl, allenyl, allenylalkyl, alkenyl, alkynyl, cyanoalkyl, alkoxy, or -NR 4> 2>R 4> 3>; R 4> 2> and R 4> 3> : H, alkyl, allenyl, allenylalkyl, alkenyl, alkynyl, or cyanoalkyl; R 7> 0> and R 7> 1> : alkyl or alkoxy; B' : H, alkyl, -(CH 2) g-Z 3>R 4> 4>, or a carbocyclic aryl group that may be substituted 1-3 times by halogen, alkyl, alkoxy, OH, CN, NO 2, amino, alkylamino, dialkylamino or carbocyclic aryl; Z 3> : bond, -O-, -NR 4> 5>-, or -S-; R 4> 4> and R 4> 5> : H, alkyl, alkenyl, alkynyl, allenyl, allenyl alkyl, or cyanoalkyl; L* : NR 4> 6>R 4> 7> or -OR 4> 8>; R 4> 6> and R 4> 7> : H, alkyl, cycloalkyl, alkenyl, alkynyl, allenyl, allenylalkyl, cyanoalkyl, -(CH 2) g-Z 4>R 5> 0>, -(CH 2) k-COR 5> 1>, -(CH 2) k-COOR 5> 1>, -(CH 2) k-CONHR 5> 1>, -SO 2R 5> 1>, aryl, aralkyl, aryloxyalkyl, arylcarbonyl, arylimino, aralkyl carbonyl, or heteroaryl (the aryl and heteroaryl groups being optionally substituted by halogen, alkyl, alkoxy, OH, CN, NO 2, cyanoalkyl, amino, mono- or dialkylamino), -(CH 2) k-Z 5>R 5> 0>, -(CH 2) k-COR 5> 1>, or -(CH 2) k-COOR 5> 1>) or R 4> 6> and R 4> 7> taken together with the N atom form a 4-8 membered non-aromatic heterocycle (optionally interupted by -CH(R 53>)-, -NR 54>-, -O-, -S- or -CO); Z 4> and Z 5> : a bond, -O-, -NR 5> 2>- or -S-; R 50> and R 52> : H, alkyl, alkenyl, alkynyl, allenyl, allenylalkyl, or cyanoalkyl; R 5> 1> : H, cycloalkyl, cycloalkylalkyl, alkyl, alkenyl, alkynyl, allenyl, allenylalkyl, cyanoalkyl, alkoxyalkyl, NR 5> 8>R 5> 9>, aryl, or aralkyl; R 5> 8> and R 5> 9> : H, alkyl, alkenyl, alkynyl, allenyl, allenylalkyl, or cyanoalkyl; R 5> 3> and R 5> 4> : H, -(CH 2) k-Z 7>R 6> 0> or -CH 2) k-COR 6> 1>; Z 7> : a bond, -NR 6> 2>-, or -S-; R 6> 0> and R 6> 2> : H, alkyl, alkenyl, allenyl, allenyl alkyl, alkynyl, or cyanoalkyl, aryl, aralkyl, arylcarbonyl, aralkylcarbonyl, pyridinyl, pyridinylalkyl, pyridinylcarbonyl, (aryl and pyridinyl groups being optionally substituted by halogen, alkyl, alkoxy, cyanoalkyl, -(CH 2) k-Z 8>R 6> 3>,or -(CH 2) k-COR 6> 4>); R 6> 1> : H, alkyl, allenyl, allenyl alkyl, alkenyl, alkynyl, cyanoalkyl, alkoxy or -NR 6> 5>R 6> 6>; R 6> 5> and R 6> 6> : H, alkyl, allenyl, allenyl alkyl, alkenyl, alkynyl, or cyanoalkyl; Z 8> : -O-, -S- or -NR 6> 7>-; R 6> 3> and R 6> 7> : H, alkyl, allenyl, allenyl alkyl, alkenyl, alkynyl, or cyanoalkyl; R 6> 4> : H, alkyl, allenyl alkyl, alkenyl, alkynyl, cyanoalkyl, alkoxy or -NR 6> 8>R 6> 9>; R 6> 8> and R 6> 9> : H, alkyl, allenyl, allenyl alkyl, alkenyl, alkynyl, or cyanoalkyl; R 4> 8> : H, alkyl, alkynyl, or cyanoalkyl; g, p : 1 - 6; k, n : 0 - 6 [Image] Provisos apply, please see DEFINITIONS An independent claim is included for the use of (III), with the proviso that when (III) is (IIIA) then A is 4-hydroxy-2,3-di-tertiary butyl phenyl, B, R 1> and R 2> are H, and L* = OH, to make pharmaceutical compositions. ACTIVITY : Antiviral; antiinflammatory; analgesic; anticonvulsant, antiparkinsonian; cerebroprotective; hemostatic; nootropic; neuroprotective; neuroleptic; antimigraine; anabolic; anti-HIV, antidiabetic; cytostatic; dermatological; immunosuppressive. MECHANISM OF ACTION : Monoamine oxidase inhibitor; lipidic peroxidation inhibitor; sodium channel modulator.

15. 发明专利

HRP20041232A2 NOVEL ARYLIMIDAZOLE DERIVATIVES, PREPARATION AND THERAPEUTIC USES THEREOF 未知
公开(公告)号：HRP20041232A2
公开(公告)日：2005-02-28
申请号：HRP20041232
申请日：2004-12-30
申请人： SOD CONSEILS RECH APPLIC , SCIENT S C R A S S
发明人： BIGG DENNIS , LIBERATORE ANNE-MARIE , LASSAUNIERE PIERRE-ETIENNE CHA
IPC分类号： C07D233/64 , A61K31/4164 , A61K31/4178 , A61P1/04 , A61P1/14 , A61P3/04 , A61P3/10 , A61P9/00 , A61P9/06 , A61P9/10 , A61P11/00 , A61P11/02 , A61P11/06 , A61P15/00 , A61P15/10 , A61P15/12 , A61P17/02 , A61P17/06 , A61P19/02 , A61P21/00 , A61P25/00 , A61P25/02 , A61P25/04 , A61P25/06 , A61P25/08 , A61P25/14 , A61P25/16 , A61P25/18 , A61P25/20 , A61P25/22 , A61P25/24 , A61P25/28 , A61P25/32 , A61P25/36 , A61P27/02 , A61P27/16 , A61P29/00 , A61P29/02 , A61P31/12 , A61P31/18 , A61P31/22 , A61P33/00 , A61P35/00 , A61P37/06 , A61P37/08 , A61P39/02 , A61P43/00 , C07D409/12 , C07D409/14 , A61K31/417
摘要： Compounds of the formula wherein the substituents are as defined in the specification which are useful for the treatment of pain.

16. 发明专利

PL363640A1 SODIUM CHANNEL MODULATORS DERIVED FROM 2-PIPERIDYLIMIDAZOLES 未知
公开(公告)号：PL363640A1
公开(公告)日：2004-11-29
申请号：PL36364001
申请日：2001-12-27
申请人： SOD CONSEILS RECH APPLIC
发明人： BIGG DENNIS , POMMIER JACQUES , LIBERATORE ANNE-MARIE
IPC分类号： A61K31/415 , A61K31/445 , A61K31/454 , A61P1/04 , A61P9/06 , A61P9/10 , A61P25/00 , A61P25/02 , A61P25/04 , A61P25/06 , A61P25/08 , A61P25/16 , A61P25/24 , A61P25/28 , A61P43/00 , C07D401/04
摘要： The invention concerns novel sodium channel modulators derived from 2-piperidylimidazoles. The inventive compounds correspond to the general formula (I), wherein: R represents a hydrogen atom or an -X-Y-R radical wherein -X-Y represents a bond, a -CO-, -CO-O--CO-NH- or -CS-NH- radical and R represents an alkyl, haloalkyl, cycloalkyl, cycloalkylalkyl, aryl or aralkyl radical, said radicals being optionally substituted; R represents in particular an alkyl, cycloalkyl, cycloalkylalkyl or aryl radical optionally substituted; and R represents a hydrogen atom or an alkyl, cycloalkyl, cycloalkylalkyl, or aryl radical optionally substituted.

17. 发明专利

BR0210285A 未知
公开(公告)号：BR0210285A
公开(公告)日：2004-06-29
申请号：BR0210285
申请日：2002-06-14
申请人： SOD CONSEILS RECH APPLIC
发明人： BIGG DENNIS , POMMIER JACQUES , LIBERATORE ANNE-MARIE
IPC分类号： C07D233/06 , A61K31/00 , A61K31/415 , A61K31/4164 , A61K31/4174 , A61P1/12 , A61P9/06 , A61P25/04 , A61P25/08 , A61P25/24 , A61P25/28 , C07D233/10 , C07D233/54
摘要： A method of treating cardiac rhythm disorders linked with neurodegenerating depression, bipolar disorders and irritable bowel disorders in warm-blooded animals in need thereof by administering a compound of the formula wherein the substituents are defined as in the specification.

18. 发明专利

ZA200305005B Sodium channel modulators derived from 2-piperidylimidazoles. 未知
公开(公告)号：ZA200305005B
公开(公告)日：2004-06-28
申请号：ZA200305005
申请日：2003-06-26
申请人： SOD CONSEILS RECH APPLIC
发明人： BIGG DENNIS , LIBERATORE ANNE-MARIE , POMMIER JACQUES
IPC分类号： A61K31/415 , A61K31/445 , A61K31/454 , A61P1/04 , A61P9/06 , A61P9/10 , A61P25/00 , A61P25/02 , A61P25/04 , A61P25/06 , A61P25/08 , A61P25/16 , A61P25/24 , A61P25/28 , A61P43/00 , C07D401/04 , C07D , A61K
摘要： The invention concerns novel sodium channel modulators derived from 2-piperidylimidazoles. The inventive compounds correspond to the general formula (I), wherein: R represents a hydrogen atom or an -X-Y-R radical wherein -X-Y represents a bond, a -CO-, -CO-O--CO-NH- or -CS-NH- radical and R represents an alkyl, haloalkyl, cycloalkyl, cycloalkylalkyl, aryl or aralkyl radical, said radicals being optionally substituted; R represents in particular an alkyl, cycloalkyl, cycloalkylalkyl or aryl radical optionally substituted; and R represents a hydrogen atom or an alkyl, cycloalkyl, cycloalkylalkyl, or aryl radical optionally substituted.

19. 发明专利

AR035613A1 COMPUESTO DERIVADO DE 2-PIPERIDILIMIDAZOL, COMPOSICION FARMACEUTICA QUE LO COMPRENDE Y SU USO EN LA FABRICACION DE UN MEDICAMENTO 未知
公开(公告)号：AR035613A1
公开(公告)日：2004-06-16
申请号：ARP010106102
申请日：2001-12-28
申请人： SOD CONSEILS RECH APPLIC
发明人： BIGG DENNIS , POMMIER JACQUES , LIBERATORE ANNE-MARIE
IPC分类号： A61K31/415 , A61K31/445 , A61K31/454 , A61P1/04 , A61P9/06 , A61P9/10 , A61P25/00 , A61P25/02 , A61P25/04 , A61P25/06 , A61P25/08 , A61P25/16 , A61P25/24 , A61P25/28 , A61P43/00 , C07D401/04 , C07D233/00 , C07D211/00
摘要： Compuesto derivado de 2-piperidilimidazol que tiene una fórmula general (1)m, en forma racémica o enantiomérica o cualquier combinación de dichas formas, donde: R1 representa un átomo de hidrógeno o un radical -X-Y-R4 donde -X-Y- representa una unión, un radical -CO-, -CO-O-, -CO-NH- o -CSNH- y R4 representa un radical alquilo, haloalquilo, cicloalquilo, cicloalquilalquilo, arilo o aralquilo, donde dicho radical aralquilo o arilo está sustituido opcionalmente entre 1 y 4 veces sobre el radical arilo por uno o más radicales que se eligen entre un átomo de halógeno y un radical alquilo, oxhidrilo o alcoxi; R2 representa un alquilo, cicloalquilo, cicloalquilalquilo, o radical arilo, donde dicho arilo está sustituido opcionalmente entre 1 y 4 veces por uno o más radicales que se eligen entre un átomo de halógeno y un radical alquilo, haloalquilo, hidroxi, alcoxi, alquiltio, ciano, nitro, NR5R6, SO2R7, arilamino o arilo, donde dicho arilamino o arilo está sustituido opcionalmente entre 1 y 4 veces sobre el grupo arilo por uno o más radicales que se eligen entre un átomo de halógeno y un radical alquilo, hidroxi, alcoxi o alquiltio; R5 y R6 representan independientemente un átomo de hidrógeno o un radical alquilo o R5 y R6 forman junto con el átomo de nitrógeno ya presente, un heterociclo con entre 5 y 7 miembros cuyos miembros adicionales se eligen entre -CH2-, -O-, -S- y -NR8-; R7 representa independientemente cada vez que interviene, un radical alquilo; R8 representa independientemente cada vez que interviene, un átomo de hidrógeno o un radical alquilo, haloalquilo, cicloalquilo, cicloalquilalquilo, arilo o aralquilo, donde dicho radical aralquilo o arilo está sustituido opcionalmente entre 1 y 4 veces sobre el radical arilo por uno o más radicales que se eligen entre un átomo de halógeno y un radical alquilo, oxhidrilo o alcoxi, o R2 representa el radical (2), donde R9, R10, R11, R12 y R13 representan, independientemente, un átomo de hidrógeno, un halógeno, el grupo OH o un radical alquilo o alcoxi; R14 representa un átomo de hidrógeno o un radical alquilo, y W no existe, o representa una unión, u -O-, -S- o -NR15-, donde R15 representa un átomo de hidrógeno o un radical alquilo, o también R2 representa el radical (3) donde R16 representa un átomo de hidrógeno o un radical alquilo, y T representa un radical -(CH2)m- con m= 1 o 2; o finalmente R2 representa el radical (4), donde R17 representa un átomo de hidrógeno o un radical alquilo; -Sigma-NR18R19 o -Sigma-CHR20R21, Sigma representa un radical alquileno lineal o ramificado que contiene C1-6; R18 y R19 representan, independientemente, un átomo de hidrógeno o un radical alquilo; R20 y R21 representan, independientemente, un átomo de hidrógeno o un radical arilo carbocíclico o heterocíclico sustituido opcionalmente entre 1 y 4 veces por uno o más sustituyentes que se eligen independientemente entre los radicales alquilo, OH, halógeno, nitro, alcoxi y NR22 R23; R22 y R23 representan independientemente, un átomo de hidrógeno o un radical alquilo; y T representa un radical -(CH2)m- con m= 1 o 2; y R3 representa un átomo de hidrógeno o un alquilo, cicloalquilo, cicloalquilalquilo, o radical arilo, donde dicho arilo está sustituido opcionalmente entre 1 y 4 veces por uno o más radicales que se eligen entre un átomo de halógeno y un radical alquilo, haloalquilo, hidroxi, alcoxi, alquiltio, ciano, nitro, NR24R25, SO2R26 o arilo sustituido opcionalmente entre 1 y 4 veces por uno o más radicales que se eligen entre un átomo halógeno y un radical alquilo, hidroxi, alcoxi o alquiltio; R24 y R25 representan independientemente un átomo de hidrógeno o un radical alquilo o R24 y R25 forman junto con el átomo de nitrógeno ya presente, un heterociclo con entre 5 y 7 miembros cuyos miembros adicionales se eligen entre --H-, -O-, -S- y -NR28-; R26 representa independientemente cada vez que interviene, un radical alquilo; y R28 representa independientemente cada vez que interviene, un átomo de hidrógeno o un radical alquilo; se entiende sin embargo que cuando R7 no representa una de los radicales (2), (3) o (4), R1 no representa un radical que se selecciona entre un átomo de hidrógeno, un radical alquilo, un radical alcoxi o un radical arilo opcionalmente sustituido; o las sales farmacéuticamente aceptables de los compuestos de fórmula general (1)m. También se describe una composición farmacéutica que comprende compuestos derivados de 2-piperidilimidazol y el uso de este tipo de compuesto en la preparación de un medicamento que tenga una actividad moduladora sobre los canales de sodio. Estos compuestos son muy útiles por ejemplo en el tratamiento o prevención del dolor, el tratamiento de la epilepsia, en el tratamiento de desórdenes del ritmo cardíaco, en el tratamiento de desórdenes relacionados con la neurodegeneración, en el tratamiento de síndrome de intestino irritable y en el tratamiento de retinopatías diabéticas.

20. 发明专利

BR0116581A 未知
公开(公告)号：BR0116581A
公开(公告)日：2004-01-06
申请号：BR0116581
申请日：2001-12-27
申请人： SOD CONSEILS RECH APPLIC
发明人： BIGG DENNIS , POMMIER JACQUES , LIBERATORE ANNE-MARIE
IPC分类号： A61K31/415 , A61K31/445 , A61K31/454 , A61P1/04 , A61P9/06 , A61P9/10 , A61P25/00 , A61P25/02 , A61P25/04 , A61P25/06 , A61P25/08 , A61P25/16 , A61P25/24 , A61P25/28 , A61P43/00 , C07D401/04
摘要： The invention concerns novel sodium channel modulators derived from 2-piperidylimidazoles. The inventive compounds correspond to the general formula (I), wherein: R represents a hydrogen atom or an -X-Y-R radical wherein -X-Y represents a bond, a -CO-, -CO-O--CO-NH- or -CS-NH- radical and R represents an alkyl, haloalkyl, cycloalkyl, cycloalkylalkyl, aryl or aralkyl radical, said radicals being optionally substituted; R represents in particular an alkyl, cycloalkyl, cycloalkylalkyl or aryl radical optionally substituted; and R represents a hydrogen atom or an alkyl, cycloalkyl, cycloalkylalkyl, or aryl radical optionally substituted.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式